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scid小鼠
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  scid mice
     Results】 The survival time of NOD/SCID mice that inoculated with 1×106 and 5×106 K562 cells were(30.3±4.3) days and (22.2±3.7) days, respectively.
     【结果】1×106及5×106K562细胞接种的NOD/SCID小鼠的生存时间分别为(30.3±4.3)d和(22.2±3.7)d;
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     The potential role of placental DX5~+CD25~+ cells in NOD/SCID mice
     NOD/SCID小鼠胎盘DX5~+CD25~+细胞水平
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     The immune reconstitution in Scid mice and the effect of T,B, NK cells on the growth potential of CNE-2Z-H_5 transplanted tumor
     Scid小鼠免疫重建及T、B和NK细胞对CNE-2Z-H_5移植瘤生长的影响
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     Methods SCID mice were subcutaneoulsy injected with HepG2 cells, 5×105 (in 0. 2 ml) in each flank, and intraperitoneally (ip) injected with 2×107(in 0. 5 ml) human PBL.
     方法 SCID小鼠双侧腋部皮下植入5×105(0.2ml)HepG2细胞,同时腹腔注射PBL 2×107(0.5 ml)。
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     C57BL/6J-scid/scid mice showed severe loss of mature T and B cells accompanied by increased percentages of NK11 cells.
     C57BL/6J-scid/scid小鼠显示成熟的T、B细胞严重丢失并伴随NK11细胞的百分比增加。
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  scid mouse
     Results It was found that every SCID mouse had an observable tumor at 6~10 days after injection (5/5 mice) and the average period of tumor formation was about 7.4±1.3 days.
     结果接种SCID小鼠后6~10d成瘤,成瘤率为5/5只,潜伏期平均(7.4±1.3)d。
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     Establishment of Human Acute Myeloid Leukemia Model in the SCID Mouse
     人急性早幼粒细胞白血病SCID小鼠模型的建立
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     Establishment of a SCID Mouse Model for Synergistic Anti-tumor Effect of Human IL-12 and B 7-1
     人IL-12和B7-1基因对HuPBL-SCID小鼠模型中人源肿瘤的协同抑制作用
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     Establishment and identification of humanized SCID mouse model
     人源化SCID小鼠模型的建立及其鉴定
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     The percentage of parasitied erythrocyted (PPE) in the BO RB SCID mouse was 15% (24h), and maxium parasitemias was 6.3% in vitro.
     B.ovata在 BO- RBC- SCID小鼠体内染虫率可达 15 %以上 ,体外培养最高染虫率为 6 .3%。
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  scid murine
     Methods The SCID murine model was established by subcutaneous implantation of human bladder cancer in mice. The 131 I labeled anti KDR monoclonal antibody (3G9) was injected into the caudal vein of mice (experimental group). The anti KDR monoclonal antibodies and saline were injected into the caudal vein of the mice (control group and blank group, respectively).
     方法 在复制SCID小鼠人膀胱癌皮下移植瘤模型的基础上 ,用1 31 Ⅰ标记抗KDR单抗 3G9,尾静脉注射荷瘤SCID小鼠作为实验组 ,以非标记抗KDR单抗 3G9及生理盐水尾静脉注射荷瘤SCID小鼠作为对照组及空白组 ,观察 1 31 Ⅰ标记抗KDR单抗对SCID小鼠人膀胱癌皮下移植瘤模型瘤体生长的抑制作用。
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  “scid小鼠”译为未确定词的双语例句
     Establishment of K562/NOD-SCID Mouse Model with Leukemia
     K562/NOD-SCID小鼠白血病模型的建立
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     Characterization of Human Lung Cancer Cell Line A549 in 615-SCID Mice
     A549人肺癌细胞系/615-SCID小鼠转移瘤的生物学特征
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     Objectives To study the effect of huBM-MSCs on immune response of mobilized huPBMNCs and in human-NOD/SCID chimera.
     目的 观察第三方huBM-MSCs在体外对动员后huPBMNCs免疫反应的影响以及huBM-MSCs在人-NOD/SCID小鼠嵌合体中的作用。
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     The Immunological Characteristics of Severe Combined Immunodeficiency (SCID) Mice
     严重联合免疫缺陷SCID小鼠的免疫学特征
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     ③MSC could promote human UCB CD34 + cells to differentiated into B-lymphocytes, granulocyte and megakaryocyte in vivo.
     ③MSC联合移植可促进人脐血CD34+细胞在NOD/SCID小鼠体内向粒系、B淋巴系和巨核系定向分化。
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  scid mice
The effects of hematopoietic stem/progenitor cells (HSPCs) expanded in the two step coculture with human bone marrow mesenchymal stem cells (hMSCs) on the hematopoietic reconstruction of irradiated NOD/SCID mice were studied.
      
