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成人all
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  adult all
     (3)Of the 16 adult ALL patients, median survival was 667±8 days, the overall survival (OS) rates at 1 year and 2 years were 88. 9%±10. 5% and 38. 9%±20. 6% respectively, while the DFS rates at 1 year and 2 years were 92. 3%±7. 4% and 40. 4%±21. 2%.
     ③16例成人ALL患者,中位生存时间667±8天,1年及2年OS率分别88.9%±10.5%、38.9%±20.6%,无病生存(DFS)率分别为92.3%±7.4%、40.4%±21.2%。
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     Bcl 2 expression in adult ALL was lower than that in ANLL and CLL.
     Bcl 2蛋白在成人ALL中的表达明显低于ANLL、CLL中的表达。
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     Results:The detecting rate of aneuploid in 84 cases of ALL was 38.1 % , of whom , 45.5 % in children ALL and 35.5 % in adult ALL .
     结果 :84例急性淋巴细胞白血病异倍体检出率为 38.1% ,其中儿童AL L4 5 .5 % ,成人 AL L35 .5 %。
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     The frequency of mutant TPMT alleles of adult ALL(1.28%, 2/156) was similar to that of the healthy Han Chinese(1.30%, 4/308).
     成人ALL患者TPMT总的突变型等位基因频率(1.28%)与健康汉族人群(1.30%)相近。
短句来源
     Methods Genomic DNA was extracted from peripheral blood leukocytes of 78 adult ALL patients and 154 healthy Han Chinese. The frequencies of four allelic variants of the TPMT gene,TPMT*2,TPMT*3A,TPMT*3B and TPMT*3C were determined using allele specific polymerase chain reaction(ASPCR) or PCR-Restriction fragment length polymorphism technique.
     方法从78例成人ALL患者和154例健康汉族人外周血提取白细胞基因组DNA,采用等位基因特异性PCR(ASPCR)和PCR结合限制性片断长度多态性(PCRRFLP)技术对TPMT2、TPMT3A、TPMT3B和TPMT3C的等位基因频率进行分析。
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  “成人all”译为未确定词的双语例句
     Results:Lymphoblastic antigens in all acute lymphoblastic leukemia cases were expressed,in which CD13 and CD33 were 46.7% and 11.1%,respectively;
     结果 :急性淋系白血病细胞均表达淋系抗原 ,4 6 .7%和 11.1%的成人ALL细胞表达CD13和CD33;
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     Results Only six TPMT*3C heterozygotes were detected in all the subjects, but TPMT*2,TPMT*3A and TPMT*3B were not detected.
     结果在成人ALL患者和健康汉族人中仅检测到6例TPMT3C杂合子,没有检到TPMT2、TPMT3A和TPMT3B。
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     Results The 24 - month disease-free survival (DFS) and overall - survival (OS) were estimated as 4.6i4.7 % and 27.h 11.9% respectively.
     结果41人成人ALL的疗效,24个月无病生存率(DFS)为4.6±4.7%。 24个月总生存率(OS)为27.1±11.9%。
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     1.Accurate rate of clear diagnosis of ALL according to FAB classification can reach 85%, and up to 95% if combined with immunology type results.
     1.本研究FAB分类中明确诊断ALL符合率达85%,结合免疫分型结果可达95%,本组细胞遗传学检查者均为成人ALL,未发现特异性染色体改变,表明MIC相结合有助于提高ALL的诊断率。
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     A logistic regression analysis revealed that children AML,adults ALL,white blood cell count>20×10 9/L,blood platelet count<50×10 9/L and no CNSL prophylaxis by intrathecal chemotherapy for ALL were risk factors for relapse.
     Logistic回归分析发现发病时儿童 AML、成人 AL L、WBC>2 0× 10 9/L、血小板数 <5 0× 10 9/L和无正规预防性鞘内注射化疗是复发的高危因素。
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  相似匹配句对
     Adult adrenoleukodystrophy.
     成人肾上腺脑白质营养不良
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     All.
     建议All.
短句来源
     ( 2 ) As for the 2 groups of All.
     ( 2 ) All.
短句来源
     Medulloblastoma in adult
     成人髓母细胞瘤
短句来源
     Objective: To analyse the relationship of morphology-immunology-cytogene (MIC) typing classification of adult acute leukemia (ALL ) to its clinical significance and prognosis.
     分析成人急性淋巴细胞白血病(ALL)的MIC:分型与临床及预后的关系。
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  adult all
In conclusion, adult ALL patients with BCR/ABL-positive have poorer prognosis.
      
In this review, we focus on technical aspects of MRD detection by flow cytometry and on the clinical data concerning the value of immunologic MRD studies as a tool for relapse prediction in adult ALL.
      
MRD quantification during treatment identified prognostic subgroups within standard-risk adult ALL patients without conventional risk factors.
      
