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细胞周期停滞
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  cell cycle arrest
     P14ARF binds to MDM2 and neutralize the MDM2-mediated degradation of P53 so as to stabilize P53 and cause P53 to accumulate in the nucleus to induce the cell cycle arrest or apoptosis.
     P14ARF可通过与MDM2的相互作用而降低MDM2介导的对P53的降解作用,稳定P53,使P53在细胞核中累积而引起细胞周期停滞或凋亡;
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     Conclusion Both 15d-PGJ2 and TGZ inhibit cell proliferation of BEL-7402 liver cancer cells,which may be due to PPAR-γ-mediated G1 cell cycle arrest in part.
     结论  15d PGJ2和TGZ均可抑制BEL 740 2细胞增殖 ,这种抑制作用可能部分与PPARγ介导的G1细胞周期停滞有关。
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     Additionally, P14ARF possesses multiple binding domains to bind to the transcription factor E2F-1 and down-regulates the E2F-l-dependant transcription to prompt cell cycle arrest and induce E2Fl-dependant apoptosis.
     另外P14ARF可通过多个结合结构域与转录因子E2F-1结合,下调E2F-1的转录活性,促使细胞周期停滞,引发E2F-1依赖性细胞凋亡。
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     Conclusions: Conclusion: 1. HCT/8 cell transfected with WAF1 gene incur cell cycle arrest in G1 phase.
     结论:1、转染WAF1基因可抑制HCT/8细胞周期的进行,使细胞周期停滞于G1期。
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     Studies on the Cell Cycle Arrest and Apoptosis Induced by Tetrazolium Violet in C6 and C127 Cancer Cells
     四唑紫罗兰对大鼠胶质瘤C6细胞和小鼠乳腺癌C127细胞的细胞周期停滞和凋亡诱导的研究
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  “细胞周期停滞”译为未确定词的双语例句
     Results The inhibitive rates of gastric carcinoma cell line MGC803 were 10.85%,32.52%,57.47%,78.94% with different concertration of rosiglitazone which was 12.5 μmol/L、25 μmol/L、 50 μmol/L、100 μmol/L respectively. The clone formation of MGC803 cell was evidently inhibited and cell cycle was arrested in G_1-phase after it was treated with rosiglitazone.
     结果12.5μmol/L、25μmol/L、50μmol/L、100μmol/L的罗格列酮对人胃癌MGC803细胞生长抑制率分别为10.85%、32.52%、57.47%、78.94%,罗格列酮处理后MGC803细胞集落形成明显受到抑制,且细胞周期停滞于G1期。
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     The rates of phase G0/G1 on the whole cell cycle of group B、C and D were significantly lower than those of group A (P<0.01), which indicated that quercetin mainly acted on G1/S check point.
     G0/G1期占细胞周期百分比,B、C、D组明显低于A组,其差异有显著性意义, 提示槲皮素主要作用于G1/S节点,导致细胞周期停滞于G1期。
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     As 2 O 3 could make maintain U373cells at G 2 /M stage,but the proportion was decreased when U373expressed Syk.
     As2O3可使U373细胞周期停滞于G2/M期,而表达Syk的U373细胞被As2O3阻滞于G2/M期的细胞比例下降。
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     G_1 phase was blocked,and apoptosis was induced in 22.6% PC3M cells.
     L-1时,细胞周期停滞在G1期,并诱导22.6%的PC3M细胞发生凋亡。
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     ②Acts on G1/S check point, blocks the cell cycle in phase G1. ③Down-regulates the level of cyclin D1 and inhibits the cell cycle progression.
     ②作用于G1/S节点,使细胞周期停滞于G1期。 ③下调cyclin D1蛋白水平,抑制细胞周期进程;
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     Cell cycle analysis revealed the percentages of G1 phase cells were increased, that of G2/M and S phase decreased linearly with the increase of concentrations of gentamicin.
     庆大霉素致细胞周期停滞于G1期。
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     The ALP granul es in the cells stained thicker and th e cells' proliferation cycle shortened.
     细胞增殖周期缩短。
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     Phosphatidylcholine and Cell Cycle
     卵磷脂与细胞周期
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     Cell cycle analysis revealed G1 phase cells increased linearly with the increase of gentamicin concentrations.
     庆大霉素致细胞周期停滞于G_1期。
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     But the LDH activity was not significantly altered in the treatment with 50 μmol·L -1 NPPB. Flow cytometry experiments showed that 50 and 25 μmol·L -1 NPPB arrested ( 84.2±2.4)% and (80.8±2.9)% of cells at G0/G1 stage, versus (70.5±1.4)% of control cells.
     NPPB使细胞周期停滞在G0/G1期。
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  cell cycle arrest
Neither cell cycle arrest nor reversion to the normal phenotype were observed in N-RAS expressing cells devoid of the p53 function.
      
