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凋亡通路
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  apoptosis pathway
     Dynamic change of TNF/TNFR1 apoptosis pathway in islets of NOD mice
     NOD小鼠胰岛内TNF/TNFR1凋亡通路的动态变化
短句来源
     Dynamic changes of FasL/Fas apoptosis pathway in islets of NOD mice
     NOD鼠胰岛细胞FasL/Fas凋亡通路的动态变化
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     With progression of disease and aggravation of isletitis, expressions of IFN-γ, TNF-ɑ, TNFR1 and CPP32 mRNA in pancreas and TNF-α, TNFR1 and CPP32 protein in islets were increased in NOD mice, suggesting that IFN-γ and TNF/TNFR1 apoptosis pathway plays a key role in type 1 diabetic pathogenesis.
     随着病程的进展和胰岛炎的加重,NOD小鼠胰腺γ干扰素(IFNγ)、肿瘤坏死因子α(TNFα)、肿瘤坏死因子受体(TNFR)1和半胱氨酸蛋白32(CPP32)mRNA表达增加,胰岛细胞及浸润的炎症细胞TNFα、TNFR1、CPP32蛋白表达增加,提示Th1细胞因子和TNF/TNFR1凋亡通路在1型糖尿病发病中起重要作用。
短句来源
     The expression of DR4 and DR5 mRNA in A549 cells treated by DDP(5 μg/mL) or TXT(0.005 μmol/L) for 4 h and 8 h was not significantly higher than that of normal control groups, P >0.05. CONCLUSIONS: The effects of reversal by drugs on TRAIL apoptosis pathway and mechanisms of resistance to TRAIL are diverse.
     5μg/mLDDP、0 005μmol/L TXT (约为4 ng/mL) 作用A549细胞4、8 h后DR4、DR5基因转录水平与对照组之间比较,差异无统计学意义,P>0 .05结论:药物干预对TRAIL凋亡通路以及耐药机制的影响存在多样性。
短句来源
     Study Progress of Mitochondria or Cytochrome C-mediated Apoptosis Pathway
     线粒体/细胞色素C介导的凋亡通路的研究进展
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  apoptotic pathway
     Conclusion Vitexicarpin induces apoptosis in K562 cells via mitochondria-controlled apoptotic pathway.
     结论 Vitexicarpin通过激活线粒体调控的凋亡通路诱导K562细胞凋亡。
短句来源
     Conclusions The block of apoptotic pathway in keloid is upstream of the pathway -the nonfunction Fas protein.
     结论 瘢痕疙瘩成纤维细胞Fas诱导的凋亡异常,是由于Fas凋亡通路的“上游事件”无功能Fas蛋白造成,与通路下游无关。
短句来源
     In further research, cytochrome c release and caspase activation were detected, which indicated the involvement of mitochondria-dependent apoptotic pathway.
     进一步的研究发现,在川楝素引发的PC12细胞凋亡的过程中,可检测到线粒体内细胞色素c的释放及caspase的激活,表明线粒体依赖的凋亡通路参与了川楝素所引发的PC12细胞凋亡。
短句来源
     Seizures trigger the apoptotic pathway of neurons.
     癫发作可启动神经元凋亡通路,线粒体位于凋亡通路的核心位置。
短句来源
     Here, we aim to elucidate its possible mechanisms in mitochondria initiated apoptotic pathway involved in human BEL-7402 and MCF-7 cells.
     本研究主要利用人肝癌BEL-7402和乳腺癌MCF-7细胞研究了力达霉素对线粒体凋亡通路相关因子的影响。
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  “凋亡通路”译为未确定词的双语例句
     Conclusion 2ME2 and As 2O 3 induce the CZ-1 cells apoptosis by different pathways.
     结论 2ME2及As2O3 分别通过不同的凋亡通路诱导CZ 1细胞凋亡。
短句来源
     Conclusion PTE-ET-18-OCH3 deposited in mitochondrion,induced the congregate of mitochondrion,and promoted subsequently apoptosis in Jurkat cells.
     结论PTE-ET-18-OCH3主要沉积于肿瘤细胞的线粒体并诱导线粒聚集,随后通过线粒体诱导的凋亡通路促发肿瘤细胞的凋亡。
短句来源
     There are mainly two apoptotic signal transduction pathways modulated by death receptor Fas, one is Fas-FADD-Caspase-8 pathway, the other is Fas-Daxx-ASK1 pathway.
     由死亡受体Fas所介导的凋亡通路主要包括Fas-FADD-Caspase-8和Fas-Daxx-ASK1两条。
短句来源
     FasL/Fas system participates in destruction of β cells in NOD mice;
     FasL/Fas凋亡通路参与NOD鼠胰岛β细胞的破坏;
短句来源
     Objective To investigate expressions of HCV core,p14 ARF , p21~(WAF1) proteins and correlation of these proteins in HCCs and HepG2 and to explore wether HCV core protein affects on p14-p53-p21 pathway in HCCs and HepG2. ?
     目的检测HCVC蛋白、p14、p21在HCC和表达野生p53HepG2中的表达,初步探讨C蛋白在HCC和HepG2中对p14-p53-p21凋亡通路的作用。
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  apoptosis pathway
These results are in good agreement with the supposition that influenza virus M1 protein is involved in a caspase-8-mediated apoptosis pathway in influenza virus infected cells.
      
