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成年鼠     
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  adult rats
     Results ① The average duration from the injection to seizure was (13.3±5.63) min in infant rats, and (22.5±5.66) min in adult rats.
     结果幼年鼠从给药至惊厥发作的时间为(13.3±5.63)min,而成年鼠为(22.5±5.66)min;
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     The RODs of P2X_2 and P2X_4 receptors immunoreactivity were both lower in neonatal rats than that in adult rats.
     在新生鼠延髓,P2X2和P2X4的表达水平均比成年鼠低。
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     The results showed that the bFGF xontents of brain were respectively 17.36±8.30pg/mg in adult rats,31.96±10.11 pg/mg in newborn rats and 56.681±15.79pg/mg in newborn rats with hypoxidosis. There were a significant defference among these three groups (P<0.05~0.005).
     结果 表明脑 b FGF含量成年鼠为 17.36± 8.30 pg/ mg,新生鼠为 31.96± 10 .11pg/ mg新生鼠缺氧组为 5 6 .6 8± 15 .79pg/ mg,各组相差具有显著意义 (P<0 .0 5~ 0 .0 1) ;
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     RAC of the adult rats with hyperoxic exposure (12.67±2.25) was higher that of exposed neonatal rats, but not significantly different from that of the adult or neonatal rats in the control group (P>0.05).
     (2)高氧新生鼠RAC值为9.50±1.05,较正常同日龄新生鼠(13.00±1.79)明显减少(P<0.05),高氧成年鼠RAC值(12.67±2.25)比高氧新生鼠为高(P<0.05),跟正常空气组新生鼠差异不明显(P>0.05)。
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     【Results】 ①The average duration from the injection with lithium-pilocarpine was 13.3±5.63mins in infant rats, and 22.5±5.66mins in adult rats;
     结果:① 幼年鼠从给药至惊厥发作的时间为13.3±5.63 min,而成年鼠为22.5±5.66 min;
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  adult rat
     Differential expression of L-type calcium channel α1 subunits on adult rat hippocampal neurons
     L-型钙通道α1亚单位在成年鼠海马神经元上的差异性表达
短句来源
     Objective To study the localization of L-type calcium channel α1 subunits CaV1.2α1C and CaV1.3α1D in CA1 and CA3 regions of adult rat hippocampus.
     目的观察L-型钙通道不同的α1亚单位在成年鼠海马不同亚区神经元中表达的变化。
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     Results: The mRNA and protein expression of TGF-βⅡ receptor of newborn rat pancreas is significantly higher than those of embryo rat of 18. 5 days and adult rat pancreas respectively (P < 0. 05).
     使用Western blot方法分别对上述不同时期SD大鼠胰腺TGF-βⅡ受体表达进行蛋白质水平的检测。 结果:新生鼠胰腺TGF-βⅡ受体表达在核酸与蛋白质水平上均明显高于18.5天胎鼠与成年鼠胰腺,差异有显著性(P<0.05)。
短句来源
     Polyomavirus Middle T Oncogene Transfer into Adult Rat Endothelial Cells
     多瘤病毒中T癌基因转导成年鼠内皮细胞
     Some meaningful results were summarized as follows:(1) In P77PMC rat brain, NR 1 gene expression during development, and NMDA receptor activity (MK 801 binding) in adult rat were higher than that of control.
     所得较有意义的结果如下:(1)在听源性惊厥易感大鼠P77PMC整个发育过程中脑内NR1mRNA的表达,以及成年鼠脑内NMDA受体活性(MK801结合)都高于对照组Wistar大鼠。
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  adult mice
     The data were statistically analyzed with SPSS 12.0 software. Results The data showed that BMD of ovariectomized mice(0.151±0.008)g/cm~(2)was significantly lower than that of aged mice(0.160±0.007)g/cm~(2),P<0.01.The BMD in both groups was lower than that in normal adult mice(P<0.01).
     结果去卵巢小鼠的骨密度显著低于增龄小鼠〔分别为(0.151±0.008)和(0.160±0.007)g/cm2,P<0.01〕,两组骨密度值均较成年鼠低(P<0.01);
短句来源
     Expression of β-defensin-4,6 in lung of sucking mice and adult mice after lipopolysaccharide stimulation
     乳鼠和成年鼠内毒素刺激后β-防御素-4、6在肺部表达的研究
短句来源
     but it has obviously up-regulated β~(minor) gene expression in hematopoietic tissue of pregnanted mice and normal adult mice(P<0.05、P<0.01).
     孕鼠(孕21d)和正常成年鼠造血组织βminor珠蛋白基因的表达量明显提高,与对照组相比存在显著性差异(P<0.05,P<0.01)。
短句来源
     Induced differentiation of bone marrow mesenchymal stem cells into cardiomyocytes-like of adult mice in vitro
     成年鼠骨髓间充质干细胞体外诱导分化为心肌样细胞
短句来源
     Objective To study the expression and regulation of β-defensin-4,6 in the lung of sucking mice and adult mice.
     目的研究小鼠β-防御素4、6在乳鼠和成年鼠肺部的表达和调控。
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  adult mouse
     Northern blot hybridization analysis revealed that sp1 and sp8 were predominantly expressed in adult mouse testis.
     Northern杂交分析显示sp1和sp8主要在成年鼠睾丸表达(Fig.4B)。
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     Experimental study on extraintestinal symptom of adult mouse with rotavirus infection
     轮状病毒感染成年鼠肠外症状的实验研究
短句来源
     Conclusion:The expression of RAG-1 in mouse embryonic brain tissue is higher than that in the adult mouse,which may be related to the process of neuron development.
     结论:在小鼠胚胎脑发育期间,RAG-1表达时序和脑发育一致,而且表达高于成年鼠
短句来源
     The results shows that the expression of PCNA gene was strong in the test of 30 days old and adult mouse;
     结果发现 :PCNA基因在30日龄和成年鼠睾丸中都有强的表达;
短句来源
     A study of isoenzyme band changes on LDH and SOD in testis of juvenlie and adult mouse were cacrried out using acrylamide gel disc electrophoresis.
     采用聚丙烯酰胺凝胶圆盘电泳分析方法,研究了幼年鼠和成年鼠睾丸乳酸脱氢酶(LDH)同工酶与超氧化物歧化酶(SOD)的酶带变化。
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      adult rats
    Ultrastructure of Type 2A Extrafusal Muscle Fibers and Muscle Spindle Intrafusal Fibers of Adult Rats after Prolonged Swimming
          
