Objective To observe the removal of tumor necrosis factor-α (TNF-α ), interleukin-6 (IL-6) and endothelin-1 (ET-1) in continuous renal replacement therapy (CRRT) on hemorrhagic fever with renal syndrome (HFRS) patients, and investigate the effect of inflammatory mediators on HFRS.
There were 105 cases in total, with 4 cases died. The cases were found all over the district, including 11 towns and 70 administrative villages. The cumulative incidence rate was 2.90 / 100000, the mortality rate was 0.11/10 000, and the case fatality rate was 3.81%.
These observations suggest that the dynamic changes of IL-6 concentrations were in accord with the developments ofHFRS and that IL-6 might be one of the factorsleading to the pathologic lesions of HFRS.
Intracerebral infection of hemorrhagic fever with renai syndrome(HF-RS ) virus proves highly pathogenic for newborn mice, but harmless for adult mice. We observed that cyclophosphamide ( CY )-immunosuppressed adult mice were Susceptible to acute infection leading to death.4-8 week old C57 mice or outbred Kunming strain mice inoculated in-tracerebrally with HFRS virus A-16 strain and immunosuppressed with four 50mg/kg CY doses at days -1, +1, + 2, + 4 (day O:virai infection), developed a lethal disease(94% mortality...
Intracerebral infection of hemorrhagic fever with renai syndrome(HF-RS ) virus proves highly pathogenic for newborn mice, but harmless for adult mice. We observed that cyclophosphamide ( CY )-immunosuppressed adult mice were Susceptible to acute infection leading to death.4-8 week old C57 mice or outbred Kunming strain mice inoculated in-tracerebrally with HFRS virus A-16 strain and immunosuppressed with four 50mg/kg CY doses at days -1, +1, + 2, + 4 (day O:virai infection), developed a lethal disease(94% mortality ) , and were mori-bund by 14-18 days postinfection. Specific virai antigen was regularly found in brain, lung, spleen, liver and kidney by indirect IF assay. His-topathologic study showed vascular changes including hyperemia, hemorr-hage, exudate, degeneratiem and necrosis of parenchymal tissues of brain, lung, liver and kidney. Based on these findings, We suggest that C57 mice or kunming strain mice may be used as an animal modei for inves-tigation of the disease.
The interleukin-6 (IL-6) concentrations in 102 serum samples sequentially collectedfrom 36 patients with hemorrhagic fever with renalsyndrome (HFRS) were determined by double antibody sandwich ELISA. It was observed that serumIL-6 concentrations in HFRS patients were elevated6 days before onset of disease and at the fever and oliguria stages of the disease in comparison with normal controls. The IL-6 concentrations in HFRSpatients reached peak value at day 6 after onset of disease and began to decrease from...
The interleukin-6 (IL-6) concentrations in 102 serum samples sequentially collectedfrom 36 patients with hemorrhagic fever with renalsyndrome (HFRS) were determined by double antibody sandwich ELISA. It was observed that serumIL-6 concentrations in HFRS patients were elevated6 days before onset of disease and at the fever and oliguria stages of the disease in comparison with normal controls. The IL-6 concentrations in HFRSpatients reached peak value at day 6 after onset of disease and began to decrease from day 7,serum IL-6 concentrations greatly increased at fever stage,peaked at oliguria stage. There were significant differences among the IL-6 concentrations in mild.middle, severe and grave type of patients with HFRS. Serum IL-6 levels were positively associatedwith urine protein in HFRS patients. These observations suggest that the dynamic changes of IL-6 concentrations were in accord with the developments ofHFRS and that IL-6 might be one of the factorsleading to the pathologic lesions of HFRS. IL-6 was closely related to the seventy of HFRS and thus it could reflect the prognosis and outcome as well as the seventy of renal impairment of HFRS patients.
To assess the value of reverse transcription polymerase chain reaction (RTPCR) and indirected ELISA for disagnosising patients sera with hemorragic fever with renal syndrome(HFRS).Methods RTPCR was used to detected hantavirus(HV) RNA and specific IgM antibody was detected by indirected ELISA in sera of patients with HFRS in different phase.Results The total positive was 847%,according to the days after onset of disease the HVRNA detection rate was 100%,60%,33.3% on the days of less the 7,8~14 and more than...
To assess the value of reverse transcription polymerase chain reaction (RTPCR) and indirected ELISA for disagnosising patients sera with hemorragic fever with renal syndrome(HFRS).Methods RTPCR was used to detected hantavirus(HV) RNA and specific IgM antibody was detected by indirected ELISA in sera of patients with HFRS in different phase.Results The total positive was 847%,according to the days after onset of disease the HVRNA detection rate was 100%,60%,33.3% on the days of less the 7,8~14 and more than 15 respectively.On the other hand,HVIgM detection rate was 64%,90%,66.6% respectively,the total IgM detection rate was 70.05%.The difference was nonsignificant (P>0.05).Conclusions RTPCR and ELISA were specific,sensitive methods for diagnosing HFRS patients.They can supply other than replace each other for raising accurately diagnositic rate.
肾病综合征出血热
nephrotic syndrome with hemorrhagic fever
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