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重症系统性红斑狼疮
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  severe systemic lupus erythematosus
     This article reports 2 cases of severe systemic lupus erythematosus (SLE) complicated by peritonitis after the dexamethasone pulse therapy.
     报告重症系统性红斑狼疮(SLE)予大剂量地塞米松冲击治疗后并发腹膜炎2例。
短句来源
     Methylprednisolone and cyclophosphamide pulse therapy of severe systemic lupus erythematosus in children
     甲泼尼龙和环磷酰胺冲击治疗儿童重症系统性红斑狼疮的临床研究
短句来源
     Objective To study the clinical effect of immunoablative chemotherapy with autologous peripheral blood stem cell rescule in patients with severe systemic lupus erythematosus (SLE).
     目的 观察免疫清除性化疗结合自体外周血造血干细胞移植 (移植 )治疗重症系统性红斑狼疮 (SLE)的疗效及安全性。
短句来源
     ObjectivesTo assess the feasibility, safety, and efficacy of intensive immunosuppression and autologous hemopoietic stem cell transplantation in severe systemic lupus erythematosus and refractory rheumatoid arthritis.
     探讨大剂量免疫抑制治疗(HDIT)并自体外周血CD34+细胞移植治疗重症系统性红斑狼疮(SLE)和难治性类风湿关节炎(RA)的可行性、疗效及安全性。
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     A study on the treatment of severe systemic lupus erythematosus with centralnervous system
     伴中枢神经系统病变的重症系统性红斑狼疮的治疗探讨
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  “重症系统性红斑狼疮”译为未确定词的双语例句
     Analysis of 10 years cases with the Pouring Treatment Method on Heavy Systemic Lupus Erythematosus
     冲击疗法治疗重症系统性红斑狼疮10年病例分析
短句来源
     Analysis of 2 cases of severe SLE complicated by peritonitis treated with dexamethasone pulse therapy
     糖皮质激素冲击治疗重症系统性红斑狼疮并发腹膜炎2例分析
短句来源
     Objective To evaluate the therapeutic effects and side effects of MMF on severe SLE patients compared with CTX.
     目的 评价霉酚酸酯 (MMF)治疗重症系统性红斑狼疮 (SLE)的有效性和安全性 ,探讨MMF治疗重症SLE的价值。
短句来源
     Methods Fourty patients with idiopathic thrombocytopenic purpura(ITP) 10 patients with auto-immune hemolytic anaemin and 20 patients with nephritis of SLE or severe systemic SLE were all treated with CTX(0.5~1.5g/m 2) infused fast intravenously,one time every four weeks and four-times at most.
     方法 选择难治性或复发性原发性血小板减少性紫癜 4 0例 ,难治性或复发性自身免疫性溶血性贫血 10例 ,狼疮性肾炎或重症系统性红斑狼疮 2 0例 ,用CTX 0 5~ 1 5 g/m2 体表面积 ,快速静滴 ,2h滴完 ,同时嘱大量饮水 ,每 4周 1次 ,最多为 4次。
短句来源
  相似匹配句对
     Systemic lupus erythematosus
     系统性红斑狼疮
短句来源
     Clinical characteristics of systemic lupus erythematosus associated with severe thrombocytopenia
     系统性红斑狼疮合并重症血小板减少的临床特征
短句来源
     The risk factors of severe infections in systemic lupus erythematosus patients
     系统性红斑狼疮患者合并重症感染的危险因素分析
短句来源
     Phamaceutical therapy in systemic lupus erythematosus
     系统性红斑狼疮的药物治疗
短句来源
     Emergency Treatment of Severe Tetanus
     重症破伤风的抢救
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  severe systemic lupus erythematosus
Treatment of severe systemic lupus erythematosus with immunoadsorption and intravenous immunoglobulins
      
We report on the case of a 25-year-old female with severe systemic lupus erythematosus (SLE) who presented with pancytopenia, fever, arthralgia and abdominal pain.
      
HLA antigens were examined in 118 unrelated patients of whom 49 had definite severe systemic lupus erythematosus (SLE).
      
A 14-year-old patient with severe systemic lupus erythematosus (SLE) and class IV glomerulonephritis presented with immunologic and clinical resistance to conventional immunosuppressive therapy for 10?months after diagnosis.
      
Clinical and immunologic effects of monthly administration of intravenous cyclophosphamide in severe systemic lupus erythematosus.
      
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Generally,treatment severe systemic lupus erythematosus(SLE)with

伴中枢神经系统(CNS)受累的多脏器病变的重症系统性红斑狼疮(SLE)治疗难度大。我们对7例患者应用大剂量皮质激素超过1月,早期予以环磷酰胺(CTX)冲击治疗。病情缓解后中等剂量皮质激素维持半年以上,并继续静脉或口服免疫抑制剂。整个治疗过程中辅以抗精神病药、转移因子、中药、H2受体拮抗剂和升血药物治疗。由于有计划、有步骤地实施治疗方案,使患者获得满意的近、远期疗效,提高了重症SLE有存活率。

We reported a case of systemic lupus erythematosus(SLE) with negative antinuclear antibodies(ANA) and elevated IgE. ANA was negative for five time at different stages of the whole course. Elevated serum IgE was detected. Cerebral infarction was found by computed tomography(CT). Immunofluorescence of renal puncture biopsy showed ball- like deposits of IgG, IgA, IgM and C3.

