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心肾     
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  heart and kidney
     The relationship of the clinical effects and traditional Chinese syndromes and types 〔including disharmony between the heart and kidney(心肾不交证), deficiency of (liverYin) and kidneyYin(肝肾阴虚证), deficiency of both Qi and Yin(气阴两虚证), Qi stagness and blood stasis(气滞血瘀证), deficiency of Yang and retention of dampness(阳虚湿阻证)〕 was analysed.
     分析两组心肾不交、肝肾阴虚、气阴两虚、气滞血瘀和阳虚湿阻不同证型与临床疗效的关系。
短句来源
     Effect of verapamil and probenecid on the permeability of CPU-86017 through the blood-brain barrier and the disposition in heart and kidney tissues
     维拉帕米和丙磺舒对CPU-86017血脑通透及其在心肾中分布的影响
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     The changes of meridin energy in insomnia patient's heart and kidney meridian
     失眠患者心肾经络能量的变化
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     The Current Situation of Combined Heart and Kidney Transplantation
     心肾联合移植的现状
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     Experimental Study on Animal Model with Yang Deficency of Heart and Kidney in Rats
     大鼠心肾阳虚证动物模型实验研究
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  heart and renal
     There were 12 deaths (mortality rate 0.38%) which included perforation of ventricular wall (2 cases), acute heart and renal failure (5 cases) and severe arrhythmia (5 cases).
     死亡12例(死亡率0.38%):心壁穿孔2例,急性心肾功能衰竭5例,严重心律失常5例。
短句来源
     Conclusion: Those patients of AMI with admission hyperylycaemia are more likely to have diabetes mellitus, later inhospital admission, and are worse in heart and renal function, and have more white blood cell count and higher mortality.
     结论:伴有入院时血糖增高的AMI患者并发糖尿病多,入院多较晚,心肾功能差,白细胞计数高,住院期间病死率高。
短句来源
     The parameters of heart rate variability (HRV) and heart rate (HR) were determined by 24hour ambulatory electrocardiography in 54 normal subjects as control and 82 diabetic patients,which including group A (30 cases without angiopathy),group B (11 cases with macroangiopathy),group C (12 cases with microangiopathy),group D (19 cases with both macro and micro angiopathy) and group E (10 cases with heart and renal dysfunction).
     采用24小时动态心电图对82例糖尿病患者进行心率变异(HRV)和心率(HR)检测。 82例分为五组:A组(无血管合并症)30例、B组(合并大血管病变)11例、C组(合并小血管病变)12例、D组(同时合并大、小血管病变)19例和E组(心肾功能不全)10例,并设正常对照组。
短句来源
     It is proposed that a good care for comatose patients, effective control of infection, prevention and treatment of heart and renal failure, and of disorders of elecrtolytes are the main measures for decreasing the mortality rate of DCI.
     脑梗塞类型也与病死率有关。 ③提出降低DCI病死率的主要措施是加强昏迷患者的护理,预防及有效控制感染,慎用降低肾灌注的药物,保护心肾功能及纠正电解质紊乱,以防止MOF的发生。
短句来源
     Conclusion:The mechanisms of antihypertensive effect and improvement of heart and renal functions by amlodipine therapy might be associated to normalization of intracellular calcium metabolism.
     结论 :氨氯地平通过纠正细胞内钙代谢紊乱而平稳降压、逆转左室重构和阻断钙在肾功能损害中的媒介作用 ,达到保护心肾功能的目的。
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  heart-kidney
     Heart-Kidney Pathogenesis of Syndrome Before and After Menopause
     绝经前后诸证心肾病机探析
短句来源
     Acupoint Application for Insomnia of Heart-Kidney Disharmony in 42 Cases
     穴位贴药治疗心肾不交型不寐42例
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     One case report of combined heart-kidney transplantation
     心肾联合移植1例
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     Ⅱtype is deficiency of heart-kidney yang, syndrome of combined stagnant-phlegm and edema.
     Ⅱ型:心肾阳虚、痰瘀水互结型;
短句来源
     The authors made a contrast observation on heart - kidney functions between 200 pregnant women and 50 non -pregnant women with both two -dimensional, Motion mode and colour Doppler ultrasonic cardiogram technology.
     本文应用二维、M型及彩色多普勒超声心动图技术,对200例妊娠期妇女及50例非孕健康妇女,进行了心肾功能的系统对照观察。
短句来源
更多       
  cardiac and renal
     The cognitive ability of the patients and educational background, drug-related adverse reaction and sex, mental state and educational background,cardiac and renal function and age, physical condition and body mass index showed highest correlation (r=-0.21、-0.33、-0.32、0.22、0.30, P<0.05 for all).
     患者的认知能力与其文化程度、药物相关不良反应与性别、心理及情绪方面与文化程度、心肾等器官功能与年龄、体质与体重指数相关性最大(r=-0.21、-0.33、-0.32、0.22、0.30,均P<0.05)。
短句来源
     MEASUREMENT OF CARDIAC AND RENAL REGIONAL BLOOD FLOW IN ANESTHETIZED RABBITS USING (51)~Cr LABELLED FROG RED BLOOD CELLS
     用(51)~Cr标记蛙红细胞技术测定家兔心肾局部血流量的实验研究
短句来源
     Objective To observe the changes of plasma neuropeptider Y(NPY)an d neurotensin(NT)levels in elderly patients with essential hypertension and the relationship between NPY,NT and damage of cardiac and renal functions.
     目的观察老年高血压病患者血浆神经肽Y(NPY)、神经降压素(NT)水平变化与心肾功能损害的关系。
短句来源
     The correlation between the changes of plasma neuropeptide Y and neurotensin levels and the damage of cardiac and renal functions in elderly patients with essential hypertension
     老年高血压病患者血浆神经肽Y、神经降压素水平变化与心肾功能损害的相关分析
短句来源
     Results Forty-eight items were included in the questionnaire, including cognitive capacity (12 items), side effects of medicine (9 items), psychological distress (7 items), cardiac and renal dysfuction (9 items), physical capacity (11 items).
     结果48个条目入选,分属认知能力(12个条目)、药物相关不良反应(9个条目)、心理及情绪(7个条目)、心肾等器官功能(9个条目)、体质(11个条目),Cronbach’sα为0.74~0.87。
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      heart and kidney
    BR inhibited both LPO and SMase activities in heart and kidney.
          
