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凋亡率
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  apoptotic rate
    The apoptotic rate in the VPA,DDP,and VPA+DDP groups was as follows:(27.05±1.63)%,(35.93±3.89)%,and(42.59±2.55)%,which was significantly higher than that in the control group(16.73±2.82)%(P<0.01).
    治疗组的凋亡率分别为(27.05±1.63)%(、35.93±3.89)%(、42.59±2.55)%,高于对照组(16.73±2.82)%;
短句来源
    4. The apoptotic rate of SKOV3 cells treated by 5μmol/L ASODN, SODN and untreated control groups were 5.73 %, 3.67%, 3.47% respectively.
    进一步证明反义寡核苷酸诱导卵巢癌细胞凋亡。 4 细胞凋亡率变化 流式细胞仪检测表明反义组细胞5μmol/L凋亡率5.73%,而正义组及空白组细胞凋亡率分别为3.67%和3.47%。
短句来源
    Results:The speed of cell growth was significantly decreased and their apoptotic rate was significantly increased compared with those of the control group(P<0.05),but no difference between Gestrinone and Mifepriston.
    结果 :加入药物后 ,细胞的生长速度减慢 ,其凋亡率较未用药组明显增加 ,差异有显著性 (P <0 .0 5 ) ,而两种药物在同一种细胞 ,相同作用时间的凋亡率无统计学意义。
短句来源
    Flow cytormetry (FCM) was used to measure the expressive rate of ER, PR , p53 protein, bcl-2 protein, cell apoptotic rate and cell proliferative cycle of 3AO cells, which were cultured with different concentration and duration of mifepristone.
    应用流式细胞仪 (FCM )检测米非司酮在不同浓度和培养时间下 ,3AO细胞的ER、PR、p5 3和bcl 2蛋白表达率、增殖率和凋亡率
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    FCM showed that estradiol increased the proportion of S phase,reduced the apoptotic rate and up-regulated the expression of bcl-2 protein.
    FCM显示E2 组细胞周期S期比例上升 ,凋亡率下降 ,细胞内bcl 2蛋白表达上升 ;
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  “凋亡率”译为未确定词的双语例句
    The apoptosis was also notably correlated with 5-Aza-CdR concentration(F=227.6,P<0.01).
    且凋亡率与5-Aza-CdR剂量成正相关(F=227.6,P<0.01)。
短句来源
    The apoptic ratios of COC1/ DDP cells with DDP combined with curcumin were significantly higher than that of only DDP and curcumin(P<0.05).
    COC1/DDP中顺铂与姜黄素联合用药与单独用顺铂相比,凋亡率明显增加(P<0.05);
短句来源
    The expressions of apoptosis- associated genes and proteins Bcl-2, Caspase-3, Smac, Survivin were studied by reverse trans-cription polymerase chain reaction (RT-PCR) and Western blot in COC1/ DDP and COC1. [Results] Using DDP to stimulate COC1/DDP and COC1 for 48 hours, the apoptic ratios were gradually increased with the increase of concentration of DDP.
    RT-PCR及Western blot法检测凋亡相关基因及蛋白Bcl-2、Caspase-3、Smac和Survivin在COC1和COC1/DDP中的表达。 结果DDP作用于COC1和COC1/DDP细胞48h后细胞随着DDP浓度的升高,凋亡率也相应增高。
短句来源
    Results: JAR cells underwent apoptosis and cycle retardation when exposed to 0.1-1.0ug/ml MTX after 24 hours but not JAR/MTX cells.
    2.5雌/m 1 MTx作用48小时后为1 .0%士0.01%,JA侧MTX细胞在无药和加药后线粒体途径的凋亡率均显著低于JAR细胞。
短句来源
    2) MTT assay was used to determin the Inhibitory concentration of NS-398 in treating RL95-2 cell. The apoptosis percentage and intracellular calcium concentration was examined by flow cytometry (FCM);
    2)MTT法检测不同浓度选择性环氧合酶-2抑制剂NS-398单用或与顺铂联用对子宫内膜癌RL95-2细胞生长的抑制率,流式细胞技术检测NS-398作用后细胞周期变化与凋亡率
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  apoptotic rate
When the concentration of thrombin is 40 U/mL, TUNEL positive cells and apoptotic rate of hippocampal neurons reached peak value, were 27.3±4.0 and (29.333±4.633)%, respectively.
      
AS PS-ODNs increased the chemotherapy sensitivity and apoptotic rate.
      
Typical nuclear condensation and apoptosis bodies were observed as early as 24 hrs after a 0.5 ?g/ml Taxol treatment; Apoptotic rate of the Taxol-treated K562 cells increased from 3.7% to 24.0% in 24 hrs.
      
