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rf阴性
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  rf negative
     In polyarticular group DR 2 was more prominant in rheumatoid factor (RF) positive group (83.3%), whereas only 22.2% in RF negative group.
     多关节型中的类风湿因子(RF)阳性组83.3%的患儿携带DR2,而RF阴性组中只有22.2%的患儿携带DR2,二者差异有非常显著意义(P<0.001);
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     In 124 cases with RA, Anti- RA33 positive rate were 32.3% in RF positive and 42.9% in RF negative . Anti- RA33 was not associated with RF(P >0.05);
     124例RA中,RF阳性组抗RA33抗体阳性率32.3%,56例RF阴性组中抗RA33抗体阳性率42.9%,RA33抗体与RF间无相关性(P>0.05);
短句来源
     Conclusion Anti Sa antibody is a valuable diagnostic parameter for RA,especially in early RA and RF negative RA. Anti Sa antibody with both 50 000 and 55 000 bands could be related to disease activity.
     结论 抗Sa抗体有助于早期RA和RF阴性RA诊断 ,同时出现 5 0 0 0 0、5 5 0 0 0两条带可能与病情活动有关。
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  rf-negative
     In the UIA ,the positive rate of anti-CCP was markedly higher in RF-negative group than in RF-positive group (P<0.05) .
     早期RA组CCP抗体在RF阴性组的阳性率高于RF阳性组 ,有显著性差异(P <0 .0 5 ) ;
短句来源
     Specifically,the ratios of T helper subsets were compared between early RA(persistence ≤ 2 years,n=17)and chronic RA(persistence > 2 years,n=16)groups,bone erosion(n=19)and non bone erosion(n=14)groups,RF-positive(n=23)and RF-negative(n=10)groups.
     并分析早期RA组(病程≤2年,17例)与非早期RA组(病程>2年,16例),骨侵蚀组(19例)与无骨侵蚀组(14例),类风湿因子(RF)阳性组(23例)与RF阴性组(10例)Th细胞亚群的比例。
短句来源
     Conclusion AKA and anti-CⅡ were much sensitive and specific in the diagnosis of RA. They can serve as a complement on the patients with RF-negative.
     结论 AKA和抗 CⅡ抗体对RA诊断具有较高的敏感性和特异性 ,二者可弥补RF阴性患者的漏诊 ;
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  “rf阴性”译为未确定词的双语例句
     Among 59 patients with negtive RF, 16(27.1%) were positive for anti-CCP, 14(23.7%) positive for anti-RA54 and 19(32.2%) positive for anti-Sa antibody .
     在 59例 RF阴性 RA患者中,16 例(27.1%)抗CCP抗体阳性,14例(23.7%)抗RA54抗体阳性,19例(32.2%)抗Sa抗体阳性。
短句来源
     Results It is found in 57 patients that the rheumatoid factor showed negative and CRP was 8.5ml/dL. The serum HLA-B_(27) were positive in 8 patients out of 57 patients. The numbers of patients clinically diagnosing JAS were 2,which are male patients.
     结果被检家族中<16岁57名,RF阴性,CRP8.5mL/dL,血清学HLA-B27阳性8人,临床诊断JAS 2人,均为男性,年龄15、16岁;
短句来源
     The prevalence of anti 64 000 autoantibody in patients with positive rheumatic factor was significantly higher than that in patients without (54 5% vs 18 8%, P <0 05).
     血清类风湿因子 (RF)阳性的病人中抗 6 4 0 0 0抗体的阳性率高于血清RF阴性者 ,二者的差异有显著性 (5 4 5 %vs 18 8% ,P <0 0 5 )。
短句来源
     The positive rate of anti-Sa was 38.7﹪ in RA patients without rheumatoid factor(RF).
     RF阳性率在抗Sa阴性组高于阳性组; 在RF阴性组中抗Sa阳性率为38.7﹪。
短句来源
     Conclusion AFA are valuable diagnostic parameter for RA,especially in the early and seronegative RA.
     结论 AFA检测对RA有诊断价值 ,特别有利于RF阴性及早期RA诊断。
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  rf negative
This was also the case when the RA group was replaced by its rheumatoid factor (Rf) positive or Rf negative subgroup.
      
