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角膜
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  cornea
    COMPARATIVE EXPERIMENTAL STUDY OF ANTIMYCOTIC EFFECT OF NIPAGIN A AND OTHER DRUGS ON THE COMMON PATHOGENIC FUNGI OF CORNEA
    尼泊金乙酯与其它抗角膜常见致病真菌药物的抑菌对比实验研究
短句来源
    Pharmarcokinetics of terbinafine eye drops in rabbits aqueous and cornea
    特比萘芬滴眼液在家兔房水及角膜中的药代动力学研究
短句来源
    Behavioral Study on Osmotic Releasing of Acyclovir Eye-gels in Isolated Cornea of Rabbits
    阿昔洛韦眼用凝胶在兔离体角膜中的渗透释药行为研究
短句来源
    Considering the properties and biological activities of heparin, hyaluronic acid and trehalose, we apply them in cornea storage medium and explore their protective activities for cornea and the mechanisms.
    课题研究内容包括肝素、透明质酸、海藻糖应用于角膜中期保存液的处方研究,含肝素和透明质酸的角膜保存液对离体角膜的保护作用研究以及含肝素和透明质酸的角膜保存液保护角膜作用机制的初步研究三个方面。
短句来源
    among them NM-568 (β-piperidino, N-[β'-(p-chlorophenylmercapto)-ethyl]-propionanilide hydrochloride) is the strongest. In comparison with sovcaine and procaine the following anaesthetic ratios were obtained by the various methods used: (1) Anaesthesia test on rabbit cornea: the surface anaesthetic potency of NM-568 is approximately the same as sovcaine, and about 1060 times that of procaine.
    其中N-(β-对-氯苯硫乙基)N-(β-哌啶基丙酰基)-苯胺盐酸盐(NM-568)的局部麻醉效能更为明显,用多种方法与沙夫卡因和普魯卡因比較試驗,获得它們的局部麻醉效价比例如下:(1)家兔角膜試驗:NM-568的表面麻醉效力約接近沙夫卡因,較普魯卡因强1060倍。
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  “角膜”译为未确定词的双语例句
    Siudies on Auxiliary Agent for Special CornealContact Lens
    特殊角膜接触镜辅助剂的研制
短句来源
    The effect of verapamil on the production of transforming growth factor β_1 in keratocytes in vitro
    异搏定对培养角膜基质细胞分泌转移生长因子-β_1的影响
短句来源
    Inhibitory effects of hydrocortisone on keratocyte-collagen degradation induced by IL-1α
    氢化可的松抑制白细胞介素1α诱导的角膜基质细胞胶原降解
短句来源
    After the treatment of 27.27ug/ml—54.55ug/ml diclofenac sodium,RCECs showd the marked inhibition whenever in 24h、48h or 72h(P<0.01)and showed dosage dependence.
    当双氯芬酸钠浓度为27.27ug/ml~54.55ug/ml时,作用24、48、72h均明显抑制角膜上皮细胞的增殖(P均<0.01),并具有剂量依赖性。
短句来源
    Its IC50 of three time-point were 3.71、3.16 and2.82μg/ml. Anti-TGF-β could inhibit the proliferation of RCSCs distinctlyin each experimental group and its IC50 of three time-point were 6.55、3.31and 3.86μg/ml. α- 2b IFN could inhibit the proliferation of RCSCs weakly,while verapamil could not.
    结果 1、汉防己甲素在各时间段各浓度组,均能明显抑制角膜基质细胞的增殖,其 24、48、72 h 的 IC50分别为 3.71、3.16 和 2.82μg/ml,并具有明显的时间剂量-效应依赖关系。
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  cornea
Fibroblasts of rabbit cornea were seeded on HA coated Ti disc, pure Ti disc and glass.
      
The Causes of Necrobiosis and Apoptosis of Cornea Epithelial Cells during Primary Acquired Keratoconus Cornea
      
We studied 56 biopsy samples of conjunctiva and 50 corneal discs excised from 28 patients with acquired keratoconus cornea.
      
Studies on the Effect of the Adhesion Protein Isolated from Bovine Eye on Cell Proliferation in the Newt Cornea
      
The effect of the adhesion protein isolated from the bovine cornea was studied on the model of mechanical injury (cross cutting of the cornea).
      
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Eighteen compounds with structures related to chlorpromazine, of which the ring was opened according to (Ⅰ), have been investigated. In mice, the sedative-tranquillizing actions of these open ring analogues of chlorpromazine disappeared, their anti-histamine action in guinea pig was significantly reduced, but the sulface anaesthetic potency on rabbit cornea was increased; among them NM-568 (β-piperidino, N-[β'-(p-chlorophenylmercapto)-ethyl]-propionanilide hydrochloride) is the strongest. In comparison with...