    Immunofluorescence studies have localized the receptor on mesangial and vascular smooth muscle cells in human heart and kidney.
          
    Primary cultures initiated from gill, muscle, gut, brain, ovary, heart and kidney were viable for up to eight months and several of the cultures were propagated for multiple passages.
          
    Early detection of primary cytomegalovirus infection after heart and kidney transplantation and the influence of hyperimmune glo
          
    At doses that were active in preventing heart and kidney allograft rejection in the rat (0.01-0.08 mg/kg i.v.), RAPA had no effect on kidney function or rat body weight gain.
          
    更多          
      heart and renal
    Autonomic control of the heart and renal vascular bed during autonomic dysreflexia in high spinal cord injury
          
    A 41-year-old man was admitted to the ICU for heart and renal failure, appearing 24 h after 5 days treatment with 5 F.U.
          
    Storage of organs in solutions with extracellular-type ion compositions might improve graft function and survival not only after lung and liver but also after heart and renal preservation.
          
    In ACI/N rats, tumors of the heart and renal pelvis were detected.
          
    Changes in cAMP formation in mononuclear leukocytes of heart and renal transplant recipients
          
    更多          
      heart-kidney
    The patient was first considered for combined liver-heart-kidney transplantation, but as his cardiac function improved slightly with an intensive dialysis program, combined liver and kidney transplantation was performed.
          
