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晚发型ad
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  late onset ad
     AIM:To investigate the relationship between Alzheimer disease(AD) and alpha 2 macroglobulin(α2M) initially so as to provide evidence for the pathogenesis of late onset AD.
     目的:初步探讨晚发型阿尔茨海默病(Alzheimerdisease,AD)与α2巨球蛋白的关系,为晚发型AD发病机制提供依据。
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     METHODS:The significance of α2M in the late onset AD was revealed through pathology of α2M in AD and the polymorphism of α2M in AD patients.
     方法:通过α2巨球蛋白在AD病理中的表现和AD患者中α2巨球蛋白的多态性,揭示α2巨球蛋白在晚发型AD中的意义。
短句来源
     CONCLUSION:It is significant to investigate the frequency, mutation, polymorphism and expression of gene α2M for the pathogenesis of late onset AD and its genic diagnosis.
     结论:研究α2巨球蛋白基因的频率、突变、多态性或表达对晚发型AD的发病机制和基因诊断有重要意义。
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  “晚发型ad”译为未确定词的双语例句
     Methods The polymorphism of the ApoE gene was detected by using PCR-RFLP technique for 68 LOAD patients, 54 EOAD patients and the control of 168. Results The most frequent genotype was ε3/ε3, but ε2/ε2 was not observed in the 3 groups.
     方法采用PCR-RFLP方法,对68例晚发型AD(LOAD)、54例早发型AD(EOAD)和168例对照组进行ApoE基因型测定,对AD患者的ApoE基因多态性进行相关分析。 结果两组人群ε3/ε3基因型比例最大,未发现ε2/ε2基因型。
短句来源
     Conclusions These data indicated that there was a significant association of microsatellite repeat polymorphisms of the flank of IDE gene and late-onset Alzheimer’s disease, The presumption is supported, in which there is a candidate gene for LOAD on chromosome 10q 23-25. The ongoing investigation of the genetic source of association and linkage in this region is clearly warranted.
     结论IDE基因5’-端侧翼的微卫星重复序列多态性与晚发型AD的呈显著性相关,支持在染色体10q23-25区域有LOAD候选相关基因的论点,对此区域进行深入研究很有价值。
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  相似匹配句对
     Ad.
     Ad.
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     Late-onset multiple sclerosis
     发型多发性硬化
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     Clinical observation of late-onset myasthenia gravis
     发型重症肌无力的临床研究
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     The size of the xenograft tumor induced by Ad.
     感染Ad.
短句来源
     AIM:To investigate the relationship between Alzheimer disease(AD) and alpha 2 macroglobulin(α2M) initially so as to provide evidence for the pathogenesis of late onset AD.
     目的:初步探讨发型阿尔茨海默病(Alzheimerdisease,AD)与α2巨球蛋白的关系,为发型AD发病机制提供依据。
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  late onset ad
Current studies are focused on identifying genetic risk factors for late onset AD.
      
These results indicated that the C/C genotype had a possible protective effect against AD development, and the T allele might be a weak risk factor for late onset AD.
      
Three genes have been identified causing earlier onset AD, and a fourth has been shown to be a risk factor for late onset AD (LOAD), while many more yet unrecognized genes are thought to contribute to susceptibility.
      
Therefore we quantified TTR in CSF and serum samples from 8 patients with early onset AD (EAD), 18 patients with late onset AD (LAD), 8 patients with vascular dementia (VAD) and 18 healthy individuals using a nephelometric method.
      
As compared with 31% of control subjects, 80% familial and 64% of sporadic late onset AD have at least one apoE4 allele.
      
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AIM:To investigate the relationship between Alzheimer disease(AD) and alpha 2 macroglobulin(α2M) initially so as to provide evidence for the pathogenesis of late onset AD. METHODS:The significance of α2M in the late onset AD was revealed through pathology of α2M in AD and the polymorphism of α2M in AD patients. RESULTS:The association between AD and α2M region on the twelfth chromatosome was analyzed with the genic linkage, and pathological symptom of α2M in AD patients was supported by many evidences....

