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aids患者
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  aids patients
     Change of expression of CD28 on peripheral CD4~+,CD8~+ T lymphocytes in HIV/AIDS patients
     HIV/AIDS患者CD28在外周血CD4~+、CD8~+ T细胞上的表达变化
短句来源
     Relationship and Significance of CD~+_4T Cells and Total Lymphocytes in Adult HIV/AIDS Patients
     成人HIV/AIDS患者CD_4~+T淋巴细胞与淋巴细胞总数的关系及其意义
短句来源
     The CCR5 and CXCR4 expressions on the CD4~(+)/CD8~(+)T lymphocytes of the HIV/AIDS patients was significantly correlated with the activation of CD4~(+)/CD8~(+) T cells(HLA-DR~(+)/CD38~(+))(P<(0.05)).
     H IV/AIDS患者CD4+T、CD8+T细胞表面CCR5、CXCR4的表达与T细胞活化(HLA-DR+)水平明显正相关(P<0.05)。
短句来源
     Results 12.5% of HIV/AIDS patients was PPD positive,meanwhile,28.2% of health was PPD positive,(P<0.05).
     结果HIV/AIDS患者中PPD阳性率12.5%,健康对照PPD阳性率28.2%(P<0.05)。
短句来源
     Results Both HIV-infected individuals and AIDS patients demonstrated that there were three types conserved neutralization epitope mutations on HIV-1 gp120 C2—C3 region, including: CD4-binding site (CD4BS), CD4-induced (CD4i) and 2G12. The mutation rates showed no significant difference (P>0.05).
     结果HIV1外膜蛋白gp120C2~C3区,HIV感染者和AIDS患者CD4结合位点(CD4BS)、CD4诱导(CD4i)、2G12三种类型中和抗体保守表位氨基酸均存在突变,两组病例表位突变率差异无统计学意义(均P>0.05);
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  “aids患者”译为未确定词的双语例句
     Expression of CD_(38) HLA-DR on CD_4~+ and CD_8~+T lymphocytes in peripheral blood of people living with HIV/AIDS
     HIV感染者/AIDS患者外周血CD_(38) HLA-DR分子在CD_4~+ CD_8~+T淋巴细胞上的表达
短句来源
     Significance of CD_4~+ in patient with HIV/AIDS
     CD_4~+在HIV感染者/AIDS患者病程中的意义
短句来源
     The expression of NK associated antigens on CD8~+ T lymphocytes in HIV-infected individuals
     NK相关抗原在HIV/AIDS患者CD8~+ T淋巴细胞上的表达
短句来源
     Analysis on Clinical Characteristics of 146 Cases of HIV/AIDS
     146例HIV/AIDS患者临床特征分析
短句来源
     Study on the relationship between values of CD_4,CD_8 and the components of peripheral blood in people living with HIV/AIDS in China.
     中国HIV/AIDS患者CD_4~+CD_8~+T淋巴细胞与外周血各组份间关系的研究
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  相似匹配句对
     A study on the hospitalization expenditures of AIDS patients in Guangdong Province
     广东省AIDS患者住院费用调查
短句来源
     Echocardiographic study of HIV positive/AIDS patients
     HIV感染/AIDS患者的超声心动图分析
短句来源
     P were analyzed retrospectively.
     P患者的资料。
短句来源
     On the Chinese Translation of the Term AIDS
     论AIDS的译名
短句来源
     Exercise Therapy for Patients Suffered from Hypertension
     高血压患者的运动疗法
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  aids patients
Proteolytic activity of polyclonal IgG antibodies (Abs) from the blood of AIDS patients was analyzed for the first time.
      
Several abzymatic criteria were applied and it was shown that RT, HSA, and β-casein hydrolyzing activities are an intrinsic property of polyclonal Abs from AIDS patients.
      
Casein-hydrolyzing Abs were detected in the blood serum for 95% of AIDS patients, and it was shown that they possess serine protease-like catalytic activity.
      
DNase activity was analyzed in 110 IgG preparations from the blood of AIDS patients.
      
It was shown with several rigid criteria that DNAase activity is an intrinsic property of antibodies (Abs) from AIDS patients.
      
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Gag-P24 is a major protein during the maturation of HIV-1 virion. A gene segment encoding Gag-P24 was cloned on pEX31, and Gag-P24 protein were expressed as MS2-Gag-P24 fusion protein under the control of PL promoter in E. coli. This represents about 20% of total bacterial proteins. Western blot and ELISA showed that the expressed product can be recognized by specific anti-P24 antibody in AIDS patients serum. This is the first demonstration of high level expression of Gag-P24 protein of HIV-1 in our country....

Gag-P24 is a major protein during the maturation of HIV-1 virion. A gene segment encoding Gag-P24 was cloned on pEX31, and Gag-P24 protein were expressed as MS2-Gag-P24 fusion protein under the control of PL promoter in E. coli. This represents about 20% of total bacterial proteins. Western blot and ELISA showed that the expressed product can be recognized by specific anti-P24 antibody in AIDS patients serum. This is the first demonstration of high level expression of Gag-P24 protein of HIV-1 in our country. The significance of the expressed recombinant Gag-P24 protein is discussed.

