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   端粒酶表达 的翻译结果: 查询用时:0.035秒
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端粒酶表达
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  expression of telomerase
     Result: The positive expression of telomerase was 88.5%(39/44).
     结果 :4 4例膀胱癌组织中端粒酶表达阳性 39例 (88 5 % )。
短句来源
     The expression of telomerase was also identified in some precancerous lesions and its level would be increased with the malignant progression.
     在某些癌前病变中亦发现有端粒酶表达,且其活性随着病变恶性程度的演进而增高。
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     8. The combined effects of quercetin and octreotide on the expression of telomerase in human breast carcinoma cell lines MCF-7 and MDA-MB-231:Expression of telomerase was downregulated by quercetin cooperated with octreotide in MCF-7 and MDA-MB-231 cells.
     8.榭皮素与奥曲肤联用对MCF一7和MDA一MB一231端粒酶表达的影响:两药联用能使MCF刀和MDA一MB一231端粒酶表达下调,但两药联用均未产生协同作用。
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     Experimental research of the expression of telomerase in corneal limbal epithelial cells
     兔角膜缘上皮细胞端粒酶表达的实验研究
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     Methods: Telomerase-PCR-ELISA was used to measure the expression of telomerase of peripheral blood mononuclear cells in 48 patients with malignant tumor, 34 patients with benign tumor and 38 healthy person as control group.
     方法采用端粒重复序列扩增-微孔板杂交法测定恶性肿瘤患者48例,良性患者34例和38例正常对照者外周血单个核细胞端粒酶表达
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  telomerase expression
     Effect of Serum of Mice Treated with Qilingyiganjian and Its Liquid of CO_2 Supercritical Fluid Extraction on Telomerase Expression in Hepatic Carcinoma Cell Line H_(22)
     芪灵益肝煎及其CO_2超临界萃取液对肝癌细胞株H_(22)端粒酶表达的影响
短句来源
     The HPV-infected tissues showed increased telomerase expression in cervical cancer(χ2=8.79,P<0.005,φ=0.44).
     (3)分析宫颈癌、慢性宫颈炎和正常宫颈组织HPV感染与端粒酶表达的关联性,发现宫颈癌组HPV感染与端粒酶表达存在关联性(φ=0.44,P<0.005);
短句来源
     However,there was no correlation between telomerase expression and HPV-18 infection(P>0.05).
     而宫颈癌组HPV-18型感染与端粒酶表达未发现关联性(P>0.05)。
短句来源
     QUANTITATIVE STUDY OF TELOMERASE EXPRESSION AND DNA CONTENT IN HEPATOCELULLAR CARCINOMA
     肝细胞癌端粒酶表达和DNA含量定量分析
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     In contrast, 81 out of the 94 patients with cancers were positive for telomerase expression ( P <0.001), 1 of 12 with gastric adenomas and 1 of 9 gastric ulcer also were positive for telomerase expression.
     正常粘膜无1 例检测到端粒酶表达,12 例胃腺瘤有1例表达端粒酶阳性,在9 例胃溃疡组织中有1 例检测到端粒酶表达,12 例胃腺瘤有1 例表达端粒酶阳性,在9 例胃溃疡组织中有1 例检测到阳性端粒酶表达
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  “端粒酶表达”译为未确定词的双语例句
     Z-ajoene causes cell cycle arrest at G_2/M and decrease of telomerase activity in HL-60 cells
     Z-ajoene引起HL-60细胞G_2/M期阻滞及端粒酶表达活性的降低
短句来源
     Results: The positive rates of telomerase assay by the two methods in NPC, NPC adjacent tissues, chronic nasopharyngitis and HNE1 cell lines were 84.2% to 85.2%, 73.3% to 69.2%, 5.3% to 12.1% and 95.5% to 91.2%, respectively.
     结果 :两种方法在NPC、癌旁、慢性鼻咽炎及HNE1细胞株端粒酶表达的阳性率非常接近 ,分别为 84.2 9%和 85 .2 9%、73.3%和6 9.2 %、5 .3%和 12 .1%及 95 .5 %和 91.2 %。
短句来源
     Effect on telomerase activity of BT-325 cells by exogenous p21 WAF1 expression
     转染P21 WAF1基因对BT-325细胞端粒酶表达的影响
短句来源
     Positive telomerase activity was found3.0%(1/30)in cervical erosion,56%(9/16)in CIN,80%(16/20)in cervical cancer and0in normal cervical samples.
     [结果]宫颈糜烂者端粒酶活性阳性率为3.0%(1/30),CIN端粒酶活性阳性率为56%(9/16),20例宫颈癌组织中端粒酶阳性表达率为80%(16/20),正常宫颈组织中端粒酶表达阴性。
短句来源
     Effect of 2, 3-dioxoindoline on apoptosis and human telomerase reverse transcriptase mRNA in SH-SY5Y cells
     2,3-吲哚醌对人神经母细胞瘤细胞SH-SY5Y凋亡和端粒酶表达的影响
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  expression of telomerase
Abstract: Previously, we identified a novel correlation between the upregulated expression of telomerase (hTERT) and cytochrome P450 1A1 (CYP1A1) in A549 human lung cancer cell line.
      
Expression of telomerase gene mTR in the testis of SD rats and its significance
      
To study the expression of mTR gene in the testis of SD rats with varied ages and its significance,in situ hybridization (ISH) techniques were applied to detect the expression of telomerase gene mTR mRNA in the testis of SD rats.
      
To study the expression of mTERT gene in the testis of SD rats and its significance, in situ hybridization (ISH) techniques were used to detect the expression of telomerase gene mTERT mRNA in the testis of SD rats.
      