    Reconstructions were made of the heart-kidney-lung complex of these animals.
          
      cardiac and renal
    Vagal and sympathetic reflexes of left ventricular origin on the efferent activity of cardiac and renal nerves on anaesthetized
          
    He suffered from recurrent cerebral infarctions, cerebellar ataxia, deafness, retinopathy, weakness, and cardiac and renal disorders.
          
    Total, cardiac and renal noradrenaline spillover to plasma were 78%, 98% and 66% lower respectively in pure autonomic failure than in normal subjects (p >amp;lt; 0.001).
          
    There have also been studies in essential hypertension, and in diabetic hypertensive patients, on the cardiac and renal effects of ACE inhibitors and MR antagonists, individually and in combination.
          
    Furthermore, loop diuretics may be associated with increased morbidity and mortality due to deleterious effects on neurohormonal activation, electrolyte balance, and cardiac and renal function.
          
    更多          


    The antifertility effect of gossypol was discovered and confirmed by Chinese Scientific workers during therecent years through experiments onanimals and clinical studies.However,It's toxicity to animals and the develop-ment of side effects in some of thesubjects following gossypol administra-tion have also been reported.In orderto analyze the cause and effect rela-tionship between the toxicity and thenature of metabolism of gossypol,wehave conducted experiments designedto obtain information concerning themetabolic...

    The antifertility effect of gossypol was discovered and confirmed by Chinese Scientific workers during therecent years through experiments onanimals and clinical studies.However,It's toxicity to animals and the develop-ment of side effects in some of thesubjects following gossypol administra-tion have also been reported.In orderto analyze the cause and effect rela-tionship between the toxicity and thenature of metabolism of gossypol,wehave conducted experiments designedto obtain information concerning themetabolic fate of gossypol in rats fol-lowing the oral administration of ~(14)C-gossypol acetic acid.Wistar male rats selected for uniformity of weight (105—200g body weight) were placed in individual metaboliccages that were designed to controlexperimental conditions.A single oraldose (94μci/35mg) of radioactive gos-sypol (sp.act.2.665μci/mg) was givento each rat in one group of experi-ments,and in another group the ratswere given labeled gossypol at thedosage of 4.5μci/5mg/day for 2—3 weeksconsecutively.The rats were anesthetized and frozen in acetone cooled to-78℃ with dry ice after varying intervals of time.Whole body andmicro-autoradiography of various or-gan tissues were performed according tothe methods described elsewhere.Ob-servations on the absorption,distribu-tion,accumulation and elimination of~(14)C-gossypol in the rat body as wellas cytopathological examination on theH.E.stained histological sections werecarried out.(1) The whole-body autoradio-graphs demonstrated that the radioac-tivity was located mainly over thegastro-intestinal tract and liver,andthe contents of different parts of the alimentary canal had the highest acti-vity 1-2 days following a single oraldose of ~(14)C-labeled gossypol.At thefourth day,there was a general increasein the activity in all tissues,and theradioactivity in the main visceral organswere rapidly reached to their highestlevel by the 9th day.Strong accumu-lation could be observed in the liver,spleen,kidney,adrenal,pancreas,mu-scle,lymph node,thymus,pitutary,testis and salivary gland in the 9th day autoradiograph.14 days after the administration,the radioactivity in alltissues and organs were markedly de-creased,Only in bones and lymphnodes still contained high activities.Most of the tissues had no detectableor having very low activity 19 daysafter the oral dosing,indicated that nolong term accumulation of gossypolretained in the visceras.(2) The pattern of absorption anddistribution of radioactivity in the bodyof rats that on continuous administra-tion of ~(14)C-gossypol (4.5μci/5mg/day)was basically similar to the rats thatreceived a single oral dose.In both dosage cases,the alimentary canaland liver had the highest activity,followed by the spleen,lymph nodes,heart,kidney,adrenal,bone marrow,salivary gland,thymus,muscle,testis,epididymis,accessory sex glands,pan-creas,lung and urinary bladder inwhich decreased their radioactivitiesin order.Gossypol was usually unde-tectable in the brain and spinal cordor having the lowest activity only,evidently there was blood-brain barrier that protected the brain against passage of gossypol.(3) The organs concerned withelimination of gossypol,spleen,lymphnode,thymus,bone marrow as well asthe reticulo-endothelial cells of variousvisceral organs (i.e.Kupffer cells ofliver,dust and septal cells of lung,lymphocytes,plasma cells and macro-phages in different tissues) showed highconcentrations of radioactivity,sugges-ted that the reticulo-endothelial systemmight play a part in the detoxicationof gossypol in the body.(4) Cytological examination reve-aled that,with the exception of thetestis,no pathological changes weredetectable in the organs and tissuessuch as liver,spleen,heart,kidney,lung,pancreas and bone marrow.Thefact that the testis is the only organthat is damaged at low dosage of gos-sypol and that the radioactivity in thetestis is lower than that in the aboveorgans indicates that the selective orhigher susceptibility of the testis togossypol is not due to concentration ofgossypol in the testis,but to a highervulnerabilit sensitivity of the testis to the drug. (5) The results revealed that there was rather high radioactivity in the endocrine organs concerned with re- production and water and salts metabo- lism (i.e.adrenal gland,pituitary andthe Leydig cells of interstitial tissuesof testis),and a significant but lowamounts of radioactivity in the nucleiof hypothalamus as well as the medianeminence,suggests the possibility thatgossypol might effect in some degreeon the above endocrine hormone secre-tions and on the autonomic nervouscenter as well.(6) The possible cause and effectcorrelation between the clinical sym-ptoms (i.e.The transient weakness,SGPT and ECG changes,hypokalemicand thirsty etc.) and gossypol adminis-tration in connection with the distribu-tion of ~(14)C-gossypol in high amountsin the corresponding tissues and organssuch as skeletal muscle,liver,heart,kidney and salivary gland in this reportwas discussed.

