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   促肝细胞再生磷酸酶-3 的翻译结果: 查询用时:0.196秒
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促肝细胞再生磷酸酶-
相关语句
  phosphatase of regenerating liver-3
     Objective To observe the expression of phosphatase of regenerating liver-3(PRL-3) in five cancer cell lines HO-8910PM,CNE-2Z,A549,JAR and BEL-7402,on which the appropriate cell lines will be chosen to clone PRL-3 gene.
     目的研究促肝细胞再生磷酸酶-3(phosphatase of regenerating liver-3,PRL-3)在5株癌细胞(HO-8910PM、CNE-2Z、A549、JAR和BEL-7402)中的表达情况,为选择合适的细胞株克隆PRL-3基因奠定基础。
短句来源
     Expression of phosphatase of regenerating liver-3 mRNA and its clinical implications in human colorectal carcinoma
     促肝细胞再生磷酸酶-3基因在结直肠癌组织中的表达及其临床意义
短句来源
     The expression of phosphatase of regenerating liver-3 in five carcinoma cell lines
     促肝细胞再生磷酸酶-3蛋白在5株癌细胞中的表达
短句来源
  “促肝细胞再生磷酸酶-3”译为未确定词的双语例句
     Objective To investigate the expression of phosphatase of regene ra ting liver 3(PRL 3)mRNA and evaluate its relationship with tumor invasion an d metastasis in human colorectal carcinoma.
     目的检测促肝细胞再生磷酸酶-3(PRL-3)mRNA在结直肠癌(CRC)中的表达,探讨其与CRC发生发展以及侵袭转移的关系。
短句来源
  相似匹配句对
     The expression of phosphatase of regenerating liver-3 in five carcinoma cell lines
     肝细胞再生磷酸酶-3蛋白在5株癌细胞中的表达
短句来源
     Expression of phosphatase of regenerating liver-3 and its clinical implications in human gastric carcinoma
     肝细胞再生磷酸酶3基因在胃癌组织中的表达及其临床意义
短句来源
     Expression of phosphatase of regenerating liver-3 mRNA and its clinical implications in human colorectal carcinoma
     肝细胞再生磷酸酶-3基因在结直肠癌组织中的表达及其临床意义
短句来源
     Objective To investigate the expression of phosphatase of regenerating liver-3(PRL- 3)and evaluate its relationship with tumor invasion,metastasis and prognosis of human gastric carcinoma.
     目的探讨肝细胞再生磷酸酶3(PRL-3)蛋白与胃癌的侵袭转移及预后的关系。
短句来源
     Purification and growth effect on hepatocyte of hepatic stimulator substance
     肝细胞再生因子的分离及肝细胞增殖作用
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Objective To investigate the expression of phosphatase of regene ra ting liver 3(PRL 3)mRNA and evaluate its relationship with tumor invasion an d metastasis in human colorectal carcinoma. Methods The expression level of PRL 3 mRNA was examined semi quantitatively in surgically resected tumor specimen s,paired paratumor normal tissues from 46 CRC patients,metastatic lymph nodes an d liver metastases from 18 cases with metastasis,adenoma tissues from 6 patients with colorectal adenoma(CRA). In addition,the mutation...

Objective To investigate the expression of phosphatase of regene ra ting liver 3(PRL 3)mRNA and evaluate its relationship with tumor invasion an d metastasis in human colorectal carcinoma. Methods The expression level of PRL 3 mRNA was examined semi quantitatively in surgically resected tumor specimen s,paired paratumor normal tissues from 46 CRC patients,metastatic lymph nodes an d liver metastases from 18 cases with metastasis,adenoma tissues from 6 patients with colorectal adenoma(CRA). In addition,the mutation of PRL 3 gene was exami ned by PCR SSCP. Results The PRL 3 mRNA level was increased in primary CRC tis sues as compared with paired paratumor normal tissues(1.6±0.7 vs. 0.4±0.1,P< 0.01),while no significant difference of its expression was found between CRA ti ssues and their adjacent normal mucosae(P >0.05). However,the PRL 3 mRNA levels of liver metastases(2.1±0.8) in 12 cases and metastatic lymph nodes(3.3±1.0) in 6 cases were significantly higher compared with the matched primary lesions,n ormal tissues and negative lymph nodes(P< 0.01). There was significant relation of the expression of PRL 3 mRNA with the clinicopathological features includin g Dukes stage,invasion depth and metastasis(P< 0.05),but no relation with sex,t umor size,degree of differentiation was found(P >0.05). Abnormal electroresis band was found in 1 of 6 cases with liver metastasis by PCR SSCP analysis. Conc lusions PRL 3 gene plays an important role in tumor invasion and metastasis and may associated with carcinogenesis and development of CRC. There might exist so me unknown mechanisms of overexpression and mutation of PRL 3 gene in CRC.

