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细胞信号网络
相关语句
  cell signaling networks
     TOPOLOGICAL STRUCTURE ANALYSIS OF CELL SIGNALING NETWORKS
     细胞信号网络拓扑结构分析
短句来源
     Enlightened by the changing research paradigm for drug exploration,the following working principles are discussed: to convert the adverse biological effects to the pharmacological ones,to lay the basis of study on the intervention on cell signaling networks,to handle the activity-toxicity relationship and the strategies for rational design.
     从新药研究模式的转变得到启发,提出如何把负面生物效应转化为药理作用,如何从干预细胞信号网络入手进行研究,如何处理活性与毒副作用的关系,以及药物合理设计的策略等。
短句来源
  cellular signaling networks
     Computer Simulation of the Stability of Cellular Signaling Networks
     细胞信号网络稳定性的计算机仿真分析
短句来源
  “细胞信号网络”译为未确定词的双语例句
     Objective: To investigate the topological structure properties of cell signaling transduction networks, in order to offer assistance for the research on the complexity of cell signaling system.
     目的 :探讨细胞信号转导网络的拓扑结构属性 ,从而为复杂性细胞信号网络系统的研究提供有益帮助。
短句来源
     Kyoto Encyclopedia of Genes and Genomes (KEGG) introduced 14 detailed charts of different cell signal transduction paths, 12 of which provided protein Entry numbers. In this thesis, these 12 charts were converted to adjacency matrix, and then merged to be one adjacency matrix using matrix calculation. Therefore, one cell signal network including 933 points and 6825 lines was created.
     京都基因和基因组百科全书Kyoto Encyclopedia of Genes and Genomes(KEGG)提供了14条细胞信号转导通路的途径图,其中12幅具有蛋白质相应的Entry号,本文将这12幅图转换为邻接矩阵,再利用矩阵运算将这些邻接矩阵合并成一个总的邻接矩阵,得到共有933个节点,6825条边的细胞信号网络总图。
短句来源
     Therefore, further study of hpc2 is not only helpful to the understanding of the mechanism of biological action of PcG proteins and expanding of the knowledge on the regulation of gene expression, but also beneficial to the discovery of potential relationship between PcG family and other signal transduction pathways for better understanding of the cellular signal transduction network.
     因此 ,对hPc2的深入研究不仅有助于进一步阐明PcG基因家族的作用机理 ,扩展人们对基因表达调控的认识 ,还有助于发现PcG基因家族与其他信号转导通路的联系 ,更好地理解细胞信号网络系统 .
短句来源
     Results: This network model obviously shows inhomogeneous topological structure, which is conducive to explaining the robust tolerance of scale-free signaling networks against errors and attacks.
     结果 :网络模型表现出明显的非同质拓扑结构 ,此结构属性有助于解释无尺度细胞信号网络对意外攻击具有惊人的强韧性 ;
短句来源
     Objective: To investigate the organization of cellular signaling transduction in an attempt to offer some assistance to the research on the complexity of cellular signaling system.
     目的探讨细胞信号转导组织规则,从而为研究复杂性细胞信号网络系统提供有益帮助。
短句来源
  相似匹配句对
     TOPOLOGICAL STRUCTURE ANALYSIS OF CELL SIGNALING NETWORKS
     细胞信号网络拓扑结构分析
短句来源
     Computer Simulation of the Stability of Cellular Signaling Networks
     细胞信号网络稳定性的计算机仿真分析
短句来源
     The exploratory analysis of cellular signal transduction network
     细胞信号转导的复杂网络分析
短句来源
     CELLULAR INFORMATION NETWORK
     细胞信息网络
短句来源
     Property and Significance of Cell Signaling Transduction Scale-Free Network
     细胞信号转导网络的无尺度属性及其意义
短句来源
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  cell signaling networks
AWP1 may, therefore, affect propofol neurosensitivity by regulating cell signaling networks by modifying PRK1 substrate phosphorylation.
      
  cellular signaling networks
In this review, we summarize current knowledge on the properties and possible signaling partners of TRPC3, and discuss the role of TRPC3 channel proteins in cellular signaling networks.
      
In the chronic state of inflammatory diseases, cellular signaling networks aimed at combating invading pathogens are often constitutively active and transmit their signals even in the absence of inflammatory agents.
      
Thus, many anti-inflammatory drugs interfere with these dys- and hyperactivated cellular signaling networks or transcription factors.
      
Most enzymes are proteinaceous; amongst others the cytoskeleton, the immune system and cellular signaling networks are realized by proteins.
      


The individual's embryogenesis, cellular proliferation and differentiation are precisely regulated by various kinds of genes in a time-dependent manner. PcG family is a group of the most important genes that related to system development. HPC2 protein which is encoded by a critical PcG gene, hpc2, associates with other PcG proteins, such as HPH, BMI-1 as well as RING1 and constitutes HPC/HPH PcG complex to maintain the repressed state of homeotic gene, so that it can regulate the body development, cellular proliferation...