    以~(14)C 标记的醋酸棉酚喂饲成年雄性大鼠,一次口服组的剂量为94微居里/35毫克;累加服药组为4.5微居里/日。分别于服药后不同时期取材制成整体或组织放射自显片。追踪标记棉酚在体内各脏器和组织中的吸收,分布和累积的定位变化动态。相应的组织切片用H、E 染色,作细胞病理学观察。结果摘述如下:1.一次口服标记棉酚后1—2天,标记物主要分布于胃、肠道和肝脏中。4—9天后,心、脾、肺、肾、胰、睾丸、附睾、附属性腺、肾上腺、垂体、胸腺、唾腺、骨髓、淋巴结和肌肉等脏器组织中的活性均迅速达到各自的高峰水平。以后标记物逐渐扩布至全身。14天后,活性明显下降。19天后,活性已不易追踪。未见有长期定位的累积现象。累加服药组的吸收和分布状态与一次服药组基本相同。2.定位于各脏器组织中的标记物活性强度以消化道为最高,其次为肝脏。以下的大体顺序为:脾、淋巴结>心、肾、垂体、肾上腺、骨髓>唾腺、胸腺、肌肉、睾丸、附睾、附属性腺、胰、肺>血液> 膀胱>脑及骨髓。骨质在后期活性略有升高。脑和脊髓的活性反应微弱,可能与血脑屏障的保护性作用有关。3.脾脏、淋巴结、胸腺、骨髓和各脏器中的网状内皮系细胞(枯否氏细胞、尘细胞、淋巴细胞、浆细胞、...

