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免疫诱导
相关语句
  immune-induced
    Differentia of the correlation between the TIMP-1 expression level and hepatic fibrosis in immune-induced rat liver fibrosis model and CCl_4-induced rat liver fibrosis model
    免疫诱导型和CCl_4诱导型大鼠TIMP-1表达水平的差异及与肝纤维化程度相关性
短句来源
    Results The serum TIMP-1 level in immune-induced rat liver fibrosis model can reflect the severity of hepatic fibrosis and the positive in situ hybridization signal of TIMP-1 mRNA is strong;
    结果免疫诱导型大鼠肝纤维化模型制备过程中其血清TIMP1水平能较好的反映肝纤维化程度,原位杂交显示TIMP1mRNA表达较强;
短句来源
    Conclusion Process of pathological changes of immune-induced rat liver fibrosis model is gradual and serum TIMP-1 level can reflect the severity of fibrosis.
    结论免疫诱导大鼠肝纤维化模型病变有一定发展过程,分期明显,血清TIMP1水平能较好的反应其肝纤维化程度;
短句来源
  immune induced
    Objective To investigate the difference of the location and expression of TIMP-1,2 liver fibrosis model in rats between immune induced and toxin induced.
    目的探讨人血白蛋白免疫诱导型及四氯化碳(CCl4)毒素诱导型所致大鼠肝纤维化模型肝组织中金属蛋白酶组织抑制因子(TIMP)定位及表达状态的差异。
短句来源
    Results Immune induced rat liver fibrosis model presented a tendency progressive aggrevation, strong expression of TIMP-1, TIMP-2 mRNA and protein and lasted for longer time, on the other hand, the toxin induced rat liver fibrosis model presented weak expression of TIMP-1, TIMP-2 mRNA and protein , and shorter period of liver fibrosis after stopping toxin attack.
    结果造模结束后,免疫诱导型模型肝组织病理改变具有进行性加重趋势,TIMP1、TIMP2mRNA及蛋白表达强度高、持续时间长; 而毒素诱导型模型具有TIMP1、TIMP2mRNA及蛋白表达强度弱、肝纤维化持续时间短等特点。
短句来源
    The TIMP-1, TIMP-2 related antigens in liver of immune induced model were expressed in myofibroblast and fibroblast. This was most obvious in portal area and fibrous septum. The positive signal located at cytoplasm, not in nucleus.
    免疫诱导实验组肝脏中TIMP1、TIMP2相关抗原表达在肌成纤维细胞、成纤维细胞,以汇管区及纤维间隔中最明显,阳性信号位于细胞胞质中,未见细胞核表达。
短句来源
    Conclusion The toxin induced rat liver fibrosis model was not appropriate for observation of anti-fibrotic drugs due to its fast sponteneous absorption, the immune induced rat liver fibrosis model is good for the observation of anti-fibrotic drug effects and study on the mechanism of liver fibrosis due to its slow sponteneous absorption, and has the trend of aggrevation within three months after.
    结论毒素诱导型肝纤维化模型自然吸收较快,不利于抗肝纤维化药物疗效的观察; 免疫诱导型肝纤维化模型自然吸收时间较慢,且在造模结束后1~3个月有逐渐加重趋势,有利于抗肝纤维化药物疗效观察及肝纤维化机制研究。
短句来源
  “免疫诱导”译为未确定词的双语例句
    [Objective]To explore the effect of IFN-α2b on inducement to CD25 and against HBV of the patients with chronic hepatitis B in vivo.
    [目的]探讨在体内IFN-α2b(干扰素-α2b)对慢性乙肝患者CD25(白细胞分化抗原25)的免疫诱导作用及其抗病毒效果。
短句来源
    THE FUNCTION OF IMMUNO-MODULATING ON CD25 BY IFN-α2b IN CHRONIC HEPATITIS B PATIENTS
    体内观察IFN-α2b对慢性乙肝患者CD25的免疫诱导作用
短句来源
    Methods Using TIMP-2 targeting asON to inhibit the expression of TIMP-2 in fibrosis liver.
    方法免疫诱导型大鼠肝纤维化模型制备过程中,尾静脉注射针对TIMP-2的反义寡核苷酸。
短句来源
    Objective To study the ability of peripheral blood dendritic cells in chronic hepatitis B virus-infected patients to induce T lymphocyte proliferation and its correlation with immune function of dendritic cells.
    目的 研究慢性乙型肝炎患者外周血树突状细胞 (DC)免疫诱导T淋巴细胞增殖的能力及其与DC免疫功能的相关性。
短句来源
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  immune-induced
Expression of adherent molecule and cyclin by ligustrazine in bone marrow of mice with immune-induced aplastic anemia
      
Mice with immune-induced aplastic anemia (AA) were given 5 mg ligustrazine intraperitoneally twice a day.
      
