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对氧磷
相关语句
  paraoxon
     Eight of them were specific for P4, four (1B3, 2B2, 3D5 and 4F1) could react to soman, their IC 50 were 10 -3 , 10 -3 , 10 -5 and 10 -6 mol/L respectively, and one (4F1) could recognize paraoxon, IC 50 being 10 -5 mol/L.
     4株 (1B3、2B2、3D5和 4F1)具有梭曼结合活性 ,其IC50 值分别为 10 -3 、10 -3 、10 -5和 10 -6mol/L ; 1株 (4F1)具有与对氧磷结合的特异性 ,其IC50 值为 10 -5mol/L。
短句来源
     The optimum hapten-carrier molecular ratios of paraoxon conjugated with Ta chypleus tridentatus hemocyanin, tetanus toxoid, diphtheria toxoid and bovine serum albumin are 300, 21-35, 19 and 11 mol/mol (10, 32-53, 30 and 17 mol/ 105daltons), respectively.
     中国鲎血蓝蛋白、破伤风类毒素、白喉类毒素和牛血清白蛋白与对氧磷偶合为人工抗原时最佳分子结合比分别为300,21-35,19和11mol/mol(10,32-53,30和17mol/15~5daltons)。
短句来源
     Inhibition studies of the esterases using four inhibitors (i. e., paraoxon, malaoxon, eserine, and carbaryl) indicated that most of general esterases in the two populations were B-type.
     用对氧磷、马拉氧磷、西维因及毒扁豆碱等 4种抑制剂对这两个种群飞蝗的酯酶进行体外抑制实验 ,结果表明 ,这两个种群的大部分酯酶属于 B-型。
短句来源
     The bimolecular rate con-stant of this reconstituted enzyme with paraoxon attained 9.0×10~8M~(-1)min~(-1).
     该重组酶与对氧磷反应的双分子速度常数高达9.0×10~8M~(-1)分~(-1)。
短句来源
     The Study of Photocatalytic Decomposition of Paraoxon Based on Nano-TiO_2 loaded on ITO Glass
     负载纳米TiO_2催化光降解有机农药对氧磷
短句来源
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  “对氧磷”译为未确定词的双语例句
     ① The frequency of paraoxonase 2 311C allele was significantly higher in the diabetic group than in the control group(43.6% ,31.1% ,χ 2=3.981,P< 0.05,OR=1.713, 95% confidential interval:1.007 to 2.914).
     ①糖尿病组对氧磷酯酶2C311等位基因频率显著高于对照组(43.6%,31.1%,χ2=3.981,P<0.05,OR=1.713,95%CI:1.007~2.914)。
短句来源
     Relationship between paraoxonase 2 S311C gene polymorphism and type 2 diabetes mellitus
     对氧磷酯酶2S311C基因多态性与2型糖尿病的关系
短句来源
     Objective To investigate the relationship between paraoxonase-1 (PON-1) activity and type 2 diabetes mellitus (T2DM) retinopathy (DR) in the elderly.
     目的探讨血清对氧磷酯酶1(PON1)活性与老年人2型糖尿病(T2DM)并发视网膜病变(DR)的关系。
短句来源
     Objective To study the relationship among serum PON1 activity, PON1Q/R192 polymorphism and atherothrombotic cerebral infarcton (ATCI) in Chinese Han people.
     目的研究中国汉族人对氧磷酯酶1(PON1)活性及PON1Q/R192基因多态性与动脉粥样硬化性血栓性脑梗死(ATCI)发病的关系。
短句来源
     Relation between paraoxonase 1 gene Q191R polymorphism and type 2 diabetes mellitus complicated with hypertension
     对氧磷酯酶1基因Q191R多态性与2型糖尿病合并高血压的关系
短句来源
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  相似匹配句对
     Production and identification of anti paraoxon monoclonal antibodies
     单克隆抗体的研制及鉴定
短句来源
     Synthesis and identification of methylparaoxon artificial antigen
     甲基人工抗原的合成及鉴定
短句来源
     THE IMMUNOLOGIC EFFECT OF PARAOXON-TETANUS TOXOID ON RABBITS
     -破伤风类毒素家兔免疫效果
短句来源
     Calculation for the example given in T.
     T.
短句来源
     nigrum and P.melanostipes.
     P.
短句来源
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  paraoxon
Serum hPON1 and liver hPON1 were determined using paraoxon as a substrate and IC50 values of these drugs exhibiting inhibition effects were found from graphs of hydratase activity (%) by plotting concentration of the drugs.
      
