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   细胞因子基因 的翻译结果: 查询用时:0.037秒
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细胞因子基因
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  cell factor gene
     Amplification of the 1.42 kb 5’ flanking regulation of the stem cell factor gene using polymerase chain reaction
     干细胞因子基因5′旁侧1.42kb调控序列的PCR扩增
短句来源
     This method was applied to investigate the partial footprinting map of 5′ flanking region from -1190 to -273 of human stem cell factor gene.
     该方法被应用对人干细胞因子基因 5′旁侧 - 1190~ - 2 73区域的DNA足纹部分作图
短句来源
     Structure analysis and bioactivity study of human stem cell factor gene expressed in Escherichia coli
     人干细胞因子基因大肠杆菌表达产物结构分析及活性研究
短句来源
     Study on high-level expression of human stem cell factor gene in E. coli
     影响人干细胞因子基因高效表达的因素探讨
短句来源
     Cloning and Function on 5′ Flanking Sequence of Human Stem Cell Factor Gene
     人干细胞因子基因5′旁侧序列的克隆和功能研究
短句来源
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  cytokine gene
     Establishment of detecting methods of Th1/Th2 cytokine gene
     Th1/Th2相关细胞因子基因检测方法的建立
短句来源
     Many cytokine gene, including IL-2,IL-4,IL-6,IL-7,IL-12,GM-CSF,TNF α,IFNγ, has been approved to apply in the pre-clinic investigation by RAC/FDA.
     许多细胞因子基因(包括IL—2、IL—4、IL—6、IL—7、IL—12、GM—CSF、TNF-α、IFN-γ)被RAC/FDA批准试用于临床,进入Ⅰ、Ⅱ期临床前研究。
短句来源
     Effects of Th1 cytokine gene on anti-CFP10 antibody production in BALB/c mice induced by Mycobacterium tuberculosis DNA vaccine
     Th1型细胞因子基因对结核分枝杆菌基因疫苗诱导BALB/c小鼠产生抗CFP10抗体水平的影响
短句来源
     Effects of Trichinella spiralis on Th1/Th2 type cytokine gene expresion in mice with TNBS colitis
     旋毛虫对三硝基苯磺酸诱导肠炎小鼠Th1/Th2类细胞因子基因表达的影响
短句来源
     Relationship between cytokine gene polymorphisms and acute rejection after renal transplantation
     细胞因子基因多态性与肾移植急性排斥反应的关系
短句来源
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  cytokine genes
     COMPARISON OF CYTOKINE GENES AND ONCOGENES EXPRESSION BETWEEN PATIENTS WITH ACUTE MYELOGENOUS LEUKEMIA M2a AND M2b
     急性髓系白血病M2a和M2b患者细胞因子基因和癌基因表达比较
短句来源
     Effect of burn injury on the expression of cytokine genes in skin
     烫伤对小鼠皮肤内炎性细胞因子基因表达的影响
短句来源
     Pro-and anti inflammatory cytokine genes expression and sepsis induced liver injury in mice
     促炎症和抗炎症细胞因子基因表达与脓毒症小鼠肝损伤的关系
短句来源
     Recently, research in cytokine genes as DNA vaccine adjuvants, became popular and absorbed more and more attention because of its construct conveniently and function effectively.
     近年来,将细胞因子基因作为DNA疫苗佐剂,由于其简便性与有效性,亦受到了人们愈来愈多的关注与重视。
短句来源
     Cloning and sequencing of three porcine cytokine genes
     猪三种细胞因子基因的克隆与序列测定
短句来源
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  “细胞因子基因”译为未确定词的双语例句
     Gene expressions of Th1 and Th2 cytokines were not related with the clinical stages and pathologic types(P=0.925,0.752,0.868,0.780,0.949).
     且Th1和Th2类细胞因子基因表达水平与肺癌的病理分型及临床分期无相关性(P值分别为0.925,0.752,0.868,0.780,0.949)。
短句来源
     1,25(OH)2D3 modulates Th cells differentiation regulating gene expression profiles of Th cytokines and transcription regulators.
     1,25(OH)2D3主要通过调节细胞因子基因和Th细胞分化信号通路中转录因子基因表达。
短句来源
     Influence and significance of chemotherapy to the gene expression of Th1 and Th2 cytokines in colon carcinoma
     化疗对结肠癌Th1和Th2类细胞因子基因表达的影响及意义
短句来源
     Changes of T-helper1/T-helper2 Special Cytokine mRNA Expression during 5 Weeks Incremental Load Training
     5周递增负荷运动训练过程中T-helper1和T-helper2相关细胞因子基因表达的变化
短句来源
     To investigate activation of nuclear factor-κB(NF-κB)and the ex pression of inflammatory cytokines in lipopolysaccharide-induced RAW264.7 cells stimulated with extract of Ginkgo biloba(EGb761).
     探讨银杏叶提取物(EGb761)对内毒素(LPS)诱导RAW264.7细胞核因子-κB(NF-κB)活化及炎性细胞因子基因表达的调节,为银杏叶提取物的临床运用提供理论依据.
短句来源
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  cell factor gene
Stem cell factor gene expression in mouse testis at different ages.
      
