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狼疮小鼠
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  lupus mice
     ObjectiveTo investigate the effect of arsenic trioxide(ATO)on the autoimmunity and survival time in BXSB lupus mice.
     目的探讨三氧化二砷(Arsenic Trioxide,ATO)对BXSB狼疮小鼠自身免疫及其生存时间的影响。
短句来源
     Effect of SHEN-YI,a Chinese herbal formula on ratio of Th1/Th2 cells within immune organs of MRL/lpr lupus mice
     肾怡对狼疮小鼠免疫器官内Th1/Th2细胞比例的调节作用
短句来源
     Expression of Transforming Growth Factor β Genes in Kidneys of BXSB Lupus Mice.
     转化生长因子β基因在BXSB狼疮小鼠肾脏中的表达
短句来源
     MethodsThe model BXSB lupus mice were randomly divided into two groups equally,the ATO treated group and the control group,17 in each group. Mice in the ATO group were given intraperitoneal injection of ATO at the daily dose of 0.4 mg/kg,once every other day for 105 days or 90 days,respectively,and the observation lasted for 210 days.
     方法BXSB狼疮小鼠随机平分两组,即ATO治疗组和对照组,ATO0.4mg/(kg.d)隔日腹腔注射至90天和105天,观察至210天实验结束,比较两组小鼠生存时间的差异;
短句来源
     Effects of Arsenic Trioxide on the Autoimmunity and Survival Time in BXSB Lupus Mice
     三氧化二砷对BXSB狼疮小鼠自身免疫及其生存时间的影响
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  “狼疮小鼠”译为未确定词的双语例句
     Methods 12-week female mice were given MMF (90mg·kg -1·d -1, po), methylprednisolone(MPS,25mg·kg -1·d -1, ip)or cyclophosphamide(CTX,25mg·kg -1·w -1, ip) for 6 months.
     方法  12周龄雌性MRL lpr/lpr自发狼疮小鼠分别予以MMF(90mg·kg-1·d-1,po)、甲基强的松龙 (MPS) (2 5mg·kg-1·d-1,ip)、环磷酰胺 (CTX) (2 5mg·kg-1·w-1,ip)治疗 2 4周。
短句来源
     Methods: Twelve-week female MRL/lpr mice were given LEF(35mg·kg-1·d-1)for 12 weeks.
     方法:用LEF35mg·kg-1·d-1治疗12周龄雌性MRL/lpr自发狼疮小鼠,并与未干预组对照。
短句来源
     Study on apoptosis and Th1/Th2 of the lupus nephritis murine models of chronic graft-versus-host disease
     慢性移植物抗宿主病狼疮小鼠模型肾组织细胞凋亡及Th1/Th2细胞因子的研究
短句来源
     In pharmacology research, inborn NZB/W F1(NZB/NZW F1 or BW) lupus-prone mice were choosed to examine the expression of ICAM-1 in serum, peripheral blood lymphocyte and monocyte and kidney respectively.
     药理学研究选用先天发病的NZB/W F1(NZB/NZW F1 or BW)自发性狼疮小鼠,分别检测了血清、外周血淋巴细胞、单核细胞和肾组织ICAM-1的表达情况。
短句来源
     Methods:12-week female MRL/lpr mice were given Rofecoxib (10mg·kg -1 ·d -1 )for 12 weeks.
     方法用特异性环氧化酶-2(COX-2)抑制剂(Rofecoxib10·kg-1·d-1)治疗12周龄雌性MRL/lpr自发狼疮小鼠,并与未干预组对照。
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  相似匹配句对
     Objective To produce a lupus nephritis model.
     目的 制备狼疮肾炎小鼠模型。
短句来源
     Effect of emodin on BXSB mice with lupus nephritis and its mechanism.
     大黄素对狼疮样BXSB小鼠的影响
短句来源
     than that in WT mice.
     通小鼠
短句来源
     Isolation and Culture of Parenchymal Cell from Mouse Liver
     小鼠肝细胞的分离培养
短句来源
     Lupus Encephalopathy
     狼疮性脑病
短句来源
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  lupus mice
Prostaglandin E2-mediated dysregulation of proinflammatory cytokine production in pristane-induced lupus mice
      
Our results showed that levels of serum and BAL PGE2 and LPS-stimulated production of PGE2 by peritoneal macrophages were remarkably increased in pristane-induced lupus mice compared to healthy controls.
      
Exogenous PGE2 enhanced production of IL-6, IL-10, and NO but decreased TNF-α by macrophages and augmented IFN-γ, IL-6, and IL-10 by splenocytes from pristane-induced lupus mice compared to healthy controls.
      
Exogenous PGE2 also enhanced production of IFN-γ, IL-6, and IL-10 by thymocytes from pristane-induced lupus mice.
      
Indomethacin (Indo), a PGE2 synthesis inhibitor, greatly inhibited LPS-induced production of IL-6 and IL-10 by macrophages from pristane-induced lupus mice, while enhanced TNF-α.
      