Sublethally-irradiated NOD/SCID mice were transplanted with ex vivo expanded HSPCs with the dose of 8.5 × 106 cells per mouse.
      
Enteroviral and Immune Mediated Myocarditis in SCID mice
      
In addition, the two descendant lines (NE11Hp15 and cNE11H) lost their capacity to induce clinical arthritis in SCID mice.
      
Interestingly, two reisolates obtained from the tick midgut reexpressed large amounts of the 22 kDa protein which was recognized by anti-OspC IS and these two reisolates induced clinical arthritis in SCID mice.
      
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  scid mouse
Ganglioside composition of a mouse brain tumor grown in the severe combined immunodeficiency (SCID) mouse
      
We evaluated the antitumor activity of S-trans, trans-farnesylthiosalicylic acid (FTS), a new inhibitor of Ras signal transduction, in a newly established SCID mouse xenotransplantation model for human MCC (seven animals per group).
      
Oligonucleotides and cisplatin were administered systemically in a human gastric cancer SCID mouse model, and Bcl-2 expression, apoptosis, tumor size, and survival were assessed.
      
This study demonstrates high-efficiency sterilisation of single cancer cells in a SCID mouse model of leukaemia using rituximab, a monoclonal antibody that targets CD20, labelled with terbium-149, an alpha-emitting radionuclide.
      
Recently, FLT has increasingly been used for the assessment of response to anticancer treatment, mainly in tumour xenograft SCID mouse models; in contrast, clinical data are scarce.
      
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Mice with severe combined immunodeficiency (SCID) disease are deficient for both T and B lymphocyte functions because of impairment of lymphoiesis. To ensure SCID mice to survive, we raised them in a plastic film isolator in which specific-pathogen-free (SPF) condition was kept, free of 12 viruses and 17 bacteria considered as common pathogens of mice, as well as endoparasites and ectoparasites.Body weights of the SCID mice 4 and 8 weeks old were the same as those of the control group of BALB/c mice. Average...

Mice with severe combined immunodeficiency (SCID) disease are deficient for both T and B lymphocyte functions because of impairment of lymphoiesis. To ensure SCID mice to survive, we raised them in a plastic film isolator in which specific-pathogen-free (SPF) condition was kept, free of 12 viruses and 17 bacteria considered as common pathogens of mice, as well as endoparasites and ectoparasites.Body weights of the SCID mice 4 and 8 weeks old were the same as those of the control group of BALB/c mice. Average litter size of the SCID mice was 3.4, slightly smaller than that of BALB/c mice, but their non-productive rate and weaned-to-born ratio were comparable to those of BALB/c mice, i. e. 27.2% and 73.5%, respectively.Circulating lymphocytes of SCID mice only comprised a small fraction of the total leukocytes of peripheral blood (10-24%), while neutrophils were 76-88%. Conversely, in BALB/c mice, lymphocytes were 75-87% and neutrophils 15-25%. Theymus glands of the SCID mice were abnormally small, and their relative weight was only about 6% of that of BALB/c mice. SCID thymus was found to consist of a rudimentary medulla without cortex and contained few lymphocytes, predominated by epithelioid cells and fibroblasts. Relative weight of SCID spleen was about 30% of that of BALB/c mice. SCID spleen follicles were empty, virtually devoid of lymphocytes, occupied by reticular cells. But red pulp of SCID spleens was normal as in BALB/c mice. SCID lymph nodes were extremely small, only 1/3-1/4 of normal size of BALB/c mice. SCID lymph nodes showed no clear cortex structure, devoid of paracortical area, lacking follicles. The whole structure of SCID lymph nodes was poorly populated by lymphocytes, but predominated by reticular cells. SCID lymphoid tissues in submucosa of small intestines were undeveloped. The follicular-like sites were mainly composed of reticular cells without lymphocytes.The SCID mice may be sued to study lymphoid differentiation, and serve as an in vivo test system for transplanted tumors and normal tissues.