Defects in the core machinery of the apoptosis pathway contribute to chemoresistance and poor outcomes in patients with acute leukemia.
      
To overcome these defects, novel molecules that target key proteins in the apoptosis pathway are being developed.
      
The aim of this study was therefore to evaluate its contribution within the caspase-dependent apoptosis pathway in a murine model of polymicrobial sepsis.
      
In conclusion, NO gas inhibited B[a]P-induced MRC-5 cells apoptosis via inhibition of JNK1 apoptosis pathway and induction of Bcl-2 and Mcl-1 anti-apoptosis pathway.
      
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  apoptotic pathway
However, there are two major pathways, the extrinsic pathway (receptor-mediated apoptotic pathway) and the intrinsic pathway (mitochondria-mediated apoptotic pathway), which are both well established.
      
Caspase-3 activation occurred in the late stages of the apoptotic pathway.
      
β-amyloid of Alzheimer's disease activates an apoptotic pathway via caspase-8
      
The clinical features of ALPS reveal the importance of the Fas apoptotic pathway in maintaining lymphocyte homeostasis and protecting against autoimmunity and lymphoid malignancy.
      
Furthermore, intercellular interactions and cell-matrix interactions can stimulate or inhibit the apoptotic pathway.
      
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Objective: To investigate whether FasL expression by exogenous FasL gene transfer had regulatory effect on drug sensitivity of tumor cells. Methods: Exogenous Fasl, gene transfer was mediated by lipofectAMINE. The FasL expression was detected bv Immunohistochemistry and RT-PCR. The growth inhibition of cytotoxic drugs on tumor cells was measured by MTT assay. Fas mRNA expression was analyzed bv Semi-quantitative RT-PCR. Results: The eukaryotic expression vector, PcDNA3-FasL and PcDNA3 were successfully transteeted...

Objective: To investigate whether FasL expression by exogenous FasL gene transfer had regulatory effect on drug sensitivity of tumor cells. Methods: Exogenous Fasl, gene transfer was mediated by lipofectAMINE. The FasL expression was detected bv Immunohistochemistry and RT-PCR. The growth inhibition of cytotoxic drugs on tumor cells was measured by MTT assay. Fas mRNA expression was analyzed bv Semi-quantitative RT-PCR. Results: The eukaryotic expression vector, PcDNA3-FasL and PcDNA3 were successfully transteeted into MCF-7 cells. The transfectant cells was named as MCF-7/FL or MCF-7/Vt respectively. FasL was expressed on MCF-7/FL but not on MCF-7/Vt or MCF-7. The cytolysis ot MCF-7/FL induced by adriamycin at concentration of 0.625 ~ 2.5 μg/ml, cisplatin of 1 .25 ~ 10 μg/ml, or methotrexate of 3 ~ 6 μg/ml respectively were all significantly enhanced compared with the cytolysis of MCF-7. Blocking FasL by using F(ab' )2-anti APO-1 antibody markedly reduced this up-regulated cytolysis induced by these drugs The significant up-regulation of Fas mRNA on MCF-7/FL was observed by Semi-quantitative RT-PCR after these drugs treatment. Conclusion: These findings indicated that FasL expression by gene transfer had up-regulation effect on drug sensitivity of tumor cells, this effect was associated with enhanced Fas expression induced by cytotoxic drugs.

目的:探讨FasL基因转染对肿瘤细胞化疗敏感性的调节效应,方法:LjpofectAMINE介导建立FasL基因修饰的乳腺癌细胞系MCF-7(?)FL,MTT法检测化疗药物对转染细胞的杀伤效应,半定量RT-PCR分析化疗药物作用前后转染细胞Fas mRNA表达水平变化,结果:经C418筛选,RT-PCR和免疫组化鉴定,建立FasL稳定表达MCF-7/FL,ADM在0.625~2.5μg′ml之间.MTX在3~6μg′ml.CDDP在1.25~10μg ml间对MCF-7FL的杀伤效应均明显高于MCF-7和转染空载体的MCF-7Vt而F(ab’)_2-APO-LMcAb可部分抑制这—增强效应,半定量RT-PCR显示上述化疗药物作用后MCF-7/FL Fas mRN水平表达显著增强,结论:外源FasL基因导入可上调肿瘤细胞对多种化疗药物的敏感性,其机制可能与化疗药物上调Fas表达从而增强瘤细胞FasL-Fas凋亡通路效应有关

Objective: To further investigate the molecular mechanism of photodynamic therapy. Methods: We used cDNA microarray technique to explore the gene expression profiles of HEPG2 cells after photodynamic therapy with hematoperphyrin monomethyl ether(HMME) in HEPG2 cells. After treated with HMME for 60 min, the HEPG2 cells were irradiated with laser, and observed by microscope with H E staining. To prepare the probes, mRNA from both control and treated cells were isolated and purified, then reversely transcribed...