Cyclin-dependent kinase inhibitor p21Waf1/Cip1 plays the key part in cell cycle arrest at the G1/S checkpoint in response to DNA damage, and is involved in the assembly of active cyclin-kinase complexes, in particular, cyclin D-Cdk4/6.
      
Some other effects of nutrient indole compounds, e.g., the inhibition of expression of the cyclin-dependent kinase 6 (CDK6) by indole-3-carbinol that leads to the cell cycle arrest in G1 phase, are also considered.
      
It was found that after NaB treatment both cell lines completely stopped proliferation due to irreversible G1/S cell cycle arrest.
      
Our previous results showed that restin might be correlated to cell cycle arrest.
      
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DNA damage is the cause of genemutation and contributes to cell transformation.The cellular response to DNA damage is complexin its components and regulation. First, DNArepair need cell cycle arrest to avoid mutationaccmulating in generated cell. Second, there isstrong connection between repair and transcription. Third, nucleotide excision repair and mismatch repair are important pathway of mutationavoidance. If any event mentioned above wasaltered, mutations would accumulate, and thechance of tumor developing...

DNA damage is the cause of genemutation and contributes to cell transformation.The cellular response to DNA damage is complexin its components and regulation. First, DNArepair need cell cycle arrest to avoid mutationaccmulating in generated cell. Second, there isstrong connection between repair and transcription. Third, nucleotide excision repair and mismatch repair are important pathway of mutationavoidance. If any event mentioned above wasaltered, mutations would accumulate, and thechance of tumor developing would increase. Therelationship between DNA repair, transcriptionand the cell cycle, and the cell transformationwere discussed.

DNA损伤是引起基因突变,导致细胞恶性转化的重要原因.DNA损伤的修复过程非常复杂,是与细胞周期调节、DNA复制和DNA转录等生命活动紧密相连的.首先DNA修复需要细胞周期停滞,避免DNA损伤进入子代细胞.其次,参与DNA转录的某些基因产物参与DNA损伤的识别,有利于转录链的优先修复.最后,DNA修复系统NER、MMR参与损伤修复.上述DNA修复过程任何环节的异常,都将造成DNA修复功能减弱,导致某些功能基因突变,从而导致细胞的恶性转化.

Purpose To investigate the practical significance of p27 expression in the diagnosis and prognostic assessment of chondrosarcomas. Methods p27 expressions were sutdied in paraffinembdded sections of the conventional chondrosarcoma by means of an immunohistochemical(SP) assay, and DNA ploidy were measured by flow cytometry. Results Chondrosarcomas with high histological grade showed a bias toward an increase in p27 expression, while normal cartilaginous tissues and benign cartilaginous tumors...

