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急性肝功能衰竭alf
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     Objective:To assess the efficacy and safety of type TECA hybrid artificial liver support system (HALSS) to treat patients with acute liver failure (ALF).
     目的 :观察TECA型组合型人工肝支持系统 (HALSS)治疗急性肝功能衰竭 (ALF)患者的有效性和安全性。
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     Objective To evaluate efficacy and safety of coupled plasma filtration adsorption (CPFA) combined with continuous veno-venous hemofiltration (CVVH) for the treatment of multiple organ dysfunction syndrome (MODS) patients with acute liver failure (ALF), and to evaluate the effect of CPFA plus CVVF on inflammatory mediators in these patients.
     目的探讨配对血浆分离吸附法(CPFA)联合连续性静-静脉血液滤过(CVVH)治疗多器官功能障碍综合征(MODS)伴急性肝功能衰竭(ALF)患者的临床疗效和安全性。
短句来源
     ObjectiveTo observe the e ff ect of NO precursor or/and NOS inhibitor on the survival of acute liver failure( ALF) rats.
     目的 探讨一氧化氮 (NO)前体及一氧化氮合酶 (NOS)抑制剂对急性肝功能衰竭 (ALF)大鼠生存的影响。
短句来源
     Objective:To observe the expression changes of nitric oxide synthase(NOS) in the liver,the lung,the kidney and the intestine of rat during acute liver failure(ALF).
     目的 :从分子和蛋白水平揭示在急性肝功能衰竭 (AL F)时不同一氧化氮合酶 (NOS)诱导产生的一氧化氮 (NO)在肝、肺、肾脏和肠组织中表达的变化。
短句来源
     Objective To analyze the causes and prognostic factors of patients with acute liver failure (ALF).
     目的 调查分析急性肝功能衰竭 (ALF)的病因、转归及影响因素。
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  相似匹配句对
     Correlations of gene with acute liver failure
     急性肝功能衰竭与基因相关性
短句来源
     Two patients died of acute hepatic failure.
     2例死于急性肝功能衰竭
短句来源
     Objective To analyze the causes and prognostic factors of patients with acute liver failure (ALF).
     目的 调查分析急性肝功能衰竭 (ALF)的病因、转归及影响因素。
短句来源
     Expression of eNOS and iNOS in rats of acute liver failure
     急性肝功能衰竭大鼠eNOS及iNOS的表达
短句来源
     Intervention studies of endotoxemia in acute liver failure rats
     急性肝功能衰竭大鼠内毒素血症的防治研究
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  acute liver failure (alf)
Acute liver failure (ALF) is an uncommon disorder that leads to jaundice, coagulopathy, and multisystem organ failure.
      
Of these patients, 45 had acute liver failure (ALF), 31 had acute decompensation of chronic liver disease, eight had graft failure and four had miscellaneous conditions.
      
Acute liver failure (ALF) is a rare condition in the pediatric population.
      
Variations in the natural history and clinical features of acute liver failure (ALF) have led to a number of different classifications and subgroupings.
      
The aim of our study is to report upon the presentation of two patients with life-threatening acute liver failure (ALF) due to amoxicillin and amoxicillin/clavulanate.
      
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Objective:To assess the efficacy and safety of type TECA hybrid artificial liver support system (HALSS) to treat patients with acute liver failure (ALF).Methods:The primary hepatocytes were separated from the swine and cultured within the bioreactor of HALSS.First,the plasma of the patients was treated by charcoal sorbent or plasma exchange,then flew through the HALSS for moderate and small molecular weight substances exchanges.Each treatment lasted 6.0~7.0 hours.Observed the changes of physiological and blood...

Objective:To assess the efficacy and safety of type TECA hybrid artificial liver support system (HALSS) to treat patients with acute liver failure (ALF).Methods:The primary hepatocytes were separated from the swine and cultured within the bioreactor of HALSS.First,the plasma of the patients was treated by charcoal sorbent or plasma exchange,then flew through the HALSS for moderate and small molecular weight substances exchanges.Each treatment lasted 6.0~7.0 hours.Observed the changes of physiological and blood biochemical parameters before and after the treatment.Results:Using our modified enzymatic digestion method,the yield of hepatocytes was (1.0~3.0)×10 10 from perswine with high viability.Type TECA-HALSS treatment resulted in beneficial effects with the levels of plasma NH 3,ALT,AST,TB and DB decreased,the level of PTA ascended.The mentality of the patients turned from coma to consciousness.All patients tolerated the procedure well,the vital signs well stable.No obvious side effects were found during the treatment.Conclusion:Type TECA-HALSS is rapid,safe and efficacious in providing temporary liver support in patients with ALF,so it would hopefully be a new method in the treatment of ALF.