    以~(14)C 标记的醋酸棉酚喂饲成年雄性大鼠,一次口服组的剂量为94微居里/35毫克;累加服药组为4.5微居里/日。分别于服药后不同时期取材制成整体或组织放射自显片。追踪标记棉酚在体内各脏器和组织中的吸收,分布和累积的定位变化动态。相应的组织切片用H、E 染色,作细胞病理学观察。结果摘述如下:1.一次口服标记棉酚后1—2天,标记物主要分布于胃、肠道和肝脏中。4—9天后,心、脾、肺、肾、胰、睾丸、附睾、附属性腺、肾上腺、垂体、胸腺、唾腺、骨髓、淋巴结和肌肉等脏器组织中的活性均迅速达到各自的高峰水平。以后标记物逐渐扩布至全身。14天后,活性明显下降。19天后,活性已不易追踪。未见有长期定位的累积现象。累加服药组的吸收和分布状态与一次服药组基本相同。2.定位于各脏器组织中的标记物活性强度以消化道为最高,其次为肝脏。以下的大体顺序为:脾、淋巴结>心、肾、垂体、肾上腺、骨髓>唾腺、胸腺、肌肉、睾丸、附睾、附属性腺、胰、肺>血液> 膀胱>脑及骨髓。骨质在后期活性略有升高。脑和脊髓的活性反应微弱,可能与血脑屏障的保护性作用有关。3.脾脏、淋巴结、胸腺、骨髓和各脏器中的网状内皮系细胞(枯否氏细胞、尘细胞、淋巴细胞、浆细胞、巨噬细胞等)均呈现高强度的放射活性。表明网状内皮系统可能参与清除棉酚的解毒过程。4.实验中出现较高活性分布的心、肝、脾、肾、肺、胰、骨髓等主要脏器组织均未见有细胞病理改变,而处于中等活性水平的睾丸曲细精管则出现明显的细胞损伤。表明生精上皮细胞对棉酚的敏感性较其他脏器组织为高。毒性反应与剂量水平在一定范围内似无正比相关,而与细胞的敏感性和耐受性的高低则有密切关系。5.与生殖及水盐代谢有关的内分泌腺:肾上腺、垂体和睾丸间质细胞均有较高的放射活性。丘脑下部有关核团及正中隆突亦有微弱的活性定位。提示了棉酚在某种条件下对上述内分泌激素分泌及植物性神经中枢产生影响的可能性。6.本报导联系临床上出现的口干、乏力及过渡性肝功能和心电图异常等毒性症状与相应脏器(唾腺、肌肉、肝及心脏)中标记棉酚活性分布的状态及其间的可能相关予以讨论。

    The ~(14)C-labeled gossypol acetic acid (Sp.Act.2.665μci/mg) used in this experiment and the care and trea-tment of animals were the same asthe previous report.Wistar adult malerats selected for uniformity of weight(about 200g) were placed in individu-al metabolic cages,the feces,urine andexpired air were collected daily formeasurement in one group of animalsfollowing a single oral dose (20μci/7.5 mg) of ~(14)C-gossypol,acetie acid.The animals were anesthetized and kil-led after varying intervals of time (i.e.12...

