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诱导作用
相关语句
  induction
    INDUCTION OF HEPATOCYTE MICROSOMAL CYTOCHROME P-450 BY SCHIZANDRIN B IN MICE
    五味子乙素对小鼠肝细胞微粒体细胞色素P-450的诱导作用
短句来源
    INDUCTION OF RIFAPENTINE ON HEPATIC DRUG-METABOLIZING ENZYMES IN MICE
    利福喷丁对小鼠肝微粒体药酶的诱导作用
短句来源
    The effects of swine bile acids-sodium salt on the inhibition of proliferation and induction of differentiation in human promyelocytic leukemia cell line HL-60
    猪胆汁酸钠对人早幼粒白血病细胞系HL-60的增殖抑制及分化诱导作用(英文)
短句来源
    Induction of Cytochrome P-450 in Rat Liver Microsomes by CTPTD Treatment
    CTPTD对大鼠肝细胞色素P-450的诱导作用
短句来源
    APOPTOSIS INDUCTION EFFECT OF LOBAPLATIN ON HL-60 CELLS
    乐铂对HL-60细胞程序化死亡诱导作用研究
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  “诱导作用”译为未确定词的双语例句
    Ketoconazole showed a reduction of CYP1A2 and 2B1/2 activities in the low dosing setting and an escalation of their activities in a high dosing setting(P<0.05,P<0.01).
    低剂量的酮康唑抑制CYP1A2和CYP2B1/2亚型的活性,高剂量却出现了诱导作用(P<0.05,P<0.01)。
短句来源
    Differentiation of HL60 Cells Induced by Sodium Selenite
    亚硒酸钠对HL-60细胞的分化诱导作用
短句来源
    Inductive effects of clausenamide compounds and schisandrin derivative on liver cytochrome P-450 in mice
    黄皮酰胺类化合物及五味子素衍化物对小鼠肝细胞色素P-450的诱导作用
短句来源
    DNA PHOTOSENSITIZATION DAMAGE INDUCED BY 2-METHY-1,4-NAPHTHONINONE
    2-甲基-1,4-萘醌对DNA光敏损伤的诱导作用
短句来源
    Nitric oxide may be involved in dopamine-induced apoptosis in PC12 cells
    一氧化氮可能参与多巴胺对PC12细胞凋亡的诱导作用
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  induction
(HereM3 denotes the vector space of 3×3 matrices over k andp>amp;gt;3.) The method of proof involves an induction, and is potentially of wide applicability.
      
Fourier transform, parabolic induction, and nilpotent orbits
      
We prove that in the symmetric space setting the functors of Fourier transform (in the sense of Deligne) and parabolic induction (in the sense of Lusztig) commute.
      
For an arbitrary ring A we construct quasi-P radical QP(A) with transfinite induction, and give another characterization of quasi-P radical: QP(A) = ∩ Ia ∣Ia.
      
Rotor broken-bar fault diagnosis of induction motor based on HHT of the startup electromagnetic torque
      
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Schizandrin B, one of the components isolated from Fructus Schizandrae, was found to have protective action on liver injury and to increase the weight of liver in mice. In order to elucidate the cause and implications of the liver enlargement by Schizandrirn B, some studies were carried out in mice. The results indicate that the content of water, protein, RNA, glycogen and total lipid per gram liver of the group given Schizandrin B was almost the same as those of the control group, but the amount of all these...

Schizandrin B, one of the components isolated from Fructus Schizandrae, was found to have protective action on liver injury and to increase the weight of liver in mice. In order to elucidate the cause and implications of the liver enlargement by Schizandrirn B, some studies were carried out in mice. The results indicate that the content of water, protein, RNA, glycogen and total lipid per gram liver of the group given Schizandrin B was almost the same as those of the control group, but the amount of all these biochemical constituents markedly increased. The DNA content per gram liver decreased, although the total amount of DNA in whole liver was the same as that of the control.In partially hepatectomized mice, Schizandrin B was also shown to increase the protein, RNA and DNA contents as well as, mitosis of liver cells. In addition, Schizandrin B Was found to enhance-the incorporation of ~(14)G-phenylalanine into liver protein, and to increase hepatic microsomal cytochrome P-450 and protein contents significantly. From these results, it may be concluded that Schizandrin B is'an inducing agent of drug metabolizing enzyme, and the enlargement of the liver caused by Schizandrin B is mainly, due to hypertrophy and to a lesser degree, hyperplasia. However, Schizandrin B is different from phenobarbital in the respectof inducing drug metabolizing enzyme. The difference is that phenobarbital also induced an increase of liver cell microsomal RNA and phospholipid contents. Besides, phenobarbital wasshown to be able to shorten the survival time of CC14-intoxicated mice, while Schizandrin B did not.