Purpose To investigate the practical significance of p27 expression in the diagnosis and prognostic assessment of chondrosarcomas. Methods p27 expressions were sutdied in paraffinembdded sections of the conventional chondrosarcoma by means of an immunohistochemical(SP) assay, and DNA ploidy were measured by flow cytometry. Results Chondrosarcomas with high histological grade showed a bias toward an increase in p27 expression, while normal cartilaginous tissues and benign cartilaginous tumors gave negative results. There was a statistical significance (t=206, P<005) between p27 expressions of chondromas and gradeⅠchondrosarcomas.In normal cartilaginous tissues, benign cartilaginous tumors and low grade (grade Ⅰ and grade Ⅱ) chondrosarcomas were mainly diploid, and in high grade ( gradeⅢ) chondrosarcomas were aneuploid. The higher p27 protein expressed, the more DNA aneuploid presented. p27 expression showed a significant direct correlation with DNA aneuploid (r=0925, P<005). Conclusions p27 protein will probably become a marker in differentiating chondromas from grade Ⅰ chondrosarcomas and a useful prognostic index of chondrosarcoma, and it may also be of some guiding significance in grading chondrosarcoma.

目的:软骨肉瘤是常见的骨恶性肿瘤之一。其形态多变、生物学行为复杂,对软骨瘤和高分化软骨肉瘤,只凭病理组织学特征鉴别它们通常是很困难的,并且软骨肉瘤组织学分级与其生物学行为时常不一致。因此,需要更为客观可靠的指标来协助诊断,指导软骨肉瘤的分级和估计软骨肉瘤的预后。肿瘤细胞周期的研究是当前肿瘤研究热点之一,肿瘤细胞周期受一系列细胞周期调节因子控制,包括G1期细胞周期素(cyclins)和相应的细胞周期素依赖激酶(cyclin-dependentkinases,CDKs),CDKs活性又受一系列细胞周期素依赖激酶抑制物(cyclin-dependentkinaseinhibitors,CDKIs)控制。p27是新近发现的CDKIs家族之一,在细胞周期增殖和分化调控中起非常重要作用。p27蛋白主要抑制G1期cyclinE-CDK2复合物及cy-clinD-CDK4/6复合物活性,它过度表达可使细胞周期停滞在G1中期。软骨肉瘤p27表达国内外尚未见报道。检测软骨肉瘤中p27表达,从而探讨p27表达与软骨肉瘤组织分级和DNA倍体的关系及其对软骨肉瘤的诊断和预后判断是否具有应用价值十分必要。方法:36例经典软骨...

目的:软骨肉瘤是常见的骨恶性肿瘤之一。其形态多变、生物学行为复杂,对软骨瘤和高分化软骨肉瘤,只凭病理组织学特征鉴别它们通常是很困难的,并且软骨肉瘤组织学分级与其生物学行为时常不一致。因此,需要更为客观可靠的指标来协助诊断,指导软骨肉瘤的分级和估计软骨肉瘤的预后。肿瘤细胞周期的研究是当前肿瘤研究热点之一,肿瘤细胞周期受一系列细胞周期调节因子控制,包括G1期细胞周期素(cyclins)和相应的细胞周期素依赖激酶(cyclin-dependentkinases,CDKs),CDKs活性又受一系列细胞周期素依赖激酶抑制物(cyclin-dependentkinaseinhibitors,CDKIs)控制。p27是新近发现的CDKIs家族之一,在细胞周期增殖和分化调控中起非常重要作用。p27蛋白主要抑制G1期cyclinE-CDK2复合物及cy-clinD-CDK4/6复合物活性,它过度表达可使细胞周期停滞在G1中期。软骨肉瘤p27表达国内外尚未见报道。检测软骨肉瘤中p27表达,从而探讨p27表达与软骨肉瘤组织分级和DNA倍体的关系及其对软骨肉瘤的诊断和预后判断是否具有应用价值十分必要。方法:36例经典软骨肉瘤未脱钙?

Objective To study the expression of p27 kip1 in breast cancer in relation to biological behavior and prognosis. Methods p27 kip1 expression at protein level was determined by immunohistochemistry technique in 181 patients with breast cancer. In addition, p27 WAF1/CIP1 , p53 and mdm 2 were examined in 106 cases of this series. Data about apoptotic index, bcl 2 and bax protein expression were available in the other 91 patients.Results Of the 181 patients, p27 kip1 expression was low in...

