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可控释放
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  controlled release
     A Study on Controlled Release Silicate Glass Inhibitor
     可控释放硅酸盐玻璃缓蚀剂的研究
短句来源
     Studies on Microencapsulation and Controlled Release of Antioxidant-BHT
     抗氧化剂BHT的微胶囊化及其可控释放研究
短句来源
     Surface Morphology and Dissolution Process of Controlled Release Phosphate Glass in Deionised Water
     可控释放磷酸盐玻璃表面形貌与水溶解过程
短句来源
     A Study on the Phaimacokinetics of the Disopyramide Controlled Release Pellets
     异丙吡胺可控释放小丸的药物代谢动力学研究
短句来源
     The preparation method of the controlled release silicate glass (CRSG) is introduced. The technological parameters are discussed.
     介绍了可控释放硅酸盐玻璃的制取,并从硅酸盐玻璃的组成、介质温度和 pH 值等方面讨论了它的可控释放性质。
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  controlled-release
     CONTROLLED-RELEASE METHODS OF MICROBE NUTRIENTS FOR BIOREMEDIATION
     营养元素的可控释放技术在生物修复中的应用
短句来源
     The property and function of chlorine dioxide,research and developmentof stable chlorine dioxide solution and solid chlorine dioxide disinfector in the world are described,and the researchof controlled-release chlorine dioxide is also discussed.
     介绍了二氧化氯的性质、作用,稳定性二氧化氯溶液及固体二氧化氯消毒剂在世界上的发展历程以及研究进展,对可控释放二氧化氯的研究进行了探讨。
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  control release
     Spontaneous Deposition of Enzyme and Drugs in Polyelectrolyte Multilayer Microcapsules and Control Release Thereof
     酶和药物在聚电解质微胶囊中的自发沉积与可控释放
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  “可控释放”译为未确定词的双语例句
     Preparation of Complex Chitosan Microcapsule and Its Application inControlled Release of Vitamin D_2
     壳聚糖复合微胶囊的研制及在维生素D_2可控释放中的应用
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     Controlledrelease and Pesticide Controlledreleasing Agents
     可控释放与农药缓释剂
短句来源
     Silica-based Materials for Controlled Drug Release
     SiO_2基药物可控释放材料
短句来源
     For the silica-based materials for drug release, matrix swelling and dissolution are usually negligible, and drug diffusion is the main mechanism.
     对于SiO2基药物可控释放材料来说,基质溶胀和基质溶解对药物可控释放的影响不大,药物扩散是释放的主要机制。
短句来源
     THE STUDY ON CONTROLLEO RELEASE OF F~- BY APPLICATION OF MODIFIED MICROPOROUS POLYPROPYLENE FILM
     改性聚丙烯微孔薄膜在氟可控释放上应用的研究
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  controlled release
New poly(3-hydroxybutyrate)-based systems for controlled release of dipyridamole and indomethacin
      
New poly(3-hydroxybutyrate)-based systems for controlled release of anti-inflammatory and anti-thrombogenic drugs have been studied.
      
Controlled Release of Farmazin from Thermosensitive Gels Based on Poly(N-vinylcaprolactam)
      
Films of chitosan-based complexes with controlled release of Levomycetin
      
Immobilization of TRAP-6 into a matrix based on lactic and glycolic acid copolymer (PLGA) prevents its destruction by peptidases located in the wound and can also provide controlled release of the peptide.
      
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  controlled-release
Controlled-release levodopa/benserazide (Madopar HBS): clinical observations and levodopa and dopamine plasma concentrations in
      
With tolcapone and the controlled-release formulation, AUC increased by 80% and t1/2 by 60%.
      
Entacapone used as an adjunct to regular or controlled-release levodopa preparations increased ON-time and reduced OFF-time by 1 to 2 h daily in Parkinson's disease patients with wearing-off.
      
Synthesis and characterization of some organopolyphosphazenes and their controlled-release characteristics
      
The polymers have been developed as microspheres to study their controlled-release characteristics for indomethacin, an anti-inflammatory drug.
      
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  control release
We investigated both Gi protein-dependent and IgE-dependent pathways that control release of histamine by PMCs derived from EAE or Complete Freund's Adjuvant (CFA) immunized rats.
      
Nonspecific α-blockers (phentolamine, dihydroergotamine) increased control release at 10 μmol/l, but only the latter amplified the response to tolbutamide.
      
In 'fixed pulse facilitation",Fc, the second pulse was kept constant, and the effect of a varying pre-pulse was measured, comparing the thus facilitated release after the fixed pulse to control release after the fixed pulse alone.
      