The results showed that ligustrazine could improve the expression of adherent molecule and cyclin D2 in the bone marrow of mice with immune-induced aplastic anemia, thereby promoting the growth of hematopoietic cells.
      
The permeability of the blood-testis barrier to lanthanum during the immune-induced aspermatogenesis and following vasectomy in
      
We also sequenced three gram-negative binding proteins (GNBPs) and two immune-induced peptides with strong homology to the GNBPs.
      
更多          
  immune induced
Characterization and cDNA cloning of an immune induced lysozyme from cultured Aedes albopictus mosquito cells.
      
Current replacement tooth methods use synthetic materials that can elicit an immune induced host rejection response.
      


ObjectiveTo find neutralizing antibody candidates against hepatitis C virus (HCV) infecti on MethodsWe constructed two eukaryotic expression vectors which contained the E1 and E2 g ene of HCV, and detected their expression in mammalian cells with transient expr ession BALB/c mice were given subculaneous injections of constructed vectors c ombined with the IL 2 gene intraepidermally and evaluated for induced humoral i mmune responses by enzyme linked immunosorbent assay (ELISA) We used an antib ody virus...

ObjectiveTo find neutralizing antibody candidates against hepatitis C virus (HCV) infecti on MethodsWe constructed two eukaryotic expression vectors which contained the E1 and E2 g ene of HCV, and detected their expression in mammalian cells with transient expr ession BALB/c mice were given subculaneous injections of constructed vectors c ombined with the IL 2 gene intraepidermally and evaluated for induced humoral i mmune responses by enzyme linked immunosorbent assay (ELISA) We used an antib ody virus interaction assay to analyze the interaction of the antisera and HCV viral particles in vitro ResultsAnti E1 and anti E2 antisera were obtained from immunized mice The serum of m ice immunized with the E2 gene immunoprecipitated the HCV isolate in source seru m and reacted with the isolates unrelated to the origin al one ConclusionsAnti E2 antibody in induced mice can cross reactively capture HCV particles, h ighlighting the possibility of generating broadly reactive anti E2 antibodies

目的 寻找可能存在的抗丙型肝炎病毒 (HCV)感染的中和抗体。方法 构建两个分别含HCVE1和E2抗原基因的真核表达载体 ,用瞬时表达法检测其在哺乳动物细胞中的表达。将构建的载体连同IL 2基因一起经皮下给BalB/c小鼠进行注射 ,然后用ELISA法检测特异性抗体产生情况。最后通过研究抗体和病毒间的相互作用分析基因免疫诱导产生的抗血清在体外与HCV的相互作用情况。结果 经过基因免疫的小鼠分别产生了E 1和E2抗体。其中 ,用含E2基因的质粒载体免疫的小鼠所产生的E2抗血清不仅可以免疫沉淀来源血清中的HCV病毒颗粒 ,而且可以和与来源株非相关的HCV病毒颗粒相互作用。结论 我们的研究表明基因免疫诱导小鼠产生的E2抗体可以和HCV病毒颗粒发生交叉反应 ,这使我们看到了诱导产生具有广泛针对性的E2抗体的希望。

Objective To study the ability of peripheral blood dendritic cells in chronic hepatitis B virus-infected patients to induce T lymphocyte proliferation and its correlation with immune function of dendritic cells.Methods Peripheral blood DCs of 10 chronic hepatitis B virus-infected patients and 10 normal human were isolated and cultured with granulocyte- macrophage-colony stimulating factor(GM-CSF), interleukin 4(IL-4), and tumor necrosis factor-alpha(TNF-α).The ability of DC to induce T lymphocyte proliferation...

Objective To study the ability of peripheral blood dendritic cells in chronic hepatitis B virus-infected patients to induce T lymphocyte proliferation and its correlation with immune function of dendritic cells.Methods Peripheral blood DCs of 10 chronic hepatitis B virus-infected patients and 10 normal human were isolated and cultured with granulocyte- macrophage-colony stimulating factor(GM-CSF), interleukin 4(IL-4), and tumor necrosis factor-alpha(TNF-α).The ability of DC to induce T lymphocyte proliferation was evaluated by a liquid scintillation counter.Results The ability of DC in patients to induce T lymphocyte proliferation (cpm,10 635±876) was significantly lower than that of controls (cpm,42 918±7 889 P <0.01).Conclusion Immune function of peripheral blood DC in chronic hepatitis B virus-infected patients than that in normal human.

