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药动学     
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  pharmacokinetics
    Study on Analytical Methods and the Pharmacokinetics of Fluoxetine and Norfluoxetine
    氟西汀与去甲氟西汀的分析方法及大鼠体内药动学研究
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    Studies on the Pharmacokinetics of 3-n-Butylphthalide in Rats and Rabbits and the Transport Mechanism in Brain
    3-正丁基苯酞体内药动学及脑内转运机理的研究
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    Studies on Pharmacy and Pharmacokinetics of Compound Butafosfan
    复方丁氨丙磷的药学与药动学研究
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    The studies on pharmacokinetics of paeoniflorin in rabbits and rats
    芍药甙在兔和大鼠体内的药动学研究
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    INFLUENCE OF OPERATION ON PHARMACOKINETICS OF GENTAMICIN IN RABBITS
    手术创伤对庆大霉素在兔体药动学的影响
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  pharmacokinetic
    THE PHARMACOKINETIC MODEL OF SUDOXICAM
    湿痛喜康的药动学模型
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    Determination of apparent pharmacokinetic parameters of anisodamine by acute mortality of mice
    用小鼠急性死亡率法测定山莨菪碱的表观药动学参数
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    Pharmacokinetic characteristics and relative bioavailability
    替沃噻吨的药动学特征与其相对生物利用度
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    Pharmacokinetic Study on Enoxacin in Healthy Chinese Volunteers
    氟啶酸在健康人体内药动学研究
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    The pharmacokinetic and pharmacodynamic studies on mannitol
    甘露醇的药动学和药效学研究
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  main pharmacokinetic
    RESULTS:The main pharmacokinetic parameters of single oral doses (8mg,16mg) were as follow:t_(1/2β)(22.8±s 2.4),(24±44) h;
    结果:口服受试制剂(单剂量8,16 mg)后,估算的阿折地平的药动学参数分别为:t_(1/2β)为(22.8±s 2.4),(24±4)h;
短句来源
    The concentration-time curve was fitted to a two-compartment model. Its main pharmacokinetic parameters were as follows:tmaxwas(2.17±1.70)h;
    盐酸二氧丙嗪浓度的血药浓度-时间曲线符合二室模型,主要药动学参数为:tmax为(2.17±1.70)h;
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    RESULTS The main pharmacokinetic parameters were as follows: t1/2(7.26±2.02)h,ρmax(1229.93±419.98)μg·L-1 ,AUC0→48( 10 031.56±2 856.78)μg·h·L-1 for females in single dose;
    结果主要药动学参数:单剂量为女t1/2(7.26±2.02)h、ρmax(1 229.93±419.98)μg·L-1、AUC0→48(10 031.56±2 856.78)μg·h·L-1;
短句来源
    Results The blood plasma Cot curve of A771726 conformed to one compartment model of the first order absorption. The main pharmacokinetic parameters of A771726(3, 6, 12 mg/kg) were T1/2ka(h): 3.91±3.43, 5.63±2.07, 6.73±1.67;
    结果A771726(3、6、12mg/kg)的血药经时过程均符合一级吸收的一房室模型,其主要药动学参数T1/2Ka(h)3.91±3.43、5.63±2.07、6.73±1.67;
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    Results: The main pharmacokinetic parameters of the reference and test flunarizine capsules were as follows: C_max(74.76±16.14)vs.
    结果:参比制剂和受试制剂在受试者体内的药动学参数分别为:Cm ax(74.76±16.14)和(70.50±14.96)μg.
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  human pharmacokinetics
    Study on Sustained Release Tablets of Labetalol Hydrochloride and its Human Pharmacokinetics
    盐酸拉贝洛尔缓释片及其药动学研究
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    Study on sustained release suppositories of tramadol hydrochloride and its human pharmacokinetics
    盐酸曲马多缓释栓的研制及其药动学
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    The human pharmacokinetics was investiga ted in nine male healthy volunteers. The relative bioavailability of nicardipine SR tablets was 109.1 ±11.1% as compared with Perdipine LA 40 capsules.
    药动学试验结果表明 ,缓释片缓释作用显著 ,与进口缓释胶囊相比 ,其相对生物利用度为 10 9.1± 11.1%
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  pharmacokinetics
PRE-CLINICAL AND CLINICAL PHARMACOKINETICS OF THE DIASTEREOMERS OF ARTEETHER, A POTENT ANTIMALARIAL
      
The pharmacokinetics of α- and β-diastereomers of Arteether, a well-known antimalarial drug and its active metabolite dihydroartemisinin (DHA) were studied in Sprague-Dawley rats, Rhesus monkeys and human volunteers.
      
Studies in rats revealed dose dependency/ non-linearity in arteether pharmacokinetics with in the dose levels used.
      
The biological activity on cancer cells and the pharmacokinetics have also been evaluated, showing a very high liver-to-skin ratio and short retention time in tissues.
      
The pharmacokinetics of Selank, an anxiolytic peptide, was also studied in brain tissues using the intranasal in vivo administration of this peptide.
      
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  pharmacokinetic
Overall the pharmacokinetic properties of both isomers were similar in rats, monkeys and humans, with β-isomer exhibiting longer elimination half-life, MRT, volume of distribution and clearance, irrespective of the route of administration.
      
Because of their complimentary pharmacokinetic characteristics, the isomeric mixture of arteether can be therapeutically more beneficial than β- isomer used alone.
      
At present, however, side effects and/or insufficient pharmacokinetic profiles have made most of the drug candidates undesirable.
      
The genetic factors involved in Parkinson's and Alzheimer's diseases are conventionally divided into pharmacodynamic and pharmacokinetic.
      
The pharmacokinetic factors play a role in Parkinson's disease (PD) at the level of metabolism of DA, dioxyphenylalanine, and tyrosine and include polymorphisms of enzymes and proteins involved in the relevant metabolic reactions.
      
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  main pharmacokinetic
The different doses had no significant effect on the main pharmacokinetic data and the kinetics seemed to be linear in dosage range 2.5-15?mg?kg-1.
      
No statistically significant differences between the main pharmacokinetic parameters of NETO and NET as well as NETO-AC and NET-AC were found.
      
Estimations of the main pharmacokinetic parameters (elimination half life: 230±102 min, total body clearance: 520±283 ml·min-1, total volume of distribution: 2.23±1.15 l·kg-1) showed no marked differences with normal patients.
      
In the group of patients with severe renal dysfunction, the main pharmacokinetic finding was a longer half-life after multiple dosing.
      
The main pharmacokinetic parameters (half-lives, total volume of distribution, total plasma clearance) were estimated in the test group by maximum-likelihood estimation using all samples and by Bayesian estimation using three samples.
      
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  human pharmacokinetics
A means of mimicking human pharmacokinetics in rats is proposed.
      
Traditional in vitro models used to simulate human pharmacokinetics and to characterize the pharmacodynamics of antibacterial agents represent a totally immunosuppressed condition.
      
These models allow comparisons among different antibiotics by simulating human pharmacokinetics.
      
Human pharmacokinetics and bioavailability of temazepam administered in soft gelatin capsules
      
Human pharmacokinetics of nitrazepam: Effect of age and diseases
      
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