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iii型前胶原     
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  type iii procollagen
     Objective To study the relationship between level of Type III procollagen (PCIII),hyaluronic acid (HA),laminin(Ln) and hepatic fibrosis.
     目的  探讨慢性病毒性肝炎血清纤维化指标III型前胶原 (PCIII) ,透明质酸 (HA)及层粘蛋白 (Ln)水平与肝纤维化程度的关系。
短句来源
     Objective To explore the relation of serum levels of hyaluronic acid(HA),laminin(LN),type III procollagen(PCIII)and type IV collagen(IV-C)with the degree of hepatic fibrosis.
     目的 研究肝纤维化指标血清透明质酸(HA)、层粘连蛋白(LH)、III型前胶原肽(PCIII)及4型胶原(IVC)水平与肝纤维化程度的关系。
短句来源
     To evaluate the expression of type I procollagen and type III procollagen mRNA by Qidan Granuless on Bleomycin induced pulmonary fibrosis in rats and to explore its pathogenesis, 160 SD rats in good conditions were randomly divided into six groups:normal control group, model group, Qidan Granules group(G1,G2) and hydrocortisonum group(H1,H2).
     观察芪丹颗粒对博莱霉素致肺纤维化鼠的I型前胶原和III型前胶原mRNA表达的影响,探讨其作用机制。 用160只SD大鼠按随机区组设计分为对照组(N)、模型组(M)、芪丹颗粒剂1组和2组(Q1、Q2)、氢化可的松1组和2组(H1、H2)共6组。
短句来源
  procollagen iii
     Effects of Qidan Granules on the Expression of Procollagen I and Procollagen III mRNA in Pulmonary Fibrosis Rats Induced by Bleomycin
     芪丹颗粒剂对肺纤维化鼠I型前胶原和III型前胶原mRNA表达的影响(英文)
短句来源
     untreated group? prescription group with wester medicine? group with yanxuesan,after the rabbits had been fed and administrated for 7 weeks,the concentrations of Fe 2+and protein,the activity of superoxide dismutast (SOD) and the concentrations of procollagen III (pcIII) and IV collagen (IVC) were detected.
     方法 :用兔自体血造成玻璃体积血模型 ,设立空白对照组、模型对照组、尿激酶对照组及根据祛瘀化痰法组方的眼血散治疗组 ,7W后观察检测玻璃体Fe2 + 浓度、蛋白浓度、超氧化物歧化酶 (Superoxidedismutase,SOD)活性及III型前胶原 (PCIII)、IV型胶原 (IVC)浓度。
短句来源
     7.All rats in group D and E were sacrificed on week 10. Liver function and levels of serum hyaluronic acid (HA), mucin (LN), collegen type IV (CIV), procollagen III (PCIII) were tested;
     检测大鼠肝功能,血清透明质酸(HA),层粘蛋白(LN),III型前胶原(PcIII),IV型胶原(CIV);
短句来源
  iii procollagen
     The expression of III procollagen mRNA in Qidan Granules group was highest at 14 day and was higher than Hydrocortisone group(P<0.05).
     芪丹组III型前胶原mRNA的表达在第14天处于最高,至28天仍维持较高的水平,芪丹组III型前胶原mRNA的表达高于模型组和氢可组(P<0.05)。
短句来源
     Qidan Granules may alleviate the process of rat pulmonary fibrosis through influence the expression of I procollagen and III procollagen mRNA.
     芪丹颗粒可减轻博莱要素诱导大鼠肺泡炎及肺纤维化的程度,其机制可能通过影响了I型和III型前胶原mRNA的代谢和表达,从而减慢肺间质纤维化的进程。
短句来源
     Objective To study the relationship between level of Type III procollagen (PCIII),hyaluronic acid (HA),laminin(Ln) and hepatic fibrosis.
     目的  探讨慢性病毒性肝炎血清纤维化指标III型前胶原 (PCIII) ,透明质酸 (HA)及层粘蛋白 (Ln)水平与肝纤维化程度的关系。
短句来源
     To evaluate the expression of type I procollagen and type III procollagen mRNA by Qidan Granuless on Bleomycin induced pulmonary fibrosis in rats and to explore its pathogenesis, 160 SD rats in good conditions were randomly divided into six groups:normal control group, model group, Qidan Granules group(G1,G2) and hydrocortisonum group(H1,H2).
     观察芪丹颗粒对博莱霉素致肺纤维化鼠的I型前胶原和III型前胶原mRNA表达的影响,探讨其作用机制。 用160只SD大鼠按随机区组设计分为对照组(N)、模型组(M)、芪丹颗粒剂1组和2组(Q1、Q2)、氢化可的松1组和2组(H1、H2)共6组。
短句来源
     Objective To explore the relation of serum levels of hyaluronic acid(HA),laminin(LN),type III procollagen(PCIII)and type IV collagen(IV-C)with the degree of hepatic fibrosis.
     目的 研究肝纤维化指标血清透明质酸(HA)、层粘连蛋白(LH)、III型前胶原肽(PCIII)及4型胶原(IVC)水平与肝纤维化程度的关系。
短句来源
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  precollagen iii
     Methods Hepatic fibrosis was induced in rats by intraperitoneal injection of 0.5ml porcine serum twice a week. Gantaikang was simultaneously administered intragastrically to rats in the intervention group at dose of 0.27g/kg·bw for 7 weeks. Then blood was collected, and serum levels of hyaluronic acid(HA), laminin(LN) and precollagen III(PCIII) were measured.
     方法 采用猪血清腹腔注射 ( 0 5ml/鼠 )建立大鼠免疫性肝纤维化模型 ,干预组造模同时给予甘泰康 ( 0 2 7g/kg·bw)灌胃 ,7周后采血 ,测定血清透明质酸 (HA)、层粘连蛋白 (LN)、III型前胶原 (PCIII)含量 ;
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      type iii procollagen
    Differential patterns of PMN-elastase and type III procollagen peptide in knee joint effusions due to acute and chronic sports i
          
