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免疫诱导
相关语句
  immunosuppression induction
    Immunosuppression induction with daclizumab and antithymocyte globulin in cardiac transplantation: clinical experience with 8 cases
    赛尼哌结合抗胸腺细胞球蛋白免疫诱导在心脏移植中应用的临床经验(附8例报告)(英文)
短句来源
    Objective To review the clinical experience of immunosuppression induction therapy to prevent acute rejection in 8 patients with cardiac transplant.
    目的总结本组8例心脏移植受者应用免疫诱导方案治疗的临床经验。
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  “免疫诱导”译为未确定词的双语例句
    Relationship between the proliferation and immunoinduction of epithelial cells and the destruction of hair follicles and sebaceous glands in keloids
    瘢痕疙瘩上皮细胞增殖和免疫诱导与毛囊-皮脂腺结构破坏
短句来源
    And the expression vectors of B7 1 and B7 2 were successfully trans fected into the rat osteosarcoma cell line UMR 106. CONCLUSION The transfected rat osteosarcoma cell lines with B7 1 and B7 2 could be used for further studies on induction of tumor specific immune responses.
    结论 成功获得大鼠 B7共刺激分子的 c DNA克隆 ,其转染的 U MR- 10 6大鼠骨肉瘤细胞可用于免疫诱导研究
短句来源
    Conclusions Induction therapy with intravenous daclizumab and antithymo- cyte globulin is effective to prevent acute rejection and alleviate organ dysfunction in cardiac transplantation, but might increase the chance of infections.
    结论心脏移植围术期采用2剂赛尼哌结合5剂ATG进行免疫诱导治疗方案能有效预防移植心脏急性排斥反应和减少器官功能损害,但可能增加感染的发生率。
短句来源
    Objective Previous studies in our laboratory have demonstrated that application of donor bone marrow cells for central immune modulation will be beneficial for allograft tolerance induction in the rabbit model.
    目的 为了减轻免疫诱导过程中对受体的侵袭 ,进一步探讨以家兔为动物模型 ,通过异体骨髓移植诱导同种皮肤移植免疫耐受。
短句来源
    2 patients were treated with Dalizumab,the other three patients used OKT3 as immune inductioin.
    其中 2例术前及术后第 5天应用抗IL 2R单克隆抗体 ,3例应用OKT3进行免疫诱导
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  immunosuppression induction
At the time of immunosuppression induction, 13 patients were enrolled in a clinical trial without induction therapy.
      


AIM In order to evaluate the effect of co stimulator B7 in tumor specific T cell activation, the cDNA clones of B7 should be obtained first. METHODS The first strand of cDNA was reverse transcripted from mRNA of SD rat spleen. Then fragments were amplified using specific primers and cloned into expression vector. RESULTS The automatic sequencing showed that the nucleotide sequences of cDNA were totally identical with those in publication. And the expression vectors of B7 1 and B7 2 were successfully trans...

AIM In order to evaluate the effect of co stimulator B7 in tumor specific T cell activation, the cDNA clones of B7 should be obtained first. METHODS The first strand of cDNA was reverse transcripted from mRNA of SD rat spleen. Then fragments were amplified using specific primers and cloned into expression vector. RESULTS The automatic sequencing showed that the nucleotide sequences of cDNA were totally identical with those in publication. And the expression vectors of B7 1 and B7 2 were successfully trans fected into the rat osteosarcoma cell line UMR 106. CONCLUSION The transfected rat osteosarcoma cell lines with B7 1 and B7 2 could be used for further studies on induction of tumor specific immune responses.

目的 为了研究共刺激分子 B7增强针对大鼠骨肉瘤的特异性细胞免疫反应 ,首先需获得大鼠 B7分子的 c DNA克隆 .方法 应用反转录 PCR的方法 ,从大鼠脾细胞 m RNA中扩增特异性片段 .结果 经测序表明 ,所获得的 c DNA克隆与已经发表的 B7- 1和 B7- 2的 c DNA序列完全一致 ,并将其表达载体转染 UMR- 10 6细胞系 .结论 成功获得大鼠 B7共刺激分子的 c DNA克隆 ,其转染的 U MR- 10 6大鼠骨肉瘤细胞可用于免疫诱导研究

Objective To review the clinical experience of immunosuppression induction therapy to prevent acute rejection in 8 patients with cardiac transplant. Methods Between June, 2000 and May, 2002, 8 patients with end-stage dilated cardiomyo- pathy undergoing orthotopic cardiac transplantation received induction therapy with two-dose daclizumab (1.0 mg/kg), given intravenously within 12 h before cardiac-transplantation surgery and two weeks thereafter, and with an initial 5-day course of intravenous antithymocyte globulin...