Group A consists of 42 RF positive patients and group B of 44 RF negative patients.
      
Twenty-four patients (57.1%) of the RF positive group and 21 (47.7%) of the RF negative group presented anti-CCP circulating antibodies.
      
In 502 female patients without talking corticosteroid, patients with MMP-3 positive and RF positive were statistically more progressive in the disability than patients with MMP-3 negative and RF negative.
      
At the latter specificity level, 2 out of 17 RF negative samples were retrieved on LIA but not on Western blot.
      
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  rf-negative
Although patients with RF-positive RA generally have more severe disease than those with RF-negative RA, RF is not a reliable predictor of disease severity in individual patients.
      
We studied 408 serum samples from the following: healthy controls (n=68), patients with rheumatoid arthritis RA; n=160, 106 RF-positive and 54 RF-negative and patients with other rheumatic diseases (n=180).
      
APF was positive in 55.7% of patients with RF-positive RA, in 35.2% of patients with RF-negative RA, in 11.1% of patients with other rheumatic diseases and in 5.9% of healthy controls.
      
Statistical differences were found between RF-positive RA and the other three groups (P=0.02, P=0.0001, P=0.0001, respectively) and between RF-negative RA and the groups of other rheumatic diseases (P=0.0001) and healthy controls (P=0.005).
      
Samples which contained high titers of anti-IL-8 antibody subclasses and complexes were RF subclass-positive, while IgM RF-negative sera showed low levels of anti-IL-8 and complexes.
      
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The clinical pictures of ankylosing spondylitis ( AS)were analyzed in 157 patients. It was found that AS occurs more frequently between 15 to 30 years of age, being more prevalent in men than in women. The incidence ratio of male to female was 14.7:1. Approximately 23.6% of patients had a positive family history with the disease. The initial joint involvement was usually located in the hip ( 33.1%) , lumbar spine ( 24.2% ) and sacroiliac joints ( 21 .7% ) , and the spine and sacroiliac joints are predominatly...

The clinical pictures of ankylosing spondylitis ( AS)were analyzed in 157 patients. It was found that AS occurs more frequently between 15 to 30 years of age, being more prevalent in men than in women. The incidence ratio of male to female was 14.7:1. Approximately 23.6% of patients had a positive family history with the disease. The initial joint involvement was usually located in the hip ( 33.1%) , lumbar spine ( 24.2% ) and sacroiliac joints ( 21 .7% ) , and the spine and sacroiliac joints are predominatly affected. The definite diagnosis of AS requires X-Ray evidence of unilateral or bilateral sacroiliitis, presence of pain at the dorsolumbar junction or in the lumbar spine with stiffness, progressive limitation of motion of the spine, limitation of chest expansion to less than 2.5cm and HLA-B2v positive and rheumatoid factor ( RF ) negative.

本文对157例强直性脊柱炎患者进行了临床分析。认为AS多初发于15—24岁之间的男性青年,男女发病比例为14.7:1。有23.6%的病人有家族史。初发关节多在髋关节(33.1%)、腰椎(24.2%)及骶髂关节(21.7%);受累关节以骶髂关节及脊柱为主。对AS的诊断必须有经X线摄片证实的单侧或双侧骶髂关节炎,并有腰背部疼痛和僵硬,脊柱活动进行性障碍,胸扩度少于2.5cm及HLA—B_(27)阳性,RF阴性.

The determination of serum anti-cardiolipin antibodies (ACA) by ELISA among 272 patients with various diseases and 81 normal controls was reported and its clinical significance was evaluated. The results showed that the positive rates of ACA in active SLE, RF positive RA, SS, PSS and infectious diseases groups were 66%, 38%, 100%, 50% and 44%for IgG; and 53%, 46%, 20%, 50% and 42% for IgG respectively. In contrast, the positive rates of both IgG and IgM-ACA in inactive SLE, RF negative arthritis and othor disease...

