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胰移植
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     Methods: The pancreas from embryonic day(E15.5),E16.5,E17.5 and E18.5 SD rat embryos were implanted into the intra-peritoneal and sub renal capsular site.
     方法:将远交系SD大鼠妊娠15.5d(E15.5)、E16.5、E17.5和E18.5的胚胰移植到成年健康SD大鼠的肾包膜下或网膜内。
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     Conclusions EPTT before RT for the type I diabetes patients with renal disorder can improve the results of RT.
     结论 对行肾移植术的I型糖尿病肾病患者 ,肾移植术前先行胎胰移植可提高I型糖尿病性肾功能衰竭患者肾移植术后的疗效
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     The synthetic inhibitor of thromboxane A2 furegrelate and teramethyl-pyrazine,when combined with CsA, Prolonged pancreatic allograft survival and Promoted the reverse of diabetic nephropathy.
     胰移植后用血栓素A2合成抑制剂Furegrelate和川芎嗪取代激素,与环孢素A合用有协同作用,可延长移植胰存活,并且对尿白蛋白排泄量的恢复作用较激素组明显。
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     ④By 16 days after implantation into mice's sub renal-capsular site without immunosuppressant,E15.5 graft underwent severe rejection and tissue necrosis.
     ④E15.5胚胰移植到小鼠体内,未经任何免疫抑制处理,16d内见到重度排斥表现并导致组织坏死。
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     Objective:To study the growth and development of embryonic pancreatic anlagen transplantation.
     目的:研究胚胎胰组织在同种异体内再生长发育的可能性,并根据不同胎龄、不同移植部位的移植胚胰生长状况,研究大鼠胚胰移植的适合胎龄和移植部位。
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  相似匹配句对
     Observation of pancreas transplant ation by ultrasonography
     移植的超声观察
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     Clinical experience in the simultaneous pancreas-kidney transplantation
     肾联合移植的体会
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     Immunology on Transplantation
     移植免疫
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     Lebertransplantation
     肝移植
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     ARTERIES OF PANCREAS
     的动脉
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  pancreas transplantation
Pancreas transplantation alone (PTA) is most useful for the treatment of debilitating, frequent hypoglycemia complicating type 1 diabetes, if renal function is adequate.
      
Evolving surgical strategies for pancreas transplantation
      
In the area of immunosuppression, steroid-free protocols, now commonplace in kidney transplants, are being applied successfully to pancreas transplantation.
      
Assessment of islet function following islet and pancreas transplantation
      
Although successful pancreas transplantation typically restores normal glucose homeostasis, islet transplantation into the liver does not completely normalize islet hormone secretion and glucose metabolism.
      
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The transplantation effectiveness of neonatal rat's islets pretreated by different methods was studied. Sixty Wistar rats were divided into five groups. The artificial diabetes mellitus of group Ⅰ to Ⅴ was produced by intraperitoneal injection of streptozotocin. Group Ⅰ was the pseudo-operative control group. Groups Ⅱ to Ⅴ were transplanted with pancreatic fragments pretreated by different methods: group n , freshly prepared fragments; group Ⅲ, cultured in RPMI-1640 medium for six days; group Ⅳ, frozen immediately...

The transplantation effectiveness of neonatal rat's islets pretreated by different methods was studied. Sixty Wistar rats were divided into five groups. The artificial diabetes mellitus of group Ⅰ to Ⅴ was produced by intraperitoneal injection of streptozotocin. Group Ⅰ was the pseudo-operative control group. Groups Ⅱ to Ⅴ were transplanted with pancreatic fragments pretreated by different methods: group n , freshly prepared fragments; group Ⅲ, cultured in RPMI-1640 medium for six days; group Ⅳ, frozen immediately after preparation; group Ⅴ , cultured and then frozen. The frozen samples were preserved in LN for 2~4 weeks and thawed in 37℃ water bath. For each diabetic rat samples from eight neonatal pancreases were transplanted to the renal subcapsular space. The observation period was 16 weeks. After transplantation a serial changes occurred in group n to Ⅴ: body weight and serum insulin content increased, blood glucose level decreased gradually. There were significant differences between group Ⅰ and groups Ⅱ to Ⅴ ( p<0.01 ). The changes in group Ⅴ were obviously different from thosein other transplanted groups (Ⅱ - Ⅳ, p<0.01). The number of insulin-containing B-cells and the contents of IGS granules in B-cells in sections of immunogold-silver staining in group Ⅴ were significantly higher than those in groups Ⅱ , Ⅲ and Ⅳ. The results suggested that transplantation effectiveness of islets pretreated by culture plus freezing is better than fresh, only cultured or only immediately frozen pancreatic islets.

本实验研究了同种乳胰胰岛移植对链脲佐菌素(STZ)所致大鼠药物性糖尿病的影响。经16周观察发现,新鲜乳胰、组织培养的乳胰和冷冻保存的乳胰,移植于糖尿病大鼠肾被膜下第3天后,宿主血糖下降、血清胰岛素上升、肾被膜下移植组织中免疫金银染色(IGSS)切片可见黑色胰岛素反应阳性细胞,细胞内免疫金银(IGS)含量明显高于糖尿病对照组胰岛中阳性细胞中的含量,逆转糖尿病的有效率为30%~50%。经过组织培养后再冷冻保存的乳胰移植组宿主的体重和血清胰岛素含量上升,血糖浓度下降,其数值均明显地优于其它3个移植组(p<0.01),移植组织中黑色胰岛素反应阳性细胞较多,细胞内IGS含量和逆转糖尿病的有效率(100%)均明显高于其它3个移植组(p<0.01)。

his paper reports transplantation of fetus pancreas with vascular pedicle and

报道胎儿带血管蒂全胰移植治疗I型糖尿病,在取材和移植方法上进行了改革和创新。不仅成倍增加了移植物血流量,还可以预防吻合口血栓形成,确保移植物存活。术后应用放免法对血中胰岛素和C-肽进行监测;应用彩色多普勒诊断仪进行血流监测,证明移植物功能性存活,获得较好的治疗效果。并提出术后不显性排斥反应的治疗是小脏器移植长期功能性存活的关键。

Pancreatic transplantation can reverse the proteinuria and renal enlargement of the incipient nephropathy in diabetic rats. Thromboxane A2 was elevated druing rejection in pancreatic transplant rats. The synthetic inhibitor of thromboxane A2 furegrelate and teramethyl-pyrazine,when combined with CsA, Prolonged pancreatic allograft survival and Promoted the reverse of diabetic nephropathy. No same effect was observed in the combined steroid and CsA group.

大鼠糖尿病受体接受胰腺移植术后,随着血糖的恢复,24小时后尿中β2-微球蛋白和白蛋白排泄量及肾重恢复正常。胰腺发生排斥时血浆中血栓素B2明显升高。胰移植后用血栓素A2合成抑制剂Furegrelate和川芎嗪取代激素,与环孢素A合用有协同作用,可延长移植胰存活,并且对尿白蛋白排泄量的恢复作用较激素组明显。结果表明,胰移植后使用血栓素A2合成抑制剂有利于预防排斥反应,并能促进合并的肾病变逆转。

 
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