目的检测促肝细胞再生磷酸酶-3(PRL-3)mRNA在结直肠癌(CRC)中的表达,探讨其与CRC发生发展以及侵袭转移的关系。方法半定量PCR测定46例CRC组织及其对应正常黏膜、6例结直肠腺瘤(CRA)及其对应正常黏膜以及18例淋巴结和肝转移灶中PRL-3mRNA相对表达水平,并分析其表达水平与临床病理学指标的关系。单链多态性分析法(PCR-SSCP)检测基因突变情况。结果46例CRC中PRL-3基因表达量较相应正常黏膜组织高,差异有统计学意义(1.6±0.7比0.4±0.1,P<0.01);6例结直肠腺瘤组织与对应的正常黏膜中PRL-3mRNA表达量差异无统计学意义(0.6±0.3比0.5±0.2,P>0.05);12例淋巴结转移灶和6例肝转移灶PRL-3基因表达量分别为2.1±0.8和3.3±1.0,显著高于原发癌肿、正常黏膜、阴性淋巴结组织中的表达(P<0.01)。PRL-3基因表达水平与CRCDukes分期、浸润深度、淋巴结和远处转移有关(P<0.05),与性别、肿瘤大小、分化程度无关(P>0.05)。PCR-SSCP分析发现,6例肝转移灶中有1例出现异常泳动条带。结论PRL-3基因在CR...

目的检测促肝细胞再生磷酸酶-3(PRL-3)mRNA在结直肠癌(CRC)中的表达,探讨其与CRC发生发展以及侵袭转移的关系。方法半定量PCR测定46例CRC组织及其对应正常黏膜、6例结直肠腺瘤(CRA)及其对应正常黏膜以及18例淋巴结和肝转移灶中PRL-3mRNA相对表达水平,并分析其表达水平与临床病理学指标的关系。单链多态性分析法(PCR-SSCP)检测基因突变情况。结果46例CRC中PRL-3基因表达量较相应正常黏膜组织高,差异有统计学意义(1.6±0.7比0.4±0.1,P<0.01);6例结直肠腺瘤组织与对应的正常黏膜中PRL-3mRNA表达量差异无统计学意义(0.6±0.3比0.5±0.2,P>0.05);12例淋巴结转移灶和6例肝转移灶PRL-3基因表达量分别为2.1±0.8和3.3±1.0,显著高于原发癌肿、正常黏膜、阴性淋巴结组织中的表达(P<0.01)。PRL-3基因表达水平与CRCDukes分期、浸润深度、淋巴结和远处转移有关(P<0.05),与性别、肿瘤大小、分化程度无关(P>0.05)。PCR-SSCP分析发现,6例肝转移灶中有1例出现异常泳动条带。结论PRL-3基因在CRC的发生发展和侵袭转移中起重要作用,其作用可能是通过基因表达上调和基因突变共同实现的。

Objective To investigate the expression of phosphatase of regenerating liver-3(PRL- 3)and evaluate its relationship with tumor invasion,metastasis and prognosis of human gastric carcinoma. Methods One hundred and twenty-one human gastric carcinoma specimens and 95 matched metastatic lymph nodes were studied.The expression of PRL-3 was detected by immunohistochemistry and the relationship with clinicopathological parameters was analyzed.Results The overall PRL-3 expression was detected in 71.9% of primary gastric...

