Beta-lactam antibiotics acylase, which was divided into cephalosporin acylase and penicilln acylase according to substrate specificity, converted the fermented cephalosporin and penicillin to 7-ACA and 6-APA.
Determination of β-Lactam Antibiotics by Potentiometry with Ion-Selective Electrodes
Complex formation in nickel(II)-glycine-β-lactam antibiotic systems
Complex formation in solutions containing Ni2+ cations, glycine anions (Gly-), and β-lactam antibiotics, namely, ampicillin (Amp), amoxicillin (Axn), and cephalexin (Cpx), is studied by pH-metric titration at 20°C and an ionic strength of 0.1 (KNO3).
Polymeric adsorbents with peptide pendants as artificial receptors for β-lactam antibiotics by mimicking the binding sites of β-
A series of polymeric adsorbents with peptide pendants were designed as the artificial receptors of β-lactam antibiotics by mimicking the structures of binding site in β-lactamases.
There are known more than 50 cassettes conferring resistance to β-lactams, aminoglycosides, trimethoprim, chloramphenicol, streptomycin, and other antibiotics.
Hydrocarbon-grown rhodococci exhibited an increased resistance to a wide range of antibiotics (aminoglycosides, linkosamides, macrolides, β-lactams, and aromatic compounds).
Ugi reaction with 5-isocyanoindoles afforded a number of amino acids, β-lactams, and tetrazoles.
The results showed that only those adsorbents in which peptide chains contained more than one lysine residues could obviously adsorb both β-lactams and that static interaction as well as hydrogen bond played an important role during the adsorption.
The MICs of the β-lactams were not affected by inoculum density.