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雌激素干预
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  estrogen interference
     AIM: To investigate the effects of estrogen interference on ab dominal adipose accumulation in C7BL/6J mice.
     目的 :研究雌激素干预对雌性C5 7BL 6J小鼠腹腔脂肪代谢的影响。
短句来源
     Effects of estrogen interference on abdominal adipose accumulation in m ice
     雌激素干预影响腹腔脂肪积聚的实验研究
短句来源
  “雌激素干预”译为未确定词的双语例句
     (4)O+E (n=9):OVX+17βestradiol[20μg/(kg·d)ih];
     雌激素干预组(O+E,n=9)予以17β雌二醇20μg/(kg·d),皮下注射;
短句来源
     3.after orchectomy operation given estrogen injection group is 25% (2/8), 25% (2/8);
     去势雄性雌激素干预组25%(2/8)、25%(2/8);
短句来源
     ③Compared with the osteoporosis model group,while the bone mineral content in cancellous bone increased obviously in the moderate load exercise group and estrogen intervention group (97.1%,88.6%,P < 0.01).
     ③与骨质疏松模型组比较,中等负荷运动组和雌激素干预组大鼠骨松质骨矿盐含量升高明显(97.1%,88.6%,P<0.01);
短句来源
     The rats in the estrogen intervention group were given 20 μg/kg 17 β-estradiol,subcutaneous injection a day,twice a week.
     雌激素干预组给予17β-雌二醇20μg/(kg·d),皮下注射,2次/周。
短句来源
     Activity of tartrate-resistant acid phosphatase in the moderate load exercise group and estrogen intervention group decreased by 31.8% and 35.0% compared with the osteoporosis model group,and the difference was very significant (P < 0.01).
     中等负荷的游泳运动训练和雌激素干预组血中的抗酒石酸酸性磷酸酶的活性相对于骨质疏松模型组下降31.8%和35.0%,差异有非常显著性意义(P<0.01)。
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  相似匹配句对
     Estrogen
     雌激素
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     The effect of estrogen on Alzheimer's disease
     雌激素对阿尔茨海默病的干预作用
短句来源
     Interventions: None.
     干预:无。
短句来源
     Effects of estrogen interference on abdominal adipose accumulation in m ice
     雌激素干预影响腹腔脂肪积聚的实验研究
短句来源
     intervention measures;
     ④干预措施;
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Obsjective To investigate the effects of 17β estradiol(E 2) and tumour necrosis factor alpha (TNFα)on the apoptosis of cultured human umbilical vein endothelial cells(HUVEC).Methods HUVEC were divided into four groups:control group,TNFα(40 μg/L) group,TNFα(40 μg/L) with E 2(1 μmol/L) group and E 2(10 μmol/L) group.Cells were gained after all groups were cultured for 24 hours.The apoptosis was assessed by flow cytometry and the expression of bcl 2 protein was measured by immunohistochemical method.Results...

Obsjective To investigate the effects of 17β estradiol(E 2) and tumour necrosis factor alpha (TNFα)on the apoptosis of cultured human umbilical vein endothelial cells(HUVEC).Methods HUVEC were divided into four groups:control group,TNFα(40 μg/L) group,TNFα(40 μg/L) with E 2(1 μmol/L) group and E 2(10 μmol/L) group.Cells were gained after all groups were cultured for 24 hours.The apoptosis was assessed by flow cytometry and the expression of bcl 2 protein was measured by immunohistochemical method.Results Compared with control,HUVEC apoptosis increased significantly (P<0.01) and bcl 2 protein expression decreased in TNFα (40 μg/L) group.17β estradiol (1 μmol/L,10 μmol/L) reduced the apoptosis induced by TNFα(P<0.001) and dincreased the expression of bcl 2 protein.Conclusions 17β Estradiol could downregulate the TNFα induced apoptosis of HUVEC and maintain integrity of endothelium,suggesting that estrogen may possess antiatherosclerotic ability.

观察 17β 雌二醇 (E2 )及肿瘤坏死因子 (TNFα)对培养的人脐静脉内皮细胞 (HUVEC)凋亡的影响。方法 将HUVEC分为 4组 ,空白对照组、TNFα(4 0 μg L)组、TNFα(4 0 μg L)加E2 (1μmol L)和E2 (10 μmol L)组 ,各组细胞经维持液培养 48h使细胞生长同步 ,加入相应药物培养 2 4h后收获细胞。采用免疫组化方法测定bcl 2蛋白表达及流式细胞仪测定细胞凋亡发生百分率。结果 TNFα诱导的细胞凋亡发生率较正常对照组明显增多 (P <0 .0 0 1) ,bcl 2蛋白表达少 ,DNA直方图上可见高大的凋亡峰 ,而雌激素干预后凋亡发生率明显降低 (P <0 .0 0 1) ,bcl 2蛋白表达增加。结论 E2 可增加bcl 2蛋白的表达 ,抑制TNFα诱导的人内皮细胞细胞凋亡的发生率 ,维持内皮细胞结构和功能的完整 ,可能为其抗动脉粥样硬化的机制之一。

Objective: To study the change of chemokine receptor CXCR2 in monocytes in postmenopausal women with coronary artery disease (CAD) after estrogen replacement therapy. Methods: Randomized placebo controlled trial was conducted in 22 post menopausal women with CAD and 20 normal menopausal women by giving 0.625 mg premarin daily or vitamin C treatment for 3 months. Serum estradiol (E 2) and chemokine receptor CXCR2 in peripheral blood monocytes were measured at 0 and 3 months of treatment. Results:(1) E 2 and...