Objective To review the clinical experience of immunosuppression induction therapy to prevent acute rejection in 8 patients with cardiac transplant. Methods Between June, 2000 and May, 2002, 8 patients with end-stage dilated cardiomyo- pathy undergoing orthotopic cardiac transplantation received induction therapy with two-dose daclizumab (1.0 mg/kg), given intravenously within 12 h before cardiac-transplantation surgery and two weeks thereafter, and with an initial 5-day course of intravenous antithymocyte globulin (100 mg/d) following transplantation. Cyclosporine or tacrolimus, mycophenolate mofetil or azathioprine, and prednisolone were applied for immunosuppression maintenance. Results No death occurred during the follow-up. Routine endomyocardial biopsies in all cases performed in the early stage detected only mild rejection, and no acute allograft or renal dysfunction was found. Three patients developed opportunistic infection, and only one had late acute rejection in the 14th post-transplantation month. Conclusions Induction therapy with intravenous daclizumab and antithymo- cyte globulin is effective to prevent acute rejection and alleviate organ dysfunction in cardiac transplantation, but might increase the chance of infections.

目的总结本组8例心脏移植受者应用免疫诱导方案治疗的临床经验。方法8例终末期扩张型心肌病患者接受同种异体原位心脏移植术,免疫诱导采用术前12 h内及术后第14天2剂赛尼哌1.0 mg/kg(抗白介素-2受体抗体)结合术后前5 d 5剂抗胸腺细胞球蛋白(ATG)100 mg/d的方法,免疫抑制维持治疗采用环孢素A(或他克莫司)+骁悉(或硫唑嘌呤)+泼尼松三联方案。结果全组无死亡,移植后早期心内膜心肌活检无明显急性排斥反应,无移植物功能不全,无明显急性肾功能不全;3例发生机会性感染,1例远期发生急性排斥反应。结论心脏移植围术期采用2剂赛尼哌结合5剂ATG进行免疫诱导治疗方案能有效预防移植心脏急性排斥反应和减少器官功能损害,但可能增加感染的发生率。

Objective Previous studies in our laboratory have demonstrated that application of donor bone marrow cells for central immune modulation will be beneficial for allograft tolerance induction in the rabbit model. Methods In this studies, based on the results obtained in the above model, for reducing the severity of the host conditioning, we treated groups in allograft with only intraosseous single injection of donor bone marrow cells. Results In comparison with our previous published data, the similar results...

Objective Previous studies in our laboratory have demonstrated that application of donor bone marrow cells for central immune modulation will be beneficial for allograft tolerance induction in the rabbit model. Methods In this studies, based on the results obtained in the above model, for reducing the severity of the host conditioning, we treated groups in allograft with only intraosseous single injection of donor bone marrow cells. Results In comparison with our previous published data, the similar results as mean allograft survival time of (88.0±6.0) days were obtained. Todetermine whether the above results could be generalized, the ear transplantation was performed using this protocol. Ears allograft survivaltime of (146.0±15.1) days were obtained. One ear transplanted from the donor was accepted for more then 1 year without any clinical signs of rejection. Conclusion The data suggest that administration of only intraosseous injection of donor bone marrow cells without need for immunosuppressive agents was sufficient to allow induction of donor-specific tolerance in rabbit model without loss of effectiveness.

目的 为了减轻免疫诱导过程中对受体的侵袭 ,进一步探讨以家兔为动物模型 ,通过异体骨髓移植诱导同种皮肤移植免疫耐受。方法 通过骨髓腔内直接注射异体骨髓细胞 ,进行骨髓移植。结果 皮片的平均存活时间是 (88.0± 6 .0 )天 (P <0 .0 0 1 )。为了探讨其普遍性 ,我们用此诱导方法 ,还进行了同种全耳移植。平均存活时间是 (1 4 6 .0± 1 5 .1 )天 ,并有 1只移植耳存活时间已超过 1年 ,未见任何排斥反应。结论 本研究证明了以家兔为动物模型 ,在不使用免疫抑制剂的情况下 ,通过骨髓腔内直接注射异体骨髓细胞 ,进行骨髓移植的方法 ,不仅在皮肤移植上可以诱导长期稳定的特异性免疫耐受 ,而且在实质性器官耳的同种移植上取得了良好的效果

 
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