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肝纤维化治疗
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  treating liver fibrosis
     Strategy for treating liver fibrosis by integration of the disease and its syndromes in traditional Chinese medicine
     中西医病证结合抗肝纤维化治疗的策略
短句来源
     Therefore, treating liver fibrosis to cure chronicle hepatitis should target on the causes, protect liver cells and enhance patient's immunologicalabilities.
     所以慢性肝炎抗肝纤维化治疗应从消除病因、抑制炎症、保护肝细胞、阻止纤维生成、加强纤维降解等方面着手,有望防治肝纤维化和肝硬化。
短句来源
     The strategy for treating liver fibrosis in chronic hepatitis patients includes dispelling the etiological factors, inhibiting the inflammatory reaction, decreasing the sedimentation of extracellular matrix, accelerating the degradation of extracellular matrix, improving the microcirculatory and metabolic disturbance, and ameliorating the complicating diseases, etc.
     慢性肝炎抗肝纤维化治疗的总体策略应包括祛除病因 ,抑制炎症反应 ,减少细胞外基质 (extracellularmatrix ,ECM )的增生与沉积 ,促进ECM降解以及改善微循环与代谢障碍 ,减少并发症等多个环节。
短句来源
     Effective etiological treatment should be considered as the first step in treating liver fibrosis in chronic hepatitis patients, and inhibiting the inflammatory reaction is one of the most important tactics for suppressing the development of fibrosis and for decreasing the incidence rate of liver cancer in chronic hepatitis patients.
     就疾病的总体而言 ,有效的病因治疗是慢性肝炎抗肝纤维化治疗的首要对策 ,而抑制炎症反应是抑制纤维化进展、降低慢性肝炎肝癌发生率的重要策略。
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  “肝纤维化治疗”译为未确定词的双语例句
     Conclusion Quercetin may have an inhibitory effect on the signal pathways of TGFβ1, including the expression of TGFβ1, FN and CTGF.
     结论 槲皮素可抑制 TGFβ1信号通路 ,包括抑制 TGFβ1、FN表达及 CTGF的基因表达 ,具有潜在的抗肝纤维化治疗作用。
短句来源
     TGFβ signal pathway and anti TGFβ strategies for treatment of liver fibrosis
     TGFβ信号转导通路及以其为靶点的肝纤维化治疗
短句来源
     Tetrandrine was used to treat liver fibrosis induced by CCl4 in rats,and its action was compared with colchicine.
     用CCl4造成大鼠肝纤维化模型,用汉防己甲素进行抗肝纤维化治疗,并与传统抗肝纤维化药物秋水仙碱进行比较。
短句来源
     Conclusion Interferon α 2α is an effective drug in treatment of the liver fibrosis in chronic hepatitis C.
     结论 干扰素α 2α对慢性丙型肝炎的抗肝纤维化治疗有较好的疗效
短句来源
     We suggested the TGF β 1 may be a mark of liver fibrosis and the blocker of the TGF β 1 may be a important drug in the treatment of liver fibrosis.
     TGFβ1拮抗剂有望成为肝纤维化治疗的重要药物。
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  相似匹配句对
     Therapy for liver fibrosis
     纤维化治疗
短句来源
     Incidence rate of liver hepatic fibrosis was added up.
     统计纤维化的发生率。
短句来源
     Adiponectin and Liver Fibrosis
     脂联素与纤维化
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     the toxic action of PZA on liver is greater than that of other antitubercular drugs.
     ?
短句来源
     Gene therapy for liver fibrosis
     纤维化的基因治疗
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AIM To study on the effects of cordyceps sinensis in liver fibrosis,and its mechanism.Colchicine was used as control therapy.METHODS Liver fibrosis was induced by CCl4 in Wistar rats.The animals were treated with cordyceps sinensis)n=24),colchicine)n=24),and normal saline)n=24),respectively.The rats were killed in batches at 4.8.12.14 weeks.Serum procollagen Ⅲ(PCⅢ)was measured by radioimmoassay and liver tissue was observed pathologically.Dynamic changes of type I,Ⅲ,Ⅳ collagens and desmin-positive cells in liver...