    The ~(14)C-labeled gossypol acetic acid (Sp.Act.2.665μci/mg) used in this experiment and the care and trea-tment of animals were the same asthe previous report.Wistar adult malerats selected for uniformity of weight(about 200g) were placed in individu-al metabolic cages,the feces,urine andexpired air were collected daily formeasurement in one group of animalsfollowing a single oral dose (20μci/7.5 mg) of ~(14)C-gossypol,acetie acid.The animals were anesthetized and kil-led after varying intervals of time (i.e.12 hours,1,2,4,9 and 14 days,3animals for each time).The bloodwas collected and various organ tis-sues as well as the contents of gastro-intestinal tract were removed,lyophili-zed and weighed ground for liquidscintillation counting by oxygen com-bustion.The free and bound gossypolwere extracted from parts of the aboveorgans,and an analysis of the ratioChanges of the free to bound gossypol(F/B) in the metabolic process wasmade.To the daily dose group,therats were given labeled gossypol atthe dosage of 4.5μci/5 mg daily and were anesthetized and killed 2 weeks,3 weeks,one and two weeks following the withdrawal of the drug (2 animalsfor each time period).Samples of tis-sues and excreta were prepared formeasurement according to the proce-dures as described above.The resultsobtained were summarized as follows.1.It was found that the injected~(14)C-labeled gossypol excreted rapidlythrough feces,urine and expired airfollowing the oral administration.Themain pathway of excretion was fromthe feces,followed by exhaled CO_2 andurine.The amount of ~(14)C eliminated in19 days was 83.50% in feces,11.73%in expired CO_2 and 2.51% in urine. The high excretion rate in feces sug-gested that the circulation and me-tabolism of gossypol through liver-bile-feces were the main pathway of elim-ination and detoxication of the gos-sypol from the body.The exhaledCO_2 appeared to be a metabolic pro-ducts of decarbonylation of formyl-~(14)C-gossypol,and thus,the decarbo-nylation is also one of the pathway ofelimination and dtoxication of gossypol.The low gossypol excretion in urine might be related to their nonionized large molecules of gossypol which were uneasied to pass through the renal glomeruli but were more favored toreabsorption by the renal tubules.2.After a single oral dose of~(14)C-labeled gossypol to male rats at thedosage of 2oμci/7.5mg/animal,thetime taken for the elimination fromthe body of one half of the radioac-tivity was 60 hours (i.e.t1/2=2.5days).According to this half-life valueof excretion,it was possible to cal-culate that the time for the clearanceof gossypol from the body would beat the 23rd day or nearly so,it wasmostly corresponding to our data thatit took 19 days to eliminate 97.74%of the dose from the animal body.3.The data obtained by radioac-tivity measurement of the tissues fromrats fed ~(14)C-labeled gossypol demon-strated that the contents and the epi-thelial lining of gastro-intestinal tractand the liver had the highest specificradioactivity.They reached their peaklevels one day following a single oral dosing.The blood also reached its peak at the first day,however,its specific activity was lower than that of the above visceral organs.The specific radioactivity in the heart,kidney,sple-en,lung,pancreas,diaphragm andtestis were low at the early stages ofdrug adiministration,but rapidly rea-ched to their peak at the 4—9th day.Among the organs,the spleen,kidneyand heart contained more higher speci-fic activity than that of other organs.The endocrine organs such as adrenal,pituitary and thyroid gland also con-tained a fairly high specific activity.Whereas,the hypothalamus,medullaoblongata and spinal cord had the lo-west activity only.The specific acti-vity in various organs decreased ingeneral with the increase of time dura-tion,and dropped to their minimumamount 19 days after the administra-tion.4.The pharmacokinetics of ~(14)C-gossypol in rats that on daily dosingwere almost the same as in the rats ofsingle oral dosing group.Two weeksfollowing the administration,all tis-sues contained radioactivity,with the brain having the lowest activity.The contents and tissues of alimentary canal as well as liver had the highest specific acitivity also,followed by spleen,kidney,heart,lung pancrease,diaphragm and testis.They reached their peak levels after 3 weeks of daily dosing.But thereafter,the specific acitivitysteadily decreased to a lower level.Two weeks after the withdrawal oftreatment,the activity in various tis-sues decreased to their minimum am-ounts.These reaults indicated thatthe pharmacokinetics of ~(14)C-gossypolin both dosage groups were basicallysimilar in distribution pattern,and thedata of quantitative measurement andautoradiographic investigation werecoincided with each other either.5.The results demonstrated thatthe ratios of free gossypol (F) to boundgossypol (B) in the contents and tissuesof different parts of the gastro-intes-tinal tract,liver,and feces were lowat the early stages of drug administr-ation.However,the value of theseratios had progressively increased withtime in both dosing grops.These data suggested that the gossypol might mainly metabolized as a binding form during early stages of medication within rat body.Subsequently,the proportion of free gossypol and other metabolites increased with time throughoxidation,hydrolysis and decarbonyla-tion of the bound gossypol in varioustissues,resulting in soluble or air formand cxcreted via feces,urine and expir-ed air.

