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hp序列
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  “hp序列”译为未确定词的双语例句
     The env gene of ALV-J is very unique, has very low homology to other ALV subgroups, however, exhibits 97% identity to EAV-HP sequence, which is existed in the normal chicken's genome.
     ALV-J env基因与其它亚群的同源性很低,但是与正常存在于鸡体内的内源性EAV-HP序列有高达97%的同源性。
短句来源
     There were 836 767 sequences ana-lyzed with BLAST, in which those with homogenicity of 40% with the identified CB sequence were categorized into H.pylori se-quences.
     BLAST分析了836 767个序列,与其同源性达40%的均为Hp序列
短句来源
     In the HP model, the number of sequences of conformations for a protein of chain length N is 2 N+1 , and the number of sequences with unique ground state may be expressed as N S:N S =a×2 N+1 (a=0 025). In these HP sequences, the sequences with 40%~60% in the percentage of H residue have a large probability of emergence.
     在HP模型中对于链长为N的紧密高分子链 ,存在着 2 N + 1 个不同的HP序列 . 我们发现可以折叠成基态且简并度为 1的蛋白质分子的HP序列数目NS 为NS =a× 2 N+ 1   (a =0 0 2 5 ) ,对应的HP序列中 ,疏水基团 (H)数目的含量为 4 0 %~ 6 0 %的序列出现的几率最大 .
短句来源
     Statistical properties of folding sequences of two-dimensional compact protein were investigated by using the enumeration calculation method.
     采用完全计数法,研究了二维紧密蛋白质链在不同HP序列时的构象性质,特别是具有唯一基态能量的折叠序列的性质.
短句来源
     1675bp.
     1207~1675hp序列编码的肽链中。
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  相似匹配句对
     HP.
     HP.
短句来源
     p sequences or R.
     p序列和R.
短句来源
     The expressivegene fragment was 333bp long .
     其寻达序列长 333hp
短句来源
     It generates 2~~(s·g(n,s)) M sequences of span.
     g(n,s)个n级M序列
短句来源
     1675bp.
     1207~1675hp序列编码的肽链中。
短句来源
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  hp sequence
For PERM we consider the expected time to solve a given problem which has captured the effect of different starting point of the given HP sequence.
      


Objective To clone the conserved regions of the genes encoding the 4 adhesins (BabA, AlpA, AlpB and HopZ) of Helicobacter pylori(H.pylori) and analyze their sequences and biological information, thus facilitating further research in the molecular mechanism and immunogenicity of H.pylori adhesins. Methods Common conserved region (designated as CB) was identified from the confirmed sequences (by ANTHEPROT V4.3c software package) of the 4 adhesin proteins. Their DNA sequences were deduced, according to which...

Objective To clone the conserved regions of the genes encoding the 4 adhesins (BabA, AlpA, AlpB and HopZ) of Helicobacter pylori(H.pylori) and analyze their sequences and biological information, thus facilitating further research in the molecular mechanism and immunogenicity of H.pylori adhesins. Methods Common conserved region (designated as CB) was identified from the confirmed sequences (by ANTHEPROT V4.3c software package) of the 4 adhesin proteins. Their DNA sequences were deduced, according to which primers specific to CB were designed for subsequent PCR, and the products were inserted directionally into pET-22b(+) vector to construct recombinant clones of the conserved region. The DNA sequences were determined with the basic local alignment sequence tool (BLAST) and the biological properties analyzed with ANTHEPROT V4.3c software package. Results The recombinant plasmid containing the CB sequence was constructed. DNA sequencing showed an open reading frame of 588 bp in length, encoding 195 amino acids. The homogenicity of conservative region of the 4 adhensin genes was above 50%. The corresponding protein possessed a relative molecular mass (M r ) of 22 500 as predicted by ANTHEPROT V4.3c software prediction, with excellent antigencity and hydrophobicity. There were 836 767 sequences ana-lyzed with BLAST, in which those with homogenicity of 40% with the identified CB sequence were categorized into H.pylori se-quences. Conclusion There are conservative regions in the 4 adhesin genes with similar homogenicity, suggesting similar mole- cular basis for adhension of the adhesins. Biological information analysis indicates that CB has excellent immunogenicity and strict species specificity.

目的克隆幽门螺杆菌(Helicobacterpylori, Hp)4种黏附素(BabA、AlpA、AlpB和HopZ)的保守区,并对其进行序列及生物信息学分析,为研究Hp黏附素的分子机制和免疫原性提供实验基础。方法利用ANTHEPROT V4.3c 软件分析已证实的Hp4种黏附素蛋白序列,发现共同保守区(命名为CB),推导出其DNA序列,设计CB特异引物,将PCR产物定向插入pET-22b(+)载体,构建保守区的重组克隆。DNA自动分析仪进行序列测定,生物信息学软件对其生物学特性进行分析。结果构建了4种黏附素共同保守区的重组质粒,测序显示CB基因长588 bp,该基因编码195个氨基酸,与4种黏附素保守区的同源性均达50%以上,ANTHEPROT V4.3c软件预测其蛋白质相对分子质量约为22 500,并显示出了良好的抗原性和疏水性。BLAST分析了836 767个序列,与其同源性达40%的均为Hp序列。结论Hp4种黏附素存在同源性接近的保守区,表明其黏附作用可能有相似的分子基础,生物信息学分析表明其具有优良的免疫原性和严格的种属特异性。

The native conformations and thermodynamic properties of compact polymers with chain length N(N≤22) are investigated by using exact enumeration calculation method and Monte Carlo simulation method employing the HP model. The average Helmholtz free energy 〈 F 〉 and average partition function 〈Z〉 can be expressed in the form of 〈F〉=aN+b, ln 〈Z〉=a′N+b′, where N is chain length of compact chains a,b and a′,b′ only depend on temperature. We also find that the compact chains with unique...

