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胃黏液腺癌
相关语句
  mucous gastric adenocarcinoma
     OBJECTIVE: To study the clinicopathological differences between mucous gastric adenocarcinoma (MGC) and non-MGC.
     目的:研究胃黏液腺癌(mucous gastriccarcinoma,MGC)和非黏液腺癌 (non MGC)的临床病理差异。
短句来源
     Clinicopathological characteristics of mucous gastric adenocarcinoma
     胃黏液腺癌的临床病理特点
短句来源
  stomach mucinous adenocarcinoma
     Significance of hTERT, E-Cadherin and Catenin-B expression in stomach mucinous adenocarcinoma
     胃黏液腺癌组织hTERT与E-cadherin和catenin-β的表达意义
短句来源
     AIM: To study the significance of human telomerase reverse transcriptase (hTERT), E-Cadberin (E-cad) and Catenin-β (β-cat) expression in the tissues of stomach mucinous adenocarcinoma.
     目的:探讨胃黏液腺癌组织中端粒酶活化催化亚单位(hTERT)与E-cadherin(E-cad),catenin-β(β-cat)的表达意义.
短句来源
     Meanwhile, stomach mucinous adenocarcinoma were mostly seen in males over 50 years, and tended to massive growth or nest growth and peritoneal - intensive infiltration, showing two categories of cell-function differentiation types: AMPFDT and mucin-secreting functional differentiation type (MSFDT). Expression of LN, LR, collagen-Ⅳ, CD44v6 and PTEN protein was significantly higher in mucinous adenocarcinoma than that in signet ring cell carcinoma.
     胃黏液腺癌多见于50岁以上男性,倾向于团块状或巢状生长,功能分化上表现为AMPFDT型和黏液分泌功能分化型(MSFDT)两种类型,生长不依赖雌激素,以腹膜广泛浸润生长为主要特点,层粘蛋白及其受体和Ⅳ型胶原、CD_(44)v_6、PTEN蛋白表达显著高于胃印戒细胞癌。
短句来源
  “胃黏液腺癌”译为未确定词的双语例句
     METHODS: The expression of hTERT, E-cad and β-cat were detected by immunohistochemical staining and in situ hybridization in 92 cases of stomach mucinous adenocarcinomas.
     方法:采用原位杂交和免疫组织化学技术,检测92例胃黏液腺癌组织中hTERT和E—cad,β—cat的表达.
短句来源
     Results ①The majority of gastric municinous adenocarcinoma samples were intestine type; the majority of signetring-cell carcinoma samples were gastric type.
     结果①胃黏液腺癌以肠型腺癌为主,胃印戒细胞癌以胃型腺癌为主。
短句来源
     RESULTS: The expression of hTERT is negative outside and positive inside of mucinous adenocarcinoma cells, and its expression in pure mucinous adenocarcinoma, papillary mucinous adenocarcinoma, signet-ring cell mucinous adenocarcinoma and mixed cell mucinous adenocarcinoma is 88.9%, 85.4%, 100.0% and 95.8% respectively. The expression ratio become higher with the malignant degree, but no significant difference was found (P>0.05).
     结果:hTERT在胃黏液腺癌组织中细胞外黏液阴性,细胞内黏液阳性; 单纯黏液癌、腺管乳头结构黏液癌、印戒细胞黏液癌和混合细胞黏液癌表达分别为88.9%,85.4%,100.0%和95.8%,显示恶性程度越高其表达率越高,但差异无显著性(P>0.05,).
短句来源
     Conclusion The histologic origin of gastric mucinous adenoma was intestinc epithelium cells;
     结论胃黏液腺癌的组织学发生是来自肠上皮的化生;
短句来源
  相似匹配句对
     Clinicopathological characteristics of mucous gastric adenocarcinoma
     黏液腺癌的临床病理特点
短句来源
     Conclusion The histologic origin of gastric mucinous adenoma was intestinc epithelium cells;
     结论黏液腺癌的组织学发生是来自肠上皮的化生;
短句来源
     Adenocarcinoma arising from aberrant pancreas in the stomach
     来源异位胰腺的腺癌
短句来源
     Significance of hTERT, E-Cadherin and Catenin-B expression in stomach mucinous adenocarcinoma
     黏液腺癌组织hTERT与E-cadherin和catenin-β的表达意义
短句来源
     A STUDY ON THE HISTOGENESIS IN GASTRIC MICRO ADENOCARCINOMA
     微小腺癌的组织发生研究
短句来源
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The increasing data show that the soluble form of Flt 1 have the ability to block the biological activity of VEGF due to its high affinity to VEGF and formation of homologous and heterogenous dimmer with transmembrane Flt 1 and KDR. The binding activity of Flt 1 focuses on its Ⅱand Ⅲ extracellular domain. cDNA fragments encoding for signal peptide and flt 1 Ⅰ~Ⅳ extracellular domain were amplified through RT PCR with a pair of specific primers from human umbilical vein endothelial cells. Then, the sflt...