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o clarify the role of intercellular adhesionmolecule-1 (ICAM-1)

利用计算机图象分析系统及免疫荧光技术研究了自发狼疮小鼠(MRLlpr/lpr)肾脏组织中细胞间粘附分子(ICAM-1)的分布及表达,同时对肾组织中免疫球蛋白及补体C3的沉积进行了定量分析,结果发现MRLlpr/lpr小鼠肾组织中ICAM-1可在毛细血管袢及系膜区有明显沉积。经用中药黄芪治疗后ICAM-1在肾组织中分市及沉积均明显减弱,治疗1组6.25±4.37%,治疗2组5.33±2.08%,狼疮组20.85±1.26%。同时免疫球蛋白及补体C3的沉积也明显减弱。结果提示ICAM-1在自发狼疮小鼠肾脏病变中起重要作用,黄芪通过免疫调节作用可以减轻自发狼疮小鼠的肾脏病变。

MPS pulse therapy is quite effective for the treatment of lupus nephritis. At present, no research work has been reported on the relationship between MPS therapy and apoptosis and ICE expression in kidneys with lupus nephritis. We investigated the effects of MPS on the number of apoptotic cells and expression of ICE mRNA in the kidneys of fourmonth old MRL lpr/lpr mice, by means of image analysis system, RT PCR and Northern blot. The results showed that in MPS group, the number of apoptotic cells in glomerular...

MPS pulse therapy is quite effective for the treatment of lupus nephritis. At present, no research work has been reported on the relationship between MPS therapy and apoptosis and ICE expression in kidneys with lupus nephritis. We investigated the effects of MPS on the number of apoptotic cells and expression of ICE mRNA in the kidneys of fourmonth old MRL lpr/lpr mice, by means of image analysis system, RT PCR and Northern blot. The results showed that in MPS group, the number of apoptotic cells in glomerular mesangium increased significantly, as compared with that of a control group ( P < 0.05 ). Besides, the number of apoptotic cells in both the peri tubule cells and peri vascular infiltrating cells was also higher in MPS group than in the control group (both P <0.01). Furthermore, higher expression of ICE mRNA was found in the treated group than in the control group. Our results suggest that MPS may induce both apoptosis and ICE mRNA expression in kidneys with nephritis, implying that apoptosis may be involved in the outcome of lupus nephritis treated with MPS.

为了探讨肾脏细胞凋亡在糖皮质激素治疗狼疮性肾炎机制中的作用,采用甲基泼尼松龙(MPS)和近交系纯合子MRL-lpr/lpr自发狼疮小鼠进行体内实验,利用计算机图像分析系统观察了MPS对狼疮小鼠肾脏细胞凋亡的诱导,并应用逆转录-巢式聚合酶链反应和Northern杂交技术观察了MPS对哺乳动物凋亡相关基因白细胞介素-1β转化酶(ICE)表达的影响。结果表明,MPS冲击治疗组小鼠肾小球系膜区细胞的凋亡数目显著高于对照组(P<0.05),肾小管间质细胞和肾血管周浸润细胞的凋亡数目也明显高于对照组(P均<0.01),治疗组肾脏细胞ICE基因的表达明显增强。研究提示,MPS能够诱导狼疮小鼠的肾脏细胞发生凋亡,ICE基因可能参与了狼疮小鼠肾脏细胞的凋亡机制。

To explore the consequences of IL-1 blocking in BXSB mice which is an experimental model for human SLE. Methods rh IL~1ra was expressed in E. coli and injected in BXSB mice. 13 of 4. 5 month-age male BXSB mice were divided into two groups, one group was injected rh 1L-1ra 10 times (twice a week) at dose of 400μg per mouse each time,another group was inJected PBS at the same time as control. We monitored serum ANA and proteinuria weekly, and detected IgG, C3 deposition and IL-6 expression in kidneys at 40th...

To explore the consequences of IL-1 blocking in BXSB mice which is an experimental model for human SLE. Methods rh IL~1ra was expressed in E. coli and injected in BXSB mice. 13 of 4. 5 month-age male BXSB mice were divided into two groups, one group was injected rh 1L-1ra 10 times (twice a week) at dose of 400μg per mouse each time,another group was inJected PBS at the same time as control. We monitored serum ANA and proteinuria weekly, and detected IgG, C3 deposition and IL-6 expression in kidneys at 40th day. Results The results showed that the increased level of serum ANA and proteinuria in treatment group were not higher than in control group, the IgG, C, deposition and IL-6 expression in kidneys and IL-6 activity in serum of the treaed group were lower than the control group, whereas no difference of GPT level in the two groups. Conclusion IL-1 might play a pathogenic role in BXSB mice. Blocking or reducing IL-1 secretion would be of beneficial to the treatment of SLE.

利用基因工程技术获得高纯度人白介素-1受体拮抗剂(IL-1ra),连续性尾静脉注射4.5月龄雄性BXSB狼疮小鼠,发现其尿蛋白水平和ANA滴度的增加幅度减少,肾脏IgG、C3沉积减轻,血清白细胞介素-6(IL-6)活性和肾脏IL-6蛋白表达减弱。提示IL-1在BXSB狼疮小鼠发病中的病理性作用及IL-1ra对该鼠可能的治疗作用。

 
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