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腺苷--
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     5. C.
     5.C.
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     heat preservation time (t)5h;
     t为5h。
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     SYNTHESIS ON DERIVATIVES OF ADENOSINE 5’-ALDEHYDE
     5-醛基腺苷衍生物的合成
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     g·L~(-1)、0.5?
     L-10、. 5 g.
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     adenosine (C-21);
     腺苷(C-21);
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  adenosine-5 ' -
Mathematical modeling of kinetics of adenosine-5'-triphosphate hydrolysis catalyzed by the Zn2+ ion in the pH range 8.5-9.0
      
The kinetics of adenosine-5'-triphosphate (ATP) hydrolysis catalyzed by Zn2+ at pH 8.5-9.0 is analyzed by numerical simulation.
      
A recent adenosine derivative (Abbott 40557) ethyl-adenosine-5'-carboxylate hydrochloride has marked and prolonged coronary vasodilator activity (2, 3).
      
The goal of this study was to determine whether the protective effects of the A3AR agonist N6-(3-iodobenzyl)adenosine-5'-N-methylcarboxamide (IB-MECA) against myocardial stunning are mediated by the A1AR.
      
The potential of99mTc labeled P1, P4-di (adenosine-5')-tetraphosphate (Ap4A) for imaging experimental atherosclerotic plaques was evaluated in New Zealand white (NZW) rabbits.
      
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Hydrocortisone acetate was administered daily by intramuscular injection (2.5mg/ 100gm body weight) to 14 adulat rats.Another 6 rats were used as controls.The ex- perimental animals were divided into 3 groups of which the first group were sacrificed 24 hours after 3 injections,the second group 24 hours after 6 injections and the third group 9 days after 6 injections.The liver of both the experimental and control animals were studied with routine histological and histochemical methods. After the hydrocortisone...

Hydrocortisone acetate was administered daily by intramuscular injection (2.5mg/ 100gm body weight) to 14 adulat rats.Another 6 rats were used as controls.The ex- perimental animals were divided into 3 groups of which the first group were sacrificed 24 hours after 3 injections,the second group 24 hours after 6 injections and the third group 9 days after 6 injections.The liver of both the experimental and control animals were studied with routine histological and histochemical methods. After the hydrocortisone treatment,the rats decreased in body weight,but the liver weight/body weight percentage increased.The parenchymal cells showed a marked de- pletion of eosinophil granules,protein and ribonucleic acid,but the content of glycogen and the activity of phosphorylase increased.There was a drop in the activity of non- specific esterase. The change of alkaline phosphatase was not consistent.The content of desoxyribo- nucleic acid and lipids and the activity of acid phosphatase and succinic dehydrogenase did not show any distinct changes.

1.本实验用成年雄雌性大白鼠20只,体重为100—200克。其中六只动物作为对照。其余动物经臀部肌肉注射氢化可的松2.5毫克/100克体重,每日一次,分为注射三次、六次和注射六次后生活9日三组。大部分动物(16只雄性动物)经绝食24小时后杀死取材,分别进行组织学及组织化学观察。2.注射氢化可的松后动物体重下降,肝重略有增加,肝重/体重百分比也随之升高。3.实验动物肝细胞中,嗜伊红性颗粒、核糖核酸以及蛋白质均显著的减少。与此相反,肝糖原合量急剧增加。与其相伴,磷酸化酶的活性也趋于增强。非特异性酯酶的活性明显的降低。4.碱性磷酸酶的变化不一致。酸性磷酸酶、三磷酸腺苷酸酶的活性以及脱氧核糖核酸的含量均无变化。脂类含量及琥珀酸脱氢酶的活性也无改变。

As a direct consequence of the interdigitating filament model of the myofibril and the corresponding theory of muscular contraction put forward by H. E. Huxley and A. F. Huxley, it is evident that the muscle would lose its ability to contract if its sarcomere had been stretched to a length greater than the sum of the lengths of primary and secondary filaments. For the honey bee striated muscle, the sum of the lengths of the two sets of filament would be about 5.4μ, on the basis of the interdigitating filament...

As a direct consequence of the interdigitating filament model of the myofibril and the corresponding theory of muscular contraction put forward by H. E. Huxley and A. F. Huxley, it is evident that the muscle would lose its ability to contract if its sarcomere had been stretched to a length greater than the sum of the lengths of primary and secondary filaments. For the honey bee striated muscle, the sum of the lengths of the two sets of filament would be about 5.4μ, on the basis of the interdigitating filament model. The glycerine extracted myofibril of the honey bee indirect flight muscle, however, still preserved its ability to contract under the action of adenosine triphosphate after the sarcomere length had been stretched to beyond 8μ. Furthermore, the microscopical structure changes of the myofibril caused by stretching the sarcomere to beyond 6μ were still reversible. These results seem to indicate that the fine structure of the myofibril of the honey bee striated muscle was probably different from that expressed by the interdigitating filament model.