The increasing data show that the soluble form of Flt 1 have the ability to block the biological activity of VEGF due to its high affinity to VEGF and formation of homologous and heterogenous dimmer with transmembrane Flt 1 and KDR. The binding activity of Flt 1 focuses on its Ⅱand Ⅲ extracellular domain. cDNA fragments encoding for signal peptide and flt 1 Ⅰ~Ⅳ extracellular domain were amplified through RT PCR with a pair of specific primers from human umbilical vein endothelial cells. Then, the sflt 1 gene was subcloned into pcDNA3 EF 1 vector, and the expression unit of EF 1 flt 1 was subcloned into shuttle vector of pAdTrack CMV, linearized pAdTrack EF 1 flt 1 was co transformed into BJ5183 cells with adenoviral genomic plasmid of pAdEasy 1. The identified recombinant DNA was transfected into 293 cells to package adenovirus. From the supernatant and cell lysis, the presence of recombinant adenovirus was proved by PCR, and RT PCR detection demonstrated the transcription of flt 1 in MGC803 cells infected with Ad Track EF 1 flt 1, and immunoprecipitation reveals that soluble Flt 1 can be secreted into the culture supernatant of infected MGC803 cells. These results indicated that tumor cells infected with the prepared recombinant adenovirus vector Ad Track EF 1 flt 1 can secrete soluble Flt 1, which will be further used for in vivo antiangiogenesis experiments.

肿瘤的生长、转移与血管形成密切相关 ,利用基因治疗的方法将抗血管形成的因子导入体内是目前肿瘤生物治疗研究的重要策略 .血管内皮细胞生长因子 (VEGF)在血管生成中起重要作用 ,因此阻断VEGF与相应受体的结合成为抗血管形成的重要靶点 .通过RT PCR从人脐静脉内皮细胞克隆了VEGF受体Flt 1的信号肽及胞外Ⅰ~Ⅳ区cDNA ,即可溶性sFlt 1的cDNA片段 .利用Ad Easy体系 ,在细菌BJ5 183中同源重组后 ,转染包装细胞 2 93,成功包装出重组flt 1腺病毒 ,利用它可有效地感染低分化胃黏液腺癌细胞株MGC80 3.经RT PCR ,免疫沉淀及免疫印迹等不同方法检测表明 ,被感染细胞能表达并分泌Flt 1的胞外区蛋白 ,为后续进行抗肿瘤血管形成的基因治疗研究奠定了基础 .

AIM:To elucidate and compare the distinctive pathobiological behaviors between signet ring-cell carcinoma (SRC) and mutinous adenocarcinoma of the stomach.METHODS: Based on the histological growth patterns and cell-function differentiation classifications of stomach carcinoma, we conducted series of comparative studies. All paraffin-embedded and frozen blocks were from the files of Cancer Institute of China Medical University. On the basis of histopathological observation, the authors applied enzymic and mucinous...