AIM:To investigate the relationship between Alzheimer disease(AD) and alpha 2 macroglobulin(α2M) initially so as to provide evidence for the pathogenesis of late onset AD. METHODS:The significance of α2M in the late onset AD was revealed through pathology of α2M in AD and the polymorphism of α2M in AD patients. RESULTS:The association between AD and α2M region on the twelfth chromatosome was analyzed with the genic linkage, and pathological symptom of α2M in AD patients was supported by many evidences. Two polymorphism sites of α2M were located on the 12P12-13,which could increase more risks to AD patients. CONCLUSION:It is significant to investigate the frequency, mutation, polymorphism and expression of gene α2M for the pathogenesis of late onset AD and its genic diagnosis.

目的:初步探讨晚发型阿尔茨海默病(Alzheimerdisease,AD)与α2巨球蛋白的关系,为晚发型AD发病机制提供依据。方法:通过α2巨球蛋白在AD病理中的表现和AD患者中α2巨球蛋白的多态性,揭示α2巨球蛋白在晚发型AD中的意义。结果:AD与12号染色体上α2M区的关联是通过基因连锁分析得到的,有大量的数据支持α2巨球蛋白基因在AD患者病理中的表现。在12P12-13位置上有两个α2巨球蛋白多态性位点,可增加AD的患病危险性。结论:研究α2巨球蛋白基因的频率、突变、多态性或表达对晚发型AD的发病机制和基因诊断有重要意义。

Objective To study the association between the apolipoprotein E(ApoE) gene polymorphism and Alzheimer disease (AD) . Methods The polymorphism of the ApoE gene was detected by using PCR-RFLP technique for 68 LOAD patients, 54 EOAD patients and the control of 168. Results The most frequent genotype was ε3/ε3, but ε2/ε2 was not observed in the 3 groups. The frequency of ApoEε4 allele carriers in LOAD cases and control was 52.5 % (43/80) and 16.1 % (27/168), respectively, and there was also a significant difference...

Objective To study the association between the apolipoprotein E(ApoE) gene polymorphism and Alzheimer disease (AD) . Methods The polymorphism of the ApoE gene was detected by using PCR-RFLP technique for 68 LOAD patients, 54 EOAD patients and the control of 168. Results The most frequent genotype was ε3/ε3, but ε2/ε2 was not observed in the 3 groups. The frequency of ApoEε4 allele carriers in LOAD cases and control was 52.5 % (43/80) and 16.1 % (27/168), respectively, and there was also a significant difference (χ2 =36.2, P< 0.0001, RR=5.76, 95 % CI=3.17-10.47). The frequency of ApoEε4 allele carriers was significantly (χ2 =6.11, P=0.0135, RR=2.40, 95 % CI=1.18-4.86) associated with EOAD. Conclusions ApoEε4 allele was significantly associated with LOAD and EOAD, It is one risk factor of AD.

目的探讨阿尔茨海默病(Alzheimerdisease,AD)与载脂蛋白E(ApoE)基因多态性的关系。方法采用PCR-RFLP方法,对68例晚发型AD(LOAD)、54例早发型AD(EOAD)和168例对照组进行ApoE基因型测定,对AD患者的ApoE基因多态性进行相关分析。结果两组人群ε3/ε3基因型比例最大,未发现ε2/ε2基因型。APOEε4携带者的频率在LOAD组中是52.5%(43/80),对照组16.1%(27/168),其差别有显著性(χ2=36.2,P<0.0001,RR=5.76,95%CI=3.17-10.47);APOEε4携带者的频率与EOAD呈显著性相关(χ2=6.11,P=0.0135,RR=2.40,95%CI=1.18-4.86)。结论ε4等位基因与LOAD、EOAD呈显著性相关,是AD的危险因素之一。

Objective To find the association between the microsatellite repeat polymorphisms of the flank of IDE gene and AD. Methods Case-control method was used to examine microsatellite repeat polymorphisms of IDE gene and the polymorphism of apolipoprotein E (APOE) gene in an ethnically homogeneous Japanese population of 82 LOAD patients, 54 EOAD patients and control of 168 healthy subjects. Four markers of microsatellite repeat were selected on the flank of IDE gene, they were (CA)n, (AC)nC(GT)n, (CA)n(CT)n and (CA)n...