    We compared the ultrastructure of type 2A extrafusal muscle fibers, the nuclear chain, and other intrafusal fibers of muscle spindle (muscle stretch mechanoreceptor) in adult rats after prolonged swimming (5-10 h/day, 10 days).
          
    Individual features of experimental adult rats may also play a certain role.
          
    A cell culture consisting mainly of satellite cells and mononuclear myoblasts was derived from femoral muscles of infant (aged 3-7 days) and adult rats.
          
    Satellite cells and myoblasts from the muscles of newborn and adult rats did not differ noticeably in their capacity for differentiation.
          
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      adult rat
    We studied the behavior and differentiation of human and rat neural stem cells after transplantation in the adult rat brain without immunosuppression.
          
    The in vitro effect of tetrahydrocortisol-apolipoprotein A-I complex on native adult rat liver DNA results in the formation of S1 nuclease sensitive fragments that are irregularly distributed throughout a genome.
          
    Expression of Menkes ATPase and Wilson ATPase in different regions of the adult rat brain
          
    Transplantation of Stem/Progenitor Cells of Human Brain into Adult Rat Brain
          
    We studied the development of stem/progenitor cells of the human brain transplanted in the adult rat brain after expansion in an in vitrotissue culture.
          
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      adult mice
    Revealing of Somatic Mosaicism in Adult Mice by DNA Fingerprinting
          
    Neonatal Administration of Buspiron Causes Changes in Intermale Aggression of Adult Mice
          
    Northern analysis of the transcript tissue distribution in adult mice confirmed higher expression of these genes in differentiated cells compared with ESC.
          
    We used the method of particle bombardment (ballistic transfection) to introduce β-galactosidase and human dystrophin genes into mouse embryos and skeletal muscles of adult mice.
          
    In the brain of adult mice, sip1 expression is mostly detected in hippocampus, dentate gyrus, and white matter of the neocortex.
          
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      adult mouse
    At the end of last century, stem cells were found in the brain of the adult mouse and rat and later in the brain of other mammals including humans.
          
    Using the resident-intruder experimental model, we created a series of dyadic encounters that comprised of a standard adult mouse or rat paired with groups of aggressive and hierarchically age-ranked small animals in a territorial aggression test.
          