AIM:To elucidate and compare the distinctive pathobiological behaviors between signet ring-cell carcinoma (SRC) and mutinous adenocarcinoma of the stomach.METHODS: Based on the histological growth patterns and cell-function differentiation classifications of stomach carcinoma, we conducted series of comparative studies. All paraffin-embedded and frozen blocks were from the files of Cancer Institute of China Medical University. On the basis of histopathological observation, the authors applied enzymic and mucinous histochemistry, immunohistochemistry, flow cytometry ( FCM) combinined with molecular biological methods to compare these two categories of gastric cancers in the DNA ploidy, proliferating kinetics, and the expression of laminin (LN) and its receptors (LR), collagen-Ⅳ, CD44v6 and PTEN proteins.RESULTS: SRC of the stomach was commonly seen in females less than 45 years, and had a tendency to diffuse growth and metastasis into ovary or uterine cervix. The majority of SRC were absorptive and mucin - producing double functional differentiation type ( AMPFDT), which growth relied on estrogen. Meanwhile, stomach mucinous adenocarcinoma were mostly seen in males over 50 years, and tended to massive growth or nest growth and peritoneal - intensive infiltration, showing two categories of cell-function differentiation types: AMPFDT and mucin-secreting functional differentiation type (MSFDT). Expression of LN, LR, collagen-Ⅳ, CD44v6 and PTEN protein was significantly higher in mucinous adenocarcinoma than that in signet ring cell carcinoma.CONCLUSION: SRC and mucinous adenocarcinoma are significantly different in morphology, ultrastructure, cell-functional differentiation and protein expression, indicating different mechanisms in carcinogenesis Combined analyses of histological growth patterns, cell-function differentiation and molecular biological typing can be significant in diagnosis and prognostic assessment for SRC and mucinous adenocarcinoma of the stomach.

目的:以胃癌组织学生长方式分型和癌细胞功能分化表型研究为基础,从形态、机能与蛋白分子水平相结合的层次,探讨胃印戒细胞癌和黏液腺癌浸润转移的生物学规律及相关分子病理学机制。 方法:本系列研究标本全部取自中国医科大学肿瘤研究所存档石蜡标本和冰冻标本。在病理形态学观察的基础上,采用酶组织化学、黏液组织化学和免疫组织化学、流式细胞技术(FCM)结合分子生物学方法检测并比较上述两型胃癌相关基因编码蛋白表达、癌细胞DNA倍体、增生细胞动力学,微卫星不稳定性和杂合性丢失等分子生物学特征。 结果:近40a研究发现,胃印戒细胞癌好发于中青年女性,组织学上倾向于弥漫性生长,以吸收-黏液分泌功能双向分化(AMPFDT)为主,生长依赖雌激素,好发卵巢和子宫颈转移。胃黏液腺癌多见于50岁以上男性,倾向于团块状或巢状生长,功能分化上表现为AMPFDT型和黏液分泌功能分化型(MSFDT)两种类型,生长不依赖雌激素,以腹膜广泛浸润生长为主要特点,层粘蛋白及其受体和Ⅳ型胶原、CD_(44)v_6、PTEN蛋白表达显著高于胃印戒细胞癌。两型胃癌酸性磷酸酶(ACP)和血管内皮生长因子(VEGF)无显著差异。 结论:胃印戒细胞癌和黏液腺...

目的:以胃癌组织学生长方式分型和癌细胞功能分化表型研究为基础,从形态、机能与蛋白分子水平相结合的层次,探讨胃印戒细胞癌和黏液腺癌浸润转移的生物学规律及相关分子病理学机制。 方法:本系列研究标本全部取自中国医科大学肿瘤研究所存档石蜡标本和冰冻标本。在病理形态学观察的基础上,采用酶组织化学、黏液组织化学和免疫组织化学、流式细胞技术(FCM)结合分子生物学方法检测并比较上述两型胃癌相关基因编码蛋白表达、癌细胞DNA倍体、增生细胞动力学,微卫星不稳定性和杂合性丢失等分子生物学特征。 结果:近40a研究发现,胃印戒细胞癌好发于中青年女性,组织学上倾向于弥漫性生长,以吸收-黏液分泌功能双向分化(AMPFDT)为主,生长依赖雌激素,好发卵巢和子宫颈转移。胃黏液腺癌多见于50岁以上男性,倾向于团块状或巢状生长,功能分化上表现为AMPFDT型和黏液分泌功能分化型(MSFDT)两种类型,生长不依赖雌激素,以腹膜广泛浸润生长为主要特点,层粘蛋白及其受体和Ⅳ型胶原、CD_(44)v_6、PTEN蛋白表达显著高于胃印戒细胞癌。两型胃癌酸性磷酸酶(ACP)和血管内皮生长因子(VEGF)无显著差异。 结论:胃印戒细胞癌和黏液腺癌虽都以旺盛的黏液分泌能力为主要特征,但他们在病理形态、超微结构、生长浸润方式、功能分化和基?

