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| | Whole-body hyperthermia(WBH) is a new modality of therapy following operation,radiotherapy, chemotherapy and immunotherapy.WBH combined with chemotherapy or radiotherapy have anti-cancer synergic effect,increasing the sensitivity of chemotherapy or radiotherapy,as well as reducing the side effect.WBH plays an important role in comprehensive therapy.Mechanism of WBH combined with chemotherapy is reviewed in this article. | | 全身热疗是继手术、放疗、化疗和生物治疗之后的又一种治疗方法,与放疗、化疗互补熏增加对放疗和化疗的敏感性,同时减轻放疗和化疗的副作用,在肿瘤的综合治疗中发挥重要作用。文章主要对全身热化疗的作用机制作一综述。 | | 文摘来源 | | Objective Study effect and reliability of the whole body thermo-chemotherapy (WBTCT) for advanced malignant tumor. Methods Use TEMET 1000 to treat 15 patients with advanced malignant tumor under general anesthesia. All patients had been treated by Thermo-therapy to whole body, and injection of DDP/5-FU during the stable period with body temperature 42-42.5℃. Evaluate the effect by clinical observ ation and by follow-up. Results The curative effects are 84.6% (11/13) relieving pain, 56.7% inhibition tumor ce... | | 目的探讨全身热化疗对晚期肿瘤的疗效及安全性。方法15例晚期恶性肿瘤患者在全麻状态下用TEMET 1000型体外循环全身热疗灌注治疗系统,进行全身加温治疗,平台期治疗温度达42-42.5℃,同时静脉滴注顺铂或(和)5-FU化疗。通过临床观察及随访追踪,初步评估疗效。结果明显止痛84.6%(11/13),抑制肿瘤有效率为56.7%(PR+SD),半年及1年病灶稳定率为66.7%(8/12)、41.7%(5/12),6个月、1年、1年6个月生存率分别为85.7%(12/14)、72.7%(8/11)、60.0%(6/10),部分患者甚至能达到消灭肿瘤的效果。结论全身热化疗对晚期肿瘤是一种安全有效的治疗方法,将为晚期恶性肿瘤病人的治疗带来新的希望。 | | 文摘来源 | | Hyperthermia has become one of the effective methods just as operation,radiotherapy,chemotherapy and biotherapy in treating tumor. Hyperthermia can also be combined with chemotherapy. Therefore,thermochemotherapy has become a new combined therapy mode. Its clinical application include: local thermotherapy combined with chemotherapy,such as interventional heated chemotherapy,intraperitoneal hyperthermia chemoperfusion,intracavitary thermochemotherapy and out-of-body hyperthermia combined with chemotherapy; w... | | 热疗是继手术、放疗、化疗和生物治疗之后的新治疗手段之一。热疗还可与化疗发挥协同作用,因此,热化疗(thermo-chemotherapy)已成为一种新的肿瘤综合治疗模式。其临床应用包括局部热疗合并化疗(如介入性热化疗、腹腔热化疗、腔内热化疗和体外热疗合并化疗)和全身热化疗。以上临床应用已取得许多经验,规范合理制定肿瘤热化疗的临床方案,使更多的肿瘤患者从中受益是进一步努力的结果。 | | 文摘来源 | |   | | << 更多相关文摘 |
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