    The anticryptosporidial effect of sodium selenite (selenium) was evaluated in a bovine fallopian tube epithelial (BFTE) cell culture system and an immunosuppressed C57BL/6N adult mouse model.
          
    Here we show that bone marrow transplantation can be used to introduce genetically modified BMM into the adult mouse brain to reveal the functions of one or more BMM genes in neuronal injury responses.
          
    Two novel cDNAs were investigated further by Northern blot analysis and were found to be expressed differentially during development; their expression was confined to the forebrain in the adult mouse.
          
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    After peritoneal injection of 2×108 syngeneic neonatal thymocytes mixed with neonatal donor heart cells, the mean survival time (MST) of allografted split hearts (C57BL-CFW) was obviously prolonged in the light irradiated (200 Rad 60Co irradiation from a back source) adult CFW host. The MST of allografts in neonatal thymocytes group is 20.0±1.8 days against 12.9 ± 1.5 days in control group and 16.2 ± 3.0 days in adult thymocytes group. The results show that neonatal thymocytes may exert an immunosuppres-sive...

    After peritoneal injection of 2×108 syngeneic neonatal thymocytes mixed with neonatal donor heart cells, the mean survival time (MST) of allografted split hearts (C57BL-CFW) was obviously prolonged in the light irradiated (200 Rad 60Co irradiation from a back source) adult CFW host. The MST of allografts in neonatal thymocytes group is 20.0±1.8 days against 12.9 ± 1.5 days in control group and 16.2 ± 3.0 days in adult thymocytes group. The results show that neonatal thymocytes may exert an immunosuppres-sive effect on the allotransplantation rejection.The analysis of various agents given pre-transplantation shows that light irradiation did not affect the MST of allografts too much, if any, while the combination of irradiation and neonatal-donor heart cell injection do prolong MST to a certain degree. The host's immune function may recover in 5-7 days after such an irradiation treatment. Further investigation shows that the combination of irradiation and neonatal donor heart cell injection may be the cause of the prolongation of MST of allografts in adult mice thymocytes group.

    经~(60)Co轻度照射(200Rad)之成年CFW小鼠,在接受2×10~8同品系新生早期胸腺细胞及供体新生心肌细胞混悬液腹腔注射后,其对同种半心移植(C57BL CFW)的排异反应明显延缓。新生鼠胸腺细胞组之移植物平均存活期(20.0±1.8天)比对照组(12.9±1.5天)和成年鼠胸腺细胞组(16.2±3.0天)显著延长。提示新生小鼠胸腺细胞对排异反应有抑制作用。 就各种术前处理对移植物存活期影响所作的分析表明,照射对移植物存活期无显著影响,在照射后的5—7天,受鼠免疫系统功能已回复正常水平。而照射联合新生供体心肌细胞注射,则在一定程度上延长移植物的存活期。进一步的分析显示,成年鼠胸腺细胞组移植物的存活期之所以较长,可能是由于受照射联合新生供体心肌细胞注射的影响。

    1.The nutrient content of yeast (Condida Y-17) grown on n-alkane studied in this experiment was comparable to that of the same type of yeast produced in other countries. Its content of lead, arsenic, mercury and benzo (a) pyrene were within the limit proposed by the Protein-Calorie Advisory Group of the United Nations System. The Content of its residual n-alkanes and total aromatic hydrocarbons were within or a little over that limit. It is a good supplementary protein feed.2.The corrected PER values were, yeast...