A new high-performance liquid chromatographic method with column-switching has been developed for the simultaneous determination of parathion and its metabolites such asp-nitrophenol and paraoxon in serum.
      
A multiresidue method for the analysis of 28 common organophosphorus pesticides and 3 of their main metabolites (paraoxon-ethyl, paraoxon-methyl and malaoxon) in a variety of crop samples has been developed.
      
Kinetic analysis suggests that the membrane transport of paraoxon is the rate-limiting step in its biodegradation.
      
The strains selected by parathion and diazinon gave rather similar resistant patterns, showing highest resistance to parathion, paraoxon and diazinon and low resistance to malathion.
      
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The antidotal effects of 2-PAM and TMB-4 were tested on mice against dipterex and paraoxon,organophosphorus compounds,in due consideration of the influence of animal sex and enviromental temperature.Results showed that there was no sex difference in the susceptibility of mice to DDVP and dipterex,but very signifi- cant difference did exist with paraoxon,the female mice being more susceptible.Enviromental temperature had marked influence on the toler- ance of mice toward organophosphorus poisoning. The toxicity...

The antidotal effects of 2-PAM and TMB-4 were tested on mice against dipterex and paraoxon,organophosphorus compounds,in due consideration of the influence of animal sex and enviromental temperature.Results showed that there was no sex difference in the susceptibility of mice to DDVP and dipterex,but very signifi- cant difference did exist with paraoxon,the female mice being more susceptible.Enviromental temperature had marked influence on the toler- ance of mice toward organophosphorus poisoning. The toxicity of DDVP was 20 times greater than dipterex.On account of its low solubility and toxicity,dipterex was not an ideal toxic agent for the screening of antidotes.TMB-4 was 1.4 times more toxic than 2-PAM,but on equivalent toxic basis the potency of the former was much greater than the latter in the treatment of paraoxon in- toxication in mice.When a low effective dose(10 mg/kg) of atropine sulfate was used in con- junction with 2-PAM or TMB-4,there was a very marked potentiation of the therapeutic effect of the latter two.The therapeutic index tests fur- ther confirmed the high potency and wide safety margin of the intramuscular injection of TMB-4. Both 2-PAM and TMB-4 when injected intraper- itoneally,could be rapidly absorbed.Their action lasted about two hours.

我们测定了有机磷杀虫剂0,0-二甲基-2,2,2-三氯代-1-羟乙基瞵酸酯(以下简称敌百虫);0,0-二甲基2,2-二氯乙烯瞵酸酯(简称敌敌畏,外文名为 DDVP)和二乙基-4硝基苯瞵酸酯(简称对氧磷,外文名 E600)的毒性,以及胆硷酯酶再激活药2-吡啶甲醛肟碘甲烷盐(简称2-PAM,商标名称为解磷毒)和双-4,4′-吡啶甲醛肟-N,N′二溴三甲烯盐(简称 TMB-4)对这些有机磷中毒动物的解救作用。不同性别的小白鼠对敌敌畏及敌百虫之敏感性无明显差别;但对于对氧磷却有明显不同,以雌性较敏感。小白鼠在不同室温时对有机磷之耐受性也有明显差异,室温过高或过低均使有机磷之毒性增加。敌敌畏之毒性比敌百虫大20倍。2-PAM 和阿托品单用时对敌百虫中毒小白鼠有明显的保护作用。2-PAM 和 TMB-4在毒性相当的基础上,对对氧磷中毒小白鼠之保护作用以 TMB-4较好,TMB-4能使对氧磷之半数致死量提高27~36倍;而2-PAM 只提高5倍。从治疗指数来看,也进一步证明 TMB-4的优越性;肌内注射吸收良好,而且疗效高,安全度大。阿托品单用时之疗效最差,但与2-PAM 或...

