Through the simulation and sieving, a comprehensive cultivating method had been taken to reach a high yield, top quality cotton, that includes growing density of 8340-8650 plants per mu, saving 6fruit branches, spraying 4. 34- 4. 96 g mepiguat chloride per mu, applying 8. 03 - 9. 00kg nitrogen, 2. 68 - 3. 01kg pentoxide per mu.