The individual's embryogenesis, cellular proliferation and differentiation are precisely regulated by various kinds of genes in a time-dependent manner. PcG family is a group of the most important genes that related to system development. HPC2 protein which is encoded by a critical PcG gene, hpc2, associates with other PcG proteins, such as HPH, BMI-1 as well as RING1 and constitutes HPC/HPH PcG complex to maintain the repressed state of homeotic gene, so that it can regulate the body development, cellular proliferation and directional differentiation. Furthermore, HPC2 has also been found to interact with some other proteins, suggesting that HPC2 may possess some other functions. Therefore, further study of hpc2 is not only helpful to the understanding of the mechanism of biological action of PcG proteins and expanding of the knowledge on the regulation of gene expression, but also beneficial to the discovery of potential relationship between PcG family and other signal transduction pathways for better understanding of the cellular signal transduction network.

生物个体的胚胎发育以及细胞的增殖、分化 ,都同时受到多种基因的严格调控 ,PcG基因家族就是一类重要的发育相关基因 .而hPc2基因是人PcG基因家族中的一个重要成员 ,其编码的HPC2蛋白 ,不仅可以和HPH、BMI 1以及RING1等其他人类PcG蛋白结合形成HPC/HPHPcG复合体 ,以蛋白复合体的形式参与对homeotic基因的表达抑制 ,以维持机体的正常发育以及细胞的增殖和定向分化 ,还发现它能与其他多种蛋白质相结合 ,提示HPC2可能具有多种功能 .因此 ,对hPc2的深入研究不仅有助于进一步阐明PcG基因家族的作用机理 ,扩展人们对基因表达调控的认识 ,还有助于发现PcG基因家族与其他信号转导通路的联系 ,更好地理解细胞信号网络系统 .

Objective: To investigate the topological structure properties of cell signaling transduction networks, in order to offer assistance for the research on the complexity of cell signaling system. Methods: Firstly, a model of complex cell signaling transduction networks was constructed in terms of available cell signaling transduction pathways and the research data of the mechanisms of biochemical action among signaling molecules. Next, its topological structure properties were analyzed at several different levels....

Objective: To investigate the topological structure properties of cell signaling transduction networks, in order to offer assistance for the research on the complexity of cell signaling system. Methods: Firstly, a model of complex cell signaling transduction networks was constructed in terms of available cell signaling transduction pathways and the research data of the mechanisms of biochemical action among signaling molecules. Next, its topological structure properties were analyzed at several different levels. Results: This network model obviously shows inhomogeneous topological structure, which is conducive to explaining the robust tolerance of scale-free signaling networks against errors and attacks. The categorizing of nodes based on the characters of nodes organization could contribute to further study of nodes network behavior. The analysis of core framework and signaling interflow of this network model could also promote the comprehension of cellular complex behaviors. Conclusion: It is imperative to study the complexity of cell signaling system by constructing networks model for analysis of its topological structure properties.

目的 :探讨细胞信号转导网络的拓扑结构属性 ,从而为复杂性细胞信号网络系统的研究提供有益帮助。方法 :首先根据已知的细胞信号转导途径以及信号转导分子间的生化作用机制的研究结果 ,构建出复杂细胞信号转导网络模型 ,进而在此模型的基础上从不同的层次对其拓扑结构属性进行分析。结果 :网络模型表现出明显的非同质拓扑结构 ,此结构属性有助于解释无尺度细胞信号网络对意外攻击具有惊人的强韧性 ;根据组织特点对节点的分类有助于对节点的网络行为进一步研究 ;对网络模型核心骨架及信号交流的分析也有助于促进对细胞复杂行为的理解。结论 :通过构建网络模型来分析细胞信号转导网络的拓扑结构属性对复杂性细胞信号系统进行研究是很有必要的。

Objective: To investigate the organization of cellular signaling transduction in an attempt to offer some assistance to the research on the complexity of cellular signaling system. Methods: By virtue of the binary character string (1and 0 character string) description pattern and IF…THEN… rule sentence to analyse the recognition among signal molecules and the organization rules of signal networks under various stimulations. Results: The binary character string pattern incarnates the complexity and diversity...

Objective: To investigate the organization of cellular signaling transduction in an attempt to offer some assistance to the research on the complexity of cellular signaling system. Methods: By virtue of the binary character string (1and 0 character string) description pattern and IF…THEN… rule sentence to analyse the recognition among signal molecules and the organization rules of signal networks under various stimulations. Results: The binary character string pattern incarnates the complexity and diversity of the recognition of signal molecules, and, morevrer offers a concise description for the specificity recognition of signal molecules; IF…THEN… organization rule not only embodies the dynamic assemble of signal molecules of singal networks, but also indicates that cells could construct sophisticated and various levels of signaling transduction rules according to the variety of environment. Conclusion: This paper promotes the understanding of the organization mechanism of signaling networks,and significantly embodies the self-adaptive and self-organization property of cell. It also improves the comprehensiou of complex self-adaptive systems.

目的探讨细胞信号转导组织规则,从而为研究复杂性细胞信号网络系统提供有益帮助。方法借助二进制字符串(即1和0字符串)描述模式和IF…THEN…规则语句对信号分子间的识别和不同刺激条件下信号网络的组织规则进行分析研究。结果二进制字符串描述模式既体现了信号分子间相互识别的复杂多样性,也为信号分子间的特异性识别提供了一种简明描述;IF…THEN…组织规则分析既充分体现了信号网络中信号分子间的动态变化组合,又表明了细胞能够根据环境变化组织成为复杂多样的不同层次信号转导规则。结论本文促进了对复杂信号网络组织机制的认识,充分体现了细胞的自适应及自组织特性,同时也促进了对复杂性自适应系统的理解。

 
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