Eighteen compounds with structures related to chlorpromazine, of which the ring was opened according to (Ⅰ), have been investigated. In mice, the sedative-tranquillizing actions of these open ring analogues of chlorpromazine disappeared, their anti-histamine action in guinea pig was significantly reduced, but the sulface anaesthetic potency on rabbit cornea was increased; among them NM-568 (β-piperidino, N-[β'-(p-chlorophenylmercapto)-ethyl]-propionanilide hydrochloride) is the strongest. In comparison with sovcaine and procaine the following anaesthetic ratios were obtained by the various methods used: (1) Anaesthesia test on rabbit cornea: the surface anaesthetic potency of NM-568 is approximately the same as sovcaine, and about 1060 times that of procaine. (2) Intracutaneous-wheal test in guinea pigs (Bülbring and Wajda's method):the potency of procaine,1; NM-568, 27.5; sovcaine, 22. (3) Sciatic nerve block test in mice: the potency of procaine, 1; NM-568, 16; sovcaine, 39. (4) Spinal anaesthesia in winter toad: the potency of procaine, 1; NM-568, 9; sovcaine, 8. In mice, the acute toxicity after intraperitoneal injection of NM-568 is about half of that of sovcaine, but 3 times greater than that of procaine; Its irritant action on the skin (Trypan blue test) and cornea in rabbits is stronger than that of sovcaine and procaine. Among these 18 analogues of chlorpromazine, NM-572 (N-γ-morpholino-propyl, N-[β'-(p-chlorophenylmercapto)-ethyl]-aniline dihydrochloride) and NM-578 (N-γ-piperi-dino-propyl, N-[β'-(p-chlorophenylmercapto)-ethyl]-aniline dihydrochloride) in large doses (about 1/5 M.L.D.) revealed an anti-electroshock effect for 2 hours.

本文报导了18个氯丙嗪裂环类似物的神经药理作用。試驗結果表明:按(Ⅰ)所示虛线剖裂吩噻嗪(即苯噻嗪,phenothiazine)环系后,它們的鎮靜鎮定作用消失,抗組織胺作用明显減弱,局部麻醉作用有所增强。其中N-(β-对-氯苯硫乙基)N-(β-哌啶基丙酰基)-苯胺盐酸盐(NM-568)的局部麻醉效能更为明显,用多种方法与沙夫卡因和普魯卡因比較試驗,获得它們的局部麻醉效价比例如下:(1)家兔角膜試驗:NM-568的表面麻醉效力約接近沙夫卡因,較普魯卡因强1060倍。(2)豚鼠皮內丘样試驗:普魯卡因的效价为1;NM-568,27.5;沙夫卡因,22。(3)小白鼠坐骨神經传导阻滞試驗:如以普魯卡因的效价为1;NM-568,16;沙夫卡因,39.(4)蟾蜍脊髓麻醉:普魯卡因的效价为1;NM-568,9;沙夫卡因,8。对小白鼠的急性毒性,NM-568較沙夫卡因約小1倍,比普魯卡因約大3倍;它对家兔皮內注射和角膜的刺激作用較普魯卡因和沙夫卡因大。氯丙嗪按上列方式裂环后,发現N-(β-对-氯苯硫乙基)N-(γ-嗎啉基)-苯胺盐酸盐(NM-572),N-(β-对-氯苯硫乙基)N-(γ-哌啶基丙基)-苯...

本文报导了18个氯丙嗪裂环类似物的神经药理作用。試驗結果表明:按(Ⅰ)所示虛线剖裂吩噻嗪(即苯噻嗪,phenothiazine)环系后,它們的鎮靜鎮定作用消失,抗組織胺作用明显減弱,局部麻醉作用有所增强。其中N-(β-对-氯苯硫乙基)N-(β-哌啶基丙酰基)-苯胺盐酸盐(NM-568)的局部麻醉效能更为明显,用多种方法与沙夫卡因和普魯卡因比較試驗,获得它們的局部麻醉效价比例如下:(1)家兔角膜試驗:NM-568的表面麻醉效力約接近沙夫卡因,較普魯卡因强1060倍。(2)豚鼠皮內丘样試驗:普魯卡因的效价为1;NM-568,27.5;沙夫卡因,22。(3)小白鼠坐骨神經传导阻滞試驗:如以普魯卡因的效价为1;NM-568,16;沙夫卡因,39.(4)蟾蜍脊髓麻醉:普魯卡因的效价为1;NM-568,9;沙夫卡因,8。对小白鼠的急性毒性,NM-568較沙夫卡因約小1倍,比普魯卡因約大3倍;它对家兔皮內注射和角膜的刺激作用較普魯卡因和沙夫卡因大。氯丙嗪按上列方式裂环后,发現N-(β-对-氯苯硫乙基)N-(γ-嗎啉基)-苯胺盐酸盐(NM-572),N-(β-对-氯苯硫乙基)N-(γ-哌啶基丙基)-苯胺盐酸盐(NM-578)在較大剂量时有抗电休克作用,但作用持續时间仅2小时。