    1.The nutrient content of yeast (Condida Y-17) grown on n-alkane studied in this experiment was comparable to that of the same type of yeast produced in other countries. Its content of lead, arsenic, mercury and benzo (a) pyrene were within the limit proposed by the Protein-Calorie Advisory Group of the United Nations System. The Content of its residual n-alkanes and total aromatic hydrocarbons were within or a little over that limit. It is a good supplementary protein feed.2.The corrected PER values were, yeast grown on n-alkane 1.18; deli pid and denucleic acid yeast grown on n-alkane 1.16; brewer's yeast 1.52; full fat soybean meal 1.81. The PER of yeast grown on n-alkane was significantly lower than those of other samples. When 0.3% DL-methionine was added to the diet, the corrected PER values increased: n-alkane grown yeast 2.32; delipid and denucleic acid n-alkane grown yeast 2.49; brewer's yeast 2.35; full fat soybean meal 2.28. The corrected PER value of casein used for correction was 2.43, it was standardized with ANRC reference protein (PER = 2.50).3.Yeast grown on n-alkane with and without removal of lipids and nucleic acid was fed to groups of rats at a dietary level of 25% and 35% respectively for 1 year. A stock diet group and a brewer's yeast diet group were used as control. In the first 3 months the weight gain and feed consumption of the rats fed n-alkanc grown yeast diet were lower than those of the two control groups. The male rats were more sensitive to the change of diet. In the later 9 months the difference of weight gain among different groups were not significant. The concentration of haemoglobin, red cell counts, white cell counts, GPTase activity, serum cholesterol levels and serum urea levels determined at the beginning and the end of the experiment were all in the normal ranges. The concentrations of n-alkanes and odd-chain fatty acids in the adipose tissue of the n-alkane grown yeast group were higher than those of the two control groups, and the difference was highly significant. The concentrations of total aromatic hydrocarbons and benzo(a) pyrene in the muscle of different groups of rats were 0.4-0.6 ppm and 0.4 ppb respectively. No detrimental effect was observed in pathological examination.4.When 5% fish meal or 3.5% casein was added to the 25% n-alkane grown yeast diet, the weight gain and feed consumption of weanling rats were improved significantly, though it was still inferior to those fed with stock diet.5.Strongly growth depressive effect was noted as the level of n-alkane grown yeast was increased to 20% in the diet. This depressive effect was neither due to the toxicity of the residual n-alkanes and aromatic hydrocarbons, nor due to the deficiencies of potassium and selenium in the diet. It might be the result of nutrient or nutrients imbalance of the diet. The appropriate amount of yeast grown on n-alkane used in mixed feed should not be more than 15%.

    1.本实验所用正烷酵母(假丝酵母Y-17)的营养素含量与国外同类产品相仿。铅、砷、汞、苯并(a)芘含量均在联合国系统蛋白质顾问小组规定的范围之内,正烷烃及总芳烃含量除部分样品稍高外亦均在该范围之内;是一个有前途的饲料蛋白质补充品。 2.测得各样品的PER值为:正烷烃不脱酵母(不脱)1.18;脱脂脱核酸酵母(双脱)1.617药用酵母1.52;全脂黄豆粉1.81,不脱酵母显著低于其他样品。于饲料中补充了0.3%DL-蛋氨酸后校正PER上升为:不脱酵母2.32;双脱酵毋2.49;药用酵母2.35;全脂黄豆粉2.28。校正用的标准品为经ANRC参考蛋白(PER为2.50)标定的国产酪蛋白,其校正PER值为2.43。 3.以含25%、35%不脱酵母和25%双脱酵母的饲料喂养断乳大白鼠一年。以常备饲料和25%的药用酵母饲料为对照。前三个月雄鼠的平均增重和进食量以常备组最好,其次是药用酵母和双脱酵母,25%和35%不脱酵坶组最差。这三组问差异显著;雌鼠对不同饲料的反应不敏感,三个25%酵母组的增重和进食量都没有显著差异,但均低于常备饲料组,在后9个月无论雌雄鼠各酵母组与常备饲料组动物的增重间不再存在统计差异,这表明这几种酵...

    1.本实验所用正烷酵母(假丝酵母Y-17)的营养素含量与国外同类产品相仿。铅、砷、汞、苯并(a)芘含量均在联合国系统蛋白质顾问小组规定的范围之内,正烷烃及总芳烃含量除部分样品稍高外亦均在该范围之内;是一个有前途的饲料蛋白质补充品。 2.测得各样品的PER值为:正烷烃不脱酵母(不脱)1.18;脱脂脱核酸酵母(双脱)1.617药用酵母1.52;全脂黄豆粉1.81,不脱酵母显著低于其他样品。于饲料中补充了0.3%DL-蛋氨酸后校正PER上升为:不脱酵母2.32;双脱酵毋2.49;药用酵母2.35;全脂黄豆粉2.28。校正用的标准品为经ANRC参考蛋白(PER为2.50)标定的国产酪蛋白,其校正PER值为2.43。 3.以含25%、35%不脱酵母和25%双脱酵母的饲料喂养断乳大白鼠一年。以常备饲料和25%的药用酵母饲料为对照。前三个月雄鼠的平均增重和进食量以常备组最好,其次是药用酵母和双脱酵母,25%和35%不脱酵坶组最差。这三组问差异显著;雌鼠对不同饲料的反应不敏感,三个25%酵母组的增重和进食量都没有显著差异,但均低于常备饲料组,在后9个月无论雌雄鼠各酵母组与常备饲料组动物的增重间不再存在统计差异,这表明这几种酵母饲料对维持成年鼠的营养效果基本上是一致的。在试验之初和结束时测大鼠血红蛋白、红细胞、白细胞、血清谷丙转氨酸、血清胆固

