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变态反应性皮炎
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  allergic dermatitis
     Detection of serum fungus specific IgE in patients with allergic dermatitis and its clinical significance
     变态反应性皮炎患者血清真菌特异性IgE的检测及其临床意义
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  相似匹配句对
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     Atopic Dermatitis
     特应性皮炎
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     Photoallergic contact dermatitis from ketoprofen in southern Sweden
     瑞典南部酮洛芬引发的光变态反应性接触性皮炎
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     Clinical Effect Observation of 4 kind of Allergic Skin Diseases Treated with Di-huang Dermatitis Oral Liquid
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  allergic dermatitis
However, an increasing number of case reports suggest that in broad use, KP can cause allergic dermatitis.
      
Multiple osteonecrosis associated with allergic dermatitis
      
In DNCB allergic dermatitis, the maximum content of the amine at 3 days after the initiation was about three times that of the control baseline.
      
In PPD reaction, the maximum content and the time course were almost similar to that in DNCB allergic dermatitis.
      
However, in KLH-induced cutaneous basophil hypersensitivity the maximum content was about ten times that in DNCB allergic dermatitis or PPD reaction, and was observed earlier, on the 2nd day.
      
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The occurence and distribution of substance P, calcitonin gene-related peptide, and neuropeptide Y in allergic contact dermatitis and normal human skin were investigated, Immunohistological localization showed that all the peptides to be presented in nerve fibers and or granular particles surrounding eccrine sweat glands in the samples of both cases, but only in the case of allergic contact dermatitis, positive staining of substance P and calcitonin gene related peptide were observed in dermis layer especially...

The occurence and distribution of substance P, calcitonin gene-related peptide, and neuropeptide Y in allergic contact dermatitis and normal human skin were investigated, Immunohistological localization showed that all the peptides to be presented in nerve fibers and or granular particles surrounding eccrine sweat glands in the samples of both cases, but only in the case of allergic contact dermatitis, positive staining of substance P and calcitonin gene related peptide were observed in dermis layer especially around blood vessels and infiltrated cells. Substance P can induce vasodilation indirectly by releasing vasoactive factors from mast cells, calcitonin gene-related peptide can act directly on blood vessels to inrease vascular permeability and cells infiltration, both actions exacerbate local inflammation. The authors believed that neuropeptides above, at least as inflammation mediators, were involved in pathological mechanism of allergic contact dermatitis.

本文用ABG免疫组化染色技术观察了P物质(SP)、降钙素基因相关胜(CGRP)、神经肽Y(NPY)等多种神经肽类物质在变应性皮炎和正常皮肤的发生及分布。结果发现:在变应性皮炎皮损的真皮浅层SP、CGRP类物质明显增加,正常皮肤中无此现象;在变应性皮炎和正常皮肤的小开腺周围及开腺导管管壁上,SP、CGRP及NPY均有不同形式的阳性染色。SP可促使皮肤肥大细胞释放组织胺等炎性介质,后者可引起血管扩张,通透性增强;CGRP则直接作用于小血管壁使之舒张,细胞成分外渗,二者均能加重局部炎性细胞浸润。作者认为:在迟发性变态反应性皮炎的发病机制中,神经胜至少作为炎性介质参与了发病过程。

Dermatitis and eczema are allergic relapsing inflammatory skin disorders. The precise mechanisms still are unclear. Experimental animal models are indispensable tools to study the pathogenic mechanisms and test novel therapy. A considerable number of mouse models have been proposed and used to study specific aspects of the disease. This paper summarizes the currently available animal models.

皮炎湿疹是常见的变应性炎症性皮肤病,病因复杂,建立动物模型对于探讨疾病发病机制及防治具有重要意义。近年来报道的鼠皮炎湿疹模型大致可分为变态反应性接触性皮炎及慢性皮炎湿疹模型、光变态反应性皮炎模型与特应性皮炎模型三类。造模方法多样,各有特点,适用于不同的研究方向。

 
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