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调节凋亡
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  regulation of apoptosis
     Conclusion: Apoptosis of extrahepatic vascular smooth muscle cell occur in patients with portal hypertension, Bax and Bcl-2 protein may involve in the regulation of apoptosis of extrahepatic vascular smooth muscle cell, which induces vascular remodeling and promotes the fromation of splanchnic high dynamic circulation
     结论:门脉高压症患者肝外血管平滑肌细胞可产生凋亡,Bax和Bcl-2蛋白参与血管平滑肌细胞凋亡的调节,凋亡与增殖失衡导致血管结构重塑,促进门脉高压症时内脏高动力循环的形成和发展。
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     Positive relationship was found between the expression of HIF-1α and p53. Conclusion The expression of HIF-1α and p53 increased in lung during hypoxia,which indicates that HIF-1α may play an important role in the expression of p53 and the regulation of apoptosis. ;
     结论 低氧可诱导小鼠肺组织中HIF 1α的表达增强 ,同时肺组织p5 3蛋白的表达上调 ,两者呈显著正相关 ,说明HIF 1α有可能参与肺组织p5 3蛋白表达的调节 ,进而调节凋亡的发生。
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  “调节凋亡”译为未确定词的双语例句
     Conclusion The NVP can inhibit the proliferation of K562 cell prominently,and the mechanism probably is that the apoptosis is induced via regulating the expression of apoptosis-associated signal transducted factors NF-κBp65,β-catenin and iNOS.
     结论NVP有明显抑制K562细胞增殖的作用,其作用机制可能通过调节凋亡相关信号传导因子NF-κBp65、-βcatenin及iNOS的表达,从而诱导白血病细胞凋亡。
短句来源
     By now the known genes that mediating apoptosis are : CD95/Fas/APO-l, bcl-2, c-myc, p53, caspases, etc.
     目前已知的调节凋亡基因有:CD95/Fas/APO-1,bcl-2,c-myc,p53,caspases等,其中死亡受体更是以其直接而确切的诱导凋亡的特性备受关注。
短句来源
     Conclusions Antibody chA21 could remarkably induce apoptosis of SKBR3 cells through regulating the expression of bax,bcl-2,Fas and caspase-3.
     结论chA21在体外可诱导SK-BR3细胞凋亡,其分子机制与调节凋亡相关基因bax、bc l-2、Fas及caspase-3的表达有关。
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     Conclusion: Apoptosis of Panc-1 induced by irradiation was intensified with CH through overcoming a high apoptotic threshold and regulating differential expression of apoptosis-related proteins.
     结论:CH通过降低Panc-1细胞的凋亡阈值,调节凋亡相关蛋白表达,抑制细胞增殖,提高射线对Panc-1细胞凋亡的诱导,以增加Panc-1细胞对射线的敏感性。
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     Conclusion: Both HIF-1α and HIF-2α play important roles in regulation of angiogenesis; moreover,HIF-1α might also regulate proliferation of tumor cells,possibly through regulating anti-apoptotic genes.
     结论:HIF-1α和HIF-2α均有一定程度调节血管生成基因的作用,但HIF-1α尚具备一定的调节肿瘤细胞增殖功能,可能通过调节凋亡抑制基因实现。
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  相似匹配句对
     Regulation of metabolism and apoptotic signal by ceramide
     神经酰胺代谢及凋亡信号调节
短句来源
     Regulation of the inhibitor of apoptosis protein family in Apoptosis
     凋亡抑制蛋白在细胞凋亡中的调节作用
短句来源
     Apoptosis of primordial germ cells
     原始生殖细胞的凋亡
短句来源
     adjusting the microclimate;
     调节小气候 ;
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     adjustment of field excitation;
     励磁调节
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  regulation of apoptosis
It is suggested that phytohormones and antioxidants participate in regulation of apoptosis in the ageing coleoptile, directly or indirectly effecting the proteolytic apparatus in the coleoptile cells.
      
Reproductive Hormones in the Regulation of Apoptosis of Neutrophils
      
ING1, a supposed tumor suppressor gene, codes for a p33 protein involved in cell proliferation control and regulation of apoptosis.
      
