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ad小鼠
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  ad mice
     The Effect of Soybean Isoflavone Active Extracts on Nerve Cells in Brain and Serum Lipoprotein and SOD Activities in AD Mice
     大豆异黄酮活性组分对AD小鼠脑海马神经元及血脂水平血清SOD活力的影响
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     Results GCs markedly enhanced the ability of learning and memory which induce by β-AP in AD mice and increased the activity of SOD and GSH-Px,and reduced MDA contents in mice brain;
     结果GCs可提高β-AP所致AD小鼠学习记忆水平; 降低脑组织MDA含量,提高SOD及GSH-Px活性;
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     Conclusions Nao Er Kang could protect mice from learning and memory disorders caused by AlCl3 by regulating expression of apoptosis-related genes in AD mice brain so that it had anti-dementia effects.
     结论 脑尔康能改善 AD小鼠学习记忆障碍具有促智作用 ,可通过调控凋亡相关基因表达 ,抗脑细胞凋亡 ,减少神经元丢失 ,而发挥抗痴呆作用
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     Conclusion: The soybean isoflavone active extracts can regulate the level of the lipoprotein in AD mice,and improve serum SOD activity.
     结论:大豆异黄酮活性组分能有效调节AD小鼠的血脂的水平,显著提高血清SOD的活性。
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     Conclusions GCs significantly improves the ability of learning and memory induced by β-AP in AD mice and its possible mechanism of action may involve: Enhancement of free radical scavengers; inhibition of lipid peroxidation; inhibition of β-AP precipitation and apoptosis in mice brain cells induced by β-AP.
     结论GCs对β-淀粉样肽所致AD小鼠学习记忆能力提高,其作用机制可能与其增强自由基清除酶活性,防止脂质过氧化作用,抑制β-AP在脑内的沉积及抑制脑细胞凋亡有关。
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  ad model mice
     HS2 can meliorate AD model mice' learning and memory deficiency and sustain the normal levels of Ach, AchE, as well as decrease the mRNA content of APP, PS1, BACE and senile plaque in their brains.
     不同剂量的HS_2能改善AD小鼠的学习记忆能力和恢复脑内Ach、AchE水平,降低APP、PS1和BACE mRNA的含量,减少脑内Aβ沉积所形成的老年斑。
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     Conclusion HS 2 can meliorate AD model mice's learning and memory deficiency as well as decrease the mRNA content of PS1, BACE and senile plaque in their brains.
     结论 不同剂量的HS2 能改善AD小鼠的学习记忆能力 ,降低PS1,BACEmRNA的含量 ,减少脑内Aβ沉积所形成的老年斑
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     Resluts By oral administration with HS 2, the capacity of learning and memory of the AD model mice was improved. HS 2 can downregulate the expression of PS1, BACE and decrease the amount of senile plaque in their brains.
     结果 低、中、高剂量的HS2 均能改善AD小鼠学习记忆 ,下调PS1和BACE基因的表达 ,减少老年斑的生成。
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  “ad小鼠”译为未确定词的双语例句
     Therapeutic effect of mouse embryonic neural stem cells replacement into hippocampus of APP/PS1 double transgenic mice of Alzheimer disease
     小鼠胚胎神经干细胞海马移植对APP/PS1双转基因AD小鼠的治疗作用
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     1. AD model
     1.AD动物模型的建立1.1 铝毒性拟AD小鼠模型的建立
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     Identification of the APP/PS1 Double Transgenic Alzheimer's Disease Mouse Model and the Relation between BMP4 Expression and the Cell Proliferation in the Hippocampus
     APP/PS1双转基因AD小鼠的鉴定及BMP4与其海马细胞增殖的关系
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     Methods AD animal model was established by a single intracerebroventricular injection of micromolar doses of β-AP_(25-35) in mice.
     方法采用小鼠脑室内一次性微量注射β-AP25-35诱发β-AP在脑内的沉积,造成AD小鼠模型。
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     With regard to this purpose, an experimental study and an epidemiological study were conducted: 1. to explore the efficiency and safety of Aβclearance from the brain of a transgenic AD mouse model, by transfecting a gene encoding an anti-Aβsingle chain antibody variable fragment (scFv).
     为此,本研究开展了AD防治的基础和流行病学两个部分的研究:1.通过在体转染人源性抗淀粉样物质(Amyloid-beta, Aβ)单链抗体基因来清除转基因AD小鼠模型脑内Aβ,探索AD防治的新方法。
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  ad mice
Passive immunization of transgenic AD mice caused a significant and rapid reduction in brain amyloid plaques within 24?h.
      
Accordingly, overexpression of the antioxidant enzyme superoxide dismutase 1 (SOD1) in neuronal cells and transgenic AD mice reduces Aβ toxicity and accumulation.
      
  ad model mice
Here we report the establishment of AD model mice, B6Tg2576, that are prone to atherosclerosis.
      