In recent years, results in adult ALL, treated with various intensified programs, have improved considerably and are nearly comparable to those obtained in childhood ALL.
      
The adult ALL cells were classified as "non-T-non-B" by surface marker analysis.
      
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he nine cases of Philadelphia chromosomepositive adult acute lymphoblastic leukemia (Ph ̄+ ALL) accounted for 29% of the total 31 cases of cases of adultAI.L in the same period. Four of the nine cases of Ph+ALL were characterized by the mosaicism of Ph chromosome and normal karyotypes. After achieving com-plete remission, two cases became Ph and 18% Ph ̄+cells remained in another case. Eight of the nine casesof Ph+ ALL were diagnosed as Blineage expressingmainly CD,_(10)CD_(19) and CD_(22) They also showed high...

he nine cases of Philadelphia chromosomepositive adult acute lymphoblastic leukemia (Ph ̄+ ALL) accounted for 29% of the total 31 cases of cases of adultAI.L in the same period. Four of the nine cases of Ph+ALL were characterized by the mosaicism of Ph chromosome and normal karyotypes. After achieving com-plete remission, two cases became Ph and 18% Ph ̄+cells remained in another case. Eight of the nine casesof Ph+ ALL were diagnosed as Blineage expressingmainly CD,_(10)CD_(19) and CD_(22) They also showed high expression of CD_2 and CD_(34) antigens. One case trans-formed into hybrid acute leukemia. High white bloodcell count and poor response to treatment in this groupof patients indicated that Ph ̄+ ALL was a poor prognostic subtype and should be treated differently fromPh ALL.

报道9例Ph染色体阳性的急性淋巴细胞白血病(Pb ̄-ALL)的临床和实验研究结果。Ph ̄-ALL占同期研究的31例成人ALL的29%。其中4例Ph染色体与正常核型嵌合,3例合并+17。病情完全缓解后2例Ph染色体消失,1例其百分比显著降低。免疫表型检测8例为B系列ALL。以、为主要表型,同时有CD_2和CD_(34)的高表达。1例病程中转变为杂合性急性白血病。上述免疫表型特点反映Ph ̄+ALL的恶性细胞起源于早期定向或多能干细胞。该组患者白细胞计数较高,治疗反应差,提示Ph ̄+ALL为一预后不良的特殊亚型,治疗上应有别于PhALL。

Objective To analyse the expression of myeloid markers and CD 34 antigen on lymphoblasts in adult ALL and its relationship with prognosis.Method Immunophenotypes were examined using indirect immunofluorescence method in 102 de novo ALL. Results The incidence of myeloid antigen expression in adult ALL was 21.6% and the commonest one was CD 33 (15.7%). There was a higher incidence of myeloid antigens expression in ALL L 2 than in ALL L 1 (25.6% vs 5.3%, P=0.05).CD 34 was expressed in lymphoblasts...

Objective To analyse the expression of myeloid markers and CD 34 antigen on lymphoblasts in adult ALL and its relationship with prognosis.Method Immunophenotypes were examined using indirect immunofluorescence method in 102 de novo ALL. Results The incidence of myeloid antigen expression in adult ALL was 21.6% and the commonest one was CD 33 (15.7%). There was a higher incidence of myeloid antigens expression in ALL L 2 than in ALL L 1 (25.6% vs 5.3%, P=0.05).CD 34 was expressed in lymphoblasts from 30 of 56 patients (53.6%).Incidence of CD 34 expression in B ALL was higher than that in T ALL (61.7% vs 11.1%, P<0.01). No relationship between CD 34 ,myeloid antigens and cell maturity was found within B ALL.There was no relation between expression of myeloid antigens and CD 34 . The CR rate in My + ALL was lower than that in My - ALL (52.6% vs 80.0%, P<0 025),and was no relation with CD 34 expression.In addition, Ph chromosome and/or bcr/abl fusion gene was positive in 35.9% of the patients,and CR rate of Ph positive patients was higher than that in Ph negative patients. Conclusion Expression of myeloid antigens was related to FAB subtype and cell maturity in adult ALL. There was no relationship between myeloid antigen expression and CR rate. A higher incidence of CD 34 expression was found in Pro B ALL than in common ALL and Pre B ALL. Expression of CD 34 had no relation with CR rate.

