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凋亡率     
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  apoptosis rate
    The nuclei of HL-60 cells showed the characteristics of apoptosis, the analysis by flow cytometry indicated that the apoptosis rate of HL-60 cells was 52% after treatment with rBTI (100 μg/ml), DNA analyzed by agarose gel electrophoresis showed "ladder" pattern.
    流式细胞术分析表明,HL-60细胞经100μg/ml重组荞麦胰蛋白酶抑制剂作用后,凋亡率达到52%; 琼脂糖凝胶电泳显示细胞DNA呈梯状降解。
短句来源
    Moreover,flow cytometry results demonstrated that Bcl-XL siRNA cells had increased apoptosis rate after addition of 20 μg/mL DDP.
    用20μg/mL顺铂处理细胞48 h,流式细胞仪检测,转染Bcl-XLsiRNA组凋亡率较转染阴性siRNA组和未转染组增加;
短句来源
    ②The apoptosis rate was increased from 3.1% in control group to 4.4 % ~ 11.0 % in valdecoxib groups at 50~400 μmol·L2-1.The proliferation index and the proportion of cell in the S and G2/M phase had the tendency to decrease,but there was statistical significance only in valdecoxib 400 μmom·L2-1 group.
    L-1戊地昔布可明显提高clone 26细胞的凋亡率,从对照的3.1%提高到4.4%~11.0%。 给予戊地昔布后,细胞的增殖指数,S期的细胞比例和G2/M期细胞有下降趋势,但只有在400μmol.
短句来源
    In the group treated with SDT,the apoptotic rate increased and the percentage of G_0/G_1、G_2/M decreased, the percentage of S increased and the apoptosis rate increased.
    SDT后凋亡率升高,G_0/G_1期、G_2/M期百分比降低,S期百分比升高、凋亡增殖比(APR)升高。
短句来源
    After B16 melanoma cells were treated with 7. 68 mg/L UA-PL-NP for 24 h, apoptosis rate was (53. 20±7. 13 ) % .
    流式检测UA-PL-NP浓度为7.68 mg/L,作用24 h后B16鼠黑色素瘤细胞的凋亡率为(53.20±7.13)%;
短句来源
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  apoptotic rate
    ③Apoptotic analysis:Flow cytometer showed pretreatment with IFN-γ(1 000 u/mL)for 24 hours and further cultured with TRAIL at indicated concentrations(100 μg/L,200 μg/L)for 24 hours,the apoptotic rate increased to(39.94±2.87)%,(48.32±3.33)%,respectively. Cell inhibition appeared obviously with invert microscope.
    ③凋亡分析:流式细胞检测发现干扰素γ(1000 U/mL)诱导24h再联合不同浓度肿瘤坏死因子相关凋亡诱导配体(100,200μg/L)作用后,凋亡率分别为(39.94±2.87)%,(48.32±3.33)%,倒置显微镜观察也可见明显的细胞抑制表现。
短句来源
    In the group treated with SDT,the apoptotic rate increased and the percentage of G_0/G_1、G_2/M decreased, the percentage of S increased and the apoptosis rate increased.
    SDT后凋亡率升高,G_0/G_1期、G_2/M期百分比降低,S期百分比升高、凋亡增殖比(APR)升高。
短句来源
    The apoptotic rate in SDT group(19.224%±6.552%) was higher than that in control group(0.320%±0.360%) (P<0.01).
    流式细胞术检测结果显示,SDT组发生了G0/G1期生长停顿,凋亡率为(19.224±6.552)%,明显高于对照组[(0.320±0.360)%](P<0.01)。
短句来源
    The apoptotic rate in the VPA,DDP,and VPA+DDP groups was as follows:(27.05±1.63)%,(35.93±3.89)%,and(42.59±2.55)%,which was significantly higher than that in the control group(16.73±2.82)%(P<0.01).
    治疗组的凋亡率分别为(27.05±1.63)%(、35.93±3.89)%(、42.59±2.55)%,高于对照组(16.73±2.82)%;
短句来源
    Effects of ETB-2 on growth of LoVo in vitro were assayed by MTT method, the pathologic changes were observed by conventional pathology, the microvessel density(MVD), proliferating cell nuclear antigen(PCNA) index and the positive rate of vascular endothelial growth(VEGP) were measured immunohistochemically and the apoptotic rate was analyzed with TDT mediated dUTP nick end labeling(TUNEL) technique, the VEGFmRNA> TGF-3-lmRNA were measured by RT-PCR.
    MTT法检测ETB-2对LoVo结肠癌细胞株体外生长的影响,常规病理观察病理变化,免疫组化检测微血管密度(MVD)、PCNA指数和VEGF阳性率,RT-PCR检测VEGFmRNA、TGF-β1mRNA,DNA原位末端标记(TUNEL)检测凋亡率
