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疾病
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    Soluble Immune Inhibitory Receptor 9.1C3/LAIR-1 and Its Significance in Pathogenesis of Some Diseases
    可溶型免疫抑制性受体9.1C3/LAIR-1分子及其与疾病关系的研究
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    Study on Protein Tyrosine Phosphotases and Protein Tyrosine Kinases Correlated with Diseases
    与疾病相关的蛋白质酪氨酸磷酸酶与酪氨酸磷酸激酶的研究
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    Clinical Application of SIL—2R Kit for Several Diseases
    几种疾病患者血清可溶性白细胞介素2受体SIL—2R检测
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    Immunohistochemical Study of Breast Diseases Using Monoclonal Antibodies SC13A and SC3A
    单克隆抗体SC13A和SC3A在乳腺疾病中的免疫组化研究
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    Changes of red blood cell immune function in several kinds of nervous system infections diseases
    几种神经系统感染性疾病的红细胞免疫功能变化
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  disease
    Studies on Association between HIV-1 Biological Characteristics and Host Genetic Background with Disease Progression
    HIV-1生物学特性及宿主遗传背景与疾病进展关系的研究
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    Research on A Grey Model for Disease Surveillema and Forecast
    疾病监测的灰色预测模型GM(1,1)研究
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    A study on interleukin-2 activity in patients with chronic obstructive pulmonary disease
    慢性阻塞性肺疾病患者白细胞介素2活性变化的研究
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    The Effect of Copper Deficiency on Disease and Immunity
    铜与疾病和免疫
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    Human Parvovirus B19 and Human Disease
    人微小DNA病毒B19与人类疾病
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  “疾病”译为未确定词的双语例句
    Statistical Studies for Drug Clinical Trials Designs and Gene-Disease Association
    关于药物临床试验设计与基因—疾病关联性的统计研究
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    Design and Characterization of Recombinant Targeting Bifunctional Fusion Protein for Therapy of Thrombosis
    靶向溶栓抗凝双功能融合蛋白的构建表达及在血栓疾病治疗中的应用研究
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    Analysis on the variation of IgG and sIgA in saliva in parodontitis by using radioimmunological method
    用放免法分析牙周组织疾病唾液IgG和sIgA的变化
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    Interleukin 6 Signal Transduction and the Strategiesin Treatment forIL-6-related Dis eases.
    白介素6的信号转导及其相关疾病的治疗策略
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    In vitro and in vivo experiments have shown that 1,25-Dihydroxyvitamin D3 and its analogue induce DC to acquire tolerogenic properties that favor the induction of regulatory rather than effector T cells.
    体内和体外实验都已证明1,25-二羟维生素D3及其类似物诱导树突细胞获得致耐受性,这一特性可被用于人类自身免疫性疾病及同种异体移植排斥的治疗。
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Introduction to Receptors in Aging Diseases: GABA Receptors
      
Demands for medicines to treat existing, reemerging and new diseases will escalate and intellectual property rights and patent protection will be increasingly challenged.
      
albicans indicates the possibility to develop drugs for skin diseases.
      
aureus provides scientific evidence for use in skin diseases and toothaches.
      
Lycium barbarum, a famous Chinese medicinal herb, has a long history of use as a traditional remedy for many diseases.
      
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Mechanisms and Issues Relating to the Use of D1-like Dopamine Receptor Agonists for Age-related Illnesses: Parkinson's Disease a
      
Furthermore, acetylcholinesterase and butyrylcholinesterase inhibitors such as tacrine, donepezil, rivastigmine, and galantamine are currently used to manage Alzheimer's disease.
      
Since amlodipine besylate is a very potent inhibitor of both cholinesterases, amlodipine besylate may, like donepezil, be useful in Alzheimer's disease treatment.
      
According to the protocol of the National Cancer Institute (NCI) in vitro disease-oriented human cells screening panel assay, 13 compounds showed promising broad spectrum antitumor activity.
      
Epidemiologic model of SIS type has a delay corresponding to the infectious period and disease-related deaths, so that the population size is variable.
      
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It has been already established that the person with erythrocyte glucose-6-phosphate dehydrogenase deficiency is liable to develop favism. It is generally accepted that the heterozygote does not develop the disease. In order to detect heterozy-got.es, the writer has used three methods (namely MR-microhistochemical elution test, MR-mierophotometric test, and glutathione stability test), and found that the MR-microhistochemical elution test is most sensitive, detecting heterozygotes in 92%. Moreover, there are...