OBJECTIVE: To study the clinicopathological differences between mucous gastric adenocarcinoma (MGC) and non-MGC. METHODS: From 1993 to 2001, 425 patients with gastric cancer were underwent gastrectomy. Among them, 37 patients (8.7%) were with MGC and 388 patients with non-MGC. The clinicopathological characteristics including prognosis between them were analyzed retrospectively.RESULTS: The mean size of tumors in MGC (9±5.1 cm) was larger than that in non-MGC (7±4.3 cm). The patients with MGC had more-invasive...

OBJECTIVE: To study the clinicopathological differences between mucous gastric adenocarcinoma (MGC) and non-MGC. METHODS: From 1993 to 2001, 425 patients with gastric cancer were underwent gastrectomy. Among them, 37 patients (8.7%) were with MGC and 388 patients with non-MGC. The clinicopathological characteristics including prognosis between them were analyzed retrospectively.RESULTS: The mean size of tumors in MGC (9±5.1 cm) was larger than that in non-MGC (7±4.3 cm). The patients with MGC had more-invasive carcinoma (Borrmann type Ⅲ plus Ⅳ; MGC: 92%, 34/37, non-MGC: 62%,241/388),more serosal invasion (T 3 plus T 4; MGC: 86%,32/37, non-MGC: 68%,264/388), and more lymph-node involvement (MGC: 95%,35/37, non-MGC: 81%,314/388) than the patients with non-MGC. The patients with MGC were more advanced in stage at the time of diagnosis (Stage Ⅲ plus Ⅳ; MGC: 92%,34/37, non-MGC: 69%,241/388) and had a higher peritoneal dissemination rate (MGC: 24%,9/37, non-MGC: 11%,43/388) and a lower curability rate (MGC: 62%,23/37, non-MGC: 78%,303/388) than the patients with non-MGC. The 1,2,5-year survival rates for MGC patients were lower than those for non-MGC patients(55.2%,32.3%,22.7 vs 75.7%,67.1%,31.4%) respectively. CONCLUSION: The poor prognosis of MGC is correlated with more advanced stage at diagnosis and more-invasive biological behavior,higher peritoneal dissemination rate and lower curable rate.

目的:研究胃黏液腺癌(mucous gastriccarcinoma,MGC)和非黏液腺癌 (non MGC)的临床病理差异。方法:对 425例胃癌中37例MGC与388例non MGC的临床病理及预后进行回顾性分析。 结果:MGC的肿瘤直径(9±5.1)cm大于 non MGC的(7±4.3)cm,浸润性更强(Bor rmannⅢ+Ⅳ型:MGC为92%、34/37,non MGC为62%、241/388),更易浸润浆膜 (T3+T4:MGC为86%、32/37,non MGC为 68%、264/388),更易发生淋巴结转移(N1 +N2:MGC为95%、35/37,non MGC为 81%、314/388)和腹膜转移(MGC为24%、 9/37,non MGC为11%、43/388);MGC中晚 期患者比例高(Ⅲ+Ⅳ:MGC为92%、34/ 37,non MGC为69%、268/388),根治性切 除率低(MGC为62%、23/37,non MGC为 78%、303/388),1、2、5年生存...

目的:研究胃黏液腺癌(mucous gastriccarcinoma,MGC)和非黏液腺癌 (non MGC)的临床病理差异。方法:对 425例胃癌中37例MGC与388例non MGC的临床病理及预后进行回顾性分析。 结果:MGC的肿瘤直径(9±5.1)cm大于 non MGC的(7±4.3)cm,浸润性更强(Bor rmannⅢ+Ⅳ型:MGC为92%、34/37,non MGC为62%、241/388),更易浸润浆膜 (T3+T4:MGC为86%、32/37,non MGC为 68%、264/388),更易发生淋巴结转移(N1 +N2:MGC为95%、35/37,non MGC为 81%、314/388)和腹膜转移(MGC为24%、 9/37,non MGC为11%、43/388);MGC中晚 期患者比例高(Ⅲ+Ⅳ:MGC为92%、34/ 37,non MGC为69%、268/388),根治性切 除率低(MGC为62%、23/37,non MGC为 78%、303/388),1、2、5年生存率(MGC为 55.2%、32.3%和22.7%,non MGC为 75.7%、67.1%和31.4%)也低。结论:MGC 预后差,与确诊时病例更多处于中晚期以 及其浸润力更强、更易发生腹膜播散、根治 性切除率低有关。

 
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