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癌断点
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  cancer breakpoijnts located
     fra,oncogenes and cancer breakpoijnts located at the same chomosome band were observed in 15 instances.
     fra、癌基因和癌断点在同一染色体带者15个。
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  “癌断点”译为未确定词的双语例句
     Astudy ofthe Relationship Between Expression of IGF- Ⅱand Fragile Sites,Cancer Breakpoints at Short Arm of Chromosome 11 in Hepatocellular Carcinoma
     肝癌中IGF-Ⅱ表达与11p染色体脆性位点、癌断点的关系
短句来源
     Of the 51, 25 were found at or near the oncogenes,and 40 were at or near the cancer breakpoints.
     51个中,25个与癌基因、40个与癌断点同位或相邻。
短句来源
     IGF- Ⅱshowed positivestaining in the tu mortissues of25 cases (n= 30) ,whichfour had both fra(11pl3) orfra (11pl5) and cancer breakpoints at11p12 - 15 ,three with fra(11pl3) ,one with breakage at 11pl5 ; One had fragilesite(11p14)of IGF- Ⅱstaining negativein HCCs(n = 5) .
     25 例(n = 30)IGF- Ⅱ阳性HCC中,伴脆性位点11p13 者3例,伴癌断点11p15 者1 例,同时伴有脆性位点11p13 或11pl5 和癌断点11p12 - 15 者4 例,5 例IGF- Ⅱ阴性HCC中仅1 例有脆性位点11pl4 。
短句来源
     To investigate the relationship between insulin -like growth factor Ⅱ(IGF- Ⅱ)gene expression andfragilesites(fra),cancerbreakpointsatshortarm ofchromosome 11(11p)in human hep atocellularcarcinoma(HCC). The expression ofIGF- Ⅱin tumortissueandfragilesitesfrom peripheral bloodlymphocyteand cancer breakpointsfrom thesame HCCpatient were detected by the method of SP im munohistochemistry and karyotypicanalysisrespectively .
     探讨人肝癌组织胰岛素样生长因子Ⅱ(IGF- Ⅱ) 的表达与11 号染色体短臂(11p) 结构改变的关系,用免疫组织化学SP法和核型分析法分别检测了同一肝癌(HCC) 患者癌组织IGF- Ⅱ和11p 部位的脆性位点、癌断点
短句来源
     The significance of fragile sites expres sive frequency of the patients group increasing, relationship between high expressive frequency of c-fra 3p 14 and lune cancer and the interrela tionship among chromosome fragile site ,cancer breakpoint, oncogene and anti-oncogene involved in fragile sites were discussed.
     提示肺癌患者的染色体不稳定性高是其患癌易感性的重要遗传基础。 本文还讨论了常见型脆性位点3p14的高表达率与肺癌的关系,以及肺癌患者的脆性位点与癌断点、癌基因、抗癌基因的相关性等问题。
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  相似匹配句对
     Temporal bone carcinoma
     颞骨
短句来源
     Pancreatic Cancer
     胰
短句来源
     fra,oncogenes and cancer breakpoijnts located at the same chomosome band were observed in 15 instances.
     fra、基因和断点在同一染色体带者15个。
短句来源
     Of the 51, 25 were found at or near the oncogenes,and 40 were at or near the cancer breakpoints.
     51个中,25个与基因、40个与断点同位或相邻。
短句来源
     The breakpoints of these translocations were adjacent to centromere.
     易位断点靠近着丝粒。
短句来源
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Detailed G-banded chromosome analyses were carried out on 180 bone marrow cells and 172 peripheral blood cells taken from 17 small cell lung cancer (SCLC) patients (Group A) and on 367 and 336 peripheral blood lymphocytes taken from 16 heavy smokers (Group B) and 20 healthy non-smokers (Group C).The results showed that Group A's structural aberration rate (32%) was higher than Group B's (22%) (P<0.01) and Group G's (2.6%) p<0.001).The difference between Group B and Group C was also significant (P< 0.001).The...

Detailed G-banded chromosome analyses were carried out on 180 bone marrow cells and 172 peripheral blood cells taken from 17 small cell lung cancer (SCLC) patients (Group A) and on 367 and 336 peripheral blood lymphocytes taken from 16 heavy smokers (Group B) and 20 healthy non-smokers (Group C).The results showed that Group A's structural aberration rate (32%) was higher than Group B's (22%) (P<0.01) and Group G's (2.6%) p<0.001).The difference between Group B and Group C was also significant (P< 0.001).The group A's numerical aberration rate (44%) was higher than that of group B's (18%) and Group C's (3.3%).All these implies that smoking is an important environmental factor causing human chromosome aberrations.The types and breakpoints of chromosome aberrations in every kary-otype analysed were described in detail.We not only discovered that smoking could cause very high rates of chromosomal structural and numerical aberrations but also noted that the breakpoints were mainly clustered in chromosomes 1,2,3,9 and 11,and were preferentially located in the regions 1q,3p14-pter,11q13,etc.Many breakpoints were near or at the map sites of the known fragile sites,oncogenes and/or cancer breakpoints.This pointed out that certain chromosomal breaks and rearrangements caused by smoking were nonrandom and could play an important role in making oncogenes and other relevant genes removed from their original sites and deregulated.Our results also showed that all SCLC patients examined had higher sensitivity to smoking.