目的分析成人急性淋巴细胞白血病(ALL)的髓系抗原、CD34表达特点及与Ph染色体表达、预后的关系。方法采用间接免疫荧光法分析102例初治ALL患者的免疫表型。结果①成人ALL髓系抗原阳性率达21.6%,其中CD33阳性最常见(阳性率为15.7%)。T系ALL和B系ALL髓系抗原表达差异无显著性。ALLL2中的阳性率高于L1(P=0.05)。在B系ALL中随细胞分化成熟阳性率逐渐降低。②CD34表达阳性率为53.6%,BALL阳性率高于TALL(P<0.01);BALL中前B祖细胞型明显高于普通型、前B细胞型和成熟B细胞型,与髓系抗原的表达无关。③髓系抗原阳性病例完全缓解(CR)率明显低于阴性病例(P<0.025);CD34表达和治疗缓解率无显著相关性。二者均与治疗达缓解的时间无关。④Ph染色体和(或)bcr/abl融合基因阳性率为35.9%,阳性病例CR率明显低于阴性病例(P<0.025)。⑤髓系抗原和CD34表达均与患者年龄、治疗前白细胞计数、肝脾肿大情况无关。结论成人ALL髓系抗原表达和FAB分型有关,与治疗缓解率呈负相关;CD34表达与ALL亚型、细胞分化程度有关,和治...

目的分析成人急性淋巴细胞白血病(ALL)的髓系抗原、CD34表达特点及与Ph染色体表达、预后的关系。方法采用间接免疫荧光法分析102例初治ALL患者的免疫表型。结果①成人ALL髓系抗原阳性率达21.6%,其中CD33阳性最常见(阳性率为15.7%)。T系ALL和B系ALL髓系抗原表达差异无显著性。ALLL2中的阳性率高于L1(P=0.05)。在B系ALL中随细胞分化成熟阳性率逐渐降低。②CD34表达阳性率为53.6%,BALL阳性率高于TALL(P<0.01);BALL中前B祖细胞型明显高于普通型、前B细胞型和成熟B细胞型,与髓系抗原的表达无关。③髓系抗原阳性病例完全缓解(CR)率明显低于阴性病例(P<0.025);CD34表达和治疗缓解率无显著相关性。二者均与治疗达缓解的时间无关。④Ph染色体和(或)bcr/abl融合基因阳性率为35.9%,阳性病例CR率明显低于阴性病例(P<0.025)。⑤髓系抗原和CD34表达均与患者年龄、治疗前白细胞计数、肝脾肿大情况无关。结论成人ALL髓系抗原表达和FAB分型有关,与治疗缓解率呈负相关;CD34表达与ALL亚型、细胞分化程度有关,和治疗缓解率无显著关系。P?

Objective Adult acute lymphocytic leukemia (ALL) is a common disease which has a poor result compared with childhood ALL with conventional chemotherapy. we present here, the result of a retrospective analysis in 41 cases of adult ALL treated with conventional chemotherapy. Methods Forty -one de novo ALL patients were treated with standard VDP/VDLP chemotherapy and had complete remission (male 26 and female 15; age 18~55, median 32). There were three ph positive, one t(4;11) and one complex chromosomal abnormality...

Objective Adult acute lymphocytic leukemia (ALL) is a common disease which has a poor result compared with childhood ALL with conventional chemotherapy. we present here, the result of a retrospective analysis in 41 cases of adult ALL treated with conventional chemotherapy. Methods Forty -one de novo ALL patients were treated with standard VDP/VDLP chemotherapy and had complete remission (male 26 and female 15; age 18~55, median 32). There were three ph positive, one t(4;11) and one complex chromosomal abnormality in cytogenetic study. Univariate analysis was performed to identify the potential prognostic factors. Results The 24 - month disease-free survival (DFS) and overall - survival (OS) were estimated as 4.6i4.7 % and 27.h 11.9% respectively. Several important prognostic factors were identified: initial WBC≥20×109/L; no remission within 28days with induction treatment; CNS involvement; subtype of ALL - L3 and ph+, t(4:11) or other complex chromosomal abnormality. Conclusion The long-term result of adult ALL was disappointing with conventional chemotherapy, particularly for patients with negative prognostic factors. New strategy of more specific or intensified therapy should be studied.

目的为进一步探讨我国成人急性淋巴细胞白血病(ALL)患者的预后因素,分析了41例常规化疗成人ALL的疗效,并对其预后因素进行分析。方法分析我院在1993年6月至1997年10月收治VDP/VDLP方案化疗缓解的成人ALL病例41例,其中Ph染色体阳性3例,t(4;11)异位1例,复合染色体异位1例,正常染色体核型和无法评估者共7例。以VDP/VDLP和蒽环类+Ara-C方案交替应用巩固。观察的截止期为1997年11月,进行生存分析及单因素预后分析(Kaplan-Meiyer、Gehan’swilcoxon检验、Log-rank检验)。结果41人成人ALL的疗效,24个月无病生存率(DFS)为4.6±4.7%。24个月总生存率(OS)为27.1±11.9%。与ALL预后相关因素为:初发时WBC>=20×109/L;诱导化疗后28d未缓解;中枢神经系统累及;ALL-L3型;ph+,t(4;11)以及其他复杂染色体异常。结论常规化疗治疗成人ALL的长期疗较较差,尤其是有不良预后因素患者,需研究和采用针对性的强化治疗策略。

 
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