Objective: To further investigate the molecular mechanism of photodynamic therapy. Methods: We used cDNA microarray technique to explore the gene expression profiles of HEPG2 cells after photodynamic therapy with hematoperphyrin monomethyl ether(HMME) in HEPG2 cells. After treated with HMME for 60 min, the HEPG2 cells were irradiated with laser, and observed by microscope with H E staining. To prepare the probes, mRNA from both control and treated cells were isolated and purified, then reversely transcribed to cDNA with the incorporation of fluorecent labeled dUTP. The probes were hybridized with a cDNA microarray representing the 1 538 genes originated from human hepatocarcinoma cells. The fluorencent signals of Cy3 and Cy5 were scanned and analyzed. Results: After laser irradiation, the HEPG2 cells showed the typical feature of apoptosis. The gene expression profiles were also changed greatly. Among the 1 538 target genes, 389(2.47%) different expression genes were detected. Most of the changed genes (nearly 80%) were down regulated. They were functionally related to cell proliferation cycle, replication, metabolism and so on. Several apoptosis associated genes were detected among those up regulated genes, encoding the key proteins involved in apoptosis signal transduction, such as CCP32,AIF,Mch2. Conclusion: The HMME photodynamic therapy can initiate the apoptosis process of HEPG2 cells, which may be regulated by mitochondial pathway.[

目的 :利用芯片技术观察血卟啉单甲醚 (HMME)光动力疗法对人原发性肝癌 HEPG2细胞基因表达的影响 ,以深入探讨其作用的分子机制。方法 :HMME加激光照射处理培养的肝癌 HEPG2细胞 ,H- E染色观察细胞形态 ;抽提细胞 m RNA,利用荧光标记 d UTP逆转录制备 c DNA探针 ,与人肝癌表达谱基因芯片杂交 ,并对 Cy3、Cy5荧光信号做扫描分析。 结果 :光照射后实验组细胞呈现凋亡形态 ;芯片扫描显示 2 .47%的检测基因 (389/15 38)出现明显表达差异 ,其中下调基因占 80 % ,多与细胞增殖调控功能有关 ;而细胞凋亡通路中几个重要关键蛋白 (CCP32、AIF、Mch2 )的基因明显上调。结论 :HMME激光疗法可诱导 HEPG2细胞凋亡 ;线粒体调控可能是凋亡发生的重要机制

The plasmid pXJ 41 p15, which contains the full length DNA coding for p15 was introduced into human melanoma cell line A375 in which p15 was deleted by DNA recombination and transfection. Using G418, the positive clones were selected. And the cell model overexpressing p15 was constructed successfully through the analysis of PCR and Western blot. It is showed that the expression of p15 was further enhanced after the cells overexpressing p15 were treated with PMA for 72 hours. In contrast of the control cells,...

The plasmid pXJ 41 p15, which contains the full length DNA coding for p15 was introduced into human melanoma cell line A375 in which p15 was deleted by DNA recombination and transfection. Using G418, the positive clones were selected. And the cell model overexpressing p15 was constructed successfully through the analysis of PCR and Western blot. It is showed that the expression of p15 was further enhanced after the cells overexpressing p15 were treated with PMA for 72 hours. In contrast of the control cells, the PKC activity was further declined in the cells overexpressing p15 after treated with PMA. At the same time, the growth rate of cell was decreased more significantly and approximate 30% apoptotic cells were found. The expression of Caspase 3(P20) was increased in the apoptotic cells. It is indicated that CKI p15 was related to PKC signal transduction in the regulation of cell proliferation and apoptosis. They may be involved in the apoptotic pathway including Caspase3, thus inducing the apoptosis of cells.

通过DNA体外重组和转染技术 ,将已构建好的含有p15基因全长的质粒 pXJ 41 p15转染p15缺失的人黑色素瘤细胞A375 ,经G418筛选出阳性单克隆 ,并经PCR、蛋白质印迹等检测 ,证明建立了 p15稳定高表达的细胞模型 .实验表明 ,经佛波酯 (PMA)长期处理 ,实验组细胞中的 p15表达水平进一步上升 ,同时观察到蛋白激酶C (PKC)活性下降 ,与对照组细胞相比 p15高表达的细胞PKC活性及细胞生长均受到较强烈的抑制 ,并能引起约 30 %的实验组细胞发生凋亡 .凋亡细胞中Caspase3P2 0亚基的水平上升 .结果表明 ,CKIp15与PKC信号系统在调节细胞增殖、凋亡的过程中具有一定的相关性 ,它们的协同作用可能启动了细胞中与Caspase相关的凋亡通路 ,使细胞发生凋亡 .

 
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