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心肌梗死家系
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  myocardial infarction pedigrees
     The Clinical Study of Serum E2,T and the Ratio of E2/T in Female Members of Myocardial Infarction Pedigrees
     心肌梗死家系女性成员血清雌激素、睾酮及其比值的变化
短句来源
     ISR and serum lipids were highly associated with the development of CHD Conclusion In the special population myocardial infarction pedigrees, both the I/D polymorphism of ACE gene and ISRwere independent risk factor of the development of CHD, but the role of ACE gene on CHD seemed not to be mediated by ISR action, ACE gene was not the heredity background of ISR
     多因素分析结果显示ACE基因型、ISR、血脂与冠心病发病密切相关。 结论在心肌梗死家系这个特殊人群中 ,ACE基因I/D多态性及ISR均是冠心病发病的独立危险因素 ,但ACE基因对冠心病的作用并非通过ISR实现的。
短句来源
  “心肌梗死家系”译为未确定词的双语例句
     Clinical study of the relation between ACE gene polymorphism and insulin resistance in pedigrees of myocardial infarction
     心肌梗死家系血管紧张素转换酶基因多态性与胰岛素抵抗关系的研究
短句来源
     Objective To investigate the relationship between insulin resistance (ISR) and different genotype of angiotension convert enzyme(ACE) as well as their role in the development of coronary heart disease (CHD) and clinical significance in pedigrees of myocardial infarction Methods 27 eligible pedigrees were selected, and all individuals were divided into three groups: Group A, including 74 patients suffered from CHD in pedigrees; Group B , including 86 healthy first degree relatives in pedigrees;
     目的 探讨心肌梗死家系成员不同ACE基因型与胰岛素抵抗 (ISR)的关系及二者在冠心病发病中的作用及其临床意义。 方法 将 2 7个合格心肌梗死家系成员分为三组 :冠心病组 74例 ,一级亲属健康组 86例 ,健康对照组 74例。
短句来源
     Aim To investigate the role of sex hormone in development of CHD by assessing the serum level of estrogen,testosterone,the ratio of E2/T and their relation with serum lipids in female member of myocardial infarction(MI) pedigrees.
     目的探讨心肌梗死家系女性成员雌激素、睾酮及其比值变化,以及其在心肌梗死家系这组特殊人群中女性冠心病发病机制中的作用。
短句来源
     Methods Female members from eligible MI pedigrees were selected,and divided into two groups,coronary group: 21 members who suffered CHD,health group: 22 healthy members in MI pedigrees.
     方法将15个合格心肌梗死家系中女性成员分为冠心病组和一级亲属健康组,设立健康对照组。
短句来源
     Results There is no difference about age,blood pressure among three groups. The level of serum estrogen of CHD members was almost as same as that of health group and control group,but the serum testosterone in coronary group was much higher than that in health group and control group.
     结果与对照组相比,各组之间年龄和血压等无统计学意义上的差异,心肌梗死家系中冠心病组雌激素水平与对照组及一级亲属健康组无统计学上的差异,但是睾酮水平高于一级亲属健康组及对照组(分别为18.07比13.27比13.08 mol/L,P<0.05);
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  相似匹配句对
     V. C higher than families G.
     V.C比家系G.
短句来源
     Pedigree analysis suggested an X-linked dominant inheritance in this pedigree.
     家系分析:
短句来源
     The Clinical Study of Serum E2,T and the Ratio of E2/T in Female Members of Myocardial Infarction Pedigrees
     心肌梗死家系女性成员血清雌激素、睾酮及其比值的变化
短句来源
     (3)the infarct size of the heart;
     (3)心肌梗死面积;
短句来源
     Clinical study of the relation between ACE gene polymorphism and insulin resistance in pedigrees of myocardial infarction
     心肌梗死家系血管紧张素转换酶基因多态性与胰岛素抵抗关系的研究
短句来源
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Objective To investigate the relationship between insulin resistance (ISR) and different genotype of angiotension convert enzyme(ACE) as well as their role in the development of coronary heart disease (CHD) and clinical significance in pedigrees of myocardial infarction Methods 27 eligible pedigrees were selected, and all individuals were divided into three groups: Group A, including 74 patients suffered from CHD in pedigrees; Group B , including 86 healthy first degree relatives in pedigrees; and group...