Objective To investigate the expression of phosphatase of regenerating liver-3(PRL- 3)and evaluate its relationship with tumor invasion,metastasis and prognosis of human gastric carcinoma. Methods One hundred and twenty-one human gastric carcinoma specimens and 95 matched metastatic lymph nodes were studied.The expression of PRL-3 was detected by immunohistochemistry and the relationship with clinicopathological parameters was analyzed.Results The overall PRL-3 expression was detected in 71.9% of primary gastric carcinoma specimens(77.9% in those with nodal metastasis,and 50% without nodal metastasis,P=0.005).The incidence of PRL-3 expression in lymph node metastasis was significantly higher than that in primary gastric cancers(P=0.009).Moreover,PRL-3 expression was closely associated with lymphatic invasion,extent of lymph node metastasis,tumor stage and poor prognosis. Conclusion PRL-3 plays an important role in tumor invasion,metastasis and poor prognosis in gastric carcinoma.

目的探讨促肝细胞再生磷酸酶3(PRL-3)蛋白与胃癌的侵袭转移及预后的关系。方法采用免疫组化方法检测121例胃癌原发灶和95例淋巴结转移灶中PRL-3的表达,分析其表达水平与临床病理资料的关系及其对胃癌预后的影响。结果PRL-3在胃癌原发灶中表达的阳性率为71.9%,其中伴淋巴结转移原发灶的表达率(77.9%)明显高于无淋巴结转移的原发灶者(50.0%),两者之间差异有统计学意义(P=0.005);淋巴结转移灶中PRL-3的表达率(91.6%)明显高于原发灶(77.9%),两者之间差异有统计学意义(P=0.009)。另外,PRL-3的表达与胃癌的淋巴管侵犯、淋巴结转移程度、TNM分期密切相关,并且与患者的预后呈负相关。结论PRL-3与胃癌的浸润转移密切相关,与患者的预后相关。

Objective To observe the expression of phosphatase of regenerating liver-3(PRL-3) in five cancer cell lines HO-8910PM,CNE-2Z,A549,JAR and BEL-7402,on which the appropriate cell lines will be chosen to clone PRL-3 gene.Methods Western blot analysis was used to detect the expression of PRL-3.Results The expression of PRL-3 was clearly detected in all the five carcinoma cell lines, with the highest expression in HO-8910PM and CNE-2Z,moderate expression in A549 and BEL-7402,and the lowest expression in JAR.Conclusion...

Objective To observe the expression of phosphatase of regenerating liver-3(PRL-3) in five cancer cell lines HO-8910PM,CNE-2Z,A549,JAR and BEL-7402,on which the appropriate cell lines will be chosen to clone PRL-3 gene.Methods Western blot analysis was used to detect the expression of PRL-3.Results The expression of PRL-3 was clearly detected in all the five carcinoma cell lines, with the highest expression in HO-8910PM and CNE-2Z,moderate expression in A549 and BEL-7402,and the lowest expression in JAR.Conclusion The expression of PRL-3 was high in cell lines HO-8910PM and CNE-2Z,which might be suitable to server as the cell line for cloning PRL-3 gene.

目的研究促肝细胞再生磷酸酶-3(phosphatase of regenerating liver-3,PRL-3)在5株癌细胞(HO-8910PM、CNE-2Z、A549、JAR和BEL-7402)中的表达情况,为选择合适的细胞株克隆PRL-3基因奠定基础。方法用Western blot分析PRL-3在5株癌细胞(HO-8910PM、CNE-2Z、A549、JAR和BEL-7402)中的表达。结果PRL-3蛋白在5株癌细胞中都有表达:在HO-8910PM与CNE-2Z中呈高度表达,在A549和BEL-7402中呈中等程度表达,而在JAR中呈低度表达。结论PRL-3在5株癌细胞中均有表达,可选择高表达的HO-8910PM或CNE-2Z细胞克隆PRL-3基因。

 
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