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阿尔茨海默症
相关语句
  alzheimer disease
     Progress in the researches of pathology of Alzheimer disease
     阿尔茨海默症病理学研究进展
短句来源
     The construction of transgenic mice of Alzheimer disease
     阿尔茨海默症转基因动物模型的建立
     Objective\ To establish a transgenic model of Alzheimer disease.
     目的 建立阿尔茨海默症转基因动物模型 ,为病因研究和药物筛选提供了一个合适的动物模型。
短句来源
     The pathological presentation of Alzheimer disease (AD), the leading cause of senile dementia, involves regionalized neuronal death and an accumulation of intraneuronal and extracellular filaments termed neurofibrillary tangles and senile plaques, respectively.
     作为老年性痴呆的主要类型,阿尔茨海默症(AD)的病理特征包括大脑局部,尤其是海马和皮层神经元退行性变化,细胞内神经原纤维缠结和细胞外老年斑沉淀,其中老年斑的主要毒性成分为β-淀粉样肽(Aβ).
短句来源
  “阿尔茨海默症”译为未确定词的双语例句
     Depending on its pathogenesis, dementia can be divided into Alzheimer's disease(AD), vascular dementia(VD) and mixed dementia.
     老年期痴呆按其发病机制的不同,又可分为阿尔茨海默症(Alzheimer's disease,AD)、血管性痴呆(Vascular dementia,VD)和混合型痴呆。
短句来源
     Alzheimer's disease is characterized by the progressive formation in the brain of senile plagues , which are mainly made up of β-amyloid.
     β淀粉样蛋白(β-Amyloid,Aβ)是阿尔茨海默症(Alzheimer'sdisease,AD)病人脑中老年斑(senile plagues, SP)的主要成分。
短句来源
     Progress in Molecular Mechanisms of β-amyloid Peptides in Alzheimer's Disease
     β淀粉样肽在阿尔茨海默症发病中的分子机制
短句来源
     Donepezil Hydrochloride, named l-benzyl-4-[(5,6-dimethoxy-l-indanon)-2-yl]methyl pyridine hydrochloride, was the second generation reversibility anticholinesterase inhibitor and the second medicament for treating Alzheime disease(AD) authorized by FDA.
     盐酸多奈哌齐,即1-苄基-4-[(5,6-二甲氧基-1-茚酮)-2-亚甲基]哌啶盐酸盐,是第二代可逆性乙酰胆碱酯酶(AChE)抑制剂,是美国食品与药物管理局(FDA)批准用于治疗阿尔茨海默症Alzheime disease(AD)的第2个药物。
短句来源
     Calcium Signal of AD Model Cell
     阿尔茨海默症模型细胞的钙信号研究
短句来源
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  相似匹配句对
     Advance in Alzheimer Disease
     阿尔茨海默的研究进展
短句来源
     Progress in the researches of pathology of Alzheimer disease
     阿尔茨海默病理学研究进展
短句来源
     Osteoporosis
     骨质疏松
短句来源
     Night Terrors
     夜惊
短句来源
     Amyloid-β immunotherapy for Alzheimer's disease
     阿尔茨海默病的免疫治疗
短句来源
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  alzheimer disease
Effect of homocysteine and nitric oxide levels on specific Computed Axial Tomography measurements in Alzheimer disease
      
We describe a patient who was clinically diagnosed with familial early-onset Alzheimer disease (AD) carrying both the E318G substitution in presenilin 1 (PSEN1) and an insertion of 7 octapeptide coding repeats in the prion protein gene (PRNP).
      
It is far from clear that DLBD represents a specific disease entity rather an intermediate variant between Alzheimer disease and idiopathic parkinsonian syndromes.
      
Pre-clinical diagnosis of Alzheimer disease combining platelet amyloid precursor protein ratio and rCBF spect analysis
      
Working memory and FDG-PET dissociate early and late onset Alzheimer disease patients
      
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Objective\ To establish a transgenic model of Alzheimer disease. Methods\ We constructed the transgene containing the human APP cDNA 695 V717I driven by PDGF promoter which expresses specifically in nervous system. The transgene was microinjected into the male pronucleus of the zygotes. The tail DNA of pups was tested by PCR and Southern blot. Results\ 887 embryos were microinjected, 482 were implanted to 20 recipient pseudopregnant mice, 3 of 35 pups carrying the transgene. Each Heterozygous founders generated...