The determination of serum anti-cardiolipin antibodies (ACA) by ELISA among 272 patients with various diseases and 81 normal controls was reported and its clinical significance was evaluated. The results showed that the positive rates of ACA in active SLE, RF positive RA, SS, PSS and infectious diseases groups were 66%, 38%, 100%, 50% and 44%for IgG; and 53%, 46%, 20%, 50% and 42% for IgG respectively. In contrast, the positive rates of both IgG and IgM-ACA in inactive SLE, RF negative arthritis and othor disease control groups were much lower, without significant differences from normal controls. ACAS positivity were related with the severity and activity of the disease in patients with SLE, RA, SS, and PSS. The thrombocytopenia in SLE, the extraarticular manifestions in RA, the articular and cutaneous lesions of Lyme disease were showed to be closely related with the high levels of ACA. The results also suggested that ACAs couid be used as a diagnostic tool for some infectious diseases and as a guide in therapy.

对272例各种疾病患者及81例正常人以ELISA方法测定了ACA水平。结果表明,活动期SLE、RF阳性的RA、SS、PSS以及各种感染性疾病患者血清IgG-ACA阳性率分别为66%、38%、100%、50%及44%;IgM-ACA阳性率分别为53%、46%、20%、50%及42%。而非活动期SLE、RF阴性的RA及其它疾病患者的ACA均值及阳性率与正常人无显著差异,提示ACA与SLE等疾病病情的严重性及活动性有关,并可作为提示感染及监督疗效的一个参考指标。

To study the correlation between disease phenotypes and HLA DR alleles in juvenile rheumatoid arthritis (JRA), the authors tested HLA DR 8 allele frequency in 50 JRA patients (systemic 17, polyarticular 15 and pauciarticular 18) and 92 normal controls by polymerase chain reaction (PCR) sequence specific oligonucleotide (SSO) methods (PCR/SSO). The frequency of HLA DR 8 in systemic JRA (35.3%) was much higher than that in control group with statistically significan difference ( P < 0.01)....

To study the correlation between disease phenotypes and HLA DR alleles in juvenile rheumatoid arthritis (JRA), the authors tested HLA DR 8 allele frequency in 50 JRA patients (systemic 17, polyarticular 15 and pauciarticular 18) and 92 normal controls by polymerase chain reaction (PCR) sequence specific oligonucleotide (SSO) methods (PCR/SSO). The frequency of HLA DR 8 in systemic JRA (35.3%) was much higher than that in control group with statistically significan difference ( P < 0.01). In polyarticular group DR 2 was more prominant in rheumatoid factor (RF) positive group (83.3%), whereas only 22.2% in RF negative group. There was an increasing tendency in the frequencies of HLA DR 1 and DR 10 in this group. A polymorphous character of HLA DR variance was observed in pauciarticular patients and HLA B 27 positivity was found in 91.7% of these patients who were all boys. These findings suggested that HLA DR 8 and DR 4 were susceptible genes in systemic JRA. The association of DR 2 with RF was considered to be a causative factor for polyarticular JRA. The pauciarticular patients with positive HLA B 27 might be in the early stage of juvenile ankylosing spondylitis.

为研究幼年类风湿关节炎(JRA)的遗传学发病特点及与疾病的相关性,应用聚合酶链反应技术(PCR)序列特异性引物和序列特异性寡核苷酸斑点杂交法,检测50例类风湿关节炎患儿。结果:JRA全身型35.0%的患儿具有HLA-DR8基因,与对照组相比,差异有非常显著意义(P<0.01)。多关节型中的类风湿因子(RF)阳性组83.3%的患儿携带DR2,而RF阴性组中只有22.2%的患儿携带DR2,二者差异有非常显著意义(P<0.001);DR1、DR10试验组有增高的趋势。少关节型的HLA-DR呈多态性分布,91.7%的患儿为HLA-B27位点阳性且全部为男性。结论:HLA-DR8或DR4是导致JRA全身型的易感因素,HLA-DR2与RF高度联锁是导致多关节型发生的因素,少关节型中未发现与之相关的DR基因,但与B27位点相关。提示患儿的检测结果可能是强直性脊柱炎的早期表现。

 
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