Objective To find the association between the microsatellite repeat polymorphisms of the flank of IDE gene and AD. Methods Case-control method was used to examine microsatellite repeat polymorphisms of IDE gene and the polymorphism of apolipoprotein E (APOE) gene in an ethnically homogeneous Japanese population of 82 LOAD patients, 54 EOAD patients and control of 168 healthy subjects. Four markers of microsatellite repeat were selected on the flank of IDE gene, they were (CA)n, (AC)nC(GT)n, (CA)n(CT)n and (CA)n respectively; according to their order on gene map they were given 4 symbols (A, B, D10S583, C,). Multiplex fluorescent-based genotyping PCR (polymerase chain reaction) was performed to identify microsatellite repeat polymorphisms of IDE gene, and PCR- RFLP(restriction fragment length polymorphism)was performed to determine the genotypes of APOE (Apolipoprotein E) gene. Results Microsatellite polymorphisms were found in these four markers in the study population, and there were significant differences in the allele frequencies of these markers between LOAD cases and controls. These alleles were A 208bp (P<0.0001), B 112bp (P= 0.0012), C 190bp (P=0.032), D10S583 199bp (P=0.0007) and 201bp (P=0.016); and only A 208 bp allele was significantly (P=0.0138) associated with EOAD. The frequency of APOEε4 allele carriers in LOAD cases and control was 52.5 % and 16.1 % (χ2 =36.2, P <0.0001, RR=5.76, 95% CI= 3.17~ 10.47). The frequency of APOEε4 allele carriers was significantly associated with EOAD (P= 0.0135). In binary logistic regression model, no significant interaction was found between IDE gene and APOE gene in LOAD or EOAD.Conclusions These data indicated that there was a significant association of microsatellite repeat polymorphisms of the flank of IDE gene and late-onset Alzheimer’s disease, The presumption is supported, in which there is a candidate gene for LOAD on chromosome 10q 23-25. The ongoing investigation of the genetic source of association and linkage in this region is clearly warranted.

目的研究人群中胰岛素降解酶基因(IDE)5’-端侧翼的微卫星重复序列多态性与阿尔茨海默病(AD)的相关性。方法采用病例-对照方法研究IDE基因5’-端侧翼的微卫星重复序列多态性、载脂蛋白E(ApoE)基因多态性与AD相关性。选择IDE基因5’端侧翼4个微卫星重复序列位点(CA)n、(AC)nC(GT)n、(CA)n(CT)n、(CA)n,按其基因图谱上的顺序分别给予A、B、D10S583、C为其编号;微卫星片段重复序列多态性的分型是用荧光标记引物PCR法,APOE的基因分型是PCR-RFLP法。结果本研究人群中IDE基因5’端侧翼的4个位点的微卫星片段重复序都有多态性;LOAD病例组和正常对照组中等位基因的分布频率有显著性差别;A208bp与EOAD显著性相关(P=0.0138);APOEε4携带者的频率在LOAD组和对照组分别为52.5%、16.1%(χ2=36.2,P<0.0001,RR=5.76,95%CI=3.17~10.47);APOEε4携带者的频率与EOAD呈显著性相关(P=0.0135);二项逻辑回归分析胰岛素降解酶基因的微卫星重复序列多态性与ApoE基因无显著性意义的相互作用。结论IDE基因...

目的研究人群中胰岛素降解酶基因(IDE)5’-端侧翼的微卫星重复序列多态性与阿尔茨海默病(AD)的相关性。方法采用病例-对照方法研究IDE基因5’-端侧翼的微卫星重复序列多态性、载脂蛋白E(ApoE)基因多态性与AD相关性。选择IDE基因5’端侧翼4个微卫星重复序列位点(CA)n、(AC)nC(GT)n、(CA)n(CT)n、(CA)n,按其基因图谱上的顺序分别给予A、B、D10S583、C为其编号;微卫星片段重复序列多态性的分型是用荧光标记引物PCR法,APOE的基因分型是PCR-RFLP法。结果本研究人群中IDE基因5’端侧翼的4个位点的微卫星片段重复序都有多态性;LOAD病例组和正常对照组中等位基因的分布频率有显著性差别;A208bp与EOAD显著性相关(P=0.0138);APOEε4携带者的频率在LOAD组和对照组分别为52.5%、16.1%(χ2=36.2,P<0.0001,RR=5.76,95%CI=3.17~10.47);APOEε4携带者的频率与EOAD呈显著性相关(P=0.0135);二项逻辑回归分析胰岛素降解酶基因的微卫星重复序列多态性与ApoE基因无显著性意义的相互作用。结论IDE基因5’-端侧翼的微卫星重复序列多态性与晚发型AD的呈显著性相关,支持在染色体10q23-25区域有LOAD候选相关基因的论点,对此区域进行深入研究很有价值。

 
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