Objective\ To establish a transgenic model of Alzheimer disease. Methods\ We constructed the transgene containing the human APP cDNA 695 V717I driven by PDGF promoter which expresses specifically in nervous system. The transgene was microinjected into the male pronucleus of the zygotes. The tail DNA of pups was tested by PCR and Southern blot. Results\ 887 embryos were microinjected, 482 were implanted to 20 recipient pseudopregnant mice, 3 of 35 pups carrying the transgene. Each Heterozygous founders generated a transgenic line that was homozygous for the transgene. Immunocytochemistry revealed plaques in pallium, cerebellum, and hippocampus. Conclusions\ Resembling animal model of the human pathogenic mechanism for the screening of proper remedies established in our laboratory and could be used for further studied.

目的 建立阿尔茨海默症转基因动物模型 ,为病因研究和药物筛选提供了一个合适的动物模型。 方法 通过显微注射方法将外源 DNA注射到小鼠受精卵的雄性原核 ,移植到假孕母鼠的输卵管。仔鼠出生后 ,经PCR及 PCR- Southern杂交检测阳性小鼠。 结果 共注射 887枚受精卵 ,存活 482枚 ,移卵后产仔 35只 ,阳性 3只。阳性鼠分别传代 ,在 F2代获得纯合子后建系。免疫组织化学显示在大脑皮层、小脑及海马的神经细胞有 Aβ沉淀形成。 结论 通过显微注射的方法已建立与人类发病机理相似的阿尔茨海默症转基因动物模型。

The step down test and morris water maze test were applied to examine the learning and acquisition ability of the transgenic mice of Alzhimer's disease. In step down test, the APP695 transgenic mice at the age of 3 months showed siginificant difference in counts of errors and latency time as comparing with those of the control group( P <0.01).In water maze test,9 months old APP695 and APP751 transgenic mice showed great difference in total counts and latency time as compared with those of the control group....

The step down test and morris water maze test were applied to examine the learning and acquisition ability of the transgenic mice of Alzhimer's disease. In step down test, the APP695 transgenic mice at the age of 3 months showed siginificant difference in counts of errors and latency time as comparing with those of the control group( P <0.01).In water maze test,9 months old APP695 and APP751 transgenic mice showed great difference in total counts and latency time as compared with those of the control group. It was suggested that the transgenic model's behavior was conformed to the behavior of the early stage of human Alzhimer's disease.

通过跳台实验和 morris水迷宫实验检验转基因小鼠的学习和记忆能力。从行为学方面验证阿尔茨海默症转基因动物模型。结果表明 ,3月龄 APP6 95转基因鼠与对照组的两次错误及触电潜伏期等 3个指标上均有极显著差异。水迷宫实验中 ,APP6 95及APP75 1转基因鼠的的错误总数与游出时间均与对照组有极显著差异。结果提示 ,该转基因鼠的表现符合老年痴呆病的早期表现。

Objective To study the neuropathological features of transgenic model for Alzheimer's disease by pathomorphological and immunohistochemical methods. Methods Tissue mass was taken from the transgenic mice's brain for dehydration and embedding, congo red staining and immunohistochemical staining. Results Immunohistochemistry revealed plaques in pallium, cerebellum and hippocampus. The expression of PS-1 in transgenic mice obviously increased comparing with control. Congo red staining showed amyloid deposition...

Objective To study the neuropathological features of transgenic model for Alzheimer's disease by pathomorphological and immunohistochemical methods. Methods Tissue mass was taken from the transgenic mice's brain for dehydration and embedding, congo red staining and immunohistochemical staining. Results Immunohistochemistry revealed plaques in pallium, cerebellum and hippocampus. The expression of PS-1 in transgenic mice obviously increased comparing with control. Congo red staining showed amyloid deposition in intercellular. Conclusion The transgenic model's pathomorphological display conform to the Alzhimer's disease and it could be used for further study.

日的通过组织病理学和免疫组织化学方法,验证阿尔茨海默症转基因动物模型。方法取转基因小鼠脑组织,冠状切面中1/3部位,脱水、包埋,进行组织病理学观察,并对相关抗体进行免疫组织化学研究。结果免疫组化显示在大脑皮层、小脑及海马的神经细胞有Aβ沉淀形成。APP转基因鼠早老素的阳性细胞数及表达量多于对照鼠。刚果红染色可见大脑皮层间有淀粉样物质形成。结论从病理学角度验证此模型的表型与人类病变的相似性,并证明早老素-1可加速淀粉样沉淀的形成,二者的作用是相互的。

 
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