我们测定了有机磷杀虫剂0,0-二甲基-2,2,2-三氯代-1-羟乙基瞵酸酯(以下简称敌百虫);0,0-二甲基2,2-二氯乙烯瞵酸酯(简称敌敌畏,外文名为 DDVP)和二乙基-4硝基苯瞵酸酯(简称对氧磷,外文名 E600)的毒性,以及胆硷酯酶再激活药2-吡啶甲醛肟碘甲烷盐(简称2-PAM,商标名称为解磷毒)和双-4,4′-吡啶甲醛肟-N,N′二溴三甲烯盐(简称 TMB-4)对这些有机磷中毒动物的解救作用。不同性别的小白鼠对敌敌畏及敌百虫之敏感性无明显差别;但对于对氧磷却有明显不同,以雌性较敏感。小白鼠在不同室温时对有机磷之耐受性也有明显差异,室温过高或过低均使有机磷之毒性增加。敌敌畏之毒性比敌百虫大20倍。2-PAM 和阿托品单用时对敌百虫中毒小白鼠有明显的保护作用。2-PAM 和 TMB-4在毒性相当的基础上,对对氧磷中毒小白鼠之保护作用以 TMB-4较好,TMB-4能使对氧磷之半数致死量提高27~36倍;而2-PAM 只提高5倍。从治疗指数来看,也进一步证明 TMB-4的优越性;肌内注射吸收良好,而且疗效高,安全度大。阿托品单用时之疗效最差,但与2-PAM 或 TMB-4合用时可使对氧磷的半数致死量分别提高21~26倍和200~400倍,有非常显著的增强后二者保护效力之作用。阿托品、2-PAM 或 TMB-4腹腔注射后迅速吸收,作用维持约2小时左右。

The enzymic properties of the cholinesterase of the venom of Naja naja atra from Zhejiang Province, such as substrate specificity, substrate inhibition and inhibition by specific inhibitors BW_(284) C_(51) and BW_(62)C_(47) are similar to those from insoluble cell structures of other animal tissues.The optimum pH of the enzyme is pH7.5 in phosphate buffer, its optimum temperature for 5minute reactions is 38~39℃. The K_m value is 1.25×10~(-4) M. The enzyme activity in dilute solution is quickly lost but it may...

The enzymic properties of the cholinesterase of the venom of Naja naja atra from Zhejiang Province, such as substrate specificity, substrate inhibition and inhibition by specific inhibitors BW_(284) C_(51) and BW_(62)C_(47) are similar to those from insoluble cell structures of other animal tissues.The optimum pH of the enzyme is pH7.5 in phosphate buffer, its optimum temperature for 5minute reactions is 38~39℃. The K_m value is 1.25×10~(-4) M. The enzyme activity in dilute solution is quickly lost but it may be protected by 0.1% gelatin.Substrate inhibition curves for the crude venom and for purified enzymes give similar K_m values. They probably indicate that no modifications in enzyme structure have taken place during the purification procedure.The enzyme is inhibited by various organophosphorus compounds and carbamates. Certain quaternary ammonium salts also inhibit the enzyme.The venom of Naja naja atra is a highly toxic substance. The MLD of the crude venom for mice when given by intraperitoneal injection is 0.88μg/g. If the cholinesterase of the crude venom has been removed by affinity chromatography the MLD of the remaining components is 0.77 μg/g. 7.5 μg/g of purified cholinesterase injected to mice does not show any lethal effect. It is probable that cholinesterase is not responsible for the toxio action of the venom.