    mRNA expression of type III procollagen was markedly increased in the allografts of the recipients infused with TGF-β-DC.
          
    Transpulmonary gradient of type III procollagen peptides: Acute effects of cardio-pulmonary bypass
          
    Type III procollagen N-peptides (PIIINPs) are believed to be released in stoichiometric amounts as type III collagen molecules are secreted from cells.
          
    Assessment of hepatic graft injury by graft effluent in rodents: N-acetyl-β-glucosaminidase and type III procollagen peptide
          
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      procollagen iii
    Their liver fibrosis criteria were examined before and after treatment.Results: The levels of serum procollagen III, hyaluronic acid, collagen IV, laminin in the two groups were significantly lower (P>amp;lt;0.
          
    Pancreatic tissue was examined using light microscopy, hydroxyproline measurement and indirect immunofluorescence, using antibodies against collagen types I, III, IV, procollagen III, fibronectin and laminin.
          
    Therefore, we aimed to analyze circulating levels of laminin, fibronectin, and procollagen III peptide (PIIIP) in patients with chronic pancreatitis (CP) and to correlate them with the morphological and functional stage, and duration of the disease.
          
    In 38 traumatic knee joint effusions the proteolytic enzyme PMN-elastase (PMN-E) and the repair marker procollagen III aminoterminal peptide (PIIINP) were determined.
          
    Only SF-126 was positively identified by immunostains for procollagen III; this was also the only cell line in which DEAE-cellulose chromatography and SDS-PAGE demonstrated interstitial collagen synthesis.
          
    更多          
      iii procollagen
    Differential patterns of PMN-elastase and type III procollagen peptide in knee joint effusions due to acute and chronic sports i
          
    mRNA expression of type III procollagen was markedly increased in the allografts of the recipients infused with TGF-β-DC.
          
    Transpulmonary gradient of type III procollagen peptides: Acute effects of cardio-pulmonary bypass
          
    Type III procollagen N-peptides (PIIINPs) are believed to be released in stoichiometric amounts as type III collagen molecules are secreted from cells.
          