本文报告我們观察拉长的蜜蜂間接飞翔肌肌原纤維收縮能力的結果。在肌小节长度超过8微米以后,三磷酸腺苷仍能引起肌原紆維的縮短,而且在肌小节拉长后出現的結构变化也是可逆的。这些結果不能在H.E.Huxley和A.F.Huxley提出的肌原紆維由两組蛋白細絲构成的模型和收縮的細絲滑行理論的基础上来解释。

This paper presents the results of experiments concerning the influence of salt concentration, adenosine triphosphate, pH value, alcohol and urea on the binding of Congo Red with the glycerinated rabbit psoas muscle and toad sartorious muscle fibers. Within a certain range of concentrations, salt promotes the binding of Congo Red with the muscle fibers and impedes the washing out of Congo Red from stained muscle fibers in solutions of similar electrolytic composition without Congo Red. Adenosine triphosphate...

This paper presents the results of experiments concerning the influence of salt concentration, adenosine triphosphate, pH value, alcohol and urea on the binding of Congo Red with the glycerinated rabbit psoas muscle and toad sartorious muscle fibers. Within a certain range of concentrations, salt promotes the binding of Congo Red with the muscle fibers and impedes the washing out of Congo Red from stained muscle fibers in solutions of similar electrolytic composition without Congo Red. Adenosine triphosphate has two distinct effects. When the salt concentration of the washing solution is low, its effect is similar to that of the other salts. If the salt concentration is already rather high, it exerts a promoting effect on the washing out process. An alkaline pH is unfavourable to the binding. Furthermore, the muscle fiber stained with alkaline Congo Red solution (pH 9—10) fails to show dichroic properties. Alcohol has a strong inhibitory effect on the binding. Urea can increase the speed of the washing out process. The nature of the binding between Congo Red and the contractile protein molecules is discussed and it is argued that both salt linkage and hydrogen bond formation may play a role.

本文报告一些外界条件对剛果紅与甘油抽提的骨骼肌肌纤維結合的影响。所用方法大体上可以分为两类:(1)将肌纤維束浸于不同的剛果紅溶液中,观察染色的速率和深度有何差別;(2)将已經染色的肌纤維束浸于其他成分和用来染色的剛果紅溶液相同,但是不含剛果紅的洗脫液中,过一定时間后改变洗脫液的成分,观察由此所引起的洗脫速率的变化。得到的結果主要如下: (一)在一定范圍內增加盐濃度能促进剛果紅和肌纤維的結合,也能减低剛果紅从已經染色的肌纤維洗脫的速率,甚至使已被洗脫的剛果紅又重新和肌纤維結合。 (二)在洗脫液不含盐或含盐較少的情况下,三磷酸腺苷的作用和其它盐类的相仿,可是在洗脫液盐濃度較高的情况下,它却能增加洗脫的速率。 (三)两类实驗結果都表示硷性溶液(pH 9—10)不利于剛果紅和肌纤維結合,而且在硷性剛果紅溶液中染色的肌纤維或已經染色的肌纤維用硷性溶液处理后都基本上不出現二向色性。 (四)甲醇和乙醇能可逆地阻止剛果紅和肌纤維結合。 (五)脲能增加剛果紅从已經染色的肌纤維中洗脫的速率。文中还討論了剛果紅分子和收縮蛋白分子結合方式的問題,认为盐鍵和氫鍵大概都在起作用,而且在肌纤維中排列有規則的一部分剛果紅分子可能...

本文报告一些外界条件对剛果紅与甘油抽提的骨骼肌肌纤維結合的影响。所用方法大体上可以分为两类:(1)将肌纤維束浸于不同的剛果紅溶液中,观察染色的速率和深度有何差別;(2)将已經染色的肌纤維束浸于其他成分和用来染色的剛果紅溶液相同,但是不含剛果紅的洗脫液中,过一定时間后改变洗脫液的成分,观察由此所引起的洗脫速率的变化。得到的結果主要如下: (一)在一定范圍內增加盐濃度能促进剛果紅和肌纤維的結合,也能减低剛果紅从已經染色的肌纤維洗脫的速率,甚至使已被洗脫的剛果紅又重新和肌纤維結合。 (二)在洗脫液不含盐或含盐較少的情况下,三磷酸腺苷的作用和其它盐类的相仿,可是在洗脫液盐濃度較高的情况下,它却能增加洗脫的速率。 (三)两类实驗結果都表示硷性溶液(pH 9—10)不利于剛果紅和肌纤維結合,而且在硷性剛果紅溶液中染色的肌纤維或已經染色的肌纤維用硷性溶液处理后都基本上不出現二向色性。 (四)甲醇和乙醇能可逆地阻止剛果紅和肌纤維結合。 (五)脲能增加剛果紅从已經染色的肌纤維中洗脫的速率。文中还討論了剛果紅分子和收縮蛋白分子結合方式的問題,认为盐鍵和氫鍵大概都在起作用,而且在肌纤維中排列有規則的一部分剛果紅分子可能是通过氫鍵和收縮蛋白分子結合的。

 
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