目的 :观察TECA型组合型人工肝支持系统 (HALSS)治疗急性肝功能衰竭 (ALF)患者的有效性和安全性。方法 :分离中国实验用小型猪肝细胞并培养于BALSS的生物反应器中。患者的血浆先经碳吸附或血浆置换后 ,循环流经BALSS的中空纤维管。每次治疗持续 6~ 7h。观察治疗前、后患者生理和血液生化指标的变化。结果 :从每只小型猪的肝脏平均可得到 (1.0~ 3.0 )× 10 10 个猪肝细胞 ,存活率 >85 %。TECA -HALSS治疗结束后 ,患者的血NH3、ALT、AST、TB、DB等水平明显降低 ;PTA水平升高 ;患者的神志由嗜睡或昏迷转为清醒。治疗中患者生命体征平稳、血电解质水平无明显改变。结论 :TECA -HALSS是一种能迅速、安全、有效地为ALF患者提供暂时的肝功能支持有效途径

ObjectiveTo observe the e ff ect of NO precursor or/and NOS inhibitor on the survival of acute liver failure( ALF) rats.MethodsModel of ALF rat was established by resecting 90% of the rat liver and the effect of NO prec ursor or/and NOS inhibitor was observed.Resu ltsAdministration of NO precursor significantly improved the liver, lung, kidney and bowel function. The rats′ survival rate at 24 h, and 72 h increased significantly, whereas NOS inhibitor deteriorated fu nctions of important organs(P<0.05).Conclusio...

ObjectiveTo observe the e ff ect of NO precursor or/and NOS inhibitor on the survival of acute liver failure( ALF) rats.MethodsModel of ALF rat was established by resecting 90% of the rat liver and the effect of NO prec ursor or/and NOS inhibitor was observed.Resu ltsAdministration of NO precursor significantly improved the liver, lung, kidney and bowel function. The rats′ survival rate at 24 h, and 72 h increased significantly, whereas NOS inhibitor deteriorated fu nctions of important organs(P<0.05).Conclusio nNO precursor alleviates the damage of the ALF rats′ tis sue structure and function of important organs, leading to an increased survival , NOS inhibitor aggravates the damage of the functions of important organs, and endangers the rat′s survival.

目的 探讨一氧化氮 (NO)前体及一氧化氮合酶 (NOS)抑制剂对急性肝功能衰竭 (ALF)大鼠生存的影响。方法 切除大鼠 90 %肝脏制备ALF模型 ,选用NO前体或NOS抑制剂诱导或抑制机体产生NO ,观察在ALF时NO对大鼠肝、肺、肾、肠等重要脏器功能及生存期的影响。结果 应用NO前体 ,ALF大鼠丙氨酸转氨酶 (ALT)显著下降 ,肝、肺、肾、肠等重要脏器组织病理损害明显减轻 ,大鼠 2 4h、72h生存率明显提高 ;NOS抑制剂使ALT明显升高 (P <0 0 5 )。结论 NO能够减轻ALF大鼠肝、肺、肾、肠等重要脏器组织结构和功能的损伤 ,有利于ALF大鼠生存 ;而NOS抑制剂则加重脏器组织结构和功能的损伤。

Objective To analyze the causes and prognostic factors of patients with acute liver failure (ALF).Methods Clinical data of 82 hospitalized patients with ALF from 1990 to 2001 were retrospectively analyzed.Results The most common cause was hepatitis B (57.3%), the others were: hepatitis A (14.6%), drug-induced (12.2%),hepatitis E (11.0%) and hepatitis C (4.9%). The total survival rate was 50% of which that due to drug-induced being the highest (100%), and that due to HCV the lowest (25%). The survial rate...

Objective To analyze the causes and prognostic factors of patients with acute liver failure (ALF).Methods Clinical data of 82 hospitalized patients with ALF from 1990 to 2001 were retrospectively analyzed.Results The most common cause was hepatitis B (57.3%), the others were: hepatitis A (14.6%), drug-induced (12.2%),hepatitis E (11.0%) and hepatitis C (4.9%). The total survival rate was 50% of which that due to drug-induced being the highest (100%), and that due to HCV the lowest (25%). The survial rate of ALF due to HEV-, HAV-and HBV was 77.8%, 50% and 36.2%, respectively. The most significant marker for predicting the prognosis of ALF was prothrombin activity, its relative risk ratio (RR) was 2.661 (P=0.0005), and the most common complications were hepatic encephalopathy, electrolyte inbalance, spontaneous bacterial peritonitis, superimpised infections, hepatorenal syndrome and gastrointestinal bleeding. The highest risk of death ALF was hepatorenal syndrome (RR=14.778, P=0.024), the rest were spontaneous bacterial peritonitis (RR=5.7,P=0.019), and hepatic encephalopathy (RR=5.318,P=0.004).Conclusion Most patients with ALF are in the age range of 12~40 years, the most common cause of ALF is hepatitis B. The highest survival rate is drug-induced and the most significant marker for predicting the prognosis is prothrombin activity. The shortest survival period is seen in hepatorenal syndrome.

目的 调查分析急性肝功能衰竭 (ALF)的病因、转归及影响因素。方法 回顾性分析我院 1990年~ 2 0 0 1年 11年间ALF临床资料 ,并进行生存分析。结果 ALF共 82例。生存分析显示 ,唯一对ALF患者生存影响有显著意义的临床指标是凝血酶原活动度 (PA ,相对危险度为 2 .661,P =0 .0 0 0 5 )。生存时间由短到长的并发症依次为肝肾综合征 (相对危险度为 14 .776,P =0 .0 2 4)、自发性细菌性腹膜炎 (相对危险度为 5 .70 ,P =0 .0 19)及肝性脑病 (相对危险度为5 .3 18,P =0 .0 0 4)。结论 ALF发病年龄以 12岁~ 40岁青年人群居多 ,最常见的病因是乙型肝炎。药物性肝炎存活率最高。对ALF患者生存影响最具意义临床的实验室指标是PA ,并发肝肾综合征者生存时间最短。

 
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