    Assessment of hepatic graft injury by graft effluent in rodents: N-acetyl-β-glucosaminidase and type III procollagen peptide
          
    更多          


    ype Ⅲ procollagen (PⅢP) hyaluronic acid(HA) and fibronectin (Fn) were assayed in patientswith COPD. with radio-immunoassay (RIA ). The re-sults were shown as follows : The mean levels of PⅢP,HA were significantly higher than thosc of normal (P<0. 05,<0.05). Plasma Fn was consistantly in lowerlevel in COPD(P<0.05). It is suggested that PⅢP,HA and Fn played a role in development of pulmonaryfibrosis and quantification of such collagen contents maybe a sensitive index to assess ihe degree of Pulmonary fi-brosis...

    ype Ⅲ procollagen (PⅢP) hyaluronic acid(HA) and fibronectin (Fn) were assayed in patientswith COPD. with radio-immunoassay (RIA ). The re-sults were shown as follows : The mean levels of PⅢP,HA were significantly higher than thosc of normal (P<0. 05,<0.05). Plasma Fn was consistantly in lowerlevel in COPD(P<0.05). It is suggested that PⅢP,HA and Fn played a role in development of pulmonaryfibrosis and quantification of such collagen contents maybe a sensitive index to assess ihe degree of Pulmonary fi-brosis and to predict the prognosis of patients withCOPD.

    采用放射免疫法测定慢性阻塞性肺疾病(COPD)患者血清III型前胶原肽(PIIIP)、透明质酸(HA)及血浆纤维结合蛋白(Fn)水平。结果表明,COPD患者血清PIIIP、HA明显高于对照组,而血浆Fn则显著降低,提示PIIIP、HA及Fn在COPD患者的致肺纤维化中具有一定作用,是反映COPD肺纤维化倾向的一种敏感指标,对判断预后具有临床意义。

    Diagnostic methods of liver fibrosis including pathological, serological and iconographical detections. Serological index of liver fibrosis including type III pro-collagen amino peptide, laminin P1, hyaluronic acid, type IV, VI collagens in serum, matrix metalloproteinase and it correlate to liver fibrosis degree. Treat of antifibrosis including for terament of primary disease development.

    肝纤维化的诊断手段主要包括病理组织学检查、血清学指标检测及影像学检查 ,其中肝活检组织病理学检查是诊断肝纤维化和肝硬化的”金标准” ,但也有其局限性 ,肝纤维化的血清学指标包括血清III型前胶原氨基端肽、血清层连蛋白P1、血清透明质酸、血清IV胶原、血清VI型胶原、基质金属蛋白酶等 ,这些指标和肝组织病理学纤维化程度有较好的相关性。抗纤维化的治疗包括针对原发病的病因治疗和针对抗肝纤维化本身的治疗。本文对此作一综述。

    OBJECTIVE To investigate the anti fibrosis effect of Zhijuzi on experimental hepatic fibrosis in rats. METHODS Rat liver fibrotic model was created by carbon tetrachloride(CCl 4).The serum hyaluronic acid,PCI,PC III and TGF β 1 were observed .Histological examination was also done. RESULTS The liver fibrosis induced by CCl 4 was ameliorated,meanwhile,HA,PCI,PC III and TGF β 1 were decreased. On the other hand, the anti fibrotic effect of zhijuzi was also demonstrated by the histological examination.CONCLUSIONS...

    OBJECTIVE To investigate the anti fibrosis effect of Zhijuzi on experimental hepatic fibrosis in rats. METHODS Rat liver fibrotic model was created by carbon tetrachloride(CCl 4).The serum hyaluronic acid,PCI,PC III and TGF β 1 were observed .Histological examination was also done. RESULTS The liver fibrosis induced by CCl 4 was ameliorated,meanwhile,HA,PCI,PC III and TGF β 1 were decreased. On the other hand, the anti fibrotic effect of zhijuzi was also demonstrated by the histological examination.CONCLUSIONS Zhijizi may be useful for the treatment of hepatic fibrosis.

    目的 :研究枳栉具子提取物的体内抗肝纤维化作用。方法 :用四氯化碳 (CCl4 )建立大鼠肝纤维化模型 ,造模开始后即给予枳栉具子提取物。实验结束后测定肝纤维化指标透明质酸、III型前胶原、I型前胶原及细胞生长转化因子 (HA、PCI、PCIII及TGF β1 )并作肝病理检查。结果 :枳栉具子提取物能显著降低血清HA、PCI、PCIII及TGF β1 含量 ;减轻肝脏胶原纤维增生程度。结论 :说明枳栉具子具有抗早期肝纤维化作用。

     
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