    1.大鼠口服标记棉酚后迅速通过粪、尿和呼气排出。粪排出量最多,占口服总剂量的83.5%;其次为呼气中的~(14)CO_2,占11.73%;尿中的含量最少,只占2.51%。经粪排出率最高,表明通过肝脏—胆汁—粪的代谢和排泄是排除体棉酚的主要途径和解毒过程。呼气中的CO_2是棉酚代谢过程中脱羰基作用的产物,这一过程也是体内棉酚解毒过程的一种方式。尿中排泄量低,可能与棉酚的非离子化态大分子结构不易通透肾小球而有利于肾小管的重吸收有关。2.大鼠一次口服标记棉酚20微居里/7.5毫克后,从体内排出总剂量的半量的时间(t(1/2))为2.5天,按排泄半量规律推算,从体内清除所需的时间约为服药后的第23天左右,与我们在第19天实测的体内残留率比例大体相符。3.分布于脏器组织中的标记棉酚的定量测定结果表明:胃、肠道内容物,胃、肠道组织和肝脏中的比活性最高,在服药后1天即到达它们的高峰强度水平。血液的活性在1天内亦到达高峰。但其比活性较上述脏器组织为低。心、肾、脾、肺、胰、膈肌和睾丸等主要脏器组织的比活性在服药后的初期较低。到第4天才达到它们各自的高峰水平。其中脾、肾、心的比活性较其他脏器为高,内分泌腺中的肾上腺、垂体和甲状腺...

    1.大鼠口服标记棉酚后迅速通过粪、尿和呼气排出。粪排出量最多,占口服总剂量的83.5%;其次为呼气中的~(14)CO_2,占11.73%;尿中的含量最少,只占2.51%。经粪排出率最高,表明通过肝脏—胆汁—粪的代谢和排泄是排除体棉酚的主要途径和解毒过程。呼气中的CO_2是棉酚代谢过程中脱羰基作用的产物,这一过程也是体内棉酚解毒过程的一种方式。尿中排泄量低,可能与棉酚的非离子化态大分子结构不易通透肾小球而有利于肾小管的重吸收有关。2.大鼠一次口服标记棉酚20微居里/7.5毫克后,从体内排出总剂量的半量的时间(t(1/2))为2.5天,按排泄半量规律推算,从体内清除所需的时间约为服药后的第23天左右,与我们在第19天实测的体内残留率比例大体相符。3.分布于脏器组织中的标记棉酚的定量测定结果表明:胃、肠道内容物,胃、肠道组织和肝脏中的比活性最高,在服药后1天即到达它们的高峰强度水平。血液的活性在1天内亦到达高峰。但其比活性较上述脏器组织为低。心、肾、脾、肺、胰、膈肌和睾丸等主要脏器组织的比活性在服药后的初期较低。到第4天才达到它们各自的高峰水平。其中脾、肾、心的比活性较其他脏器为高,内分泌腺中的肾上腺、垂体和甲状腺的比活性亦较高。而神经系统中的丘脑下部、延脑和脊髓的比活性则均较低。各脏器的比活性随时间而递减下降,到第19天后均下降至微量水平。4.连续给药组脏器组织中的标记棉酚分布动态与上述一次给药组基本相同。连续每日服药2周后,所有组织均出现放射活性,其中脑组织的比活性最低,胃、肠道壁及其内容物以及肝的比活性最高。其次为脾、肺、心、肾、胰、膈肌和睾丸。这些主要脏器在连续服药3周后达到各自的比活性高峰水平。以后即逐渐下降。停药2周后均下降至微量水平。上述结果表明两个给药组的棉酚分布的变化动态基本一致,定质和定位的结果亦基本相符。5.棉酚的代谢:两个服药剂量组的胃、肠道组织,肝组织,胃、肠道内容物和粪中的游离棉酚(F)和结合棉酚(B)的比值,在服药后的初期均较小。以后随时间而逐渐递增。反映了棉酚在体内的早期代谢形式以结合棉酚为主,以后在脏器组织中通过氧化、分解或转化,游离棉酚及其代谢产物的比例增加,通过粪、尿和呼气(脱羰基后的CO_2)排出。