SCID小鼠是一种T和B淋巴细胞严重缺陷的动物,是肿瘤学和免疫学等学科研究的很有用的模型。 将SCID小鼠饲养于塑料薄膜隔离器内,保持无特定病原体状态。其平均每窝产仔数为3.4只,不育率为27.2%,离乳率为73.5%。该小鼠胸腺无皮质结构,髓质保留,缺乏淋巴细胞;脾脏内滤泡呈淋巴细胞脱空状态;淋巴结皮质区不明显,整个淋巴结呈淋巴细胞脱空状态;小肠粘膜下淋巴样组织无淋巴细胞聚集。外周血淋巴细胞仅占白细胞总数的10-24%。该小鼠基本符合免疫学试验要求。

The super severe combined immunodeficient mice(superscid)is a newly established mouse strain which was constructed by introducing the bg gene into C.B-17 scid mice.To identify its cellular immunologic haracteristics,we examined the T、natural killer(NK)and lymphokine-activated killer (LAK)cell activity in this mouse strain.The NK cell activity was studied by measuring the cytotoxicity to NK sensitive cell(YAC-1)and the influence of poly Ⅰ-C on it.The LAK cell activity was examined by measuring the cytotoxicity...

The super severe combined immunodeficient mice(superscid)is a newly established mouse strain which was constructed by introducing the bg gene into C.B-17 scid mice.To identify its cellular immunologic haracteristics,we examined the T、natural killer(NK)and lymphokine-activated killer (LAK)cell activity in this mouse strain.The NK cell activity was studied by measuring the cytotoxicity to NK sensitive cell(YAC-1)and the influence of poly Ⅰ-C on it.The LAK cell activity was examined by measuring the cytotoxicity aganist NK resistant cell(p815).

超重症联合免疫缺陷小鼠(B.C.B-17scid-beige)是将自然杀伤细胞(NK)缺陷基因(bg 基因)导入重症联合免疫缺陷病小鼠(C.B-17scid)体内得到的一种新品系小鼠.为确定该鼠基本细胞免疫特征,我们测定了该鼠 T、NK 和淋巴因子激活的杀伤细胞(LAK)等的功能,以及聚肌胞(poly I-C)对该鼠 NK 细胞活性的影响。该小鼠脾淋巴细胞不能针对 T 细胞有丝分裂原刀豆蛋白(ConA)的刺激而产生增殖反应。同正常对照小鼠相差非常显著(P<0.01)。该鼠 NK 细胞活性(对 YAC-1细胞杀伤活性)明显低于亲代 scid 小鼠和正常小鼠(P<0.01),经聚肌胞(100μg/只)预先刺激后该鼠 NK 细胞活性未见增加.而亲代 scid 小鼠则有明显增加。该鼠脾脏细胞经白细胞介素—2刺激后,LAK 细胞活性(对 P815细胞杀伤活性)明显低于亲代 scid 小鼠和正常小鼠(P<0.01)。上述结果表明 B、C、B-17scid-beige 小鼠是一种 T、NK和 LAK 细胞联合免疫缺陷小鼠,该鼠 B 细胞功能也是缺陷的(详见它文)。上述缺陷是 scid 基因和 bg 基因共同作用的结果,该动...

