CAP 25 nmol/L shifted the steady-state activation curve ofICa-Lto the left and changed half activation potential (V0.5) from (-20.76±2.0) mV to (-26.71±2.0) mV (P<0.05), indicating that low-dose CAP may modify the voltage-dependent activation of calcium channel.
CAP 25 nmol/L可明显使稳态激活曲线左移,激活中点电压(V0.5)由-20.76±2.0mV变至-26.71±3.0mV(P<0.05),表明低浓度CAP改变了钙通道激活的电压依赖性。
Results showed that LFD had a dramatic postive inotropic effect on the isolated rats'left ventricular papillary muscle(P<0.05). This effect was not influenced by propranolol(a beta-adrenergic blocker),but verapamil(a calcium-channel blocker)obviously antagonized it.
The addition of a calcium channel blocker verapamil and a chelating agent EGTA to inhibit Ca2+ influx from the medium eliminated the AP spike and diminished reversible alkalization of the external solution.
After entering into the cell through the N-type calcium channel, calcium binds to calmodulin, and triggers calcium release from intracellular calcium store by activating the caffeine-sensitive but ryan-odine-insensitive mechanism.
CACNA1S gene encodes the α1 subunit of the calcium channel.
Removing Ca2+ from the bath or using calcium channel antagonist (CdCl2, Nifedipine) greatly inhibited the [Ca2+]i increase induced by ONOO-1, suggesting that the opening of L-Ca2+ channel makes a great contribution to the [Ca2+]i increase.
Identification and characterization of human neuronal voltage-gated calcium channel gamma 3 subunit gene
H2O2 has been recently shown to accelerate the overall channel opening process in voltage-dependent calcium channels in plant and animal cells.
Study of the activity of calcium channels that are regulated by intracellular calcium stores in mouse embryonic stem cells
The inhibitor of voltage-dependent calcium channels diltiazem (10 and 100 μM) decreased the rate of ovulation in Ringer solution but did not affect it in a chloride-free medium or decreased the ovulation inhibitory effect of this medium.
Role of Calcium Channels in Phytochrome-Mediated Regulation of Gravitropic Response
The effect of the inhibitors of calcium channels on red-light (R)-mediated inhibition of gravitropic bending was studied in excised wheat (Triticum aestivumL.) coleoptiles.
Using isolation cell procedure and whole cell recording, we found that 10 μM quinidine (34.77±6.5%, n=5) and 0.5 μM flecainide (50.46±6.2%, n=4) decrease calcium current in human atrium.
It is concluded that, at therapeutical concentrations, quinidine and flecainide modify the action potential plateau phase in a different manner, which is not only related to the calcium current decrease.
It is implied that this effect is mediated via ICa, the inward calcium current, which makes a larger than normal contribution to direct contractile activation in hypothermic myocardium.
Influence of phorbol esters on contractile force, action potential and calcium current of isolated guinea-pig heart tissues
In isolated ventricular cardiomyocytes the inward calcium current was halved by either 1 μmol/l PDB or 10 μmol/l PMA.
Dual Effect of Inorganic Calcium-Channel Blockers on Contraction of Smooth Muscles of the Frog
Treatments with alternative techniques like DCA, TEC and ELCA as well as phamacological attempts like GP IIb/IIIA inhibitors, vasodilators and calcium-channel blockers do not improve outcome.
Conclusions The alpha-blocker terazosin is as effective as atenolol when combined with either an ACE inhibitor or a calcium-channel blocker as a part of a multidrug regimen to achieve sufficient blood pressure control.
It has been shown that various calcium-channel antagonists may delay plaque formation in animal models.
On balance, the articles reviewed prove that dihydropyridine calcium-channel blockers score particularly well in the prevention of cardiovascular complications in diabetic patients with hypertension.