The data first suggest that increasing expression and splitting ofbcl-2 mRNA may play an important role in apoptosis of VEC induced by rattlesnake venom, and this finding is helpful to understanding the role ofbcl-2 in regulation of apoptosis.
      
Among them, Bcl-2 family proteins, TNF and p53 play pivotal roles in the regulation of caspase activation and in the regulation of apoptosis.
      
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AIM To evaluate the mechanism that natural anti keratin autoantibody (AK auto Ab) inhibits the proliferation of keratinocytes (KC) and squamous cell carcinoma (SCC). METHODS Normal human KC and SCC were cultured and then treated with AK auto Ab in different titres. MTT and Immunohistochemical technology were used to test it. RESULTS AK autoAb inhibited the proliferation of KC and SCC with relation to dose effection. It also inhibited the expression of c Myc in KC and SCC. To Bcl 2, it had the same...

AIM To evaluate the mechanism that natural anti keratin autoantibody (AK auto Ab) inhibits the proliferation of keratinocytes (KC) and squamous cell carcinoma (SCC). METHODS Normal human KC and SCC were cultured and then treated with AK auto Ab in different titres. MTT and Immunohistochemical technology were used to test it. RESULTS AK autoAb inhibited the proliferation of KC and SCC with relation to dose effection. It also inhibited the expression of c Myc in KC and SCC. To Bcl 2, it had the same effect on SCC, but had little influence on its expression in KC, which was related to apoptosis. CONCLUSION AK auto Ab plays an important role in the proliferation of KC and SCC by regulating the protein related to apoptosis.

目的 探索天然抗角蛋白自身抗体 (AK auto Ab)对培养角质形成细胞及鳞癌细胞凋亡相关蛋白的表达影响 .方法 经体外培养人角质形成细胞及鳞癌细胞 ,以不同滴度的天然抗角蛋白自身抗体作用 ,并用 MTT法及免疫组化检测 .结果  AK auto Ab对二者的增殖有着明显的抑制作用 ,且呈一定的剂量 -效应关系 .可促进二者凋亡相关蛋白 c- Myc的表达 ;对 Bcl- 2在 SCC中的表达表现为抑制作用 ,而对其在KC中的表达作用却不明显 .结论 天然抗角蛋白自身抗体对培养角质形成细胞及鳞癌细胞的增殖起着抑制作用 ,并可能通过调节凋亡相关蛋白的表达来实现

AIM To explore the effect of wild type p53 gene transfer mediated via recombinant adenovirus vector on tumor cell apoptosis induced by anticancer agent cisplatin. METHOD Eukaryotic expression plasmid pAdCMV p53 or pAdCMV luc, together with pJM17 containing adenovirus genome DNA, was co transfected into human kidney cell 293 with liposome lipofectamine. Recombinant p53 adenovirus(Ad p53) and recombinant luc adenovirus(Ad luc) were generated and identified by dual PCR. Oral cancer cell KB firstly was infected...

AIM To explore the effect of wild type p53 gene transfer mediated via recombinant adenovirus vector on tumor cell apoptosis induced by anticancer agent cisplatin. METHOD Eukaryotic expression plasmid pAdCMV p53 or pAdCMV luc, together with pJM17 containing adenovirus genome DNA, was co transfected into human kidney cell 293 with liposome lipofectamine. Recombinant p53 adenovirus(Ad p53) and recombinant luc adenovirus(Ad luc) were generated and identified by dual PCR. Oral cancer cell KB firstly was infected by two recombinant adenoviruses and then treated with cisplatin. The effect of p53 gene on apoptosis induction, and expression level of bcl 2 and bax genes in Ad p53 infected tumor cells were observed. RESULTS E1 deficient and replication defective Ad p53 and Ad luc were generated by homologous recombination in virus packaging cell 293. Western blot indicated that wild type p53 gene was transferred and expressed in Ad p53 infected KB cells. Northern blot showed that bcl 2 mRNA expression level was markedly reduced and bax mRNA level was increased in Ad p53 infected cells, compared with Ad luc infected cells. Flow cytometry and in situ end labeling suggested that the cells treated with Ad luc and cisplatin did not undergo apoptosis; The cells treated with Ad p53 and cisplatin were induced a marked apoptosis. The number of cell death in the latter group was more than the former. CONCLUSION p53 gene plays a key role in the apoptosis of tumor cells induced by cisplatin by down regulating the expression level of bcl 2 gene and up regulating expression level of bax gene. The application of recombinant p53 adenovirus in combination with cisplatin might help to overcome the resistance to chemotherapeutic drug of p53 null tumor cells in clinical anticancer treatment.