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  apoptosis rates
    Results The apoptosis rates were 5.7%,12.0%,19.4%,21.7% at 0,8,16,24 Gy,respectively at the 48th hour after completion of radiation.
    结果MHCC97H细胞照射后48小时,0、8、16、24 Gy组的凋亡率分别为5.7%、12.0%、19.4%、21.7%;
短句来源
    When SW480 cells were treated with oxaliplatin at the concentration of 0,0.03,4.0 and 100 μg/ml,the apoptosis rates of SW480 cell were(0.15±0.09)%,(0.43±0.17)%,(6.92±0.81)% and(11.76±1.25)%,respectively.
    奥沙利铂浓度为0,0.03,4.0,100μg/ml时SW480细胞的凋亡率分别为(0.15±0.09)%、(0.43±0.17)%、(6.92±0.81)%、(11.76±1.25)%。
短句来源
    After used the ADM,we found that the apoptosis rates of the L02/HBx had been promoted more obviously than that of the L02/HBx without disposing to the the ADM,FCM also showed that the propotion of L02/HBx still falled in G1 phase and rose in S phase compared with control groups,the diploid cells decreased and the aneuploid cells increased obviously.
    经阿霉素处理后,L02/HBx细胞的凋亡率大大增加,G1期细胞的比例仍比对照组低,S期细胞的比例亦比对照组高,二倍体细胞的比例显著降低,非整倍体细胞的比例明显增加。
短句来源
    The result of flow cytometry showed that matrine could induce apoptosis of PA-1 cells, stop the growth of them at G1 period and restrain mitosis of cells. And the apoptosis rates of 1.0,0.5,0.25 mg/ml concentration of matrine were declined in order after they affected the cells for 24 hours.
    流式细胞仪检测1.0mg/ml、0.5mg/ml、0.25mg/ml浓度的苦参碱作用24h后PA-1细胞的凋亡率依次下降; 有明显的G1期阻滞作用,且具有剂量依赖性。
短句来源
    The apoptosis rates of the HHUA cells treated with 6×10-7mol/L of exemestane for 72 h were assessed by flow cytometry analysis technique.
    应用流式细胞仪(FCM)检测6×10-7mol/L依西美坦作用的子宫内膜癌HHUA细胞的凋亡率;
短句来源
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  ratio of apoptosis
    Sub-G1 peak wasdetected by FCM, with the ratio of apoptosis being 7.8%-34. 38%.
    FCM显示DNA直方图上出现典型的亚二倍体“凋亡峰”,凋亡率在7.8%—34.38%。
短句来源
    Results:The frequency of the expression of Bak and Bcl xL protein in normal pancreatic tissue was 2/10 and 4/10 respectively, ratio of apoptosis was 2/10 .The frequency of the expression of Bak and Bcl xL protein in pancreatic cancer was 79.7%(47/59) and 32.2%(19/59)respectively, the ratio of apoptosis was 74.6%(44/59) .
    结果 :Bak、Bcl xL蛋白在正常胰腺组织表达率分别为 2 / 10 ,4 / 10 ,凋亡率为 2 / 10 ; 在胰腺癌组织的表达率分别为 79.7% (47/5 9) ,32 .2 % (19/ 5 9) ;
短句来源
    Results In the medium which contain less folate, the ratio of apoptosis was increased, the growth of L,02 were stimulated ,manifesting the percentage of G0G1 cells decreased.
    结果:L02在叶酸缺乏状态下凋亡率增加,生长旺盛,表现为细胞总数增多,G0、G1期细胞比例下降。
短句来源
    The ratio of apoptosis was(4.69±0.60)%,(21.15±3.10)%,(33.15±2.40)%,(40.87±1.50)% and(48.47±1.02)% respectively by FCM.
    流式细胞仪检测显示不同浓度凋亡率分别为(4.69±0.60)%、(21.15±3.10)%、(33.15±2.40)%、(40.87±1.50)%、(48.47±1.02)%;
短句来源
    ② 10~(-8) mol·L~(-1) 1,25(OH)_2D_3 could markedly inhibit K562 cells growth and induce cells apoptosiswith most of cells being arrested in G_2/M phase. The ratio of apoptosis increased from 4.1%(control group) to 26.5%(treatment group),P<0.01;
    ②10-8mol. L-11,25(OH)2D3可明显抑制K562细胞增殖,促进凋亡,凋亡率从4.1%(对照组)增至26.5%,P<0.01;
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  apoptosis rate
Only NPSLE patients exhibited an increased neglect-apoptosis rate after incubation with culture medium; however, the neglect-apoptosis rate was associated with lymphopenia in both series of patients.
      
