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累积毒性
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  cumulative toxicity
     A method based on cumulative toxicity for evaluating pharmacokinetics of oral traditional Chinese medicine in animals
     用累积毒性原理评价口服中药体内过程
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  “累积毒性”译为未确定词的双语例句
     The toxicity of Cu accumulated in fish is stronger than that of Zn. 
     Zn、Cu存积随饵料中的含量增加而增加,Cu的累积毒性大于Zn。
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  相似匹配句对
     Toxicity of Ionic Liquids
     离子液体的毒性
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     Toxicity of Vitamine
     维生素的毒性
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     A method based on cumulative toxicity for evaluating pharmacokinetics of oral traditional Chinese medicine in animals
     用累积毒性原理评价口服中药体内过程
短句来源
     TOXICITY AND BIOACCUMULATION OF GERMANIUM IN TWO MICROALGAE Spirulina platensis AND Dunaliella salina
     锗对两种微藻的毒性及其在细胞中的累积
短句来源
     RESEARCH ON CUMULATIVE ENVIRONMENTALIMPACT ASSESSMENT
     累积环境影响评价研究
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  cumulative toxicity
A long follow up of cured patients has shown that the cumulative toxicity from treatment related complications rivals the mortality from Hodgkin's disease.
      
Weekly docetaxel in minimally pretreated cancer patients: A dose-escalation study focused on feasibility and cumulative toxicity
      
This is a dose-escalation study of weekly docetaxel particularly focused on the feasibility of long-term administration and characterisation of cumulative toxicity.
      
It is hoped that this decrease in total body exposure will also reduce the cumulative toxicity seen when misonidazole is administered repeatedly.
      
No effect of cumulative toxicity on the median GFR was found during maintenance therapy, nor did the median GFR improve.
      
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An experiment in the requirements for Zn and Cu in diets of balck sea bream larvae was performed with the orthogonal design. The effects of diets with different Zn and Cu levels on the rate of body weight increase were studied.Their different effects were compared and the relationships between the contents of Zn and Cu in diets and that in fish bodies were analyzed.The results show that proper content of Zn in diet of black sea bream larvae is 6.8 mg/kg and the content of Cu in the diet must be less than 1.2...

An experiment in the requirements for Zn and Cu in diets of balck sea bream larvae was performed with the orthogonal design. The effects of diets with different Zn and Cu levels on the rate of body weight increase were studied.Their different effects were compared and the relationships between the contents of Zn and Cu in diets and that in fish bodies were analyzed.The results show that proper content of Zn in diet of black sea bream larvae is 6.8 mg/kg and the content of Cu in the diet must be less than 1.2 mg/kg. The nutritional function of Zn is more than that of Cu.The accumulation of Zn and Cu in fish body increases with the increase of Zn and Cu level in diets. The toxicity of Cu accumulated in fish is stronger than that of Zn.

通过正交设计,进行了黑鲷幼鱼对Zn、Cu营养需求的试验,比较了饵料中不同含量的Zn、Cu对黑鲷幼鱼增重效果的影响及Zn、Cu影响作用的大小,分析了饵料中不同含量的Zn、Cu对黑鲷幼鱼体内Zn、Cu存积的影响。结果表明饵料中添加少量Zn(6.8~20.5mg/kg)有助于黑鲷幼鱼生长,Cu对其增重的作用不大,Cu的添加量以少于1.2mg/kg为宜;Zn的营养作用大于Cu;Zn、Cu存积随饵料中的含量增加而增加,Cu的累积毒性大于Zn。

In this paper, adriamycin carboxymethyldextran magnetic nanoparticles (ADR CMD MNPs) were prepared. After i.v. administration in mice, acute toxicity, cumulative toxicity and the distribution profiles of heart were studied both for free adriamycin(ADR) and ADR CMD MNPs. The results showed conjugation with CMD MNPs, the acute toxicity of ADR was decreased significantly, the LD 50 value of ADR CMD MNPs was 5.06 times as high as that of the free ADR. Altogether, the cumulative toxicity of conjugate MNPs...

In this paper, adriamycin carboxymethyldextran magnetic nanoparticles (ADR CMD MNPs) were prepared. After i.v. administration in mice, acute toxicity, cumulative toxicity and the distribution profiles of heart were studied both for free adriamycin(ADR) and ADR CMD MNPs. The results showed conjugation with CMD MNPs, the acute toxicity of ADR was decreased significantly, the LD 50 value of ADR CMD MNPs was 5.06 times as high as that of the free ADR. Altogether, the cumulative toxicity of conjugate MNPs is significantly decreased as expressed by the mortality, the loss for both weight and leucocyte after repeated injection. Tissue distribution studies show the reduced cardiac uptake of ADR after i.v. which possibly contributes to minimizing the cardiotoxic effect of ADR.

以阿霉素 (ADR)为药物模型 ,制备了阿霉素 -羧甲基葡聚糖磁性毫微粒 (ADR- CMD MNPs) ,对比研究了静脉给药后其与阿霉素普通制剂对小鼠的急性毒性作用、累积毒性作用以及药物在动物心肌组织的分布情况 ,结果表明 :相对于普通制剂 ,阿霉素的磁性毫微粒制剂的急性毒性明显降低 ,L D50 值达到阿霉素普通制剂的5 .0 6倍 ,连续给药情况下小鼠的死亡率、体重和白细胞损失都有明显下降 ;药物分布实验表明阿霉素磁性毫微粒制剂静脉给药后在小鼠心肌组织中的浓度和积累作用明显低于普通制剂 ,这对降低阿霉素固有的对心肌组织毒副作用非常有利

Toxic evaluation of petroleum ether and methyl tin were carried out in the present experiment by introduction of silkworm larvae, Bombyx mori as biological indicator. Gradient concentration of the tested chemicals were fed to third or fourth instar silkworm larvae. Results showed that petroleum ether can cause silkworm larva in narcosis if directly sprayed on its body and affect normal growth and development if fumed mulberry leaves in high concentration. The toxicity of tin methylcaptals to silkworm larvae...

Toxic evaluation of petroleum ether and methyl tin were carried out in the present experiment by introduction of silkworm larvae, Bombyx mori as biological indicator. Gradient concentration of the tested chemicals were fed to third or fourth instar silkworm larvae. Results showed that petroleum ether can cause silkworm larva in narcosis if directly sprayed on its body and affect normal growth and development if fumed mulberry leaves in high concentration. The toxicity of tin methylcaptals to silkworm larvae were found in very low concentration and its accumulative effects also observed.

本试验用家蚕为指示生物来评价化学药品的毒性,通过对家蚕品种菁松×皓月和丰一×54A 的幼虫添食石油醚和甲基硫醛锡的毒性试验,初步结果认为,石油醚对蚕有昏迷作用但并不直接影响其生长发育,但桑叶对其熏气后被破坏营养,从而影响蚕的正常生长发育;甲基硫醛锡具有较强的的毒性,其毒性不仪与浓度有关,还与添毒的时间长短有关即有累积毒性作用。产量高体质弱的春用杂交种菁松×皓月比体质强健的夏秋用杂交种丰一×54A更容易受影响。

 
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