Objective: To study the change of chemokine receptor CXCR2 in monocytes in postmenopausal women with coronary artery disease (CAD) after estrogen replacement therapy. Methods: Randomized placebo controlled trial was conducted in 22 post menopausal women with CAD and 20 normal menopausal women by giving 0.625 mg premarin daily or vitamin C treatment for 3 months. Serum estradiol (E 2) and chemokine receptor CXCR2 in peripheral blood monocytes were measured at 0 and 3 months of treatment. Results:(1) E 2 and CXCR2 levels in the CAD group was lower than that in the normal group ( P <0.01). (2) After premarin treatment, E 2 level was significantly increased( P <0.01), but chemokine receptor CXCR2 level was significantly decreased ( P <0.01) both in the CAD group and the normal groups, and the change in the CAD group was much larger than that in the normal group ( P <0.05); (3) There was a significant negative correlation between E 2 level and chemokine receptor CXCR2 level ( r =-0.46). Conclusion:The cardioprotective effect of estrogen replacement therapy may be due to estrogen induced chemokine receptor CXCR2 decrease in monocytes.

目的 :探讨经雌激素替代治疗后的绝经后冠心病妇女外周血单核细胞趋化因子受体 CXCR2的变化。方法 :选 2 2例已绝经的冠心病妇女为观察组 ,2 0例绝经后健康妇女作为对照组。两组受试者又随机分为干预组和安慰剂组 ,干预组口服结合型雌二醇 (倍美力 ) ,每日 0 .6 2 5 mg,连续 3个月。安慰剂组口服安慰剂 (维生素 C)。观察对象均分别于用药前及用药 3个月末抽血测血清雌二醇 ( E2 )水平、外周血单核细胞趋化因子受体 CXCR2蛋白表达水平。 结果 :( 1)治疗前冠心病组血清 E2 、CXCR2蛋白水平显著低于正常对照组 ( P<0 .0 1) ;( 2 )经过雌激素干预治疗 3个月后 ,绝经后妇女血清 E2 水平均显著上升( P<0 .0 1) ,外周血单核细胞趋化因子受体 CXCR2水平均显著下降 ( P<0 .0 1) ,且冠心病组较对照组变化更明显 ;( 3)血清 E2水平与 CXCR2水平变化呈显著负相关 ( r=-0 .46 )。 结论 :雌激素替代治疗后的绝经后妇女外周血单核细胞趋化因子受体CXCR2下调 ,且有冠心病者变化更明显 ,提示与雌激素的心脏保护作用有关

Objective To characterize the effects of E2 on the expression of matrix metalloproteinases (MMPs) and tissue inhibitor of matrix metalloproteinases (TIMPs) in normal human osteoblast (hOB) in order to understand the mechanism of postmenopausal osteoporosis . Methods ELISA were used to show the actions of E2 on secretion of MMPs and TIMPs by hOB. Gelatin zymogram and ELISA was done to examine the effects of E2 on activity of MMPs.Results E2 inhibited the secretion of MMP-1 in hOB culture. E2 seemed to...

Objective To characterize the effects of E2 on the expression of matrix metalloproteinases (MMPs) and tissue inhibitor of matrix metalloproteinases (TIMPs) in normal human osteoblast (hOB) in order to understand the mechanism of postmenopausal osteoporosis . Methods ELISA were used to show the actions of E2 on secretion of MMPs and TIMPs by hOB. Gelatin zymogram and ELISA was done to examine the effects of E2 on activity of MMPs.Results E2 inhibited the secretion of MMP-1 in hOB culture. E2 seemed to have no influence on the expression of MMP-2 and TIMP-1 protein in hOB culture, it also have no effect on the activation of latent MMP-2. Conclusion Deficiency of estrogen as seen in postmenopausal women may decrease inhibiting effect on MMP-1 in human osteoblasts, which could lead to the increasing degradation of bone matrix and bone resorption followed by acceleration of bone loss. It probably is one of the key pathogenesis of postmenopausal osteoporosis.

目的探讨雌二醇(17β-estradiol,E2)对正常人成骨细胞(hOB)基质金属蛋白酶(MMP)及其抑制因子(TIMP)的影响和绝经后骨质疏松的发病机制。方法hOB予雌激素干预后,MMP和TIMP用ELISA检测,MMP活性用明胶酶谱法和ELISA检测。结果观察到发现E2抑制hOBMMP-1蛋白质表达(P<0.001)。E2对hOBMMP-2分泌及蛋白质激活无影响(P>0.05)。E2对hOBTIMP-1蛋白质表达亦无影响(P>0.05)。结论雌激素不足可通过减弱其对成骨细胞MMP-1的抑制作用,促进骨吸收,此可能为绝经后骨质疏松的发病机制之一。

 
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