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疾病
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20 cases of cerebrovascular occlusive diseases are presented and therapeutic effects between this drug and other conventional drugs are compared. The initial effect from UK. therapy group is usually seen during the first 4 days after treatment. In those days, there is a significant difference between the cases of UK. group and the control, but the total percentage of improvement in 10 days shows no marked difference between these two groups (60% in UK. group; 50% in control group.)In analyzing the results, and...

20 cases of cerebrovascular occlusive diseases are presented and therapeutic effects between this drug and other conventional drugs are compared. The initial effect from UK. therapy group is usually seen during the first 4 days after treatment. In those days, there is a significant difference between the cases of UK. group and the control, but the total percentage of improvement in 10 days shows no marked difference between these two groups (60% in UK. group; 50% in control group.)In analyzing the results, and together with reviewing of literature, 2 items are presented for discusion;1. The mechanism of treatment of these disorder with small dose UK. may be focused evoking the intrinsic fibrinolytic system in the body preventing the evolution of thrombus and improving colleteral circulation.2. During UK. therapy, several note worthy points are emphasized: choise of proper indications early administration as quick as possible (initial dose 40,000—80,000u/day by seperated doses), by slow intravenous injection rather than by infusion, in combination with other conventional drugs rather than use it alone. 4—7 days of therapeutic course is recommended, and gradually decrease the dosage afterward.

本文报告用尿激酶(以下简称UK.)治疗20例脑血管闭塞性疾病的效果。并且与用“常规药物”进行治疗的20例进行了比较。结果表明UK.组开始见效时间,主要集中于疗程的前4天,而且前4天中的任何一天,共有效病例数均与对照组有显著性差异。但10天内总的有效率两组无显著性差异(UK.组为60%;对照组50%)。 在分析其原因时,结合复习有关文献,我们讨论了两个问题:1.小剂量UK.治疗本病的作用机制:可能为激活机体内在的纾溶系统、阻止血栓的进展、改善侧枝血循。2.应用UK.治疗本病的某些值得注意之点:选择适应症,力争早期用药,开始剂量为40,000~80,000单位/日,分次给药,静脉缓慢注射较静脉点滴为好,配合“常规药物”比单用UK为洼。疗程4~7天,逐渐减量。

1) We have measured the CSF contents of CAMP of 27 normal Chinese adults and established a normal value of 12.66±1.0 pmole/ml.2) We have measured the CSF contents of CAMP of 154 patients with various diseases of the nervous system and found a significant increase in carotid occlusion (within 14 days), intracerebral hemorrhage, subarachnoid hemorrhage, active epilepsy, tuberculous meningitis, cysticercosis cerebralis and compressions on the spinal cord as compared to normal value. Among them the increase in tuberculous...

1) We have measured the CSF contents of CAMP of 27 normal Chinese adults and established a normal value of 12.66±1.0 pmole/ml.2) We have measured the CSF contents of CAMP of 154 patients with various diseases of the nervous system and found a significant increase in carotid occlusion (within 14 days), intracerebral hemorrhage, subarachnoid hemorrhage, active epilepsy, tuberculous meningitis, cysticercosis cerebralis and compressions on the spinal cord as compared to normal value. Among them the increase in tuberculous meningitis is the most striking one. As to vertebral occlusion (within 14 days), TIAs static epilepsy, encephalitis, cysticercosis cellulosae cutis, degenerative and functional diseases the values are within normal range.3) Some possible mechanisms responsible for the increase of CAMP content in CSF in some pathological conditions have been briefly discussed.

(一)测定了27例正常中国人脑脊液中CAMP的浓度,正常值为12.66±1.00微微克分子/毫升。 (二)测定了154例各类神经系统疾病脑脊液中CAMP的浓度,发现颈内动脉梗塞后14天内,脑内出血、蛛网膜下腔出血、癫痫发作期、结核性脑膜炎、脑囊虫、脊髓压迫症患者脑脊液中CAMP的浓度与正常人相比有明显升高,其中结核性脑膜炎尤为显著。至于椎动脉梗塞后14天内、暂时性脑缺血样发作、癫痫间歇期、脑炎、皮下囊虫、变性疾病、功能性疾病则属正常。 (三)对某些病理情况下脑脊液CAMP升高的可能的机制进行了简要的讨论。

Three hundred twenty-four patients over 60 admitted during April 1963 to March 1981 are analysed. Among them, 255 cases (78.70%) suffered from encephalopathy, 51 cases (15.74%) from spinal disorders, 14 cases (4.32%) from cerebro-spinal and peripheral neuropathy and 4 cases(1.33%)from other neurologic changes. Complications sueh as pneumonia, gastrointestinal bleeding and urinary tract infection were more commonly seen. The aged neurologic patients have a higher mortality, thus, adequate treatment and nursing...

Three hundred twenty-four patients over 60 admitted during April 1963 to March 1981 are analysed. Among them, 255 cases (78.70%) suffered from encephalopathy, 51 cases (15.74%) from spinal disorders, 14 cases (4.32%) from cerebro-spinal and peripheral neuropathy and 4 cases(1.33%)from other neurologic changes. Complications sueh as pneumonia, gastrointestinal bleeding and urinary tract infection were more commonly seen. The aged neurologic patients have a higher mortality, thus, adequate treatment and nursing care are of uttermost importance.

本文将我院神经科19年内的5,846例住院病人中324例老年病人作了临床分析。324例以脑部疾病为大多数。按疾病性质有颅脑外伤、神经系统肿瘤、脑血管疾病、神经系统炎症性和变性疾病。根据资料分析,老年病人有较多的并发症,以肺炎、消化道出血和尿路感染较为常见。老年神经系统疾病有较高的死亡率,因此合宜的治疗和护理对预防并发症有其重要性。

 
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