AIM To study on the effects of cordyceps sinensis in liver fibrosis,and its mechanism.Colchicine was used as control therapy.METHODS Liver fibrosis was induced by CCl4 in Wistar rats.The animals were treated with cordyceps sinensis)n=24),colchicine)n=24),and normal saline)n=24),respectively.The rats were killed in batches at 4.8.12.14 weeks.Serum procollagen Ⅲ(PCⅢ)was measured by radioimmoassay and liver tissue was observed pathologically.Dynamic changes of type I,Ⅲ,Ⅳ collagens and desmin-positive cells in liver tissue were studied by immunohistochemical technique.RESULTS Cordyceps sinensis and colchicine were both able to markedly reduce serum PCⅢ level,and reduce Ⅰ,Ⅲ,Ⅳ collagen deposition in liver tissue,and then prevent the formation of pseudo-lobule and cirrhosis.Desmin-positive cell number in liver tissue in two treated groups was much lower than that in normal saline one.CONCLUSION Both Cordyceps sinensis and colchicine had satisfactory effect on hepatic fibrosis.They can inhibit proliferation and transition of hepatic fat-storing cells)desmin-positive cells),so as to reduce collagen synthesis and deposition in liver.Cordyceps sinensis may be a useful anti-fibrotic drug in chronic liver diseases as it has no side-effect.

目的:以秋水仙碱为对照,观察冬虫夏草对实验性肝纤维化的治疗效果,并探讨其机理。方法:用CCl_4诱导大鼠肝纤维化,分别以生理盐水、秋水仙碱、冬虫夏草各24只进行治疗。实验第4,8,12,14周分批处死动物,测量血清Ⅲ型前胶原含量,取肝组织进行病理观察,并用免疫组化技术观察肝组织Ⅰ,Ⅲ,Ⅳ型胶原,结蛋白阳性细胞的动态变化。结果:两种药物均能明显降低血清Ⅲ型前胶原含量,并减轻肝组织Ⅰ,Ⅲ,Ⅳ型胶原的沉积,最终防止肝假小叶及肝硬化形成。动物经药物治疗后肝组织内结蛋白阳性细胞数均明显低于生理盐水组。结论:冬虫夏草与秋水仙碱均有良好的抗肝纤维化作用,它们能抑制肝内储脂细胞(结蛋白阳性细胞)的增殖和转化,从而减少胶原合成及在肝窦周沉积。冬虫夏草无毒副作用,可能是一种有前途的抗肝纤维化药物。

In fibrosis of liver due to its inflammatory lesions, the HA, ADA, GST. are much higher than that of the normalcy. This abnormality occurs with increasing

肝炎肝纤维化者血清透明质酸、腺苷脱氨酶、谷光甘肽—S—转移酶显著高于健康人,并按肝郁脾虚型、气滞血瘀型、热郁血瘀型依次递增,各证型间有非常显著差异。经中医辨证治疗后,肝功能改善,前二项指标数值下降。证明中医药对乙型肝炎肝纤维化治疗有效。

Aim: In order to inquire into the action of Astragalus membranaceus on anti-hepatic fibrosis. Methods:①The rat fibrosis model was induced by albumin immune complex.②A herbal compound 861, with Salvia miltiorrhiza and Astragalus membranaceus being its chief component, was used as control. ③Optical and electron microscopic analysis, immunohistochemical staining of collagen, and biochemical determination of hepatic collagen content were used as research means. Results: The severity of fibrosis and ultrastructural...

Aim: In order to inquire into the action of Astragalus membranaceus on anti-hepatic fibrosis. Methods:①The rat fibrosis model was induced by albumin immune complex.②A herbal compound 861, with Salvia miltiorrhiza and Astragalus membranaceus being its chief component, was used as control. ③Optical and electron microscopic analysis, immunohistochemical staining of collagen, and biochemical determination of hepatic collagen content were used as research means. Results: The severity of fibrosis and ultrastructural changes were significantly reduced by Astragalus membranaceus. Image analysis indicated significant attenuation of total collagen and collagen type Ⅰ、Ⅲ and Ⅴ content after Astragalus membranaceus treatment. Biochemical determination of hepatic collagen content, calculated from hydroxyproline concentration, Showed significant reduction by Astragalus membranaceus, moreover, it showed more marked suppression of tatal collagen by herbal compound 861 than Astragalus membranaceus alone. Conclusion: The combined use of Astragalus membranaceus with other herbs according to traditional medicine theory is rational and may strengthen the antifibrotic effect.

目的:研究中药黄芪的抗肝纤维化作用,对比观察中药861合剂及其组分之一黄芪对肝纤维化的治疗作用。方法:采用大鼠白蛋白免疫损伤性肝纤维化动物模型,通过光镜、电镜观察、胶原免疫组化染色及胶原蛋白生化测定。结果,黄芪可使大鼠肝纤维化程度及超微结构的病理改变明显减轻,减少总胶原及Ⅰ、Ⅱ、Ⅴ型胶原在肝内的沉积,随着疗程的延长,作用更为显著。同时以肝总胶原蛋白含量为指标,黄芪的抗肝纤维化作用不如中药861合剂。结论:黄芪与其它成份组成中药复方可加强抗纤维化作用。

 
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