应用G显带方法,分析了17名重度吸烟者的小细胞肺癌(SCLC)患者骨髓和外周血细胞的180和172个核型;16名健康吸烟者和20名健康非吸烟者外周血淋巴细胞的367和336个核型。详细记载了畸变的类型和断点,不仅发现吸烟能引起很高的染色体结构和数目畸变,而且看到畸变的染色体片段和断点主要涉及1、2、3、9和11号染色体的某些区域,如1q,3p14—pter,11q13等。许多染色体断裂部位与目前已知的、并描绘在染色体模式图上的癌基因,染色体脆性部位和个体瘤细胞中发现的染色体重排的断点(癌断点)的位置重合或接近,本工作对3组人染色体畸变率和重排类型的分析,发现SCLC患者几乎都是对香烟烟雾作用敏感的个体。

A preliminary study of the fraglie sites(fra),chromosome aberrations (CA)and sister chromatid exchanges(SCE)was carried out in peripheral blood of 30 patients and with ovarian malignancies,10 of beniign ovarian tumors 30 of normal controls. Results obtained showed fra,CA and SCE in patients of ovarian malignancies were very significantly higher the other two groups(P<0.01),and those of the benign tumor group were also found higher than the normal controls(P<0.01).51 fras wereidentified in malignant tumor group...

A preliminary study of the fraglie sites(fra),chromosome aberrations (CA)and sister chromatid exchanges(SCE)was carried out in peripheral blood of 30 patients and with ovarian malignancies,10 of beniign ovarian tumors 30 of normal controls. Results obtained showed fra,CA and SCE in patients of ovarian malignancies were very significantly higher the other two groups(P<0.01),and those of the benign tumor group were also found higher than the normal controls(P<0.01).51 fras wereidentified in malignant tumor group ,3p14 was most frequently observed.Of the 51, 25 were found at or near the oncogenes,and 40 were at or near the cancer breakpoints.fra,oncogenes and cancer breakpoijnts located at the same chomosome band were observed in 15 instances.Positive correlation between fra and CA(r=0.78,P<0.05)was noticed in the malignant cases,but not of that between the fra and SCE,Howevet,the latter was found to be positively corrdlated among the various chromosomal groups r=0.78,P<0.05) of ovarian malignancies. higher percentage has been observed in groups A and C. relationship among fra,CA and SCE in the development of ovarian malignancies and a significant rise of 3p 14 in patient with malignancies were briefly discussed.

对卵巢恶性肿瘤30例、良性瘤10例及正常妇女30例的外周血染色体脆性部位(fra)、畸变(CA)及姊妹染色单体互换(SCE)作了检测。结果:恶性瘤fra、CA及SCE率较良性瘤及正常对照明显升高(P<0.01)良性瘤者亦明显高于正常对照(P<0.01)。恶性瘤检出51个fra(147次)中,以3p14最多,占21.1%。51个中,25个与癌基因、40个与癌断点同位或相邻。fra、癌基因和癌断点在同一染色体带者15个。恶性瘤的fra与CA率间呈显著正相关(r=0.79,P<0.01);fra与SCE虽无相关性,但在累及染色体各组别上却存在明显正相关(r=0.78,P<0.05).

Chromosome fragile site of peripheral lymphocytes were examined in 25 patients with lung cancer and 20 nomal individuals.The resule showed that fragile site expressive frequencies including spontaneous and induced with Ara-C in the patients group were higher than that of the controls. The significance of fragile sites expres sive frequency of the patients group increasing, relationship between high expressive frequency of c-fra 3p 14 and lune cancer and the interrela tionship among chromosome fragile site...

Chromosome fragile site of peripheral lymphocytes were examined in 25 patients with lung cancer and 20 nomal individuals.The resule showed that fragile site expressive frequencies including spontaneous and induced with Ara-C in the patients group were higher than that of the controls. The significance of fragile sites expres sive frequency of the patients group increasing, relationship between high expressive frequency of c-fra 3p 14 and lune cancer and the interrela tionship among chromosome fragile site ,cancer breakpoint, oncogene and anti-oncogene involved in fragile sites were discussed.

作者检测了30例肺癌患者和20例正常对照个体自发和阿糖胞苷诱发的外周血淋巴细胞染色体脆性位点表达率。结果显示:患者组自发和阿糖胞苷诱发的脆性位点表达率显著高于对照组。提示肺癌患者的染色体不稳定性高是其患癌易感性的重要遗传基础。本文还讨论了常见型脆性位点3p14的高表达率与肺癌的关系,以及肺癌患者的脆性位点与癌断点、癌基因、抗癌基因的相关性等问题。

 
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