将编码人类免疫缺陷病毒Ⅰ型(HIV-1)核心蛋白(Gag)P24的大部分基因片段,插入大肠杆菌表达载体pEX31A中,获得的表达产物MS2-Gag融合蛋白占菌体总蛋白的20%左右。Western blot结果证明,这种表达产物能被艾滋病(AIDS)患者血清中的特异性抗体所识别。这是国内首次报道在大肠杆菌中高效表达人类免疫缺陷病毒Ⅰ型核心蛋白。对表达的重组核心蛋白的意义及应用前景进行了讨论。

Antigenic or mitogenic activation of cells bearing CD+ receptor is an essential prerequisite for their infection with the human immunodefiency virus (HIV). The presence of some microbial antigens/mitogens associated with certain oral flora in HIV-positive individuals may be a mediating factor in the potential oral transmission of HIV to an uninfected individual. To demonstrate the activation potential of oral flora of individuals with AIDS as well as of normal individuals, extracts of saliva were used to elicit...

Antigenic or mitogenic activation of cells bearing CD+ receptor is an essential prerequisite for their infection with the human immunodefiency virus (HIV). The presence of some microbial antigens/mitogens associated with certain oral flora in HIV-positive individuals may be a mediating factor in the potential oral transmission of HIV to an uninfected individual. To demonstrate the activation potential of oral flora of individuals with AIDS as well as of normal individuals, extracts of saliva were used to elicit blastic transformation of normal peripheral blood lymphocytes. These lymphocytes were then exposed in vitro toHlV, the virus replication in those measured by detection of viral reverse transcriptase activity and by the expression of the viral core protein P24. Lymphocyte activation and subsequent virus expression was significantly augmented in HIV-infected individuals, while in normal, uninfected individuals, blastic transformation was actually suppressed.

在实验条件下,CD~+_4淋巴细胞需经抗原或有丝分裂原激活才能受到HIV的增殖性感染。HIV患者口腔中的某些微生物性抗原或有丝分裂原可能是HIV经口传播的一个介导因素。本文研究了AIDS患者和正常人口腔菌群成分的这种作用,结果表明,某些HIV感染者唾液中的成分,可能是口腔菌的蛋白质成分,能激发正常人外周血淋巴细胞转化和促进HIV在其中的增殖;而正常非HIV感染者的唾液中缺乏这种成分,甚至抑制淋巴细胞转化。

In this study, five hybridoma cell lines secreting anti-rHIV-env1 peptide monoclonal antibodies ( McAbs ) were established by fusing mouse myeloma cell line NS-1 with spleen cells from BALB/c mice immunized with recombinant HIV-1 antigen. These hybridomas steadily secreted McAbs after continuous in vitro cultivation for six months and storage in liquid nitrogen. These McAbs fell into the class of IgM. Analysis of relative affinities of four McAbs showed that the protein concentration of 50% maximum binding of...

In this study, five hybridoma cell lines secreting anti-rHIV-env1 peptide monoclonal antibodies ( McAbs ) were established by fusing mouse myeloma cell line NS-1 with spleen cells from BALB/c mice immunized with recombinant HIV-1 antigen. These hybridomas steadily secreted McAbs after continuous in vitro cultivation for six months and storage in liquid nitrogen. These McAbs fell into the class of IgM. Analysis of relative affinities of four McAbs showed that the protein concentration of 50% maximum binding of the 3 McAbs ( F7,D6, B10) was o. 9-5. 0 μg/ml. Anti-HIV-gpl20 antibodies in the positive sera from four patients were detected by blocking-ELISA. McAb B10 possessed component of specific antibodies in all the sera. Because HlV-e.nvj antigen has the property of high variation, these findings suggest that McAbs against high conservative domain of HIV-env1 can be used in the diagnosis of various types of AIDS.

用rHIV-env_1肽免疫BALB/c小鼠脾细胞与小鼠骨髓瘤NS-1细胞融合,经4次克隆化获5株杂交瘤细胞系,其分泌抗体类型均属IgM。经连续传代6个月及液氮冻存9个月,分泌抗体特性无明显变化。5株McAb对rHIV-env_1肽或HIV-1均能明显地识别。用ELISA间接法测定各株McAb的相对亲和力,有3株(F7、B10、D6)McAb的50%最大结合浓度介于0.9~5μg/ml之间,用已如HIV-gp120抗体阳性血清阻断4株McAb与相应抗原的结合试验,所获结果各异。其中McAb B10与rHIV-env_1肽抗原的结合均可被4份HIV-gp120抗体阳性血清明显阻断,故初步认为B10McAb与抗HIV-gp120抗体中的保守肽段具有共同成分,抗HIV-env_1肽高度保守肽段的McAb,对艾滋病(AIDS)患者和人类免疫缺陷病毒(HIV)感染者的诊断具有实际应用价值。

 
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