Objective To study the expression of p27 kip1 in breast cancer in relation to biological behavior and prognosis. Methods p27 kip1 expression at protein level was determined by immunohistochemistry technique in 181 patients with breast cancer. In addition, p27 WAF1/CIP1 , p53 and mdm 2 were examined in 106 cases of this series. Data about apoptotic index, bcl 2 and bax protein expression were available in the other 91 patients.Results Of the 181 patients, p27 kip1 expression was low in 121 (66.9%) and high in 60 (33.1%), respectively. p27 kip1 expression level was correlated with histological grade, tumor size, axillary lymph node status, post operative recurrence, invasion and metastasis. It was also correlated with bcl 2, bax, p53, p21 WAF1/CIP1 , and mdm 2 expression levels. Univariate analysis demonstrated better disease free survival in patients with higher p27 kip1 expression than in those with lower expression. However, by Cox multivariate analysis, p27 kip1 expression level was not found to be of independent prognostic significance. Conclusion As an inhibitor of cyclin dependent kinase, p27 kip1 favors prognosis of human breast cancer not only by arresting cell cycle in G 1 phase but also inducing cancer cell apoptosis.

目的 研究p27kip1 在乳腺癌组织中的表达水平,及其与生物学行为的关系和对预后的作用。方法 以免疫组化法检测181 例乳腺癌组织p27kip1 蛋白表达水平,其中91 例进行了凋亡指数、凋亡相关蛋白bcl2 、bax 的测定,另有106 例检测了p21WAF1/CIP1 、p53、mdm2 蛋白表达水平。结果 本组181 例中,p27kip1 蛋白阳性125 例,占69 .1% ;低表达者121 例,占66.9 % ;高表达者60 例,占33.1 % 。乳腺癌组织p27kip1 蛋白水平与病理组织学分级、癌周浸润程度、肿块大小、腋淋巴结转移情况、TNM 分期、术后局部复发与转移均相关,与bcl2 、bax、p53 、p21WAF1/CIP1 、mdm2 蛋白表达水平亦相关。单因素生存分析结果,p27kip1蛋白高表达组5 年无病生存率93 .7% 优于低表达组64.7% ( P= 0.0001) 。Cox 模型多因素分析未显示p27kip1 蛋白表达水平是独立的预后指标。结论 细胞周期蛋白依赖性激酶抑制剂(Cki)p27kip1 在乳腺癌中具有一定预后价值;p27kip1 不仅在细胞周期停滞$$...

目的 研究p27kip1 在乳腺癌组织中的表达水平,及其与生物学行为的关系和对预后的作用。方法 以免疫组化法检测181 例乳腺癌组织p27kip1 蛋白表达水平,其中91 例进行了凋亡指数、凋亡相关蛋白bcl2 、bax 的测定,另有106 例检测了p21WAF1/CIP1 、p53、mdm2 蛋白表达水平。结果 本组181 例中,p27kip1 蛋白阳性125 例,占69 .1% ;低表达者121 例,占66.9 % ;高表达者60 例,占33.1 % 。乳腺癌组织p27kip1 蛋白水平与病理组织学分级、癌周浸润程度、肿块大小、腋淋巴结转移情况、TNM 分期、术后局部复发与转移均相关,与bcl2 、bax、p53 、p21WAF1/CIP1 、mdm2 蛋白表达水平亦相关。单因素生存分析结果,p27kip1蛋白高表达组5 年无病生存率93 .7% 优于低表达组64.7% ( P= 0.0001) 。Cox 模型多因素分析未显示p27kip1 蛋白表达水平是独立的预后指标。结论 细胞周期蛋白依赖性激酶抑制剂(Cki)p27kip1 在乳腺癌中具有一定预后价值;p27kip1 不仅在细胞周期停滞中有作用,还有可能诱导DNA受损的细胞进入编程

 
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