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凋亡阈值
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  apoptotic threshold
     HCC cells apoptotic threshold were determined, i.e.ADM was 1.0 μg/mL and CDDP was 1.5μg/mL (The clinical apoptotic sensitive dosages were ADM 20 mg/m2 and CDDP 30 mg/m2. CONCLUSION: HCC cells apototic threshold of ADM and CDDP were efficient in clinical chemotherapy.
     2 5例未经治疗的HCC细胞和HepG - 2细胞的ADM、CDDP敏感性检测表明 ,ADM的凋亡阈值为 1 0 μg/mL ,CDDP的凋亡阈值为 1 5 μg/mL。 临床凋亡敏感剂量分别为ADM 2 0mg/m2 ,CDDP 30mg/m2 。
短句来源
     The apoptotic threshold of hepatoma cells was 5.0 @mol/L As2O3 or 1.0 μmol/L As2O3 + 1.0 g/L CDA- II .
     但两药联合应用的凋亡阈值是1.0μmol/L As2O3+1.0 g/L CDA-II。
短句来源
     Conclusion: Apoptosis of Panc-1 induced by irradiation was intensified with CH through overcoming a high apoptotic threshold and regulating differential expression of apoptosis-related proteins.
     结论:CH通过降低Panc-1细胞的凋亡阈值,调节凋亡相关蛋白表达,抑制细胞增殖,提高射线对Panc-1细胞凋亡的诱导,以增加Panc-1细胞对射线的敏感性。
短句来源
     A Study on Apoptotic Threshold of Anticancer Drugs in Hepatocellular Carcinoma
     抗癌药物诱导肝细胞肝癌凋亡阈值的研究
短句来源
  “凋亡阈值”译为未确定词的双语例句
     Conclusion Gastrin and CCK are able to increase the threshold of cholangiocarcinoma cell for apoptosis,and the mechanism is associated with up regulation of bcl 2 expression.
     结论 胃泌素和CCK具有提高凋亡阈值、抑制胆管癌细胞凋亡的作用 ,其机制与上调bcl 2基因表达有关
短句来源
     Conclusions CCK is able to increase the threshold for apoptosis by upregulating bcl - 2 gene expression in human cholangiocarcinoma cells.
     反义bcl-2寡核苷酸转染能逆转CCK-8S对凋亡的抑制作用。 结论CCK能提高凋亡阈值、抑制胆管癌细胞凋亡,其机制与上调bcl-2基因表达有关。
短句来源
     Conclusion CDA- II and As2O3 can induce apoptosis of the hepatoma cells, and display a significant synergic effect.
     结论 CDA-Ⅱ可以降低肝癌细胞的凋亡阈值,增加肝癌细胞对As2O3的敏感性。
短句来源
     In the condition of stress , the expressions of Caspase-3 and Livin α show rising tendency at the same time , this expression up-regulates the threshold of apoptosis, and keeps moderate apoptosis of cytotrophoblast cells physically and pathologically.
     【结论】在正常早孕胎盘组织中低表达Caspase3的同时相对高表达Livinβ和低表达Livinα,在外界应激原的诱导下Livinα的表达随Caspase3表达的增加而呈平行上升趋势,上调“凋亡阈值”,从而保证了生理和病理状况下早孕胎盘组织滋养层细胞的适度凋亡;
短句来源
     ConclusionsGastrin is able to increase the threshold for apoptosis by upregulating bcl-2 gene expression in human cholangiocarcinoma cells.
     结论胃泌素能提高凋亡阈值、抑制胆管癌细胞凋亡 ,其机理与上调bcl 2表达有关
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  相似匹配句对
     Apoptosis of primordial germ cells
     原始生殖细胞的凋亡
短句来源
     A Study on Apoptotic Threshold of Anticancer Drugs in Hepatocellular Carcinoma
     抗癌药物诱导肝细胞肝癌凋亡阈值的研究
短句来源
     Apoptosis of articular chondrocytes
     关节软骨细胞的凋亡
短句来源
     Nerve Threshold Value Detector
     神经阈值探测仪
短句来源
     Measurements of Seismesthesia Threshold of 314 Normal Persons
     正常人振动觉阈值
短句来源
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  apoptotic threshold
Apoptotic threshold of adriamycin and cisplatin in hepatocellular carcinoma
      
Objective: To investigate the apoptotic threshold of adriamycin (ADM) and cisplatin (CDDP) on hepatocellular carcinoma (HCC).
      
Results: The apoptotic threshold of ADM and CDDP were 1.0 μg/ml and 1.5μg/ml respectively (its clinical dosage was 20 mg and 30 mg respectively).
      
Conclusion: Understanding apoptotic threshold of anticancer drugs may reduce clinical dosages of anticancer drugs and reduce the incidence of multidrug resistance (MDR).
      
Our results suggest that a single low dose of cyclophosphamide modulates the expression of galectin-1 and Bcl-2 by tumors, which could in turn influence the apoptotic threshold of spleen mononuclear cells.
      
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Cell apoptosis is one of the most important self -stabilization mechanism for multi - cellular organism, itsdisnormality is important for etiology of leukemia. So,methods intervening cell apoptosis may become new thera-peutic strategy for leukemia. These methods at least in-clude: a) changing threshold of tumor cell apoptosis, bydown - regulating translation of apoptosis - inhibiting genesuch as Bcl - XL, or up - regulating translation of apopto-sis - inducing gene such as Bax; b) application of Fas, tu-mor...

