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   肾小管间质 在 泌尿科学 分类中 的翻译结果: 查询用时:0.853秒
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  renal tubulointerstitial
Expression of connective tissue growth factor in renal tubulointerstitial fibrosis in rats and its pathogenic role
      
In order to explore the role of connective tissue growth factor (CTGF) in the pathogenesis of renal tubulointerstitial fibrosis, 48 Wistar rats were randomly divided into sham-operated and unilateral ureteral obstruction (UUO) group.
      
The renal tubulointerstitial injury index was evaluated according to the MASSON staining.
      
On the post-UUO day 7, the protein level of CTGF was positively related to the renal tubulointerstitial injury index (r=0.62,P>amp;lt;0.01), the expression of TGF-β1 (r=0.85,P>amp;lt;0.01), col I (r=0.78,P>amp;lt;0.01), and PAI-1 (r=0.76,P>amp;lt;0.01).
      
The role of protease activated receptor-2 (PAR-2) in the renal tubulointerstitial lesion induced by unilateral ureteral obstruction (UUO) was explored.
      
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  tubular interstitial
A patient with myoglobininduced acute tubular interstitial nephritis was found to have initially an asymmetric renal affection as evidenced by renography.
      
Tubular interstitial alterations in these disorders other than cast nephropathy were firmly documented when careful ultrastructural studies were conducted experimentally and using clinical material.
      
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This paper reports and analyses the immunofluorescence features of 20 children with IgA nephropathy, and correlation between immunofluorescence features, clinical manifest and pathological changes in kidney. According to the children without GBM deposition of IgA or with GBM deposition of IgA, twenty patients were grouped in to two groups, namely group 1 (8 cases) and 2 (12 cases). The patients who had the symptoms of acute glomerulonephritis or persistent hematuria at onset of the disease were in group 2. The...

This paper reports and analyses the immunofluorescence features of 20 children with IgA nephropathy, and correlation between immunofluorescence features, clinical manifest and pathological changes in kidney. According to the children without GBM deposition of IgA or with GBM deposition of IgA, twenty patients were grouped in to two groups, namely group 1 (8 cases) and 2 (12 cases). The patients who had the symptoms of acute glomerulonephritis or persistent hematuria at onset of the disease were in group 2. The severity of glomerular damages of both groups had significant difference. The children with more severe glomerular damages (≥2) were significantly more in group 2. The children with more severe tubular atrophy and/or interstitial fibrosis (≥++) in group 2 were also more than in group 1. We failed to demostrated correlation between the deposition of IgM in glomeruli and glomerulosclerosis. Although the patients with IgA immunofluorescence ≥ + + were significant more in group 2. but the patients with IgA≥+++ in group 9 were not significant more than in group 1 .

本文报告和分析了20例小儿IgA肾病的免疫荧光表现及其与临床表现和病理改变之间的关系。8例IgA单独沉积于系膜区(组1);12例同时有毛细血管壁沉积(组2)。临床上以急性肾炎和持续血尿起病者均在组2。两组虽各有1例肾病综合征,但组1病例对皮质激素治疗呈完全效应,组2病例则为部分效应。组2肾小球病变≥2度,肾小管间质病变≥++者显著多于组1(P <0.05)。肾小球有无IgM沉积和小球有无硬化改变无关。虽然IgA荧光强度≥++在组2显著多于组1(P<0.05),但≥+++两组无显著差异。

To evaluate the degree of tubulointerstitial lesions and their significance in renal biopsy specimens, a clinicopathological study was carried out in 669 cases of primary glomerulonephritis, 131 cases of lupus nephritis, and 20 cases of tubulointerstitial nephritis. The degree of tubulointerstitial lesions was assessed semiquantitatively by light microscopic observation and was correlated with histopathological and clinical parameters at biopsy. Tubulointerstitial changes were most prominent in focal segmental...

To evaluate the degree of tubulointerstitial lesions and their significance in renal biopsy specimens, a clinicopathological study was carried out in 669 cases of primary glomerulonephritis, 131 cases of lupus nephritis, and 20 cases of tubulointerstitial nephritis. The degree of tubulointerstitial lesions was assessed semiquantitatively by light microscopic observation and was correlated with histopathological and clinical parameters at biopsy. Tubulointerstitial changes were most prominent in focal segmental sclerotic nephritis and IgA nephropathy besides crescentic nephritis. In lupus nephritis, the changes were most evident in Type Ⅳ. In primary tubulointerstitial nephritis, only chronic tubulointerstitial lesions similar to those seen in lupus nephritis were observed. In the above 3 types of nephritis, the degree of tubulointerstitial changes was related to the character of the glomerular injury and also to the degree of impairment of renal function at the time of biopsy. Thus, semiquantitative evaluation of tubulointerstitial lesions in renal biopsy may reflect the severity of glomerulr damage, and be helpful in the assessment of prognosis: in the 3 types of nephritis.

作者对669例原发性肾小球肾炎,131例狼疮性肾炎以及20例小管间质性肾炎患者肾穿刺活检标本用光镜观察,半定量分析肾小管间质损害的程度,并观察与组织病理类型的关系。皮质区小管间质损害的程度在原发性肾小球肾炎中,除新月体性肾炎外,以局灶节段硬化性肾小球肾炎和IgA肾病较突出:在狼疮性肾炎中以第Ⅳ型较明显:在原发性小管间质性肾炎中,仅慢性型小管问质的损害类似于原发性及狼疮性肾炎。上述三种类型的肾炎中,小管间质损害的程度与肾小球损害的性质有关,与肾活检时肾功能减损的程度有关。因此,皮质区小管间质损害的半定量测定,反映了肾小球损害的严重度,并有助于估计预后。

223 patients, aged 50~71 years, were biopsied because of a history of renal disease. All of these patients, the incidence of primary glomerulonephritis is about 65.5%, secondary renal disease is 34.5%. In a comparison with patients of younger age groups, it appeared that membranous nephropathy was the most commonly primary glomerulonephritis, the diabetes, amyloidosis had a significantly higher incidence in secondary glomerulonephritis in the elderly. Main clinical features were nephrotic syndrome (37.7%) and...

223 patients, aged 50~71 years, were biopsied because of a history of renal disease. All of these patients, the incidence of primary glomerulonephritis is about 65.5%, secondary renal disease is 34.5%. In a comparison with patients of younger age groups, it appeared that membranous nephropathy was the most commonly primary glomerulonephritis, the diabetes, amyloidosis had a significantly higher incidence in secondary glomerulonephritis in the elderly. Main clinical features were nephrotic syndrome (37.7%) and persistent proteinuria and hematuria (36.8%). In conclusion, we feel renal biopsy in the elderly is essential for the diagnosis and management of some clinical situations,such as acute renal failure and nephrotic syndrome.

本文回顾性分析223例高龄肾脏病患者肾脏病变的病理分型及临床特点。其中原发性肾炎占65.5%;各类继发性肾脏病占34.5%,且随着年龄增长,继发性肾脏病的发病率逐渐增加。原发性肾炎中,以膜性肾病最常见;继发性者则以糖尿病、肾淀粉样变性多见。近年来,高龄患者中急性间质性肾炎及坏死性血管炎有所增多.肾病综合征及持续性尿检异常是最常见的初发临床表现,ARF的发病率有所升高。与青年人相比,高龄患者存在明显的肾小管-间质受损害的实验室及病理改变证据。

 
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