目的 探讨野生型 p5 3基因对顺铂诱导肿瘤细胞凋亡的影响。方法 用重组p5 3腺病毒 (Ad p5 3)和重组luc腺病毒 (Ad luc)分别感染 p5 3缺失的口腔癌细胞KB ,观察外源p5 3基因对顺铂诱导肿瘤细胞凋亡的影响。 结果 流式细胞术和原位末端标记显示用Ad luc与顺铂联合处理KB细胞不能诱导凋亡发生 ,用Ad p5 3与顺铂联合处理则诱导出较明显的细胞凋亡 ,表明p5 3可增强KB细胞对顺铂的敏感性 ;Northernblot显示 p5 3可下调bcl 2基因表达及上调bax基因的表达。结论 p5 3可能通过调节凋亡相关基因的表达水平而在顺铂诱导的肿瘤细胞凋亡中发挥重要作用 ,重组p5 3腺病毒与顺铂联合应用有助于克服 p5 3失活肿瘤细胞的耐药性。

AIM To find a molecular, specific and efficient drug screening method for apoptosis, we studied the possibility of Xenopus leavis eggs cell free system (XS 200) and observed the process of apopotosis in system. METHODS We studied the influence of different kinds of drugs including hormone: estradiol and its partial antagonist anordiol; the extracts of Chinese herb: triterpenes and polysaccharides; small molecular drug: aspirin, sodium salicylate and a new compound ZXS 1; vitamin C and recombinant protein:...

AIM To find a molecular, specific and efficient drug screening method for apoptosis, we studied the possibility of Xenopus leavis eggs cell free system (XS 200) and observed the process of apopotosis in system. METHODS We studied the influence of different kinds of drugs including hormone: estradiol and its partial antagonist anordiol; the extracts of Chinese herb: triterpenes and polysaccharides; small molecular drug: aspirin, sodium salicylate and a new compound ZXS 1; vitamin C and recombinant protein: rhTFAR19 on apoptosis in XS 200. XS 200 was pre incubated with drugs for 30 min and added with cytochrome C of threshold (0.0625 μmol·L -1 ) and mouse liver nuclei. Total DNA was prepared and identified by agarose gel electrophoresis. RESULTS Only rhTFAR19 could promote the apoptotic process in XS 200. CONCLUSION XS 200 could become a useful tool for drug screening.

目的 为寻找具有分子水平、特异、快速、可用来筛选具有调节凋亡作用药物的方法 ,非洲爪蟾卵非细胞体系 (XS 2 0 0 )作为一种药物的筛选平台 ,研究其作为筛选药物方法的可能性。对体系内凋亡过程的影响进行了初步的研究。方法 药物 (激素 :雌激素及其部分拮抗剂 ,中药提取物 :灵芝三萜和多糖 ,小分子药物 :阿司匹林、水杨酸钠和乙酰唑胺 ,维生素C及重组蛋白rhTFAR19)预先与XS 2 0 0共孵育 ,然后加入阈剂量 (0 .0 6 2 5 μmol·L- 1)的细胞色素C和小鼠肝细胞核 ,提取总DNA进行电泳鉴定。结果 rhTFAR19对XS 2 0 0凋亡过程有直接的促进作用 ,而其他药物则无明显作用。结论 XS 2 0 0可以成为一个良好的分子水平的药物筛选平台 ,特异筛选具有调节凋亡作用的药物。

 
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