五味子乙素系从中药五味子分离出的成分之一,有抗肝损伤和解毒作用,同时亦引起小鼠肝脏重量增大。经进一步研究,发现五味子乙素对正常小鼠肝脏每克组织中水分、蛋白质、RNA、糖原及总脂含量均无明显影响,但在整个肝脏中上述成分含量均显著增加。每克肝组织中DNA含量稍降低,整个肝脏中DNA含量则无明显变化。对部分切除肝脏的小鼠再生肝,五味子乙素能明显引起整个肝脏中蛋白质,PLNA和DNA含量以及细胞核分裂数增加。此外,五味子乙素能显著促进~(14)C-苯丙氨酸掺入肝脏蛋白质,并使肝细胞微粒体细胞色素P-450及蛋白质含量显著增加。以上结果表明,五味子乙素对药酶有诱导作用,其引起的肝脏增大主要系肝实质细胞体积增大,同时伴有肝细胞增生。五味子乙素引起的肝脏增大似非病理性损害的表现,而是由于诱导药酶同时出现肝细胞肥大的表现。

2, 6-di-tert-butyl-phenol (2,6-DTBT), 3, 5-di-tert-butyl-4-hydroxylbenzyl-dimethylamine (BDMA), 3,5-di-tert-butyl-4-hydroxyl-benzyl-phosphonic-diethylester (1222),di (3,5-di-tert-butyl-4-hydroxyl-benzyl-phosphonic-monoethylester) nickelic salt (2002) are a series of phenol antioxides. The main results of this study are as follows:(1)The acute toxic effect of the four antioxides was determined and "index of acute toxicity" (LD_(50)/slope of LD_(50)-dose-response regression curve), a synthetical indication to...

2, 6-di-tert-butyl-phenol (2,6-DTBT), 3, 5-di-tert-butyl-4-hydroxylbenzyl-dimethylamine (BDMA), 3,5-di-tert-butyl-4-hydroxyl-benzyl-phosphonic-diethylester (1222),di (3,5-di-tert-butyl-4-hydroxyl-benzyl-phosphonic-monoethylester) nickelic salt (2002) are a series of phenol antioxides. The main results of this study are as follows:(1)The acute toxic effect of the four antioxides was determined and "index of acute toxicity" (LD_(50)/slope of LD_(50)-dose-response regression curve), a synthetical indication to evaluate acute toxicity was also recommended; (2) In vivo, all of them had the tendency to increase blood cholinesterase activity in rats and mice. The effects of 1222 and 2002 which required certain metabolic conversion were determined both in vivo and vitro experiments; (3) After sereral administrations to animals in a short time, these compounds appeared to becomo Inducers of liver microsome enzymes with more potent inductive effects of 2,6-DTBP and BDMA than the other two.

2,6-二叔丁基苯酚(2,6-DTBP)、3,5-二叔丁基-4-羟基苄基二甲胺(苄甲胺)、3,5-二叔丁基-4-羟基苄基膦酸二乙酯(1222)和双[3,5-二叔丁基-4-羟基苄基膦酸单乙酯]镍盐(2002)是一组酚类抗氧剂。本研究主要结果如下: (1)测定了四种化合物的急性毒性,并提出了“急性毒性指数”(LD_(50)/LD_(50)-剂量反应回归直线斜率)这一评价急性毒性的综合指标。 (2)在体内实验,四种化合物均可使大鼠和小鼠的血ChE活性增加,并通过体外实验证明,1222和2002的这种作用需要经过一定的代谢转化。 (3)短期多次给药后,四种化合物均出现鼠肝微粒体酶诱导剂的作用,其中以2,6-DTBP和苄甲胺的诱导作用较强。

In clinical treatment of psychosis artane is usually administered in combination with chlorpromazine(CPZ) to relieve the extrapyramidal side effects caused by CPZ. Several authors have reported that CPZ plasma level was lowered by artane because it inhibited the absorption of CPZ from the gastrointestinal tract.In the present investigation, the effect of artane on the rate of CPZ metabolism in mouse liver microsomal system was examined. It was found that after administration of artane in the dose range from...

In clinical treatment of psychosis artane is usually administered in combination with chlorpromazine(CPZ) to relieve the extrapyramidal side effects caused by CPZ. Several authors have reported that CPZ plasma level was lowered by artane because it inhibited the absorption of CPZ from the gastrointestinal tract.In the present investigation, the effect of artane on the rate of CPZ metabolism in mouse liver microsomal system was examined. It was found that after administration of artane in the dose range from 25 mg/kg to 87.5 mg/kg(i p daily) to mice for three days, the rate of CPZ metabolism by mouse liver microsomes in vitro was markedly increased, and the hepatic cytochrome P-450 concentration of mice was also increased significantly. The results indicate that artane possesses inducing effect on mouse liver drug metabolism enzymes. This may be the main cause of the increased rate of CPZ metabolism in liver microsomal system by artane.

本文以氯丙嗪为底物研究了安坦对小鼠肝微粒体药酶的诱导作用,发现当每日腹腔注射安坦25mg~87.5mg/kg时,连续三天,可使氯丙嗪在含有肝微粒体的体外反应系统中的代谢速率明显加快。安坦这种诱导作用的强度略高于苯巴比妥。小鼠用安坦后肝微粒体中细胞色素P-450含量显著提高,这可能是安坦能加速氯丙嗪体外代谢速率的一个主要原因。

 
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