(1) The analgesic potency of acepromazine in a dose of 0.5 mg/kg was somewhat inferior to that of morphine (2mg/kg). By combining these two drugs, the analgesic effect was summated and the duration of action was prolonged. (2) After intracerebral injection, acepromazine produced more prominent tranquilizing and hypothermic effects than those elicited by hypodermic administration. It could also potentiate the hypothermic action of chloral hydrate and antipyrin. (3) Acepromazine, applied locally or injected...

(1) The analgesic potency of acepromazine in a dose of 0.5 mg/kg was somewhat inferior to that of morphine (2mg/kg). By combining these two drugs, the analgesic effect was summated and the duration of action was prolonged. (2) After intracerebral injection, acepromazine produced more prominent tranquilizing and hypothermic effects than those elicited by hypodermic administration. It could also potentiate the hypothermic action of chloral hydrate and antipyrin. (3) Acepromazine, applied locally or injected subcutaneously, produced definite surface anaesthesia in rabbit's cornea and potentiated the anaesthetic action of procaine. (4) The vasopressor response to 5 γ/kg of adrenaline in the anaesthetized cats was reduced by 2.5 γ/kg of acepromazine and reversed by 5 γ/kg of the antagonist. The contraction of the nictitating membrane due to preganglionic sympathetic stimulation and injection of adrenaline was reduced by the larger dose. (5) When the periarterial nerves of Finkleman's preparation were stimulated, the motor activity of the isolated rabbit's ileum was decreased and the tone was reduced. This inhibitory response to the nerve stimulation was potentiated by acepromazine and chlorpromazine in the concentrations of 1:1,000,000-4:1,000,000. It is concluded that acepromazine and chlorpromazine do not interfere, with the release of noradrenaline from the post-ganglionic sympathetic nerve endings.

(1)采用热水刺激小白鼠尾巴法試驗鎮痛作用,乙酰普馬嗪0.5毫克/公斤可使“疼痛”反应出現时間延迟,較盐酸嗎啡(2毫克/公斤)为弱;二者均以半量合并应用,鎮痛作用强度虽未見加强,但鎮痛时間則延长。(2)脑室內注射乙酰普馬嗪,可立即引起小白鼠安靜,并使其体溫明显下降;皮下注射同剂量时,安靜及降溫作用均不显著,但可明显加强安替比林及水合氯醛的降溫作用。(3)乙酰普馬嗪局部滴药及皮下注射均可产生角膜麻醉,并可加强普魯卡因的表面麻醉作用,尤以皮下注射法为强。(4)乙酰普馬嗪2.5微克/公斤即可減弱腎上腺素的升压作用;5微克/公斤时,使后者作用翻轉,并使电刺激交感神經节前纤維及注射腎上腺素所引起的瞬膜收縮反应減弱。(5)在离体兔神經——迴腸标本,电刺激交感神經节后纤維引起腸张力下降,运动減弱,乙酰普馬嗪及氯丙嗪均可加强此交感反应。

F30066 caused severe gastro-intestinal irritation and lowered body temperature in normal rabbits. It potentiated both the stimulant effect of cardiazol and the depressant effect of sodium pentobarbital on central nervous system of mice. In isolated rabbit's heart, F30066 decreased the contractility. Experiments on perfused guinea pig lung indicated that F30066 constricted bronchioles. The signs of acute poisoning in rabbits consisted of paralysis of limbs, respiratory depression, and convulsions. One rabbit...

F30066 caused severe gastro-intestinal irritation and lowered body temperature in normal rabbits. It potentiated both the stimulant effect of cardiazol and the depressant effect of sodium pentobarbital on central nervous system of mice. In isolated rabbit's heart, F30066 decreased the contractility. Experiments on perfused guinea pig lung indicated that F30066 constricted bronchioles. The signs of acute poisoning in rabbits consisted of paralysis of limbs, respiratory depression, and convulsions. One rabbit suffering from acute poisoning exhibited cardiac arrhythmia.

F30066对家兔胃肠道有强烈的刺激作用;对小白鼠的中枢神经系统与戊巴比妥钠有协同作用,也与五甲烯四氮唑有协同作用。它能使正常家兔的体温下降,使离体兔心收缩力减弱,使豚鼠小支气管平滑肌收缩。中毒家兔临死时四肢麻痹、呼吸减慢、角膜反射消失、交替出现强直性及阵攣性痉攣,最后因呼吸停止而死亡。一只中毒家兔于呼吸减慢前出现心跳不规律。

 
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