The native conformations and thermodynamic properties of compact polymers with chain length N(N≤22) are investigated by using exact enumeration calculation method and Monte Carlo simulation method employing the HP model. The average Helmholtz free energy 〈 F 〉 and average partition function 〈Z〉 can be expressed in the form of 〈F〉=aN+b, ln 〈Z〉=a′N+b′, where N is chain length of compact chains a,b and a′,b′ only depend on temperature. We also find that the compact chains with unique ground states have similar relationship in the thermodynamic property and the chain length. In the HP model, the number of sequences of conformations for a protein of chain length N is 2 N+1 , and the number of sequences with unique ground state may be expressed as N S:N S =a×2 N+1 (a=0 025).In these HP sequences, the sequences with 40%~60% in the percentage of H residue have a large probability of emergence. We find that many structures are the same in those unique ground state, and the values of degeneration of structure are 3 3~4 0 (10≤ N ≤16). In the processing of folding, the change of energy is fast in the beginning of folding, slow in the middle of floding and also fast in the end of folding of proteins.

采用二维HP模型用精确计数法和MonteCarlo方法研究了链长为N(≤ 2 2 )的紧密高分子链的构象和热力学性质 .发现不同HP序列的紧密高分子链的平均自由能和平均配分函数与链长N存在关系 :〈F〉=aN+b , ln〈Z〉=a′N +b′ .同时发现对于可折叠成基态且简并度为 1的紧密高分子链 ,其平均自由能和平均配分函数与链长N也存在相似的关系 .在HP模型中对于链长为N的紧密高分子链 ,存在着 2 N + 1 个不同的HP序列 .我们发现可以折叠成基态且简并度为 1的蛋白质分子的HP序列数目NS 为NS =a× 2 N+ 1   (a =0 0 2 5 ) ,对应的HP序列中 ,疏水基团 (H)数目的含量为 4 0 %~ 6 0 %的序列出现的几率最大 .同时在这些紧密高分子链中有些具有相同的结构 ,发现结构的‘简并度’为 3 3~ 4 0 (10≤N≤ 16 ) .在紧密高分子链折叠过程中 ,折叠的初期能量下降比较快 ,折叠的中期能量下降比较缓慢 ,折叠的后期能量下降也是比较快

Objective: To investigate whether initial periodontal therapy may affect the presence of oral Helicobacter pylori(Hp), and to compare the genotype of Helicobacter pylori in oral cavity and that in stomach. Methods: 56 patients with gastric Hp and periodontitis were enrolled in this study. PCR was carried out to identify the presence of Hp in the samples before and after initial periodontal therapy(group 1) or medicine therapy(group 2). DNA sequence of PCR products of 5 patients and 1 Hp infected patient's...

Objective: To investigate whether initial periodontal therapy may affect the presence of oral Helicobacter pylori(Hp), and to compare the genotype of Helicobacter pylori in oral cavity and that in stomach. Methods: 56 patients with gastric Hp and periodontitis were enrolled in this study. PCR was carried out to identify the presence of Hp in the samples before and after initial periodontal therapy(group 1) or medicine therapy(group 2). DNA sequence of PCR products of 5 patients and 1 Hp infected patient's relative was compared and analyzed. Results: Four weeks after medicine therapy, the rate of Hp in oral cavity was singnificantly lower in group 1 than that in group 2 (3.0% vs 26.1%, P<0.05). An identical sequence of oral and stomach Hp was found in 1 patient, most likely identical in 1 case, difference of 1~4 bases in 2 cases. In 1 case and his family oral Hp showed three different types of DNA sequences. Conclusion: There may be multi- Hp strain existing in oral cavity. Oral colonization of Hp may imply that there is a risk of the relapses of gastric and duodenal Hp infection.

目的 :明确牙周基础治疗与口腔幽门螺杆菌 (Helicobacterpylori ,Hp)存在的关系。分析胃Hp与口腔Hp的基因型 ,以明确胃与口腔的Hp是否具有同源性。 方法 :选择 5 6例有慢性中度牙周炎且胃镜活检Hp感染阳性患者分为 2组。提取所有口腔样本中的DNA ,PCR扩增 ,比较药物治疗组与药物治疗加牙周基础治疗组治疗前后 2组口腔Hp检出率的差别。对比分析其中 5位患者和 1位家属胃和口腔PCR产物的序列。结果 :2组患者不同的治疗后口腔Hp检出率有显著性差别 ( 3 .0 %vs 2 6.1% ,P <0 .0 5 )。胃和口腔Hp的序列相比较 ,相同者 1例 ,可能相同者 1例 ,有 1~ 4个碱基不同者 2例。 1例患者及其家属口腔中均检出Hp ,两者的序列有 3个不同。 结论 :牙周基础治疗有助于口腔Hp的根除。口腔中有可能同时存在多个Hp菌株 ,口腔Hp与胃Hp感染的复发或再感染有关

 
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