After lymphocyte incubation with autologous serum, only NPSLE patients exhibited a significant negative correlation between the neglect-apoptosis rate and the number of peripheral lymphocytes.
      
The total apoptosis rate is positively proportional to reaction duration and concentration of quercetin used.
      
The maximum apoptosis rate being (88.76±2.35)% was obtained when the concentration was 50.0 μmol/L and the cells were treated with quercetin for 72 hours.
      
The highest apoptosis rate was found to reach 13.38% by flow cytometry at 6 h after EMP irradiation.
      
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  apoptotic rate
When the concentration of thrombin is 40 U/mL, TUNEL positive cells and apoptotic rate of hippocampal neurons reached peak value, were 27.3±4.0 and (29.333±4.633)%, respectively.
      
AS PS-ODNs increased the chemotherapy sensitivity and apoptotic rate.
      
Typical nuclear condensation and apoptosis bodies were observed as early as 24 hrs after a 0.5 ?g/ml Taxol treatment; Apoptotic rate of the Taxol-treated K562 cells increased from 3.7% to 24.0% in 24 hrs.
      
After irradiation and addition of curcumin, the expression of hMSH2 mRNA increased and the cellular apoptotic rate also increased at the same time.
      
Apoptotic rate was quantified by flow cytometry (FCM).
      
更多          
  apoptosis rates
Seventy-two hours after transfection, apoptosis rates of the two RNAi groups were 21.51% and 26.28%, both of which were higher than control Lovo's (9.03%).
      
Apoptosis rates of Raji cells treated with Bcl-2 oligodeoxynucleotide/radiation combination and radiation-treated cells alone, respectively.
      
From zero to 36 h, the apoptosis rates of 8 different phases and other indexes were observed.
      
The apoptosis rates in the cells were all less than 2% and had no significant difference among the groups.
      
Treatment with TSA (200 and 400 μg/L) for 24 h, the apoptosis rates of Daudi cells were (14.74±2.04) % and (17.63±1.25) %, respectively.
      
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  ratio of apoptosis
Induced for 18 h by CD34+ cells transfected with FasL or without, the ratio of apoptosis of U937 cells was (5.0±1.3)%, (10.8±0.6)% (P>amp;lt;0.01), respectively.
      
The ratio of apoptosis of T cells was 12.1±1.5% when CD34+ cells transfected with FasL was used as stimulus cells, much higher than that of CD34+ cells non-transfected (3.2±1.1%,P>amp;lt;0.01).
      
The ratio of apoptosis to mitosis was calculated because it can give a better indication of any shift in the dynamic status of the tumors.
      
The ratio of apoptosis to PCNA appears to be a marker that predicts response to this therapy.
      
  其他


In order to understand the influence of rh-IL-3 and rh-GM-CSF on apoptosis of leukemic cells under the effect of Ara-C, the myeloid leukemic cell line HL-60 was studied by using DNA gel electrophoresis, flow cytometry, McAb C-myc, McAb bc1-2 and CFU-L. From 0 to 36 hours, the apoptosis rates of 8different phases and other indexes were observed. It showed that with prolonged time of drug incubation,apoptosis of HL-60 cells increased progressively from 1. 5 % at 0 hour to 36. 4 % at 36 hour. This effect can be...

In order to understand the influence of rh-IL-3 and rh-GM-CSF on apoptosis of leukemic cells under the effect of Ara-C, the myeloid leukemic cell line HL-60 was studied by using DNA gel electrophoresis, flow cytometry, McAb C-myc, McAb bc1-2 and CFU-L. From 0 to 36 hours, the apoptosis rates of 8different phases and other indexes were observed. It showed that with prolonged time of drug incubation,apoptosis of HL-60 cells increased progressively from 1. 5 % at 0 hour to 36. 4 % at 36 hour. This effect can be enhanced obviously by rh-IL-3 and rh-GM-CSF, apoptosis rates increased from 7-6% to 19. 6 %. At the same time, the killing rate of leukemic cells was increased. C-myc expression was decreased and bcl-2 expression did not display apparent change. Interestingly, the normal hemopoietic cells were less affected by these two kinds of cytokines. These provided a theoretical basis for concurrent use of rh-IL-3, rh-GM-CSF and cytotoxic drugs with the purpose of elevating remission rate during the phase of induced remission of leukemia.