Objective To investigate the relationship between insulin resistance (ISR) and different genotype of angiotension convert enzyme(ACE) as well as their role in the development of coronary heart disease (CHD) and clinical significance in pedigrees of myocardial infarction Methods 27 eligible pedigrees were selected, and all individuals were divided into three groups: Group A, including 74 patients suffered from CHD in pedigrees; Group B , including 86 healthy first degree relatives in pedigrees; and group C, including 74 healthy volunteers Polymerase chain reaction (PCR) was used to detect the ACE gene Insert/Delete polymorphism; Radioimmunological and biochemical method were used to asses serum insulin, glucose, and serum lipids; Oral Glucose Tolerance Test(OGTT) was used to calculate the ISR value the parameters between the groups were compared by using t test and the frequency of genotypes between the groups was compared by using χ 2 test the Logist regress analysis was used to study the relation between those clinical parameters and the development of CHD Results Compared with the healthy control group, the frequent of DD genotype was hight in group A(χ 2=6 3, P <0 05), but there was no difference between group B and group C(χ 2=1 2, P >0 05) In all groups of pedigreed (including the healthy relatives), the ISR value, serum TC?TG were higher than those in the control group But ISR value was no significant different among different genotypes The result of multiple factor analysis showed that all of genotypes of ACE?ISR and serum lipids were highly associated with the development of CHD Conclusion In the special population myocardial infarction pedigrees, both the I/D polymorphism of ACE gene and ISRwere independent risk factor of the development of CHD, but the role of ACE gene on CHD seemed not to be mediated by ISR action, ACE gene was not the heredity background of ISR

目的 探讨心肌梗死家系成员不同ACE基因型与胰岛素抵抗 (ISR)的关系及二者在冠心病发病中的作用及其临床意义。方法 将 2 7个合格心肌梗死家系成员分为三组 :冠心病组 74例 ,一级亲属健康组 86例 ,健康对照组 74例。应用多聚酶链反应方法对各组ACE基因插入 /缺失 (I/D)多态性进行检测 ,应用放免法及生化技术测量血清胰岛素、血糖、血脂 ,通过口服葡萄糖耐量实验结果计算ISR值。对各组计数指标采用t检验进行比较 ,对各组基因型频率采用 χ2 检验 ,对各临床指标与ACE基因型及冠心病的发病关系采用logistic回归进行统计分析。结果 与对照组比较 ,心肌梗死家系中冠心病组缺失等位基因DD基因型频率显著高于对照组 (χ2 =6 3,P <0 0 5 ) ,而一级亲属健康组与对照组比较无显著性差异 (χ2 =1 2 ,P >0 0 5 )。家系中包括一级亲属健康组在内的各组成员的ISR值、血清总胆固醇、甘油三酯水平均高于对照组 (P <0 0 5 ) ,但各基因型之间的ISR值、血脂各项无显著性差异 (P >0 0 5 )。多因素分析结果显示ACE基因...

目的 探讨心肌梗死家系成员不同ACE基因型与胰岛素抵抗 (ISR)的关系及二者在冠心病发病中的作用及其临床意义。方法 将 2 7个合格心肌梗死家系成员分为三组 :冠心病组 74例 ,一级亲属健康组 86例 ,健康对照组 74例。应用多聚酶链反应方法对各组ACE基因插入 /缺失 (I/D)多态性进行检测 ,应用放免法及生化技术测量血清胰岛素、血糖、血脂 ,通过口服葡萄糖耐量实验结果计算ISR值。对各组计数指标采用t检验进行比较 ,对各组基因型频率采用 χ2 检验 ,对各临床指标与ACE基因型及冠心病的发病关系采用logistic回归进行统计分析。结果 与对照组比较 ,心肌梗死家系中冠心病组缺失等位基因DD基因型频率显著高于对照组 (χ2 =6 3,P <0 0 5 ) ,而一级亲属健康组与对照组比较无显著性差异 (χ2 =1 2 ,P >0 0 5 )。家系中包括一级亲属健康组在内的各组成员的ISR值、血清总胆固醇、甘油三酯水平均高于对照组 (P <0 0 5 ) ,但各基因型之间的ISR值、血脂各项无显著性差异 (P >0 0 5 )。多因素分析结果显示ACE基因型、ISR、血脂与冠心病发病密切相关。结论在心肌梗死家系这个特殊人群中 ,ACE基因I/D多态性及ISR均是冠心病发病的独立危险因素 ,但ACE基因对冠心病的作用并非通过ISR实现的。

Aim To investigate the role of sex hormone in development of CHD by assessing the serum level of estrogen,testosterone,the ratio of E2/T and their relation with serum lipids in female member of myocardial infarction(MI) pedigrees. Methods Female members from eligible MI pedigrees were selected,and divided into two groups,coronary group: 21 members who suffered CHD,health group: 22 healthy members in MI pedigrees.Control group was consisted of 22 healthy volunteers from non CHD pedigrees.Serum estrogen,testosterone,and...