Objective To investigate the change of dopamine D 2 receptor and its relationship with memory in Alzheimer disease (AD) model rate using D 2 imaging agent 125 I IBZM.\ Methods\ AD model rats which memory loss similar to the amnesia of AD patients were established by giving muscarinic receptor antagonist scopolamine(Sco). 125 I IBZM was injected into the model and control rats through the tail vein, 2h after injection the brains were rapidly removed, sectioned coronally with a microtome,...

Objective To investigate the change of dopamine D 2 receptor and its relationship with memory in Alzheimer disease (AD) model rate using D 2 imaging agent 125 I IBZM.\ Methods\ AD model rats which memory loss similar to the amnesia of AD patients were established by giving muscarinic receptor antagonist scopolamine(Sco). 125 I IBZM was injected into the model and control rats through the tail vein, 2h after injection the brains were rapidly removed, sectioned coronally with a microtome, exposed and developed into autoradiogram and analyzed in GS 250 image analysis system.\ Results\ After they were given Sco, the rats recent memory degenerated, the number of 10d (group Ⅰ) and 40d (group Ⅱ) model rats hit by electrical stimulus were (0.86±0.12)min -1 and (0.92±0.16)min -1 respectively. It was significantly more than that of the control rats (0.26±0.04)min -1 and (0.22±0.06)min -1 ( t=13.54,11.91,P <0.05), and there also showed significant difference between Ⅰ and Ⅱ model group ( t=2.89,P <0.05). The 125 I IBZM D 2 autoradiography and analysis showed that the striatum (ST)/frontal cortex(FC) uptake ratio was 4.173±0.281, 2.897±0.27 for Ⅰ and Ⅱ model rats, respectively, it was lower than that of the control rats ( t=5.87,7.16,P <0.05), and it was significant difference between Ⅰ and Ⅱ model group ( t=3.21,P <0.05).\ Conclusion\ D 2 imaging agent 125 I IBZM could sensitively reflect the reduction of D 2 receptor in ST in AD model which consistent with the memory loss. We suppose that the D 2 imaging might afford an important molecular nuclear medical measure to clarify the mchanism of AD. [

1目的 探讨阿尔茨海默病 (AD)小鼠模型多巴胺 D2 受体的变化及其与记忆等变化之间的关系。 2方法 采用毒蕈碱 (M)受体阻断剂东莨菪碱 (Sco)建立与 AD记忆障碍相似的小鼠模型 ,分别给予模型及对照组小鼠尾静脉注射 1 2 5 I- IBZM,2 h后断头、取脑 ,行冠状面冷冻切片放射自显影及图像分析。 3结果 模型 10 d( )组及40 d ( )组遭电击次数分别为 (0 .86± 0 .12 ) m in- 1 ,(0 .92± 0 .16 ) min- 1 ,而对照组分别为 (0 .2 6± 0 .0 4) min- 1 和(0 .2 2± 0 .0 6 ) min- 1 ,与对照组比较差异有显著性 (t=13.5 4,11.91,P<0 .0 5 ) ;模型组间比较差异有显著性 (t=2 .89,P<0 .0 5 )。 D2 受体放射自显影图像分析示 , 组脑纹状体 (ST) /额叶 (FC)放射性摄取比值分别为 4.173±0 .2 81,3.897± 0 .2 74,均明显低于对照组 (t=5 .87,7.16 ,P<0 .0 5 ) ; , 组间比较差异显著 (t=3.2 1,P<...

1目的 探讨阿尔茨海默病 (AD)小鼠模型多巴胺 D2 受体的变化及其与记忆等变化之间的关系。 2方法 采用毒蕈碱 (M)受体阻断剂东莨菪碱 (Sco)建立与 AD记忆障碍相似的小鼠模型 ,分别给予模型及对照组小鼠尾静脉注射 1 2 5 I- IBZM,2 h后断头、取脑 ,行冠状面冷冻切片放射自显影及图像分析。 3结果 模型 10 d( )组及40 d ( )组遭电击次数分别为 (0 .86± 0 .12 ) m in- 1 ,(0 .92± 0 .16 ) min- 1 ,而对照组分别为 (0 .2 6± 0 .0 4) min- 1 和(0 .2 2± 0 .0 6 ) min- 1 ,与对照组比较差异有显著性 (t=13.5 4,11.91,P<0 .0 5 ) ;模型组间比较差异有显著性 (t=2 .89,P<0 .0 5 )。 D2 受体放射自显影图像分析示 , 组脑纹状体 (ST) /额叶 (FC)放射性摄取比值分别为 4.173±0 .2 81,3.897± 0 .2 74,均明显低于对照组 (t=5 .87,7.16 ,P<0 .0 5 ) ; , 组间比较差异显著 (t=3.2 1,P<0 .0 5 )。4结论 多巴胺 D2 受体示踪剂 1 2 5 I- IBZM能够敏感地反映出 AD模型鼠 ST D2 受体的下降 ,D2 受体显像将为阐明AD的发病机制提供重要的分子核医学手段。

Applying scopolamine and ischemia\|reperfustion to establish murine models for Alzheimer's disease(AD) and vascular dementia(VD),respectively,might help explicate the formula mechanism of Danggui Shaoyao San(DSS).In comparison with the normal group,step\|through latency taken by mice injured with scopolamine got shortened( P<0.01 ),step\|through and step\|down number of errors increased ( P<0.05~0.01 );Both drugs used to promote blood circulation and nourish the blood (DCS) and drugs used to nourish the...

