The 5－hydroxytryptamine－containing immunoreactive (5-HT-TR) neurons of the rat ileum were investigated by means of immunohistochemistry,utilizing an antibody against serotonin.
The purpose of this study was to observe the effects of substance P (SP) on the contractile response of longitudinal muscle with myenteric plexus (LM-MP) of rat ileum induced by 5-HT in vitro and to analyse its mechanism.
(2)When GnRH analogue Alarelin(from 1. 0X10-8mol/L to 1. 0X 10-6mol/L) was added to the culture medium of ileum tissue, the level of glucagon immunoreactive substance in the medium was increased with the increment of GnRH analogue concentration.
Compared with the normal group, the content of OFR in ileomucosa, hepatic and pulmonary tissues in ACST and choledochostomy group both increased markedly (P<0.05,<0.01,<0.001, separately); the activities of PLA2 were greatly raised (P<0.05,<0.01,<0.001, separately).
Forskolin and phorbol-12,13-dibutyrate increased KRP phosphorylation at Ser13 from 25 to 100% but did not produce contraction in rat ileum.
Unlike selenate uptake, selenite uptake was not Na+ dependent, neither in pig small intestine nor in sheep jejunum and rat ileum.
The results clearly show that selenate transport across the BBM of pig jejunum and ileum, sheep jejunum, and rat ileum is partially energized by a transmembrane Na+ gradient.
Thus, insulin introduced in the lumen of the rat ileum in conjunction with sodium cholate and aprotinin, appears to be rapidly absorbed by the epithelial cells and transferred to the circulation through a transcytotic pathway.
The antagonistic activity of tested drugs against acetylcholine-induced contraction of rat ileum and oxotremorine-induced salivation and tremor in the mouse was also studied.
Loperamide is a novel type of antidiarrheal agent. In mice Loperamide was shown to be a potent blocker of 15-methyl-PGF_(2a)-induced diarrhea and charcoal progression in the intestine. The inhibitory potency of Loperamide was greater than that of morphine and atropine. The results of experiments on isolated smooth muscles showed that Loperamide inhibited the contractive response of rat jejunum to 15-methyl-PGF_(2a). However, it increased the contractive response of uterus to 15-methyl-PGF_(2a). Loperamide in...
Loperamide is a novel type of antidiarrheal agent. In mice Loperamide was shown to be a potent blocker of 15-methyl-PGF_(2a)-induced diarrhea and charcoal progression in the intestine. The inhibitory potency of Loperamide was greater than that of morphine and atropine. The results of experiments on isolated smooth muscles showed that Loperamide inhibited the contractive response of rat jejunum to 15-methyl-PGF_(2a). However, it increased the contractive response of uterus to 15-methyl-PGF_(2a). Loperamide in dose of 2.5×10~(-7) g/ml stimulated but in dose of 10~(-6) g/ml inhibited the spontaneous contraction of rat uterus. Loperamide antagonized the action of 15-methyl-PGF_(2a) on increasing jejunum secretion. This antagonizing effect could not be reversed by naloxane. The LD_(50) of Loperamide in mice was determined to be 77.9 mg/kg by intraperitoneal injection.
The stimulating effect of Substance P(SP)on the longitudinal muscle
P 物质(Sp)能引起大鼠回肠纵行肌收缩并呈剂量依赖性。阈上剂量的Sp(10~(-7)M)可以增强Ach、5-HT 的收缩效应;减弱或消除NE 的抑制效应,阈下剂量的Sp(5×10~(-7)M)可以加强5-HT 的收缩效应,但对Ach、NE 无明显影响。结果提示:SP 可能作为兴奋性递质与经典递质一道共同调节消化道的运动,同时,Sp 对5-HT 可能还具有某种调制作用。
The evidence from in vivo studies showed that glucose polymer enhanced intestinal calcium absorption. However, the mechanism with which calcium absorption is increased by glucose polymer administration is not clear. Calcium uptake by isolated everted rat ileal gut sac was used as a technique in an effort to explore the effect of this carbohydrate on calcium uptake under in vitro conditions.As a comparison, ileal sacs were treated with buffer and sugar solutions at an equivalent dose. The results showed that...
The evidence from in vivo studies showed that glucose polymer enhanced intestinal calcium absorption. However, the mechanism with which calcium absorption is increased by glucose polymer administration is not clear. Calcium uptake by isolated everted rat ileal gut sac was used as a technique in an effort to explore the effect of this carbohydrate on calcium uptake under in vitro conditions.As a comparison, ileal sacs were treated with buffer and sugar solutions at an equivalent dose. The results showed that all three sugars, as compared to buffer treatment, enhanced calcium uptake by ileal sacs, lactose 30.7%, glucose polymer 33% and glucose 24.7%, indicating a non-specific mechanism is involved in intestinal calcium absorption.
大鼠回肠
rat ileum
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