After irradiation and addition of curcumin, the expression of hMSH2 mRNA increased and the cellular apoptotic rate also increased at the same time.
      
Apoptotic rate was quantified by flow cytometry (FCM).
      
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Objective To examine the relationship between apoptosis and proliferating cell nuclear antigen (PCNA) in the cervical careinoma. Methods Using TDT/dUTP nick end labeing and immunohistochemical method, we examined 53 samples ofcervical squamous cell carcinoma. Results The results showed that the positive rates of apoptosis and expression of PCNA were different in careinoma tissue with different degrr of differentiation. The higher the diferentiation, the higher the rate of apoptosis, and the lower the differentiation,...

Objective To examine the relationship between apoptosis and proliferating cell nuclear antigen (PCNA) in the cervical careinoma. Methods Using TDT/dUTP nick end labeing and immunohistochemical method, we examined 53 samples ofcervical squamous cell carcinoma. Results The results showed that the positive rates of apoptosis and expression of PCNA were different in careinoma tissue with different degrr of differentiation. The higher the diferentiation, the higher the rate of apoptosis, and the lower the differentiation, the higher the expressive rate of PCNA. Therefore, the higher the ratio of positive PCNA expres sion number/positive apoptosis numder, the lower the degree of differentiation of squamous cell earcnoma and the poorer its Prog nosis. Conclusions The ratio of PCNA and apoptosis may be a reliable index to judge the Prgnosis of cervical cdrcinoma.

目的检测宫颈鳞癌细胞凋亡与PCNA比值与宫颈癌预后的关系。方法应用原位末端标记法(TUNEL)及免疫组化技术对53例宫颈鳞癌石蜡包埋组织进行检测。结果不同分化程度癌组织中细胞凋亡和增殖细胞核抗原(PCNA)的阳性率不同。分化程度高,细胞凋亡率高;分化程度低,PCNA阳性率高。同时有细胞凋亡和PCNA阳性表达的低分化最高。结论二者的比值可能是判定宫颈癌预后的一个可靠指标。

Objective: To investigate the rule of allicin induced apoptosis. Methods: Terminal

目的:探讨大蒜素诱导卵巢癌细胞株OVCA-3凋亡规律。方法:应用DNA断裂点标记(TUNEL)法、DNA凝胶电泳以及光镜等技术观察有关细胞的凋亡情况。结果:0.01~100μg/ml的大蒜素作用OVCA-3细胞2h及10μg/ml的大蒜素作用OVCA-3细胞不同时间,锥虫蓝染色阳性率均在18.5%以下。TUNEL显示:1~100μg/ml的大蒜素作用OVCA-3细胞2h,即出现典型的细胞凋亡特征;50μg/ml时凋亡率为65.9%。结论:一定剂量范围内的大蒜素可在直接杀伤作用较小的情况下明显诱导OVCA-3细胞凋亡,不会因细胞坏死而引起炎症反应,这对于大蒜素应用于临床将有重要意义。

Objectve:To elucidate the patterns of cisplatin induced apoptosis and its role in cancer chemotherapy.Methods:In two ovarian carcinoma cell lines one sensitive to cisplatin(COC 1) and the other with acquired resistance(COC 1/DDP),to measure the cell viability by trypan blue dye exclusion assay,to observe the apoptotic cells by light microscope,electron microscope and flow cytometry,and to measure the cell cycle.Results:The most prominent effect on cell cycle kinetics was a slowdown in S Phasc transit during...

Objectve:To elucidate the patterns of cisplatin induced apoptosis and its role in cancer chemotherapy.Methods:In two ovarian carcinoma cell lines one sensitive to cisplatin(COC 1) and the other with acquired resistance(COC 1/DDP),to measure the cell viability by trypan blue dye exclusion assay,to observe the apoptotic cells by light microscope,electron microscope and flow cytometry,and to measure the cell cycle.Results:The most prominent effect on cell cycle kinetics was a slowdown in S Phasc transit during which the cells underwent apoptosis,COC 1 and COC 1/DDP had different apoptotic rates.Conclusions:Inducement of apoptosis was one of the pharmaceutic mechanisms of cisplatin and acquired resistance was associated with apoptosis.

目的:探讨顺铂作用于卵巢癌细胞的作用机理。方法:通过电镜、光镜、流式细胞仪等方法观察顺铂诱导人亲代和耐药卵巢癌细胞COC1 、COC1/DDP凋亡,进行细胞周期分析及计算凋亡率。结果:顺铂引起细胞S期增多、S期细胞凋亡,COC1 、COC1/DDP细胞凋亡率不同。结论:顺铂药理机制之一是诱导细胞凋亡,耐药与凋亡减少有关。

 
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