Applying scopolamine and ischemia\|reperfustion to establish murine models for Alzheimer's disease(AD) and vascular dementia(VD),respectively,might help explicate the formula mechanism of Danggui Shaoyao San(DSS).In comparison with the normal group,step\|through latency taken by mice injured with scopolamine got shortened( P<0.01 ),step\|through and step\|down number of errors increased ( P<0.05~0.01 );Both drugs used to promote blood circulation and nourish the blood (DCS) and drugs used to nourish the spleen and disperse the pathogenic damp (FBZ) in DSS at low dosage,made step\|through latency longer ( P<0.05 ),decreased obviously step\|through and step\|down number of errors ( P<0.05~0.01 ).If DCS and FBZ were in combination with each other,their cooperative melioration would be furthered;Compared with the sham operational group,step\|through latency taken by ICR mice injured with ischemia\|reperfusion got shortened( P<0.01 ),step\|through number of errors increased ( P<0.01 ),However,it was FBZ other than DCS that could at high dosage elongate step\|through latency ( P<0.05 ),decrease obviously step\|through number of errors ( P<0.01 ),antagonize selectively the memory impairment of ICR mice induced by ischemia\|reperfusion,those discovery maybe indicated that to nourish the spleen and disperse the pathogenic damp played a more important role in the prevention and treatment of senile dementia than to promote blood circulation and nourish the blood.

分别用东莨菪碱与反复缺血再灌注制备阿尔采末病 (AD)与血管性痴呆 (VD)模型 ,考察当归芍药散 (DSS)防治老年期痴呆的配伍机理。避暗法与跳台法检测发现 ,AD组较正常组潜伏期缩短 (P <0 .0 1) ,错误次数增多 (P <0 .0 5~ 0 .0 1) ;VD组较假手术组潜伏期缩短 (P <0 .0 1) ,错误次数增多 (P <0 .0 1) ,DSS中活血补血药组 (DCS)与健脾利湿药组 (FBZ)可协同延长AD小鼠潜伏期 ,减少错误次数 (P <0 .0 5~ 0 .0 1) ;对VD小鼠 ,仅FBZ可延长潜伏期 (P <0 .0 5 ) ,减少错误次数 (P <0 .0 1) ,提示FBZ较DCS可能具有更大的防治意义。

Objective: To investigate Chinese herbs with the effect on significantly improving the cognitive function and retention of patients with Alzheimer's disease. Method: AD mouse models were established by injecting poly β AP 25 35 into the cerebral ventricle of mice. The curative effects of traditional Chinese herbs Dangguishaoyaosan, Chaihujialonggumulitang and two herbs (CHP Ⅰ and CHP Ⅱ) developed by the authors on improving the memory and cognitive function of AD mouse models were studied by the detection...

Objective: To investigate Chinese herbs with the effect on significantly improving the cognitive function and retention of patients with Alzheimer's disease. Method: AD mouse models were established by injecting poly β AP 25 35 into the cerebral ventricle of mice. The curative effects of traditional Chinese herbs Dangguishaoyaosan, Chaihujialonggumulitang and two herbs (CHP Ⅰ and CHP Ⅱ) developed by the authors on improving the memory and cognitive function of AD mouse models were studied by the detection of behavioral and histochemical tests, with piracetam serving as control. Result: CHP II has profound curative effects on improving the memory and cognitive function of AD like animal model. Conclusion: The present study indicates that it has a satisfactory prospect to seek new drugs from Chinese herbs to treat AD.

目的 :探索对阿尔茨海默病 (AD)病人认知和记忆能力具有明显改善作用的中药方剂。方法 :通过Balb/c小鼠侧脑室微量注射聚集态 β 淀粉样多肽 (β AP2 5 35) ,建立模拟AD的小鼠动物模型 ,并通过行为学实验和脑组织组织化学检测 ,研究了中医经典药方柴胡加龙骨牡蛎汤、当归芍药散和作者自己研制的两种中药复方CHPI和CHPⅡ对该小鼠模型认知和记忆能力的疗效作用。同时 ,以西药脑复康做对照。结果 :CHPⅡ对AD模型小鼠的认知和记忆能力具有明显的改善。结论 :本研究提示从中药中寻找治疗AD的药物具有较好的前景

 
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