Detection of telomerase activity and the expression of telomerase subunits in the patients with acute myelogenous leukaemia
      
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  telomerase expression
There was a significant correlation between the expression of telomerase with histological grade (ω=0.44, P>amp;lt;0.005), but no correlation was found between telomerase expression and HPV-18 (P>amp;gt;0.05).
      
These discoveries have led to the proposal that telomerase expression can be used as a helpful marker for diagnostic and prognostic purposes in humans.
      
Therefore, we conclude that AdTE1 is preferentially attenuated only in cells that are permanently devoid of telomerase expression such as senescent cells.
      
We investigated whether testicular telomerase activity is due to telomerase expression in all cells or expression in a limited number of cells.
      
Regulation of telomerase expression in human lymphocytes
      
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Shortening of the chromosome causedby DNA incompleted replication of chromosomeend (telomeres) at each cell division leads thecells to lose proliferative capacity and senescence.Telomerase elongates telomeric DNA.And the unlimted cell proliferation needs telomerase activation. About 85% of malignacyexpress positive for telomerase.The formationsand functions of telomeres and the effects oftelomerase on the telomere synthessis arereviewed.The measuring of telomerase and therelationship between cancer cell and...

Shortening of the chromosome causedby DNA incompleted replication of chromosomeend (telomeres) at each cell division leads thecells to lose proliferative capacity and senescence.Telomerase elongates telomeric DNA.And the unlimted cell proliferation needs telomerase activation. About 85% of malignacyexpress positive for telomerase.The formationsand functions of telomeres and the effects oftelomerase on the telomere synthessis arereviewed.The measuring of telomerase and therelationship between cancer cell and activation oftelomerase are also introduced.The possibility ofthe cancer treatment by the telomerase inhibitionis discussed.

细胞分裂中染色体因其末端(端粒)的DNA不能完全复制而短缩,使细胞逐渐失去增殖能力而衰老.端粒酶可延长染色体末端DNA,端粒酶的活化使细胞无限增殖.85%左右的恶性肿瘤端粒酶表达阳性,生殖细胞和无限繁殖的细胞系中端粒酶表达也呈阳性.文章综述了端粒的构成和功能、端粒酶在端粒合成中的作用,介绍了端粒酶活性的测定方法、细胞恶变与端粒酶激活的关系,并论及通过抑制端粒酶活性来治疗癌症的可能性.

Using a polymerase chain reaction based telomerase activity assay (TRAP),we examined telomerase activity in 5 normal bladder tissues, 4 bladder infection tissues, 42 bladder cancer tissues and 42 adjacent noncancerous bladder tissues. None of the normal and inflammatory bladder tissue exhibited telomerase activity. 32 of the 42(76.19%) bladder cancer tissues revealed telomerase activity. In the adjacent normal tissue taken from the bladder cancer, 11 of the 42(26.19%) were telomerase positive. The telomerase...

Using a polymerase chain reaction based telomerase activity assay (TRAP),we examined telomerase activity in 5 normal bladder tissues, 4 bladder infection tissues, 42 bladder cancer tissues and 42 adjacent noncancerous bladder tissues. None of the normal and inflammatory bladder tissue exhibited telomerase activity. 32 of the 42(76.19%) bladder cancer tissues revealed telomerase activity. In the adjacent normal tissue taken from the bladder cancer, 11 of the 42(26.19%) were telomerase positive. The telomerase is more frequently activated in advance ,not well differentiation bladder tumors. The results indicate: telomerase activation has strong relationship with the invasion and development of bladder cancer. The telomerase activation of the paracancer tissue shows the possibility of microinvasion.

应用聚合酶链反应(PCR)为基础的端粒酶活性检测方法(TRAP法),对5例正常膀胱组织、4例膀胱炎症组织、42例膀胱癌组织和癌旁正常组织进行检测。正常膀胱组织和膀胱炎症组织无端粒酶活性,膀胱癌组织端粒酶表达阳性率76.2%,癌旁组织阳性率为26.2%,端粒酶活化与膀胱癌分期分级呈正相关。结果提示:端粒酶活化与膀胱癌浸润发展密切相关,癌旁组织端粒酶活化提示肿瘤微浸润可能。

To understand the expression patterns of telomerase activity in different types of acute leukemia(AL) and during remission state, the mononuclear cells of different bone marrow samples were isolated by desity gradient centrifugation. Telomerase activity of the samples was assayed by telomeric repeat amplification protocol(TRAP) with the cell extracts and the TRAP products were resolved in PAGE. The results showed that the telomerase activity was at higher levels in the acute leukemia compared with the normal...

To understand the expression patterns of telomerase activity in different types of acute leukemia(AL) and during remission state, the mononuclear cells of different bone marrow samples were isolated by desity gradient centrifugation. Telomerase activity of the samples was assayed by telomeric repeat amplification protocol(TRAP) with the cell extracts and the TRAP products were resolved in PAGE. The results showed that the telomerase activity was at higher levels in the acute leukemia compared with the normal controls. Of the acute nonlymphocytic leukemia(ANLL), the telomerase activity presented as M2a>M5b>M1>M3b. Of the acute lymphocytic leukemia(ALL), the acitivity presented as L1>L2. The activity assayed in M2a and L2 remission was as high as that in the normal group. It indicated that the expression of telomerase was enhanced differently among the subtypes of ANLL and ALL, and was downregulated during the AL remission. It implicates that the expression patterns of telomerase activity in AL is associated with the different proliferation states and differentiation properties of the AL cells.

采用端粒重复序列扩增技术及聚丙烯酰胺凝胶电泳对急性白血病患者各类型及治疗缓解后端粒酶活性的表达进行了研究。结果发现:各型急性白血病端粒酶活性均有不同程度的增强,治疗缓解后恢复。讨论了端粒酶表达的变化及其意义

 
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