报告 1例抗核抗体阴性 IgE升高的重症系统性红斑狼疮,在整个病程中 5次抗核抗体阴性,血清 IgE水平高于正常。颅 CT示脑梗塞。肾脏穿刺免疫荧光见 IgG,IgM,IgA及 C3呈团块状沉积。

Objective To evaluate the therapeutic effects and side effects of MMF on severe SLE patients compared with CTX.Method All 106 severe SLE patients were randomly allocated to 2 groups:MMF treatment group (53 patients):1 5 g/d for 3 months,1 0 g/d for following 3 months,and then 0 5~0 75 g/d;IVCTX treatment group:0 75 g/m 2 per month for 6~12 months.Prednisone was used in all patients.Clinical and laboratory parameters including SLE DAI,Hb,platelet,urine protein,albumin,SCr,aCL,ANA and anti dsDNA were...

Objective To evaluate the therapeutic effects and side effects of MMF on severe SLE patients compared with CTX.Method All 106 severe SLE patients were randomly allocated to 2 groups:MMF treatment group (53 patients):1 5 g/d for 3 months,1 0 g/d for following 3 months,and then 0 5~0 75 g/d;IVCTX treatment group:0 75 g/m 2 per month for 6~12 months.Prednisone was used in all patients.Clinical and laboratory parameters including SLE DAI,Hb,platelet,urine protein,albumin,SCr,aCL,ANA and anti dsDNA were observed.Results After 3 month treatment,all clinical and laboratory parameters were significantly improved in MMF group,while only partial parameters were improved in CTX group.Hb and platelet increased and urine protein and anti dsDNA decreased faster in MMF group than in CTX group.At month 6 the clinical and laboratory parameters improved significantly in both groups ( P <0 01).Side effect incidence such as digestive tract reaction,infection,leukopenia,hairloss,liver dysfunction,menopause,was less in MMF group than in CTX group ( P <0 01).Conclusion Like CTX,MMF is effective for severe SLE, but its action appears more quickly and its side effects occur less than those of CTX,suggesting that MMF can be used as an alternative immuno suppressive drug in severe SLE.

目的 评价霉酚酸酯 (MMF)治疗重症系统性红斑狼疮 (SLE)的有效性和安全性 ,探讨MMF治疗重症SLE的价值。方法 采用随机对照方法 ,并选用环磷酰胺 (CTX)作为对照。两组共治疗重症SLE 10 6例 ,其中MMF组 5 3例 ,采用激素联合MMF (1 0~ 1 5g/d)治疗 ,CTX组 5 3例 ,采用激素联合CTX冲击治疗。观察指标包括SLE疾病活动性指数、血红蛋白、血小板、2 4h尿蛋白总量、血清白蛋白、补体C3、血肌酐、抗心磷脂抗体 (aCL)、ANA、抗 dsDNA等。结果 治疗 3个月时MMF组临床观察指标均明显改善 ,CTX组只有部分指标明显改善 ,MMF组提高血红蛋白和血小板、降低尿蛋白和抗 dsDNA的作用强于CTX组。治疗 6个月时两组临床观察指标均明显改善 (P <0 0 1) ,MMF组改善程度略高于CTX组 (P >0 0 5 )。不良反应 :MMF组胃肠道症状、脱发、感染、白细胞减少、肝功能损害及停经的发生率明显低于CTX组 (P <0 0 1)。结论 MMF与CTX治疗重症SLE疗效相同 ,并略优于CTX ,MMF起效快于CTX ,MMF不良反应...

目的 评价霉酚酸酯 (MMF)治疗重症系统性红斑狼疮 (SLE)的有效性和安全性 ,探讨MMF治疗重症SLE的价值。方法 采用随机对照方法 ,并选用环磷酰胺 (CTX)作为对照。两组共治疗重症SLE 10 6例 ,其中MMF组 5 3例 ,采用激素联合MMF (1 0~ 1 5g/d)治疗 ,CTX组 5 3例 ,采用激素联合CTX冲击治疗。观察指标包括SLE疾病活动性指数、血红蛋白、血小板、2 4h尿蛋白总量、血清白蛋白、补体C3、血肌酐、抗心磷脂抗体 (aCL)、ANA、抗 dsDNA等。结果 治疗 3个月时MMF组临床观察指标均明显改善 ,CTX组只有部分指标明显改善 ,MMF组提高血红蛋白和血小板、降低尿蛋白和抗 dsDNA的作用强于CTX组。治疗 6个月时两组临床观察指标均明显改善 (P <0 0 1) ,MMF组改善程度略高于CTX组 (P >0 0 5 )。不良反应 :MMF组胃肠道症状、脱发、感染、白细胞减少、肝功能损害及停经的发生率明显低于CTX组 (P <0 0 1)。结论 MMF与CTX治疗重症SLE疗效相同 ,并略优于CTX ,MMF起效快于CTX ,MMF不良反应显著低于CTX ,MMF的风险 /效果比率较CTX低 ,是治疗重症SLE的一个值得应用的免疫干预药物

 
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