These studies on the human SCF promoter are important in our understanding of how stem cell factor gene expression is regulated in the testis.
      
  cytokine gene
Organ-Specific Cytokine Gene Expression in Sepsis - an Experimental Study in a Two-Hit Septic Model
      
The ratio between cytokine gene expression and GAPDH expression was calculated.
      
Such studies involve major histocompatibility complex, cytokine gene polymorphisms, T cell studies, and microarray-based expression technology.
      
We have developed a murine model of this vascular targeting approach where transfection of the tumor cells with a cytokine gene causes them to induce the expression of an experimental marker (MHC Class II) on tumor endothelium.
      
T cell antigen receptor (TCR) ligation triggers a cascade of intra-cellular signaling events that culminate in T cell activation, cytokine gene expression, differentiation, or apoptosis.
      
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  cytokine genes
Association of polymorphisms of cytokine genes (IL1B, IL1RN, TNFA, LTA, IL6, IL8, and IL10) with chronic obstructive pulmonary d
      
These transcriptional factors have been shown to be necessary for a variety of expressions of cytokine genes.
      
An overview of genetic associations of cytokine genes with infectious disease is presented, together with discussion of recent studies in a number of infectious diseases including hepatitis, HIV, malaria, and sepsis.
      
In human lupus, casecontrol studies have established associations of SLE with certain major histocompatibility class II alleles, complement deficiencies, and polymorphisms of Fcψ receptor genes, a complement-related gene, and cytokine genes.
      
The recent interest in the genetic polymorphisms of cytokine genes and their association with juvenile idiopathic arthritis has provided association with a number of cytokine alleles.
      
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Under stimulation of PHA,PHA + TPA,or PHA + PTS the time ke-netics of DNA,RNA,protein synthesis and lymphokine secretion by human lymph node cell expressed different responses. The PTS did not increase the DNA and RNA synthesis, but increased the protein synthesis ( 60% ) . TPA increased the RNA synthesis ( 18% ) , therefor increased the protein synthesis ( 40% ) . Both of TPA and PTS increased the production of 5 kinds of lymphokines (IL-1 , IL-2 , IL-3, BCGF, TFNr). We infer that PTS and TPA increase the lymphokine...

Under stimulation of PHA,PHA + TPA,or PHA + PTS the time ke-netics of DNA,RNA,protein synthesis and lymphokine secretion by human lymph node cell expressed different responses. The PTS did not increase the DNA and RNA synthesis, but increased the protein synthesis ( 60% ) . TPA increased the RNA synthesis ( 18% ) , therefor increased the protein synthesis ( 40% ) . Both of TPA and PTS increased the production of 5 kinds of lymphokines (IL-1 , IL-2 , IL-3, BCGF, TFNr). We infer that PTS and TPA increase the lymphokine production through different gene regulation. TPA Promotes the translation of lymphokine mRNA。

观察人淋巴结细胞在植物血凝素(PHA,1%)、PHA+乙酸豆寇佛波醇(TPA,10μg/L)或PHA+人参三醇型皂甙(PTS,10mg/L)刺激下,DNA、RNA和蛋白质合成以及细胞因子诱生的时间动力学。结果表明,PTS通过促进PHA活化淋巴结细胞的蛋白质合成(160%)而促进5种细胞因子(IL-1、IL-2、IL-3、BCGF、IFNr)诱生,TPA则通过促进RNA合成(118%)和蛋白质合成(140%)最终促进上述5种细胞因子诱生。我们推测TPA促进了各种细胞因子基因的转录,而PTS则促进了各种细胞因子mRNA的转译。