    The present study was designed to investigate the effect of gossypol on the distribu tion kinetics and excretions of ~(42)K in rats by using autoradiographic and quantitative measurement techniques. After oral administration of gossypol to male rats at a dosage of 5~10 mg/day for 4~17 weeks, the animals were subjected to an intravenous(via vena sublingualis) injection of a dose of ~(42)K proportional to their body weight, and then one group of animals were anaesthetized and frozen in acetone cooled to -78℃ with...

    The present study was designed to investigate the effect of gossypol on the distribu tion kinetics and excretions of ~(42)K in rats by using autoradiographic and quantitative measurement techniques. After oral administration of gossypol to male rats at a dosage of 5~10 mg/day for 4~17 weeks, the animals were subjected to an intravenous(via vena sublingualis) injection of a dose of ~(42)K proportional to their body weight, and then one group of animals were anaesthetized and frozen in acetone cooled to -78℃ with dry ice at varying time intervals after injection for whole-body and micro-autoradiographical observation; and another group the animals were killed at the same time intervals with samples of blood and tissues removed for analysis. It was found that the viscera take up ~(42)K rapidly after injection, among them the kidney, heart, spleen, pancreas, and the gastrointestinal tract appeared to be the earliest to reach their peak levels of radioactivity with their rapid uptake rates, next followed by cartilage, skeletal muscle, liver, adipose tissue, Lung, skin and testis the erythrocytes and brain tissues were took up most slowly. The plasma specific radioactivity decreased at about 30 minutes following injection to a level lower than that of the heart kidney and skeletal muscle, and thereafter maintained in a state of relative equilibrium. The pattern of distribution, kinetics and the uptake rates of ~(42)K radioactivity in viscera and blood of gossypol treated rats did not differ significantly from that of the controls. However, a tendency of somewhat higher excretion rates of urine ~(42)K in the gossypol treated rats was evident, among them a very small proportion of animals were found to be with loner ~(42)K activity in viscera and plasma concomitant with a higher rate of urine ~(42)K excretion. This phenomenon suggested the possibility that gossypol might induce renal potassium depletion. The effect of gossypol on potassium metabolism and the possible mechanism of renal K depletion induced by gossypol were analyzed and discussed.

    本实验用同位素~(42)钾(~(42)KGl)示踪放射自显影定位以及定量测定方法研究棉酚对大鼠钾代谢的影响及其与低血钾的可能关系。动物连续喂服棉酚(剂量为5~10毫克/日/鼠)4-17周后按体重从舌下静脉注射50~100微居里~(42)KGl溶液。于注射后不同时距冷冻动物制成放射自显片观察,另取心、肾、骨骼肌、血和尿进行γ线闪烁定量测定。实验结果表明:(1)~(42)K注入体内后迅速与体内钾交换而摄入于脏器组织中,其中肾、心、脾、胰及胃肠道管壁出现放射活性高峰的时间最早,摄入速度最快。以下依次为软骨、肌肉、肝、皮下脂肪、肺、皮肤及睾丸,而以红细胞和脑脊组织的摄入速度最慢。血浆~(42)K的放射强度在注入体内30分钟后即降至较心、肾和肌肉为低的相对恒定水平。(2)大鼠服棉酚后,各脏器和血液中~(42)K的单位放射强度、摄入速度和分布动态,一般与对照组无明显差异,但肾脏的尿排~(42)K率则有增高倾向。其中少数动物在尿~(42)K排出率增高的同时,血浆和脏器~(42)K均明显下降。提示棉酚引起肾性失钾的可能性。本文对棉酚影响K代谢及引起肾性失钾的可能机理予以分析和讨论。

     
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