Cell apoptosis is one of the most important self -stabilization mechanism for multi - cellular organism, itsdisnormality is important for etiology of leukemia. So,methods intervening cell apoptosis may become new thera-peutic strategy for leukemia. These methods at least in-clude: a) changing threshold of tumor cell apoptosis, bydown - regulating translation of apoptosis - inhibiting genesuch as Bcl - XL, or up - regulating translation of apopto-sis - inducing gene such as Bax; b) application of Fas, tu-mor necrosis factof, and other relative factors; c) exploita-tion of apoptosis - inducing factors, such as arsenic triox-ide, etc.

细胞凋亡是多细胞生物体的重要自稳机制之一,它的异常在白血病发病学上具有重要作用。相应地,干预细胞凋亡的手段可望成为白血病治疗的新策略。这些手段至少包括:①下调Bcl-X_L等凋亡抑制基因或上调Bax等凋亡诱导基因的表达,改变肿瘤细胞凋亡的阈值;②Fas及肿瘤坏死因子等相关物的应用;③凋亡诱导物(如三氧化二砷)的开发,等等。

Purpose]To investigate the apoptotic threshold of ADM and CDDP on hepatocellular carcinoma (HCC). [Method]Sensitivities of ADM and CDDP on HCC were studied by primary cell culture. [Result] The apoptotic threshold of ADM and CDDP were 1.0μg/ml and 1.5μg/ml respectively(its clinical dosages were 20mg and 30mg respectively). [Conclusion] Cnderstanding apoptotic threshold of anticancer drugs may reduce clinical dosages of anticancer drugs and reduce the incidence of multidrug resistance(MDR).

[目的]探讨阿霉素(ADM)、顺铂(CDDP)作用于肝细胞肝癌(HCC)的细胞凋亡阈值。[方法]采用原代细胞培养技术,研究18例HCC对ADM和CDDP的敏感性。[结果]ADM和CDDP作用于HCC的细胞凋亡阈值分别为1.0μg/ml,1.5μ/ml(临床剂量分别为20mg和30mg)。[结论]寻求抗癌药物的细胞凋亡阈值可减少抗癌药物的临床剂量和多药耐药性的出现。

AIM:To study the thershold of hepatocellular carcinoma (HCC) apoptosis induced by adriamycin (ADM) and cis-diamminedichloroplatinum(CDDP). METHODS: Using primary human hepatocellular carcinoma culture, immunofluorescence staining of Hoechst 33 258 in HCC cells ,and flow cytometric assay. RESULTS:24 h after HCC cells were cultured with ADM or CDDP, it were found there were dispersive fluorescences in normal cells nuclei, and compact particulate fluorescences in apoptosis cells nuclei by immunofluorescence staiming...

AIM:To study the thershold of hepatocellular carcinoma (HCC) apoptosis induced by adriamycin (ADM) and cis-diamminedichloroplatinum(CDDP). METHODS: Using primary human hepatocellular carcinoma culture, immunofluorescence staining of Hoechst 33 258 in HCC cells ,and flow cytometric assay. RESULTS:24 h after HCC cells were cultured with ADM or CDDP, it were found there were dispersive fluorescences in normal cells nuclei, and compact particulate fluorescences in apoptosis cells nuclei by immunofluorescence staiming of Hoechst 33 258. The rate of HCC cells apoptosis was dependent on doses of ADM and CDDP. HCC cells apoptotic threshold were determined, i.e.ADM was 1.0 μg/mL and CDDP was 1.5μg/mL (The clinical apoptotic sensitive dosages were ADM 20 mg/m2 and CDDP 30 mg/m2. CONCLUSION: HCC cells apototic threshold of ADM and CDDP were efficient in clinical chemotherapy.

目的 :了解抗癌药物顺铂 (CDDP)、阿霉素 (ADM)诱导肝细胞肝癌 (HCC)的细胞凋亡阈值。方法 :采用肿瘤细胞原代培养技术、活细胞萤光染色法和流式细胞仪定量分析。结果 :顺铂或阿霉素与细胞共同培养后 ,荧光显微镜下见正常细胞核呈弥散均匀荧光 ,凋亡细胞核内颗粒状荧光。随抗癌药物 (ADM、CDDP)剂量的增加 ,诱导人肝癌细胞的细胞凋亡率也增加 ,但以ADM 1.0 μg/mL和 2 0 μg/mL及CDDP 1 5 μg/mL和 3 0 μg/mL作用明显。ADM 2 0 μg/mL可导致HCC细胞凋亡 75 % ,CDDP 3 0 μg/mL可致HCC细胞凋亡 75 %。 2 5例未经治疗的HCC细胞和HepG - 2细胞的ADM、CDDP敏感性检测表明 ,ADM的凋亡阈值为 1 0 μg/mL ,CDDP的凋亡阈值为 1 5 μg/mL。临床凋亡敏感剂量分别为ADM 2 0mg/m2 ,CDDP 30mg/m2 。结论 :本文获得的ADM和CD DP诱导HCC细胞凋亡的临床阈值对临床肿瘤化疗有一定的指导意义

 
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