浙江眼镜蛇蛇毒胆碱酯酶具有乙酰胆碱酯酶的特征,有以下几点事实:1.乙酰胆碱酯是酶的最适底物;2.过量底物抑制酶活性;3.BW_(62)C_(47)、BW_(284)C_(51)是典型的真性酶抑制剂,对蛇毒胆碱酯酶也同样具有抑制作用。眼镜蛇蛇毒胆碱酯酶最适pH为7.5(0.1M磷酸缓冲液)。反应5分钟时的最适温度在38~39℃,K_m值是1.25×10~(-4)M。稀酶溶液不稳定,在0.1%白明胶中可保护酶活力。原蛇毒和纯化后的胆碱酯酶的底物抑制图形和K_m值是类似的,这说明纯化过程中酶没有矫变。蛇毒中的胆碱酯酶被多种有机磷化合物如二异丙基磷酰氟、敌敌畏、对氧磷所抑制。一些氨基甲酸酯和含季铵盐的化合物也表现有抑制。浙江眼镜蛇毒有较大的毒性,小白鼠腹腔注射最小致死剂量是0.88微克/克,用亲和层析分离除去胆碱酯酶后仍保留有蛇毒的毒性,最小致死剂量是0.77微克/克,纯化的胆碱酯酶含7.5微克/克蛋白,动物未致死,说明蛇毒的主要毒性并不是胆碱酯酶。

The enzymic properties of the cholinesterase of the venom of Naja naja atra fromZhejiang Province,such as substrate specificity,substrate inhibition and inhibitionby specific inhibitors BW_(284)C_(51) and BW_(62)C_(47) are similar to those from insoluble cellstructures of other animal tissues.The optimum pH of the enzyme is pH 7.5 in phosphate buffer,its optimumtemperature for 5minute reactions is 38~39℃.The K_m value is 1.25×10~(-4) M.The enzyme activity in dilute solution is quickly lost but it may be protected...

The enzymic properties of the cholinesterase of the venom of Naja naja atra fromZhejiang Province,such as substrate specificity,substrate inhibition and inhibitionby specific inhibitors BW_(284)C_(51) and BW_(62)C_(47) are similar to those from insoluble cellstructures of other animal tissues.The optimum pH of the enzyme is pH 7.5 in phosphate buffer,its optimumtemperature for 5minute reactions is 38~39℃.The K_m value is 1.25×10~(-4) M.The enzyme activity in dilute solution is quickly lost but it may be protected by0.1% gelatin.Substrate inhibition curves for the crude venom and for purified enzymes givesimilar K_m values.They probably indicate that no modifications in enzyme structurehave taken place during the purification procedure.The enzyme is inhibited by various organophosphorus compounds and carba-mates.Certain quaternary ammonium salts also inhibit the enzyme.The venom of Naja naja atra is a highly toxic substance.The MLD of the crudevenom for mice when given by intraperitoneal injection is 0.88μg/g.If the cholines-terase of the crude venom has been removed by affinity chromatography the MLD ofthe remaining components is 0.77μg/g.7.5μg/g of purified cholinesterase injectedto mice does not show any lethal effect.It is probable that cholinesterase is notresponsible for the toxic action of the venom.

浙江眼镜蛇蛇毒胆碱酯酶具有乙酰胆碱酯酶的特征,有以下几点事实:1.乙酰胆碱酯是酶的最适底物;2.过量底物抑制酶活性;3.BW_(62)C_(47)、BW_(284)C_(51)是典型的真性酶抑制剂,对蛇毒胆碱酯酶也同样具有抑制作用。眼镜蛇蛇毒胆碱酯酶最适pH 为7.5(0.1M 磷酸缓冲液)。反应5分钟时的最适温度在38~39℃,K_m 值是1.25×10~(-4)M。稀酶溶液不稳定,在0.1%白明胶中可保护酶活力。原蛇毒和纯化后的胆碱酯酶的底物抑制图形和K_m 值是类似的,这说明纯化过程中酶没有矫变。蛇毒中的胆碱酯酶被多种有机磷化合物如二异丙基磷酰氟、敌敌畏、对氧磷所抑制。一些氨基甲酸酯和含季铵盐的化合物也表现有抑制。浙江眼镜蛇毒有较大的毒性,小白鼠腹腔注射最小致死剂量是0.88微克/克,用亲和层析分离除去胆碱酯酶后仍保留有蛇毒的毒性,最小致死剂量是0.77微克/克,纯化的胆碱酯酶含7.5微克/克蛋白,动物未致死,说明蛇毒的主要毒性并不是胆碱酯酶。

 
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