    Albino mice are animals commonly used for experimental studies on malaria. It is very necessary to find a strain of mice most susceptible to the P. yoelii-A. stephensi system. Thus, experimental studies were carried out on 9 inbred strains of mice (SMMC/A, SMMC/B, SMMC/C, SMMC/D, C57BL, C3H, 615, SMMC/C×615, Jin-bai N0.1)and one outbred strain (Kuming strain) by means of both sporozoite-and blood-induced infections. The results obtained are summarized as follows.(1) Although all of the 10 strains became patent...

    Albino mice are animals commonly used for experimental studies on malaria. It is very necessary to find a strain of mice most susceptible to the P. yoelii-A. stephensi system. Thus, experimental studies were carried out on 9 inbred strains of mice (SMMC/A, SMMC/B, SMMC/C, SMMC/D, C57BL, C3H, 615, SMMC/C×615, Jin-bai N0.1)and one outbred strain (Kuming strain) by means of both sporozoite-and blood-induced infections. The results obtained are summarized as follows.(1) Although all of the 10 strains became patent after blood inoculation, producing an infection rate of 100%, yet there exists a very significant difference in susceptibility to sporozoite-induced infection between different strains of the test mice. Six strains of them including SMMC/C were found most susceptible to infection, reaching 100% patency. (2) As compared with others, the SMMC/C strain had the shortest prepatent period (4.22±0.43 days) with the least difference in the time of first appearance of the parasites in the circulating blood amongst individuals of this strain. (3) When the anopheline mosquitoes fed on each of the 10 strains, SMMC/C strain was found most infective to the vector with the gland infection rate of 73.20±5.9%. From all the results obtained, with A. stephensi as its transmitter, out of the 10 strains the SMMC/C is considered the most susceptible and suitable animal model for experimental studies on rodent malariaThe observations made on the SMMC/C mice showed the following results. (1) Five thousand sporozoites per mouse intraporitoneally inoculated were required to ensure an infection rate of 100%. (2) More than 90% of the mice became infected following intraporitoneal inoculation of the sporozoites which were preserved in the glucose normal saline mixed with albino rat serum (1:1 in ratio) either at 3-5° or at 23-25° up to 24 hrs after dissection from the mosquitose. (3) Ambient temperature of 18-20℃ was most favourable to development of the parasite in the mice. (4) Young mice were most susceptible to the sporozoite-induced infection, the adult being second to them.All the experimental results obtained are discussed.

    小鼠为疟疾实验研究最常用的动物。寻求出小鼠对约氏疟原虫易感的品系(株),对疟疾实验研究是非常需要的。本文报告9株近交小鼠及一株远交小鼠对约氏疟原虫(Plasmodium yoelii yoclii)—斯氏按蚊(Anopheles stephensi)系统的敏感性的实验结果,经蚊传和血传试验表明:(1)输血转种所有小鼠均极敏感,而子孢子感染则各鼠株之间有差异,SMMC/C株等6个鼠株最为敏感,阳性率为100%;(2)子孢子感染的原虫血症出现时间,以SMMC/C株最早,並且出现时间比较一致;(3)斯氏按蚊对各阳性鼠株的易感性以SMMC/C株的腺感染率最高(73.20±59.2%)。因而,认为小鼠SMMC/C株—斯氏按蚊系统作为鼠疟实验动物模型较为适宜。另外,本文还报告,在约氏疟原虫感染SMMC/C鼠株实验中发现(1)每鼠接种子孢子5000个可使全部鼠感染上;(2)子孢子在鼠血清葡萄糖生理盐水在3~5 C或23~25 C下体外保存24小时后,90%以上的小鼠被感染上;(3)环境温度18~20 C对小鼠感染疟原虫发育最适宜;(4)幼鼠对子孢子感染最敏感,成年鼠次之。 对本试验结果进行了讨论。

     
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