Kinetics of production of IL-1, IL-6 and TNFa induced by endotoxin from human monocytes as well as their relationships were studied using cytokine bioassays and immu nocytochemical staining methods. The results showed that accu mulation of IL-1 β, IL-6 and TNFa molecules in cytoplasma and their release into supernatants had different kinetic patterns from each others, reflecting the difference in gene activation, transcription, translation and release of these three cytokines. In addition, only part of monocytes...

Kinetics of production of IL-1, IL-6 and TNFa induced by endotoxin from human monocytes as well as their relationships were studied using cytokine bioassays and immu nocytochemical staining methods. The results showed that accu mulation of IL-1 β, IL-6 and TNFa molecules in cytoplasma and their release into supernatants had different kinetic patterns from each others, reflecting the difference in gene activation, transcription, translation and release of these three cytokines. In addition, only part of monocytes synthesize IL-1 β, IL-6 and TNFα, suggesting the presence of different cytokineproducing monocyte subsets.

采用生物活性测定法和免疫细胞化学染色法.观察了内毒素诱导正常人单核细胞产生白细胞介素(?).白细胞介素6和肿瘤环死因子的动态过程.以及彼此之间的相互关系。结果表明,三种细胞因子的胞浆内累积和释放均有各自不同的时相变化.反映出这三种细胞因子基因活化、转录、翻译和释放过程的差异.此外.仅部分单核细胞合成这三种细胞因子.提示可能存在合成细胞因子的不同单核细胞亚群

In the present study,we have established an experimental model of human IL-6 gene thera-py with fibroblasts as cellular delivery and then observed its in vivo IL-6 level at different time.650-bp-long hIL-6 eDNA was inserted into Xho Ⅰ site of expression vector BCMGNeo carryingNeo~R gene and the resulting recombinant expression vector BCMGNeo-IL-6 was identified by re-striction enzyme digestion.BCMGNeo-IL-6 was transfected into NIH3T3 fibroblast cells by cal-cium phosphate coprecipitation method.A fibroblast...

In the present study,we have established an experimental model of human IL-6 gene thera-py with fibroblasts as cellular delivery and then observed its in vivo IL-6 level at different time.650-bp-long hIL-6 eDNA was inserted into Xho Ⅰ site of expression vector BCMGNeo carryingNeo~R gene and the resulting recombinant expression vector BCMGNeo-IL-6 was identified by re-striction enzyme digestion.BCMGNeo-IL-6 was transfected into NIH3T3 fibroblast cells by cal-cium phosphate coprecipitation method.A fibroblast cell clone secreting IL-6 activity in the cul-ture supernatants,and then analysed by Southern blot.The cell clone was expanded in vitro,en-capsulated into collagen and implanted i.p.into mice.Serum IL-6 could be detected even after15 days implantation.These results demonstrated that fibroblast cells could mediate in vivotransfer and efficient expression of hIL-6 gene,suggesting that this kind of gene therapy is reli-able.

细胞因子基因治疗是近年来生物治疗的重要进展。本文以人IL-6基因为治疗目的基因,以成纤维细胞为载体细胞,建立了人IL-6基因疗法的实验模型,并动态观察了其体内IL-6分泌水平.将650bp的人IL-6 cDNA 插入到携有Neo~R 基因的表达载体BCMGNeo 的Xho I 位点上,对此重组表达载体进行限制性酶切鉴定。用磷酸钙共沉淀法将BCMGNeo-IL-6转入NIH3T3成纤维细胞中,通过G418抗性筛选、有限稀释和上清中IL-6活性的测定,从多株阳性克隆中筛选到一株高分泌IL-6(184.6U/ml)的克隆株。对此阳性克隆进行了Southern 杂交分析。将此阳性克隆体外扩增、包裹入胶原中,然后移植入小鼠腹腔内,可从小鼠血清中(直至移植后15天)检测出IL-6,明成纤维细胞能成功地将IL-6基因导入体内并有效表达,证明该基因疗法是可行的。

 
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