It has been already established that the person with erythrocyte glucose-6-phosphate dehydrogenase deficiency is liable to develop favism. It is generally accepted that the heterozygote does not develop the disease. In order to detect heterozy-got.es, the writer has used three methods (namely MR-microhistochemical elution test, MR-mierophotometric test, and glutathione stability test), and found that the MR-microhistochemical elution test is most sensitive, detecting heterozygotes in 92%. Moreover, there are 17 females with history of favism 10 out of 17 females with history of favism are found to be heterozygotes. This indicates clearly that heterozygotes are liable to suffer the disease after ingestion of fava beans.In addition, according to the degree of expressivity shown by the microhistoche-mical elution method, the heterozygotes can be devided into three types: the reactive, the intermediate, and the non-reactive. Out of 44 cases of heterozygote, there are 29 cases of reactive type (65.9%), evidently being more than the other two types. Among 11 cases of heterozygotes with history of favism, there are 10 reactive including the intermediate. This illustrates that the occurrence of favism is more or less related to the degree of expressivity. Therefore, the reactive and intermediate types should be included as an object of prophylactic measures.

蚕豆病是进食蚕豆后引起的一种急性溶血性疾病。己经查明,红细胞中缺乏6-磷酸葡萄糖脱氢酶是对蚕豆敏感的主要原因。这种酶缺乏是按伴性不完全显性规律遗传的。一般认为,携带此病理基因的杂合子不发病。本文探讨鉴定杂合子较敏感的方法,并研究杂合子是否发病。在比较了高铁血红蛋白还原试验微量洗脱法、微量比色法和谷胱甘肽稳定性试验后认为,前法较后二法敏感。 用上述三种方法检查了17例有蚕豆病史的女性,证明其中10例为杂合子,6例为纯合子。说明杂合子可以发病。若将杂合子按微量洗脱法显示的表现度分为三型:即反应型、中间型和非反应型,则有患病史的杂合子绝大多数属于反应型及中间型(11例中之10例)。说明杂合子是否发病与其表现度有关。故建议在预防工作中,将此二型列入预防对象。

A procedure for phenotyping hyperlipoproteinemia is presented. 0.1 ml of a saturated solution of Sudan Black-B in petroleum ether-alcohol solvent (1:4) and 0.05 ml absolute ethyl alcohol was added to 1 ml of serum. After incubation for 20 min at 37℃ and removal of excess dye by centrifuging, 0.04 ml of the stained serum was applied to filter paper for electrophoretic separation. The optimal conditions for paper electrophoresis were an albuminated "tris" buffer, pH 8.9, ionic strength 0.42 M in terms of tris...

A procedure for phenotyping hyperlipoproteinemia is presented. 0.1 ml of a saturated solution of Sudan Black-B in petroleum ether-alcohol solvent (1:4) and 0.05 ml absolute ethyl alcohol was added to 1 ml of serum. After incubation for 20 min at 37℃ and removal of excess dye by centrifuging, 0.04 ml of the stained serum was applied to filter paper for electrophoretic separation. The optimal conditions for paper electrophoresis were an albuminated "tris" buffer, pH 8.9, ionic strength 0.42 M in terms of tris with EDTA and boric acid concentrations at 0.017 M and 0.061 M respectively; potential gradient 5~6 volts/cm and a current of 0.75~1 mA/strip.

近年来冠心病的发病率和死亡率很高,青中年人中发病率亦日趋增多,因此冠心病成为现代医学研究的重大课题。作者初步建立了一个重复性较好,操作简便,费用经济,适用于临床实验室的脂蛋白纸上电泳预染分型法.以便为高脂蛋白血症分型提供较多的线索。一、用苏丹黑B石油醚-无水乙醇饱和溶液先染血清,后在含1%白蛋白的TEB(三羟甲基氯基甲垸-乙二胺四乙酸-硼酸)缓冲液中,电压160V,电流0.75~1.O毫安/滤纸条,电泳16小时,能使40微升正常血清在滤纸上出现除原点外还有三条着色区带,即β-脂蛋白,前β-脂蛋白及α-脂蛋白。正常人脂餐后,在原点与β-脂蛋白间还有乳糜微粒及前β-脂蛋白“拖尾”区带出现。二、用门诊数十名患者血清,分别电泳20次观察方法的重复性。结果:β-,前β-及α-脂蛋白相应地为43.O±O.42(S.E.)%,33.7±0.52(S.E.)%及23.4±0.47(S.E.)%。三、测定了33名(男18名,女15名),平均年龄为43.7岁,一般健康良好,无脂类代谢疾病的本医学院教职工的脂蛋白:α-,β-和前β-脂蛋白相应为187±42毫克/100毫升,241.3±34.2毫克/100毫升及75.2...

