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  renal circulation
Nonmodulation is a process in which there is a disorder in angiotensin-dependent control of the renal circulation and adrenal aldosterone release.
      
The endothelial L-arginine/nitric oxide pathway and the renal circulation
      
The present study was undertaken to investigate the putative role of this lipid mediator in the vascular reactivity of the renal circulation, using the experimental model of the isolated perfused rabbit kidney.
      
Furthermore, the administration of PAF into the renal circulation induced dose-related and long-lasting vasodilator responses, which were blocked by the PAF receptor antagonists.
      
Perfusion of the kidneys with the angiotensin II-converting enzyme inhibitor captopril (10?μM) also significantly prevented the deleterious effects of high glucose challenge in the renal circulation.
      
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In anesthetized cats, bubble flow meter was used to measure the arterial flows and blood pressure (BP). The blood flows of brain (CBF), kidney (RBF) and hind limb (LBF) were found to be respectively 130±65, 173±71 and 3.7±1.6ml/min/100g. The vascular resis:ances of brain (CVR), kidney (RVR) and hind limb (LVR) were respectively 1.0±0.4, 0.8±0.4 and 40±15 mm Hg/ml/min/100g. After an intravenous injection of the alkaloid (10—40μg/kg) isolated from Veratrum maackii, the BP, CBF and RBF all decreased. The blood...

In anesthetized cats, bubble flow meter was used to measure the arterial flows and blood pressure (BP). The blood flows of brain (CBF), kidney (RBF) and hind limb (LBF) were found to be respectively 130±65, 173±71 and 3.7±1.6ml/min/100g. The vascular resis:ances of brain (CVR), kidney (RVR) and hind limb (LVR) were respectively 1.0±0.4, 0.8±0.4 and 40±15 mm Hg/ml/min/100g. After an intravenous injection of the alkaloid (10—40μg/kg) isolated from Veratrum maackii, the BP, CBF and RBF all decreased. The blood flows decreased remarkably at the beginning, but slowly recovered after 5 minutes. During the hypotension, CVR and RVR showed a decline for 10—30 minutes. Intraarterial injection of 3μg/kg yielded a diminution of CBF and RBF, accompanied with an augmentation of CVR and RVR. These changes passed off in 1 minute. Hence the dilatation of cerebral and renal vessels seemed to play a certain role in the hypotensive mechanism of Veratrum maackii. Its influence on the cerebral and renal circulations were transitory and reversible. Intravenous injection of 10—20μg/kg lowered the LBF and increased the LVR. This action was demonstrated to result mainly from the muscular tetanus caused by the alkaloid.

应用气泡流量計測定了麻醉猫的周围动脉血流动力和血压(BP)。脑、腎与后肢血流量(CBF,RBF,LBF)分別为130±65,173±71与3.7±1.6毫升/分/100克。脑、腎及后肢血管阻力(CVR,RVR,LVR)分別为1.0±0.4,0.8±0.4及40±15毫米汞柱/毫升/分/100克。 靜脉注射馬氏藜芦硷10—40微克/公斤,BP下降,CBF及RBF減少,血流減少开始显著,5分鉀后慢慢恢复。BP下降时,CVR及RVR降低,可維持10—30分钟。动脉注射3微克/公斤,CBF及KBF減少,CVR及RVR上升,1分钟即趋原水平。由此,可以认为馬氏藜芦硷的降压机制中,脑和腎血管舒张起一定的作用,該药对脑和腎循环的影响是短暫的、可恢复的。 馬氏藜芦硷10—20微克/公斤,可使LBF減少,LVR增加,証明系由于肌肉攣縮所致。

 
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