目的 研究慢性乙型肝炎患者外周血树突状细胞 (DC)免疫诱导T淋巴细胞增殖的能力及其与DC免疫功能的相关性。方法 慢性乙型肝炎患者 1 0例 ,从外周血中分离单个核细胞 ,在含rhGM -CSF、rhIL - 4、TNF -α的完全培养基中诱导培养为DC ,并与同种异体T细胞作用 ,用液体闪烁仪观察DC对T细胞增殖的作用。另选取健康成人 1 0例作为正常对照。结果 慢性乙型肝炎患者组DC其诱导同种异体T淋巴细胞增殖的能力每分钟液闪计数 (cpm为 1 0 635± 876) ,明显低于正常对照组 (cpm为 42 91 8±7889,P <0 .0 1 )。结论 慢性乙型肝炎患者外周血DC免疫功能低下

Objective To investigate the difference of the location and expression of TIMP-1,2 liver fibrosis model in rats between immune induced and toxin induced. Methods Immune rats were injected with 20% human serum albumin and intoxic rats with CCL 4 respectively , then liver tissue of rats stained with HE, VG and observed with electron microscope. The location and expression of TIMP-1, TIMP-2 protein and mRNA were studied. Results Immune induced rat liver fibrosis model presented a tendency progressive aggrevation,...

Objective To investigate the difference of the location and expression of TIMP-1,2 liver fibrosis model in rats between immune induced and toxin induced. Methods Immune rats were injected with 20% human serum albumin and intoxic rats with CCL 4 respectively , then liver tissue of rats stained with HE, VG and observed with electron microscope. The location and expression of TIMP-1, TIMP-2 protein and mRNA were studied. Results Immune induced rat liver fibrosis model presented a tendency progressive aggrevation, strong expression of TIMP-1, TIMP-2 mRNA and protein and lasted for longer time, on the other hand, the toxin induced rat liver fibrosis model presented weak expression of TIMP-1, TIMP-2 mRNA and protein , and shorter period of liver fibrosis after stopping toxin attack. The TIMP-1, TIMP-2 related antigens in liver of immune induced model were expressed in myofibroblast and fibroblast. This was most obvious in portal area and fibrous septum. The positive signal located at cytoplasm, not in nucleus. Such distribution and location were also revealed in the in situ hybridization.Conclusion The toxin induced rat liver fibrosis model was not appropriate for observation of anti-fibrotic drugs due to its fast sponteneous absorption, the immune induced rat liver fibrosis model is good for the observation of anti-fibrotic drug effects and study on the mechanism of liver fibrosis due to its slow sponteneous absorption, and has the trend of aggrevation within three months after.

目的探讨人血白蛋白免疫诱导型及四氯化碳(CCl4)毒素诱导型所致大鼠肝纤维化模型肝组织中金属蛋白酶组织抑制因子(TIMP)定位及表达状态的差异。方法分别以20%人血白蛋白进行免疫攻击和CCl4毒素攻击大鼠,造模结束后对大鼠肝组织进行HE、VG染色及电镜观察;同时研究TIMP1、TIMP2蛋白及mRNA定位及表达状态。结果造模结束后,免疫诱导型模型肝组织病理改变具有进行性加重趋势,TIMP1、TIMP2mRNA及蛋白表达强度高、持续时间长;而毒素诱导型模型具有TIMP1、TIMP2mRNA及蛋白表达强度弱、肝纤维化持续时间短等特点。免疫诱导实验组肝脏中TIMP1、TIMP2相关抗原表达在肌成纤维细胞、成纤维细胞,以汇管区及纤维间隔中最明显,阳性信号位于细胞胞质中,未见细胞核表达。原位杂交检测结果亦相似。结论毒素诱导型肝纤维化模型自然吸收较快,不利于抗肝纤维化药物疗效的观察;免疫诱导型肝纤维化模型自然吸收时间较慢,且在造模结束后1~3个月有逐渐加重趋势,有利于抗肝纤维化药物疗效观察及肝纤维化机制研究。

 
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