超重症联合免疫缺陷小鼠(B.C.B-17scid-beige)是将自然杀伤细胞(NK)缺陷基因(bg 基因)导入重症联合免疫缺陷病小鼠(C.B-17scid)体内得到的一种新品系小鼠.为确定该鼠基本细胞免疫特征,我们测定了该鼠 T、NK 和淋巴因子激活的杀伤细胞(LAK)等的功能,以及聚肌胞(poly I-C)对该鼠 NK 细胞活性的影响。该小鼠脾淋巴细胞不能针对 T 细胞有丝分裂原刀豆蛋白(ConA)的刺激而产生增殖反应。同正常对照小鼠相差非常显著(P<0.01)。该鼠 NK 细胞活性(对 YAC-1细胞杀伤活性)明显低于亲代 scid 小鼠和正常小鼠(P<0.01),经聚肌胞(100μg/只)预先刺激后该鼠 NK 细胞活性未见增加.而亲代 scid 小鼠则有明显增加。该鼠脾脏细胞经白细胞介素—2刺激后,LAK 细胞活性(对 P815细胞杀伤活性)明显低于亲代 scid 小鼠和正常小鼠(P<0.01)。上述结果表明 B、C、B-17scid-beige 小鼠是一种 T、NK和 LAK 细胞联合免疫缺陷小鼠,该鼠 B 细胞功能也是缺陷的(详见它文)。上述缺陷是 scid 基因和 bg 基因共同作用的结果,该动物为建立人—免疫缺陷动物模型提供了一种更为理想的受体小鼠,并为基础免疫学研究提供了一种新的研究工具。

Cloned CNE-2Z variants cells(CNE-2L2 and CNE2L4)in suspension form were injected into subcutaneous costal region of SCID mice(severe combined immunodeficiency mice)and BALB/c(nu/nu)nude mice.All tumor bearing mice were sacrified on 56th day after transplantation.The results indicate that CNE2L2 tranplanted into SCID mice is a highly metastatic variant which produced lymphatic metastasis in 100%(7/7)of the cases and lung metastasis in 71%(5/7)of the cases, while CNE2L4 transplanted into SCID mice is a low metastatic...

Cloned CNE-2Z variants cells(CNE-2L2 and CNE2L4)in suspension form were injected into subcutaneous costal region of SCID mice(severe combined immunodeficiency mice)and BALB/c(nu/nu)nude mice.All tumor bearing mice were sacrified on 56th day after transplantation.The results indicate that CNE2L2 tranplanted into SCID mice is a highly metastatic variant which produced lymphatic metastasis in 100%(7/7)of the cases and lung metastasis in 71%(5/7)of the cases, while CNE2L4 transplanted into SCID mice is a low metastatic variant which produced lung metastasis in 13%(1/8)of the cases and no lymphatic metastasis is found.The results also indicate that SCID mice can benefit the expression of metastasis phenotype of the transplanted cells,and suggest that SCID mice can be a more suitable in vivo model compared to BALB/c(nu/nu)nude mice for study the cancer biological characters.This experiment also shows that the tumor cell number inoculated into subcutaneous costal region are related to the expression of metastasis phenotype higher rate of metastasis result from more numbers of cells transplanted subcutaneously.

将人类鼻咽癌不同克隆株的细胞悬液移植在严重联合免疫缺陷(SCID)小鼠和BALB/c(un/un)裸小鼠的颈背侧皮下,56d后处死全部动物进行观察。结果发现,在SCID小鼠体内移植后CNE2L2为高转移克隆株,其淋巴结转移率为100%,肺转移率为71%;而CNE2L4为低转移克隆株,其肺转移率为13%,淋巴结未见癌转移。这是从1个细胞母系中新筛选出的1个高转移和1个低转移的癌细胞克隆株。实验结果还显示,同BALB/c(un/un)裸小鼠相比,SCID小鼠的恶性表型的表达能力高。另外,皮下移植时肿瘤细胞的数量可能与转移表型的表达有相关性,移植的瘤细胞数越多,转移率越高,反之亦然。

 
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