FG therefore was considered to control release of AMK and to maintain a high AMK concentration in tissues surrounding the implantation site.
      
The inhibitory power of cromoglycate increased as the concentration of antigen was decreased and the corresponding control release of histamine declined.
      
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In order to carry out the in vivo studies, gas liquid chromatography wasselected for determining microgram levels of disopyramide in urine. And enzymemultiplied immunoassay technique was selected for measuring trace of disopyramidein plasma. Four subjects took part in investigations both on free drug and on thecontrolled release pellets in a cross over way without controlling the acidity ofurine. There was a direct correlation between the rate of urinary excretion and theplot of the concentration of plasma levels...

In order to carry out the in vivo studies, gas liquid chromatography wasselected for determining microgram levels of disopyramide in urine. And enzymemultiplied immunoassay technique was selected for measuring trace of disopyramidein plasma. Four subjects took part in investigations both on free drug and on thecontrolled release pellets in a cross over way without controlling the acidity ofurine. There was a direct correlation between the rate of urinary excretion and theplot of the concentration of plasma levels against time. The release of disopyramidefrom the controlled release pellets showed a sustained and smooth release effect. Further more, the urinary excretion rates of disopyramide following the rectaladministration of the suppositories containing the controlled release pellets inside tothree subjects were very similar to those occurring after the oral administration ofthe same pellets.

本文选用气体色谱法测定尿中之异丙吡胺,并用结合酶免疫测定法测定血浆中的浓度作对照,对美国试制的本品进行了可控释放剂型的研究。实验结果表明一次服用本制剂,即可平稳地维持24小时一定范围的血药浓度,尿排药速率及血药浓度对时间的曲线基本吻合,并证明口服及直肠服用后的药-时曲线基本一致。

Two different retard tablets and one controlled release pellets of disopyramidephosphate were studied in four healthy subjects. Urinary excretion rates were followed after single oral 250 mg doses. The dissolution rate of each dosage formwas measured in gradient pH phosphate buffers. Rank order correlation was seenbetween in vitro and vivo profiles of disopyramide released. One of the retard tablets didn't show a controlled release effect, but it gave adelayed release about one and half an hour following the...

Two different retard tablets and one controlled release pellets of disopyramidephosphate were studied in four healthy subjects. Urinary excretion rates were followed after single oral 250 mg doses. The dissolution rate of each dosage formwas measured in gradient pH phosphate buffers. Rank order correlation was seenbetween in vitro and vivo profiles of disopyramide released. One of the retard tablets didn't show a controlled release effect, but it gave adelayed release about one and half an hour following the administration. Both thetwo retard tablets gave great inter subject variation in vivo tests. While the release of the drug from the controlled release pellets was smoothand slow, and inter subject variation was not great.

通过体外实验与体内实验将异丙吡胺的两种剂型,即缓释片与可控释放小丸加以对比。实验结果证明可控释放小丸可维持血中稳定的、一定的浓度,且个体差异小,缓释片则或不能维持血中一定的药物浓度,或个体差异大。

Usinga determining modified dissolution rate apparatus,disopyra-mide controlled release pellets were chosen as the objects of studies.Gradi-ent PH phosphate buffers and PH 6.9 phosphate buffer were used respective-ly for the two dosage forms(oral and rectal)as dissolution media.Theurinary excretion profile fits in a triexponertial equation.The curveswere made by the dissolution data in vitro and pharmacokinetic Parame-ters in vivo.Four different batches,two different forms of the drug(saltor base),single dose...

Usinga determining modified dissolution rate apparatus,disopyra-mide controlled release pellets were chosen as the objects of studies.Gradi-ent PH phosphate buffers and PH 6.9 phosphate buffer were used respective-ly for the two dosage forms(oral and rectal)as dissolution media.Theurinary excretion profile fits in a triexponertial equation.The curveswere made by the dissolution data in vitro and pharmacokinetic Parame-ters in vivo.Four different batches,two different forms of the drug(saltor base),single dose and multiple doses,two different routes of admi-nistration(oral or rectal)and different subjects(female or male)werestudied.All the curves calculated from dissolution data in vitro agreedclosely with the results in vivo.

以异丙吡胺可控释放小丸为对象,以pH递增的磷酸盐缓冲液为介质,求得体外溶出实验的释放度,将其代入体内药代动力学曲线的三项指数方程,模拟出体内药代动力学曲线,证明了计算曲线与实际曲线的一致性。

 
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