近年来冠心病的发病率和死亡率很高,青中年人中发病率亦日趋增多,因此冠心病成为现代医学研究的重大课题。作者初步建立了一个重复性较好,操作简便,费用经济,适用于临床实验室的脂蛋白纸上电泳预染分型法.以便为高脂蛋白血症分型提供较多的线索。一、用苏丹黑B石油醚-无水乙醇饱和溶液先染血清,后在含1%白蛋白的TEB(三羟甲基氯基甲垸-乙二胺四乙酸-硼酸)缓冲液中,电压160V,电流0.75~1.O毫安/滤纸条,电泳16小时,能使40微升正常血清在滤纸上出现除原点外还有三条着色区带,即β-脂蛋白,前β-脂蛋白及α-脂蛋白。正常人脂餐后,在原点与β-脂蛋白间还有乳糜微粒及前β-脂蛋白“拖尾”区带出现。二、用门诊数十名患者血清,分别电泳20次观察方法的重复性。结果:β-,前β-及α-脂蛋白相应地为43.O±O.42(S.E.)%,33.7±0.52(S.E.)%及23.4±0.47(S.E.)%。三、测定了33名(男18名,女15名),平均年龄为43.7岁,一般健康良好,无脂类代谢疾病的本医学院教职工的脂蛋白:α-,β-和前β-脂蛋白相应为187±42毫克/100毫升,241.3±34.2毫克/100毫升及75.2±29.3毫克/100毫升。四、讨论了不同类型高脂蛋白血症中脂蛋白的异常及分型在临床应用上的意义。

One hundred and fifty-five children in Peking with mental retardation were examined karyologically with the aid of peripheral blood culture techniques. A total of 74 patients were found to have abnormal karyotypes. The results of chromosome analysis are as follows:1. Forty patients had the clinical and cytogenetic features of Down's syndrome, of which 36 were trisomic for chromosome 21 [47, XX(or XY), + 21]; 2 were translocation between D group and G group [46, XX, - D, +t(DqGq)]; 2 were translation between...

One hundred and fifty-five children in Peking with mental retardation were examined karyologically with the aid of peripheral blood culture techniques. A total of 74 patients were found to have abnormal karyotypes. The results of chromosome analysis are as follows:1. Forty patients had the clinical and cytogenetic features of Down's syndrome, of which 36 were trisomic for chromosome 21 [47, XX(or XY), + 21]; 2 were translocation between D group and G group [46, XX, - D, +t(DqGq)]; 2 were translation between G group and G group [46, XX (or XY), - G, +t(GqGq)].2. 2 patients had trisomic 18 [47, XX, +18].3. 7 had large short arm of G group [46, XX (or XY), Gp +].4. 1 had translocation of long arm in E group chromosome [46, XY, Eq+].5. 1 had large short arm of a D group [46, XX, Dp + ].6. 1 had translocation of long arm in a G group [46, XY, Gq+].7. 1 had an extra small chromosome of the G group [47, XY, + Gq - ].8. 21 had large Y chromosome [46, XYq+].9. 81 had normal chromosome complements [46, XX (or XY)].The clinical and cytogenetic characteristics of the patients were discribed, the relationships between chromosomal abnormality and mental retardation were discussed.

本文应用染色体组型分析法,研究了155例先天性大脑发育不全儿童的染色体,分析结果可以分成如下几种类型。先天愚型:第21染色体三体征[47,XX(或XY),+21]36例,D/G易位[46,XX,-D,+t(DqGq)]2例,G/G易位[46,XX(或XY),-G,+t(GqGq)]2例;第18染色体三体征[47,XX(或XY)+18]2例;E组染色体长臂易位(46,XY,Eq+)1例;G组长臂易位(46,XY,Gq+)1例;一个额外的G组小染色体(47,XY,+Gq-)1例;此外还有大Y染色体(46,XYq+)21例;G组短臂增大[46,XX(或XY),Gp+]7例;D组短臂增大(46,XX,Dp+)1例。有染色体改变者共74例,未见染色体改变者81例。染色体组型分析可以作为大脑发育不全等遗传疾病诊断的工具之一。

 
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