为研究在阿糖胞苷(Ara-C)的作用下,基因重组的人白细胞介素3(rh-IL-3)、粒单祖细胞集落刺激因子(rh-GM-CSF)对白血病细胞凋亡的影响,选用了HL-60白血病细胞系,采用DNA电泳、流式细胞仪检测、单克隆抗体C-myc、bcl-2抗原表达的分析以及白血病细胞集落的培养观察方法,观察了0~36h8个不同时相凋亡率与其他指标的变化,表明Ara-C凋亡的作用随药物孵育时间的延长而逐渐增强,凋亡率从0h的1.5%升至36h后的36.4%,而IL-3和GM-CSF能使这种作用明显提高,使凋亡率从7.6%升至19.6%,并能增强Ara-C对白血病细胞的杀灭,引起HL-60细胞C-myc抗原表达下降,而bcl-2抗原表达变化不大,同时发现这两种细胞因子对正常造血细胞影响较小,这为临床上白血病诱导缓解期联用rh-IL-3、rh-GM-CSF和细胞毒药物,提高缓解率,提供了理论依据。

In order to study the role of apoptosis on halo nevus development, we studied the expression of bcl 2 in 8 patients with halo nevus and 8 patients with melanocytic nevus using immunohistochemical methods. All 8 patients with halo nevus and 3 of 8 patients with melanocytic nevus expresed bcl 2, but the staining was significantly weaker in the patients with melanocytic nevus. Because the expression of bcl 2 was obviously different in the tissues of the two types of nevus, the authors believe that the over expression...

In order to study the role of apoptosis on halo nevus development, we studied the expression of bcl 2 in 8 patients with halo nevus and 8 patients with melanocytic nevus using immunohistochemical methods. All 8 patients with halo nevus and 3 of 8 patients with melanocytic nevus expresed bcl 2, but the staining was significantly weaker in the patients with melanocytic nevus. Because the expression of bcl 2 was obviously different in the tissues of the two types of nevus, the authors believe that the over expression for bcl 2 may be related to the autoimmune mechanism of halo nevus development, and it may be a homeostatic response to high rate of apoptosis in the tissues of halo nevus.

为了研究细胞凋亡在晕痣发生中的作用,我们对8例晕痣和8例痣细胞痣患者皮损进行了bcl-2原癌基因产物(B-celllymphoma/leukemia2geneproduct,以下简称bcl-2)的免疫组化观察。结果表明8例晕痣均见有bcl-2的阳性表达,8例痣细胞痣仅有3例表达bcl-2,而且染色明显较弱,大部分组织呈阴性表达。由于两种痣bcl-2表达明显不同,作者认为晕痣组织内bcl-2的过量表达与晕痣发生的自身免疫机制有关,可能是痣组织内对痣细胞的高凋亡率的一种自动平衡反应

Objective:To investigate the characteristics and regulation of apoptosis in acute myeloid leukemic cells.Methods:Flow cytometry,DNA electrophoresis and Northern blot were used to analyze the expression of bclXL before and after Vp16 treatment,and the relationships between bclXL expression and apoptotic sensitivity, clinical features and prognosis were also analyzed.Results:Most of the leukemic cells from AML patients overexpressed bclXL mRNA.The expression of bclXL was still maintained high level after...

Objective:To investigate the characteristics and regulation of apoptosis in acute myeloid leukemic cells.Methods:Flow cytometry,DNA electrophoresis and Northern blot were used to analyze the expression of bclXL before and after Vp16 treatment,and the relationships between bclXL expression and apoptotic sensitivity, clinical features and prognosis were also analyzed.Results:Most of the leukemic cells from AML patients overexpressed bclXL mRNA.The expression of bclXL was still maintained high level after Vp16 treatment in patients with pretreatment overexpression.These patients were resistant to apoptosis,poor responsed to chemotherapy and associated with adverse prognostic features,such as high WBC counts,local leukemic infiltrations.Bone marrow cells from long term remission AML patients and normal controls also showed bclXL downregulation after in vitro Vp16 treatment,but the apoptotic rates were lower than that in nonremissive AML.Conclusion:Overexpression of bclXL played an important role in leukemogenesis and drug resistance.Downregulation of bclXL was necessary but not sufficient to initiate apoptosis.

目的:探讨急性髓系白血病(AML)细胞凋亡径路的特征及调控模式。方法:运用流式细胞仪(FACS)、DNA电泳、Northernblot分析技术,观察了化疗药物足叶乙甙(Vp16)作用于原代AML细胞前后,bcl-XL表达与凋亡的敏感性、临床特征、预后的关系。结果:绝大部分AML高表达bcl-XLmRNA病例经Vp16处理后,其bcl-XL虽然下调,但仍维持较高水平,并对凋亡诱导不敏感,与高白细胞数、髓外浸润等不良预后特征相关,化疗后不易缓解,处于长期缓解中的病例经Vp16处理后,bcl-XL亦表达下调,但凋亡率远低于AML细胞。结论:bcl-XL高表达与AML的发生、维持和化疗耐药性相关,bcl-XL高表达下调是凋亡启动的基础,但本身不足以引致凋亡。

 
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