Aim To investigate the role of sex hormone in development of CHD by assessing the serum level of estrogen,testosterone,the ratio of E2/T and their relation with serum lipids in female member of myocardial infarction(MI) pedigrees. Methods Female members from eligible MI pedigrees were selected,and divided into two groups,coronary group: 21 members who suffered CHD,health group: 22 healthy members in MI pedigrees.Control group was consisted of 22 healthy volunteers from non CHD pedigrees.Serum estrogen,testosterone,and serum lipids were assayed. Results There is no difference about age,blood pressure among three groups.The level of serum estrogen of CHD members was almost as same as that of health group and control group,but the serum testosterone in coronary group was much higher than that in health group and control group.There is no difference between the latter two groups. Especially,the ratio of E2/T in coronary group was significant lower,compared with the healthy group.Additionally,the ratio of E2/T was positively related to HDLC,while negatively related to TC,TG,LDLC. Conclusion In MI pedigrees,the development of CHD in female members has no relation with the level of endogenous estrogen,while the level of endogenous testosterone especially the ratio of E2/T seems to play an important role during this event through influencing the lipid metabolism.

目的探讨心肌梗死家系女性成员雌激素、睾酮及其比值变化,以及其在心肌梗死家系这组特殊人群中女性冠心病发病机制中的作用。方法将15个合格心肌梗死家系中女性成员分为冠心病组和一级亲属健康组,设立健康对照组。应用放射免疫法测量每个受试对象血清雌激素和睾酮的水平,并对血清雌激素/睾酮与血脂各项指标进行相关性分析。结果与对照组相比,各组之间年龄和血压等无统计学意义上的差异,心肌梗死家系中冠心病组雌激素水平与对照组及一级亲属健康组无统计学上的差异,但是睾酮水平高于一级亲属健康组及对照组(分别为18.07比13.27比13.08 mol/L,P<0.05);冠心病组血清雌激素/睾酮比值显著低于一级亲属健康组及对照组(分别为16.71比23.25比24.87,P<0.05),而一级亲属健康组与对照组之间差异无显著性(P>0.05)。相关性分析显示,血清雌激素/睾酮比值与高密度脂蛋白胆固醇呈正相关,与胆固醇、低密度脂蛋白胆固醇和甘油三酯呈负相关。结论在心肌梗死家系这个特殊人群中女性内源性雌激素水平与心绞痛、心肌梗死之间未见相关性,而内源性雄激素水平与之则可能有正相关性,...

目的探讨心肌梗死家系女性成员雌激素、睾酮及其比值变化,以及其在心肌梗死家系这组特殊人群中女性冠心病发病机制中的作用。方法将15个合格心肌梗死家系中女性成员分为冠心病组和一级亲属健康组,设立健康对照组。应用放射免疫法测量每个受试对象血清雌激素和睾酮的水平,并对血清雌激素/睾酮与血脂各项指标进行相关性分析。结果与对照组相比,各组之间年龄和血压等无统计学意义上的差异,心肌梗死家系中冠心病组雌激素水平与对照组及一级亲属健康组无统计学上的差异,但是睾酮水平高于一级亲属健康组及对照组(分别为18.07比13.27比13.08 mol/L,P<0.05);冠心病组血清雌激素/睾酮比值显著低于一级亲属健康组及对照组(分别为16.71比23.25比24.87,P<0.05),而一级亲属健康组与对照组之间差异无显著性(P>0.05)。相关性分析显示,血清雌激素/睾酮比值与高密度脂蛋白胆固醇呈正相关,与胆固醇、低密度脂蛋白胆固醇和甘油三酯呈负相关。结论在心肌梗死家系这个特殊人群中女性内源性雌激素水平与心绞痛、心肌梗死之间未见相关性,而内源性雄激素水平与之则可能有正相关性,高睾酮血症及低血清雌激素/睾酮比值可能通过对血脂代谢来影响和促进冠心病的发生、发展。

 
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